HRP20120644T1 - Farmaceutski pripravak - Google Patents
Farmaceutski pripravak Download PDFInfo
- Publication number
- HRP20120644T1 HRP20120644T1 HRP20120644AT HRP20120644T HRP20120644T1 HR P20120644 T1 HRP20120644 T1 HR P20120644T1 HR P20120644A T HRP20120644A T HR P20120644AT HR P20120644 T HRP20120644 T HR P20120644T HR P20120644 T1 HRP20120644 T1 HR P20120644T1
- Authority
- HR
- Croatia
- Prior art keywords
- pharmaceutical preparation
- pharmaceutical composition
- agent
- preparation according
- group containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract 4
- 150000002337 glycosamines Chemical class 0.000 claims abstract 3
- ALLWOAVDORUJLA-UHFFFAOYSA-N Rebamipida Chemical compound C=1C(=O)NC2=CC=CC=C2C=1CC(C(=O)O)NC(=O)C1=CC=C(Cl)C=C1 ALLWOAVDORUJLA-UHFFFAOYSA-N 0.000 claims abstract 2
- 150000001767 cationic compounds Chemical class 0.000 claims abstract 2
- 229910001411 inorganic cation Inorganic materials 0.000 claims abstract 2
- 229950004535 rebamipide Drugs 0.000 claims abstract 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 4
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- 208000003556 Dry Eye Syndromes Diseases 0.000 claims 1
- 206010013774 Dry eye Diseases 0.000 claims 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims 1
- MSWZFWKMSRAUBD-QZABAPFNSA-N beta-D-glucosamine Chemical compound N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-QZABAPFNSA-N 0.000 claims 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims 1
- 239000004327 boric acid Substances 0.000 claims 1
- 229960003511 macrogol Drugs 0.000 claims 1
- 229960003194 meglumine Drugs 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 239000006172 buffering agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Farmaceutski pripravak naznačen time da sadrži (1) rebamipid, (2) amino šećer, te (3) pufersko sredstvo, koje nema anorganski kation. Patent sadrži još 7 patentnih zahtjeva.
Claims (8)
1. Farmaceutski pripravak naznačen time da sadrži (1) rebamipid, (2) amino šećer, te (3) pufersko sredstvo, koje nema anorganski kation.
2. Farmaceutski pripravak prema zahtjevu 1 naznačen time da amino šećer je barem jedan odabran iz skupine koja sadrži D-glukozamin i meglumin.
3. Farmaceutski pripravak prema zahtjevu 1 ili 2 naznačen time da pufersko sredstvo je barem jedno odabrano iz skupine koja sadrži bornu kiselinu, fosfornu kiselinu i amino kiselinu.
4. Farmaceutski pripravak prema bilo kojem zahtjevu 1 do 3, naznačen time da nadalje sadrži sredstvo za podešavanje pH.
5. Farmaceutski pripravak prema bilo kojem zahtjevu 1 do 4, naznačen time da nadalje sadrži sredstvo za rastapanje.
6. Farmaceutski pripravak prema zahtjevu 5 naznačen time da sredstvo za je barem jedno odabrano iz skupine koja sadrži polivinilpirolidon i makrogol.
7. Farmaceutski pripravak prema bilo kojem zahtjevu 1 do 6 naznačen time da farmaceutski pripravak je oftalmološki farmaceutski pripravak.
8. Farmaceutski pripravak prema bilo kojem zahtjevu 1 do 7 naznačen time da je za uporabu kod liječenja suhoće oka pomoću topikalne primjene na oko.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008160084 | 2008-06-19 | ||
PCT/JP2009/061553 WO2009154304A2 (en) | 2008-06-19 | 2009-06-18 | A pharmaceutical composition |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120644T1 true HRP20120644T1 (hr) | 2012-08-31 |
Family
ID=41334556
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HRP20120644AT HRP20120644T1 (hr) | 2008-06-19 | 2012-08-08 | Farmaceutski pripravak |
Country Status (27)
Country | Link |
---|---|
US (1) | US20110124682A1 (hr) |
EP (1) | EP2285413B1 (hr) |
JP (1) | JP5441934B2 (hr) |
KR (1) | KR20110027786A (hr) |
CN (1) | CN102099056B (hr) |
AR (1) | AR072212A1 (hr) |
AU (1) | AU2009261101B2 (hr) |
BR (1) | BRPI0915427A2 (hr) |
CA (1) | CA2725487A1 (hr) |
CO (1) | CO6280502A2 (hr) |
CY (1) | CY1113214T1 (hr) |
DK (1) | DK2285413T3 (hr) |
ES (1) | ES2389583T3 (hr) |
HK (1) | HK1149496A1 (hr) |
HR (1) | HRP20120644T1 (hr) |
IL (1) | IL209329A (hr) |
MX (1) | MX2010013733A (hr) |
MY (1) | MY150558A (hr) |
NZ (1) | NZ589517A (hr) |
PL (1) | PL2285413T3 (hr) |
PT (1) | PT2285413E (hr) |
RU (1) | RU2538694C2 (hr) |
SI (1) | SI2285413T1 (hr) |
TW (1) | TWI495634B (hr) |
