CY1113214T1 - Φαρμακευτικη συνθεση - Google Patents

Φαρμακευτικη συνθεση

Info

Publication number
CY1113214T1
CY1113214T1 CY20121100960T CY121100960T CY1113214T1 CY 1113214 T1 CY1113214 T1 CY 1113214T1 CY 20121100960 T CY20121100960 T CY 20121100960T CY 121100960 T CY121100960 T CY 121100960T CY 1113214 T1 CY1113214 T1 CY 1113214T1
Authority
CY
Cyprus
Prior art keywords
pharmaceutical composition
present
rhamamipide
revamipide
cornea
Prior art date
Application number
CY20121100960T
Other languages
English (en)
Inventor
Shun-Ichiro Sumida
Shinichi Ishikawa
Original Assignee
Otsuka Pharmaceutical Co., Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co., Ltd filed Critical Otsuka Pharmaceutical Co., Ltd
Publication of CY1113214T1 publication Critical patent/CY1113214T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Ενα αντικείμενο της παρούσας εφεύρεσης είναι να παράσχει μια φαρμακευτική σύνθεση η οποία περιέχει ρεβαμιπίδη, η οποία δεν είναι απαραίτητο να επαναδιασπαρεί, έχει επαρκή διαφάνεια, και εμφανίζει ουδέτερο έως ασθενώς όξινο pΗ για να μη βλάπτει τον κερατοειδοεπιπεφυκότα ενός ασθενούς που πάσχει από ξηροφθαλμία. Η παρούσα φαρμακευτική σύνθεση περιέχει (1) ρεβαμιπίδη, (2) ένα αμινοσάκχαρο και (3) ένα ρυθμιστικό μέσον, το οποίο δεν έχει ανόργανο κατιόν.
CY20121100960T 2008-06-19 2012-10-16 Φαρμακευτικη συνθεση CY1113214T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2008160084 2008-06-19
EP09766752A EP2285413B1 (en) 2008-06-19 2009-06-18 A pharmaceutical composition

Publications (1)

Publication Number Publication Date
CY1113214T1 true CY1113214T1 (el) 2016-04-13

Family

ID=41334556

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100960T CY1113214T1 (el) 2008-06-19 2012-10-16 Φαρμακευτικη συνθεση

Country Status (27)

Country Link
US (1) US20110124682A1 (el)
EP (1) EP2285413B1 (el)
JP (1) JP5441934B2 (el)
KR (1) KR20110027786A (el)
CN (1) CN102099056B (el)
AR (1) AR072212A1 (el)
AU (1) AU2009261101B2 (el)
BR (1) BRPI0915427A2 (el)
CA (1) CA2725487A1 (el)
CO (1) CO6280502A2 (el)
CY (1) CY1113214T1 (el)
DK (1) DK2285413T3 (el)
ES (1) ES2389583T3 (el)
HK (1) HK1149496A1 (el)
HR (1) HRP20120644T1 (el)
IL (1) IL209329A (el)
MX (1) MX2010013733A (el)
MY (1) MY150558A (el)
NZ (1) NZ589517A (el)
PL (1) PL2285413T3 (el)
PT (1) PT2285413E (el)
RU (1) RU2538694C2 (el)
SI (1) SI2285413T1 (el)
TW (1) TWI495634B (el)
UA (1) UA100164C2 (el)
WO (1) WO2009154304A2 (el)
ZA (1) ZA201008584B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201322982A (zh) * 2011-11-01 2013-06-16 Otsuka Pharma Co Ltd 用於治療前眼疾病之藥劑，該藥劑包含瑞巴派特及眼淚保持劑
TW201417814A (zh) * 2012-09-28 2014-05-16 Otsuka Pharma Co Ltd 包括瑞巴派特之醫藥組成物
KR101692578B1 (ko) * 2013-04-18 2017-01-03 삼진제약주식회사 레바미피드 또는 이의 전구체를 포함하는 안구건조증의 예방 또는 치료를 위한 경구용 약제학적 조성물
WO2015034008A1 (ja) * 2013-09-05 2015-03-12 大塚製薬株式会社 レバミピドの局所止血用途
JP6854587B2 (ja) * 2015-04-17 2021-04-07 ロート製薬株式会社 医薬製剤
KR102307958B1 (ko) 2015-10-01 2021-10-05 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
KR20170039347A (ko) * 2015-10-01 2017-04-11 삼진제약주식회사 레바미피드를 함유하는 신규한 점안 조성물 및 이의 제조방법
CA3016809C (en) 2016-03-14 2024-03-12 Santen Pharmaceutical Co., Ltd. Antiseptic agent comprising meglumine or salt thereof
CN106491530B (zh) * 2016-12-13 2019-11-29 湖北远大天天明制药有限公司 一种眼用药物组合物
KR101840256B1 (ko) * 2017-09-21 2018-03-21 대우제약 주식회사 레바미피드를 함유하는 새로운 안구건조증 치료용 점안 조성물 및 이의 가용화 및 안정화 방법
KR101923519B1 (ko) * 2018-06-26 2019-02-27 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
KR20200019451A (ko) 2018-08-14 2020-02-24 대우제약 주식회사 레바미피드를 함유하는 안구 건조증 치료용 수용성 다회용 점안제 조성물 및 이의 가용화 및 안정화 방법
JP6744952B2 (ja) * 2019-05-28 2020-08-19 ロート製薬株式会社 眼科用組成物
KR102615076B1 (ko) 2021-07-14 2023-12-19 대우제약 주식회사 안정한 레바미피드 점안제의 대용량 제조 방법
KR102659338B1 (ko) 2023-05-18 2024-04-19 국제약품 주식회사 안구건조증 치료용 약제학적 조성물

