HRP20120517T1 - Postupak priprave derivata halobifenil ilciklopropanekarboksilne kiseline - Google Patents
Postupak priprave derivata halobifenil ilciklopropanekarboksilne kiseline Download PDFInfo
- Publication number
- HRP20120517T1 HRP20120517T1 HRP20120517AT HRP20120517T HRP20120517T1 HR P20120517 T1 HRP20120517 T1 HR P20120517T1 HR P20120517A T HRP20120517A T HR P20120517AT HR P20120517 T HRP20120517 T HR P20120517T HR P20120517 T1 HRP20120517 T1 HR P20120517T1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- formula
- fluoro
- dichloro
- biphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08158022A EP2133322A1 (en) | 2008-06-11 | 2008-06-11 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| PCT/EP2009/003288 WO2009149797A1 (en) | 2008-06-11 | 2009-05-08 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120517T1 true HRP20120517T1 (hr) | 2012-07-31 |
Family
ID=40120119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20120517AT HRP20120517T1 (hr) | 2008-06-11 | 2009-05-08 | Postupak priprave derivata halobifenil ilciklopropanekarboksilne kiseline |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8076505B2 (enExample) |
| EP (2) | EP2133322A1 (enExample) |
| JP (1) | JP5642067B2 (enExample) |
| KR (1) | KR101257217B1 (enExample) |
| CN (1) | CN102046576B (enExample) |
| AT (1) | ATE552230T1 (enExample) |
| AU (1) | AU2009256959B2 (enExample) |
| BR (1) | BRPI0909560A2 (enExample) |
| CA (1) | CA2723878C (enExample) |
| CO (1) | CO6331461A2 (enExample) |
| DK (1) | DK2285765T3 (enExample) |
| ES (1) | ES2384368T3 (enExample) |
| GE (1) | GEP20135800B (enExample) |
| HR (1) | HRP20120517T1 (enExample) |
| IL (1) | IL209209A (enExample) |
| MA (1) | MA32297B1 (enExample) |
| ME (1) | ME01160B (enExample) |
| MX (1) | MX2010012285A (enExample) |
| MY (1) | MY150280A (enExample) |
| NZ (1) | NZ589087A (enExample) |
| PL (1) | PL2285765T3 (enExample) |
| PT (1) | PT2285765E (enExample) |
| RU (1) | RU2502721C2 (enExample) |
| SI (1) | SI2285765T1 (enExample) |
| UA (1) | UA101835C2 (enExample) |
| WO (1) | WO2009149797A1 (enExample) |
| ZA (1) | ZA201007977B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101088272B1 (ko) * | 2003-02-21 | 2011-11-30 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산추출물 |
| JP5996428B2 (ja) * | 2009-08-04 | 2016-09-21 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | １−（２−ハロビフェニル−４−イル）−シクロプロパンカルボン酸の誘導体の調製方法 |
| CA2794940A1 (en) | 2010-04-01 | 2011-10-06 | Chiesi Farmaceutici S.P.A. | Novel polymorphs and salts |
| KR20130079353A (ko) * | 2010-04-21 | 2013-07-10 | 키에시 파르마슈티시 엣스. 피. 에이. | 트랜스티레틴 아밀로이드증 치료용 1-(2-플루오로비페닐-4-일)-알킬 카복실산 유도체 |
| EP2575797A1 (en) | 2010-06-04 | 2013-04-10 | Chiesi Farmaceutici S.p.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases |
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| AR090581A1 (es) | 2012-04-04 | 2014-11-19 | Chiesi Farma Spa | Derivados de acidos 1-(2-halo-bifenil-4-il)-alcancarboxilicos para el tratamiento de enfermedades neurodegenerativas |
| CN105658615A (zh) * | 2013-06-24 | 2016-06-08 | 奇斯药制品公司 | 用于制备1-(2-氟[1,1′-联苯]-4-基)-环丙烷甲酸衍生物的改进方法 |
| EP2818460A1 (en) | 2013-06-24 | 2014-12-31 | ZaCh System S.p.A. | Cyclopropanation of substituted phenylacetonitriles or phenyl acetates |
