BR112017005209A2 - compostos moduladores de pirrolopiridina substituída por metila e trifluorometila de rorc2 e seu uso - Google Patents

compostos moduladores de pirrolopiridina substituída por metila e trifluorometila de rorc2 e seu uso

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Publication number
BR112017005209A2
BR112017005209A2 BR112017005209A BR112017005209A BR112017005209A2 BR 112017005209 A2 BR112017005209 A2 BR 112017005209A2 BR 112017005209 A BR112017005209 A BR 112017005209A BR 112017005209 A BR112017005209 A BR 112017005209A BR 112017005209 A2 BR112017005209 A2 BR 112017005209A2
Authority
BR
Brazil
Prior art keywords
methyl
rorc2
trifluoromethyl substituted
modulating compounds
substituted pyrrolopyridine
Prior art date
Application number
BR112017005209A
Other languages
English (en)
Inventor
Christopher Flick Andrew
Zamaratski Edouard
Mattias Wennerstål Göran
David Trzupek John
Xing Li
Zhang Liying
Edward Schnute Mark
L Vazquez Michael
Kaila Neelu
Jones Peter
Richard Mente Scot
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to BR122017023934A priority Critical patent/BR122017023934A2/pt
Publication of BR112017005209A2 publication Critical patent/BR112017005209A2/pt

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K5/00—Feeding devices for stock or game ; Feeding wagons; Feeding stacks
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K7/00—Watering equipment for stock or game
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A23K50/48—Moist feed
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • B65D2577/00—Packages formed by enclosing articles or materials in preformed containers, e.g. boxes, cartons, sacks, bags
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    • B65D85/00—Containers, packaging elements or packages, specially adapted for particular articles or materials
    • B65D85/70—Containers, packaging elements or packages, specially adapted for particular articles or materials for materials not otherwise provided for

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Mechanical Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Zoology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Food Science & Technology (AREA)
  • Birds (AREA)
  • Ceramic Engineering (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)

Abstract

a presente invenção refere-se a pirrolopiridinas substituídas por metila e trifluorometila, suas composições farmacêuticas, métodos de modulação da atividade de ror¿ e/ou redução da quantidade de il-17 em um indivíduo, e métodos de tratamento de vários distúrbios médicos utilizando tais pirrolopiridinas e suas composições farmacêuticas.
BR112017005209A 2014-09-26 2015-09-22 compostos moduladores de pirrolopiridina substituída por metila e trifluorometila de rorc2 e seu uso BR112017005209A2 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122017023934A BR122017023934A2 (pt) 2014-09-26 2015-09-22 composto modulador de pirrolopiridina substituída por metila e trifluorometila, composição e uso

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462055811P 2014-09-26 2014-09-26
US201562110048P 2015-01-30 2015-01-30
US201562209124P 2015-08-24 2015-08-24
PCT/IB2015/057314 WO2016046755A1 (en) 2014-09-26 2015-09-22 Methyl-and trifluoromethyl-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof

Publications (1)

Publication Number Publication Date
BR112017005209A2 true BR112017005209A2 (pt) 2017-12-12

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BR122017023934A BR122017023934A2 (pt) 2014-09-26 2015-09-22 composto modulador de pirrolopiridina substituída por metila e trifluorometila, composição e uso
BR112017005209A BR112017005209A2 (pt) 2014-09-26 2015-09-22 compostos moduladores de pirrolopiridina substituída por metila e trifluorometila de rorc2 e seu uso

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US (5) US9670201B2 (pt)
EP (1) EP3197882A1 (pt)
JP (1) JP6224870B2 (pt)
KR (1) KR101933328B1 (pt)
CN (1) CN106715416B (pt)
AP (1) AP2017009800A0 (pt)
AU (2) AU2015323380B2 (pt)
BR (2) BR122017023934A2 (pt)
CA (1) CA2905407A1 (pt)
CL (1) CL2017000716A1 (pt)
CO (1) CO2017002427A2 (pt)
CR (1) CR20170108A (pt)
CU (1) CU24407B1 (pt)
DO (1) DOP2017000087A (pt)
EA (1) EA030635B1 (pt)
GE (1) GEP20186927B (pt)
GT (1) GT201700063A (pt)
IL (1) IL250675A0 (pt)
MA (1) MA40759A (pt)
MD (1) MD20170027A2 (pt)
MX (1) MX2017003956A (pt)
NI (1) NI201700031A (pt)
NZ (1) NZ729252A (pt)
PE (1) PE20170703A1 (pt)
PH (1) PH12017500494A1 (pt)
SG (1) SG11201701329QA (pt)
SV (1) SV2017005395A (pt)
TN (1) TN2017000074A1 (pt)
TW (1) TWI583685B (pt)
UA (1) UA119569C2 (pt)
UY (1) UY36322A (pt)
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ZA (2) ZA201701292B (pt)

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MA40759A (fr) 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
WO2016120850A1 (en) 2015-01-30 2016-08-04 Pfizer Inc. Sulfonamide-subsituted indole modulators of rorc2 and methods of use thereof
US10336748B2 (en) 2015-01-30 2019-07-02 Pfizer Inc. Methyoxy-substituted pyrrolopyridine modulators of RORC2 and methods of use thereof
CN109071516B (zh) 2015-12-15 2021-08-31 阿斯利康(瑞典)有限公司 新颖的化合物
CN105753866A (zh) * 2016-04-05 2016-07-13 叶芳 一种4-卤素-7-氮杂吲哚及其制备方法
EP3638661A1 (en) 2017-06-14 2020-04-22 Astrazeneca AB 2,3-dihydroisoindole-1-carboxamides useful as ror-gamma modulators
CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
KR20200094493A (ko) 2019-01-30 2020-08-07 김남형 음성사후분포그램추출기와 tts 및 보코더를 이용한 음성 변조 어플리케이션의 동작방법
US20230242537A1 (en) * 2020-04-30 2023-08-03 Janssen Pharmaceutica Nv Imidazopyrimidines as modulators of il-17
CN114591137B (zh) * 2022-05-10 2022-09-09 上海赛默罗生物科技有限公司 螺桨烷类衍生物的合成方法
WO2023232870A1 (en) 2022-05-31 2023-12-07 Immunic Ag Rorg/rorgt modulators for the treatment of virus infections like covid-19

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