BR112015006726A2 - Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica - Google Patents

Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica

Info

Publication number
BR112015006726A2
BR112015006726A2 BR112015006726A BR112015006726A BR112015006726A2 BR 112015006726 A2 BR112015006726 A2 BR 112015006726A2 BR 112015006726 A BR112015006726 A BR 112015006726A BR 112015006726 A BR112015006726 A BR 112015006726A BR 112015006726 A2 BR112015006726 A2 BR 112015006726A2
Authority
BR
Brazil
Prior art keywords
compound
pharmaceutical composition
kinases
pharmaceutically acceptable
compositions
Prior art date
Application number
BR112015006726A
Other languages
English (en)
Other versions
BR112015006726B1 (pt
Inventor
Xi Ning
Original Assignee
Calitor Sciences Llc
Sunshine Lake Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calitor Sciences Llc, Sunshine Lake Pharma Co Ltd filed Critical Calitor Sciences Llc
Priority to BR122021014786-8A priority Critical patent/BR122021014786B1/pt
Publication of BR112015006726A2 publication Critical patent/BR112015006726A2/pt
Publication of BR112015006726B1 publication Critical patent/BR112015006726B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPOSTO, COMPOSIÇÃO FARMACÊUTICA, E, USO DE UM COMPOSTO OU DE UMA COMPOSIÇÃO FARMACÊUTICA. A presente invenção fornece derivados heteroaromáticos e sais farmacêuticos aceitáveis e formulações dos mesmos úteis na modulação da atividade da proteína cinase, especialmente fosfatidilinositol 3-cinases (PI3 cinases) e mTOR e na modulação das atividades de sinalização inter- e/ou intracelulares tais como proliferação, diferenciação, apoptose, migração e invasão. A invenção também fornece composições farmaceuticamente aceitáveis que compreendem tais compostos e métodos de usar as composições no tratamento de distúrbios hiperproliferativos em mamíferos, especialmente seres humanos.
BR112015006726-3A 2012-11-14 2013-11-10 Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica BR112015006726B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122021014786-8A BR122021014786B1 (pt) 2012-11-14 2013-11-10 Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261726139P 2012-11-14 2012-11-14
US61/726139 2012-11-14
PCT/US2013/069366 WO2014078211A1 (en) 2012-11-14 2013-11-10 Heteroaromatic compounds as pi3 kinase modulators and methods of use

Publications (2)

Publication Number Publication Date
BR112015006726A2 true BR112015006726A2 (pt) 2017-08-22
BR112015006726B1 BR112015006726B1 (pt) 2021-11-23

Family

ID=50681898

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015006726-3A BR112015006726B1 (pt) 2012-11-14 2013-11-10 Composto, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica

Country Status (16)

Country Link
US (1) US9926324B2 (pt)
EP (2) EP2919784B1 (pt)
JP (1) JP6268183B2 (pt)
KR (1) KR102148679B1 (pt)
CN (1) CN104755085B (pt)
AU (1) AU2013345107B2 (pt)
BR (1) BR112015006726B1 (pt)
CA (1) CA2889346C (pt)
ES (1) ES2661380T3 (pt)
HK (1) HK1210956A1 (pt)
MY (1) MY180641A (pt)
RU (1) RU2665036C9 (pt)
SG (1) SG11201502725TA (pt)
TW (1) TWI574962B (pt)
WO (1) WO2014078211A1 (pt)
ZA (1) ZA201502575B (pt)

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CN104496940B (zh) * 2014-01-06 2017-03-15 广东东阳光药业有限公司 一种制备bcr‑abl抑制剂中间体的方法
WO2015192761A1 (zh) * 2014-06-17 2015-12-23 辰欣药业股份有限公司 作为mTOR/PI3K抑制剂的吡啶并[1,2-a]嘧啶酮类似物
CN105503877A (zh) 2014-09-24 2016-04-20 和记黄埔医药（上海）有限公司 咪唑并哒嗪类化合物及其用途
BR112017013031A2 (pt) 2014-12-19 2018-01-02 Janssen Pharmaceutica Nv derivados de imidazopiridazina ligados à heterociclila como inibidores de pi3kbeta
WO2016097347A1 (en) * 2014-12-19 2016-06-23 Janssen Pharmaceutica Nv IMIDAZOPYRIDAZINE DERIVATIVES AS ΡΙ3Κβ INHIBITORS
EP3472160B1 (en) * 2016-06-16 2021-02-24 Janssen Pharmaceutica NV Bicyclic pyridine, pyrazine, and pyrimidine derivatives as pi3k beta inhibitors
WO2018017633A1 (en) 2016-07-21 2018-01-25 Bristol-Myers Squibb Company TGF Beta RECEPTOR ANTAGONISTS
JP2019534266A (ja) 2016-10-14 2019-11-28 江蘇恒瑞医薬股▲ふん▼有限公司 ５員ヘテロアリール環の架橋した環誘導体、その製造方法およびその医学的使用
CN108164525B (zh) * 2016-12-08 2020-09-08 沈阳药科大学 一种抗肿瘤化合物的制备方法和用途
JP7300394B2 (ja) 2017-01-17 2023-06-29 ヘパリジェニックス ゲーエムベーハー 肝再生の促進又は肝細胞死の低減もしくは予防のためのプロテインキナーゼ阻害
FR3064364A1 (fr) * 2017-03-27 2018-09-28 S.P.C.M. Sa Methode de dosage de polymeres cationiques
CN118201896A (zh) * 2021-09-10 2024-06-14 传达治疗有限公司 PI3K-α抑制剂和其使用方法
TW202400175A (zh) * 2022-05-10 2024-01-01 美商傳達治療有限公司 PI3Kα抑制劑及其使用方法

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Also Published As

Publication number Publication date
CA2889346A1 (en) 2014-05-22
BR112015006726B1 (pt) 2021-11-23
WO2014078211A1 (en) 2014-05-22
RU2665036C9 (ru) 2018-11-12
EP3299019B1 (en) 2019-10-09
AU2013345107A1 (en) 2015-04-30
JP6268183B2 (ja) 2018-01-24
KR20150083833A (ko) 2015-07-20
TWI574962B (zh) 2017-03-21
CN104755085A (zh) 2015-07-01
JP2015536994A (ja) 2015-12-24
EP2919784A4 (en) 2016-07-06
EP2919784B1 (en) 2017-12-20
HK1210956A1 (en) 2016-05-13
MY180641A (en) 2020-12-04
RU2665036C2 (ru) 2018-08-27
ES2661380T3 (es) 2018-03-28
EP2919784A1 (en) 2015-09-23
US9926324B2 (en) 2018-03-27
CA2889346C (en) 2018-09-25
EP3299019A1 (en) 2018-03-28
RU2015116102A (ru) 2017-01-10
SG11201502725TA (en) 2015-05-28
TW201422615A (zh) 2014-06-16
KR102148679B1 (ko) 2020-08-27
US20140134133A1 (en) 2014-05-15
ZA201502575B (en) 2016-11-30
AU2013345107B2 (en) 2016-02-25
CN104755085B (zh) 2018-05-01

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
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