UA (1) | UA100164C2 (hr) |
WO (1) | WO2009154304A2 (hr) |
ZA (1) | ZA201008584B (hr) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW201322982A (zh) | 2011-11-01 | 2013-06-16 | Otsuka Pharma Co Ltd | 用於治療前眼疾病之藥劑,該藥劑包含瑞巴派特及眼淚保持劑 |
TW201417814A (zh) * | 2012-09-28 | 2014-05-16 | Otsuka Pharma Co Ltd | 包括瑞巴派特之醫藥組成物 |
KR101692578B1 (ko) * | 2013-04-18 | 2017-01-03 | 삼진제약주식회사 | 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물 |
WO2015034008A1 (ja) * | 2013-09-05 | 2015-03-12 | 大塚製薬株式会社 | レバミピドの局所止血用途 |
JP6854587B2 (ja) * | 2015-04-17 | 2021-04-07 | ロート製薬株式会社 | 医薬製剤 |
KR20170039347A (ko) * | 2015-10-01 | 2017-04-11 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
KR102307958B1 (ko) | 2015-10-01 | 2021-10-05 | 삼진제약주식회사 | 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법 |
US11324829B2 (en) | 2016-03-14 | 2022-05-10 | Santen Pharmaceutical Co., Ltd. | Antiseptic agent comprising meglumine or salt thereof |
CN106491530B (zh) * | 2016-12-13 | 2019-11-29 | 湖北远大天天明制药有限公司 | 一种眼用药物组合物 |
KR101840256B1 (ko) * | 2017-09-21 | 2018-03-21 | 대우제약 주식회사 | 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법 |
KR101923519B1 (ko) * | 2018-06-26 | 2019-02-27 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
KR20200019451A (ko) | 2018-08-14 | 2020-02-24 | 대우제약 주식회사 | 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법 |
JP6744952B2 (ja) * | 2019-05-28 | 2020-08-19 | ロート製薬株式会社 | 眼科用組成物 |
KR102615076B1 (ko) | 2021-07-14 | 2023-12-19 | 대우제약 주식회사 | 안정한 레바미피드 점안제의 대용량 제조 방법 |
KR102659338B1 (ko) | 2023-05-18 | 2024-04-19 | 국제약품 주식회사 | 안구건조증 치료용 약제학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR004214A1 (es) * | 1995-10-12 | 1998-11-04 | Otsuka Pharma Co Ltd | Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas |
JP3093661B2 (ja) * | 1995-10-12 | 2000-10-03 | 大塚製薬株式会社 | 眼疾患治療剤 |
CN1413112A (zh) * | 1999-11-11 | 2003-04-23 | 武田药品工业株式会社 | 含有稠合哒嗪衍生物的滴鼻剂 |
TWI340650B (en) * | 2004-01-21 | 2011-04-21 | Otsuka Pharma Co Ltd | Amine saly of carbostyril derivative |
TWI363626B (en) * | 2004-11-15 | 2012-05-11 | Otsuka Pharma Co Ltd | Aqueous ophthalmic suspension of crystalline rebamipide |
TWI415629B (zh) * | 2006-10-26 | 2013-11-21 | Otsuka Pharma Co Ltd | 含有瑞巴匹特之水性醫藥懸浮物及其製造方法 |
-
2009
- 2009-06-18 DK DK09766752.1T patent/DK2285413T3/da active
- 2009-06-18 KR KR1020117001269A patent/KR20110027786A/ko active IP Right Grant
- 2009-06-18 PT PT09766752T patent/PT2285413E/pt unknown
- 2009-06-18 MY MYPI20105480 patent/MY150558A/en unknown
- 2009-06-18 AU AU2009261101A patent/AU2009261101B2/en not_active Ceased
- 2009-06-18 SI SI200930313T patent/SI2285413T1/sl unknown
- 2009-06-18 CA CA2725487A patent/CA2725487A1/en not_active Abandoned
- 2009-06-18 US US12/999,967 patent/US20110124682A1/en not_active Abandoned
- 2009-06-18 PL PL09766752T patent/PL2285413T3/pl unknown
- 2009-06-18 MX MX2010013733A patent/MX2010013733A/es active IP Right Grant
- 2009-06-18 ES ES09766752T patent/ES2389583T3/es active Active
- 2009-06-18 CN CN200980122871.8A patent/CN102099056B/zh not_active Expired - Fee Related
- 2009-06-18 NZ NZ589517A patent/NZ589517A/xx not_active IP Right Cessation
- 2009-06-18 UA UAA201100566A patent/UA100164C2/ru unknown
- 2009-06-18 RU RU2011101713/15A patent/RU2538694C2/ru not_active IP Right Cessation
- 2009-06-18 WO PCT/JP2009/061553 patent/WO2009154304A2/en active Application Filing
- 2009-06-18 EP EP09766752A patent/EP2285413B1/en not_active Not-in-force
- 2009-06-18 JP JP2010549965A patent/JP5441934B2/ja not_active Expired - Fee Related
- 2009-06-18 BR BRPI0915427A patent/BRPI0915427A2/pt not_active IP Right Cessation
- 2009-06-18 TW TW098120372A patent/TWI495634B/zh not_active IP Right Cessation
- 2009-06-19 AR ARP090102253A patent/AR072212A1/es unknown
-
2010
- 2010-11-15 IL IL209329A patent/IL209329A/en not_active IP Right Cessation
- 2010-11-30 ZA ZA2010/08584A patent/ZA201008584B/en unknown
-
2011
- 2011-01-19 CO CO11005099A patent/CO6280502A2/es not_active Application Discontinuation
- 2011-04-14 HK HK11103774.3A patent/HK1149496A1/xx not_active IP Right Cessation
-
2012
- 2012-08-08 HR HRP20120644AT patent/HRP20120644T1/hr unknown
- 2012-10-16 CY CY20121100960T patent/CY1113214T1/el unknown
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