BRPI0909560A2 - processo de preparação de derivaods de ácido 1-(2-halo-bifenil-4-il)-ciclopropano carboxílico - Google Patents

processo de preparação de derivaods de ácido 1-(2-halo-bifenil-4-il)-ciclopropano carboxílico

Info

Publication number
BRPI0909560A2
BRPI0909560A2 BRPI0909560A BRPI0909560A BRPI0909560A2 BR PI0909560 A2 BRPI0909560 A2 BR PI0909560A2 BR PI0909560 A BRPI0909560 A BR PI0909560A BR PI0909560 A BRPI0909560 A BR PI0909560A BR PI0909560 A2 BRPI0909560 A2 BR PI0909560A2
Authority
BR
Brazil
Prior art keywords
preparing
biphenyl
halo
carboxylic acid
acid derivative
Prior art date
Application number
BRPI0909560A
Other languages
English (en)
Portuguese (pt)
Inventor
Benoit Folleas
Fausto Pivetti
Hubert Botte
Thomas Delacroix
Original Assignee
Chiesi Farma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farma Spa filed Critical Chiesi Farma Spa
Publication of BRPI0909560A2 publication Critical patent/BRPI0909560A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0909560A 2008-06-11 2009-05-08 processo de preparação de derivaods de ácido 1-(2-halo-bifenil-4-il)-ciclopropano carboxílico BRPI0909560A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08158022A EP2133322A1 (en) 2008-06-11 2008-06-11 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
PCT/EP2009/003288 WO2009149797A1 (en) 2008-06-11 2009-05-08 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number Publication Date
BRPI0909560A2 true BRPI0909560A2 (pt) 2015-09-22

Family

ID=40120119

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0909560A BRPI0909560A2 (pt) 2008-06-11 2009-05-08 processo de preparação de derivaods de ácido 1-(2-halo-bifenil-4-il)-ciclopropano carboxílico

Country Status (27)

Country Link
US (1) US8076505B2 (enExample)
EP (2) EP2133322A1 (enExample)
JP (1) JP5642067B2 (enExample)
KR (1) KR101257217B1 (enExample)
CN (1) CN102046576B (enExample)
AT (1) ATE552230T1 (enExample)
AU (1) AU2009256959B2 (enExample)
BR (1) BRPI0909560A2 (enExample)
CA (1) CA2723878C (enExample)
CO (1) CO6331461A2 (enExample)
DK (1) DK2285765T3 (enExample)
ES (1) ES2384368T3 (enExample)
GE (1) GEP20135800B (enExample)
HR (1) HRP20120517T1 (enExample)
IL (1) IL209209A (enExample)
MA (1) MA32297B1 (enExample)
ME (1) ME01160B (enExample)
MX (1) MX2010012285A (enExample)
MY (1) MY150280A (enExample)
NZ (1) NZ589087A (enExample)
PL (1) PL2285765T3 (enExample)
PT (1) PT2285765E (enExample)
RU (1) RU2502721C2 (enExample)
SI (1) SI2285765T1 (enExample)
UA (1) UA101835C2 (enExample)
WO (1) WO2009149797A1 (enExample)
ZA (1) ZA201007977B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法
KR20130036210A (ko) * 2010-04-01 2013-04-11 키에시 파르마슈티시 엣스. 피. 에이. 신규 다형체 및 염
ES2526522T3 (es) * 2010-04-21 2015-01-13 Chiesi Farmaceutici S.P.A. Derivados del ácido 1-(2-fluorobifenil-4-il)alquil carboxílico para la terapia de la amiloidosis transtiretina
CN102905701A (zh) 2010-06-04 2013-01-30 奇斯药制品公司 用于治疗朊病毒病的1-(2-氟联苯-4-基)-环丙烷羧酸衍生物
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
EP2834214A1 (en) 2012-04-04 2015-02-11 Chiesi Farmaceutici S.p.A. Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases
EP2818460A1 (en) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
CA2915773A1 (en) 2013-06-24 2014-12-31 Chiesi Farmaceutici S.P.A. Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
WO2015181094A1 (en) 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
CN107698462A (zh) * 2017-10-10 2018-02-16 重庆科脉生物化工有限公司 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法
AU2022338032A1 (en) 2021-08-31 2024-03-07 Cerespir Incorporated Co-crystals

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4507294B2 (ja) * 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP4502293B2 (ja) * 1999-06-04 2010-07-14 長瀬産業株式会社 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用
JP2004091342A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
WO2006133559A1 (en) * 2005-06-14 2006-12-21 Merck Frosst Canada Ltd. Reversible inhibitors of monoamine oxidase a and b
JP5272345B2 (ja) * 2006-08-28 2013-08-28 東ソー株式会社 ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法

Also Published As

Publication number Publication date
MA32297B1 (fr) 2011-05-02
DK2285765T3 (da) 2012-06-04
EP2285765B1 (en) 2012-04-04
GEP20135800B (en) 2013-04-10
SI2285765T1 (sl) 2012-08-31
CN102046576B (zh) 2013-08-21
PT2285765E (pt) 2012-06-21
AU2009256959A1 (en) 2009-12-17
ZA201007977B (en) 2012-02-29
EP2285765A1 (en) 2011-02-23
NZ589087A (en) 2012-03-30
CA2723878C (en) 2016-06-28
HK1152292A1 (en) 2012-02-24
IL209209A (en) 2014-05-28
MY150280A (en) 2013-12-31
JP2011523953A (ja) 2011-08-25
KR101257217B1 (ko) 2013-04-22
CO6331461A2 (es) 2011-10-20
UA101835C2 (uk) 2013-05-13
AU2009256959B2 (en) 2014-03-27
RU2010146299A (ru) 2012-07-20
MX2010012285A (es) 2010-12-01
EP2133322A1 (en) 2009-12-16
JP5642067B2 (ja) 2014-12-17
KR20110010633A (ko) 2011-02-01
CN102046576A (zh) 2011-05-04
ES2384368T3 (es) 2012-07-04
ATE552230T1 (de) 2012-04-15
US20090312426A1 (en) 2009-12-17
ME01160B (me) 2013-03-20
RU2502721C2 (ru) 2013-12-27
IL209209A0 (en) 2011-01-31
HRP20120517T1 (hr) 2012-07-31
PL2285765T3 (pl) 2012-08-31
US8076505B2 (en) 2011-12-13
CA2723878A1 (en) 2009-12-17
WO2009149797A1 (en) 2009-12-17

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 10A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2513 DE 06-03-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.