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3093661B2 (ja) * 1995-10-12 2000-10-03 大塚製薬株式会社 眼疾患治療剤
AR004214A1 (es) * 1995-10-12 1998-11-04 Otsuka Pharma Co Ltd Una preparación de gotas oftálmicas para la cura de enfermedades oftálmicas
EP1243271A1 (en) * 1999-11-11 2002-09-25 Takeda Chemical Industries, Ltd. Nasal drops containing fused pyridazine derivatives
TWI340650B (en) * 2004-01-21 2011-04-21 Otsuka Pharma Co Ltd Amine saly of carbostyril derivative
TWI363626B (en) * 2004-11-15 2012-05-11 Otsuka Pharma Co Ltd Aqueous ophthalmic suspension of crystalline rebamipide
TWI415629B (zh) * 2006-10-26 2013-11-21 Otsuka Pharma Co Ltd 含有瑞巴匹特之水性醫藥懸浮物及其製造方法

Also Published As

Publication number Publication date
NZ589517A (en) 2012-09-28
BRPI0915427A2 (pt) 2015-11-03
HK1149496A1 (en) 2011-10-07
RU2538694C2 (ru) 2015-01-10
AR072212A1 (es) 2010-08-11
JP5441934B2 (ja) 2014-03-12
IL209329A0 (en) 2011-01-31
HRP20120644T1 (hr) 2012-08-31
MY150558A (en) 2014-01-30
EP2285413A2 (en) 2011-02-23
MX2010013733A (es) 2011-01-21
CN102099056A (zh) 2011-06-15
DK2285413T3 (da) 2012-08-27
RU2011101713A (ru) 2012-07-27
TWI495634B (zh) 2015-08-11
CO6280502A2 (es) 2011-05-20
AU2009261101B2 (en) 2013-11-07
IL209329A (en) 2014-09-30
ES2389583T3 (es) 2012-10-29
SI2285413T1 (sl) 2012-09-28
PL2285413T3 (pl) 2013-01-31
AU2009261101A1 (en) 2009-12-23
CA2725487A1 (en) 2009-12-23
KR20110027786A (ko) 2011-03-16
CN102099056B (zh) 2014-10-01
US20110124682A1 (en) 2011-05-26
PT2285413E (pt) 2012-09-07
ZA201008584B (en) 2012-01-25
WO2009154304A3 (en) 2010-12-02
WO2009154304A2 (en) 2009-12-23
EP2285413B1 (en) 2012-08-08
UA100164C2 (ru) 2012-11-26
JP2011524854A (ja) 2011-09-08
TW201006800A (en) 2010-02-16

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