| US20150335596A1 (en) | 2014-05-26 | 2015-11-26 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
| CN107698462A (zh) * | 2017-10-10 | 2018-02-16 | 重庆科脉生物化工有限公司 | 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法 |
| CA3230151A1 (en) | 2021-08-31 | 2023-03-09 | Cerespir Incorporated | Co-crystals |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4507294B2 (ja) * | 1999-05-27 | 2010-07-21 | チッソ株式会社 | ビアリール誘導体の製造方法 |
| JP4502293B2 (ja) * | 1999-06-04 | 2010-07-14 | 長瀬産業株式会社 | 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用 |
| JP2004091342A (ja) * | 2002-08-29 | 2004-03-25 | Matsushita Electric Ind Co Ltd | 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子 |
| KR101088272B1 (ko) * | 2003-02-21 | 2011-11-30 | 키에시 파르마슈티시 엣스. 피. 에이. | 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산추출물 |
| ITMI20030311A1 (it) * | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| AU2006257670A1 (en) * | 2005-06-14 | 2006-12-21 | Merck Frosst Canada Ltd | Reversible inhibitors of monoamine oxidase A and B |
| JP5272345B2 (ja) * | 2006-08-28 | 2013-08-28 | 東ソー株式会社 | ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法 |
| JP5996428B2 (ja) * | 2009-08-04 | 2016-09-21 | シエシー ファルマセウティチィ ソシエタ ペル アチオニ | １−（２−ハロビフェニル−４−イル）−シクロプロパンカルボン酸の誘導体の調製方法 |
-
2008
- 2008-06-11 EP EP08158022A patent/EP2133322A1/en not_active Withdrawn
-
2009
- 2009-05-08 PL PL09761360T patent/PL2285765T3/pl unknown
- 2009-05-08 NZ NZ589087A patent/NZ589087A/en not_active IP Right Cessation
- 2009-05-08 RU RU2010146299/04A patent/RU2502721C2/ru not_active IP Right Cessation
- 2009-05-08 AU AU2009256959A patent/AU2009256959B2/en not_active Ceased
- 2009-05-08 EP EP09761360A patent/EP2285765B1/en active Active
- 2009-05-08 MX MX2010012285A patent/MX2010012285A/es active IP Right Grant
- 2009-05-08 ES ES09761360T patent/ES2384368T3/es active Active
- 2009-05-08 ME MEP-2010-200A patent/ME01160B/me unknown
- 2009-05-08 GE GEAP200911997A patent/GEP20135800B/en unknown
- 2009-05-08 AT AT09761360T patent/ATE552230T1/de active
- 2009-05-08 DK DK09761360.8T patent/DK2285765T3/da active
- 2009-05-08 MY MYPI2010005220A patent/MY150280A/en unknown
- 2009-05-08 KR KR1020107027903A patent/KR101257217B1/ko not_active Expired - Fee Related
- 2009-05-08 JP JP2011512846A patent/JP5642067B2/ja not_active Expired - Fee Related
- 2009-05-08 HR HRP20120517AT patent/HRP20120517T1/hr unknown
- 2009-05-08 PT PT09761360T patent/PT2285765E/pt unknown
- 2009-05-08 BR BRPI0909560A patent/BRPI0909560A2/pt not_active IP Right Cessation
- 2009-05-08 SI SI200930272T patent/SI2285765T1/sl unknown
- 2009-05-08 CA CA2723878A patent/CA2723878C/en active Active
- 2009-05-08 WO PCT/EP2009/003288 patent/WO2009149797A1/en not_active Ceased
- 2009-05-08 UA UAA201013287A patent/UA101835C2/uk unknown
- 2009-05-08 CN CN2009801196647A patent/CN102046576B/zh not_active Expired - Fee Related
- 2009-05-15 US US12/466,660 patent/US8076505B2/en active Active
-
2010
- 2010-11-08 ZA ZA2010/07977A patent/ZA201007977B/en unknown
- 2010-11-09 IL IL209209A patent/IL209209A/en not_active IP Right Cessation
- 2010-11-11 MA MA33338A patent/MA32297B1/fr unknown
- 2010-11-16 CO CO10143043A patent/CO6331461A2/es active IP Right Grant
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