ATE552230T1 - Verfahren zur herstellung von derivaten aus 1-(2- halobiphenyl-4-yl)-cyclopropancarboxylsäure - Google Patents
Verfahren zur herstellung von derivaten aus 1-(2- halobiphenyl-4-yl)-cyclopropancarboxylsäureInfo
- Publication number
- ATE552230T1 ATE552230T1 AT09761360T AT09761360T ATE552230T1 AT E552230 T1 ATE552230 T1 AT E552230T1 AT 09761360 T AT09761360 T AT 09761360T AT 09761360 T AT09761360 T AT 09761360T AT E552230 T1 ATE552230 T1 AT E552230T1
- Authority
- AT
- Austria
- Prior art keywords
- halobiphenyl
- cyclopropanecarboxylic acid
- producing derivatives
- derivatives
- producing
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08158022A EP2133322A1 (en) | 2008-06-11 | 2008-06-11 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| PCT/EP2009/003288 WO2009149797A1 (en) | 2008-06-11 | 2009-05-08 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE552230T1 true ATE552230T1 (de) | 2012-04-15 |
Family
ID=40120119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT09761360T ATE552230T1 (de) | 2008-06-11 | 2009-05-08 | Verfahren zur herstellung von derivaten aus 1-(2- halobiphenyl-4-yl)-cyclopropancarboxylsäure |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8076505B2 (enExample) |
| EP (2) | EP2133322A1 (enExample) |
| JP (1) | JP5642067B2 (enExample) |
| KR (1) | KR101257217B1 (enExample) |
| CN (1) | CN102046576B (enExample) |
| AT (1) | ATE552230T1 (enExample) |
| AU (1) | AU2009256959B2 (enExample) |
| BR (1) | BRPI0909560A2 (enExample) |
| CA (1) | CA2723878C (enExample) |
| CO (1) | CO6331461A2 (enExample) |
| DK (1) | DK2285765T3 (enExample) |
| ES (1) | ES2384368T3 (enExample) |
| GE (1) | GEP20135800B (enExample) |
| HR (1) | HRP20120517T1 (enExample) |
| IL (1) | IL209209A (enExample) |
| MA (1) | MA32297B1 (enExample) |
| ME (1) | ME01160B (enExample) |
| MX (1) | MX2010012285A (enExample) |
| MY (1) | MY150280A (enExample) |
| NZ (1) | NZ589087A (enExample) |
| PL (1) | PL2285765T3 (enExample) |
| PT (1) | PT2285765E (enExample) |
| RU (1) | RU2502721C2 (enExample) |
| SI (1) | SI2285765T1 (enExample) |
| UA (1) | UA101835C2 (enExample) |
| WO (1) | WO2009149797A1 (enExample) |
| ZA (1) | ZA201007977B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2514384C (en) * | 2003-02-21 | 2012-04-10 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
| WO2011015287A2 (en) * | 2009-08-04 | 2011-02-10 | Chiesi Farmaceutici S.P.A. | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| CN106431900A (zh) * | 2010-04-01 | 2017-02-22 | 奇斯药制品公司 | 新的多晶型物和盐 |
| CA2796933A1 (en) | 2010-04-21 | 2011-10-27 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis |
| KR20130080795A (ko) | 2010-06-04 | 2013-07-15 | 키에시 파르마슈티시 엣스. 피. 에이. | 프리온 질환의 치료를 위한 1-(2-플루오로비페닐-4-일)-시클로프로판카복실산 유도체 |
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| AR090581A1 (es) | 2012-04-04 | 2014-11-19 | Chiesi Farma Spa | Derivados de acidos 1-(2-halo-bifenil-4-il)-alcancarboxilicos para el tratamiento de enfermedades neurodegenerativas |
| EP2818460A1 (en) | 2013-06-24 | 2014-12-31 | ZaCh System S.p.A. | Cyclopropanation of substituted phenylacetonitriles or phenyl acetates |
| HK1223605A1 (zh) | 2013-06-24 | 2017-08-04 | 奇斯药制品公司 | 用於制备1-(2-氟[1，1’-联苯]-4-基)-环丙烷甲酸衍生物的改进方法 |
| US20150335596A1 (en) | 2014-05-26 | 2015-11-26 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
| CN107698462A (zh) * | 2017-10-10 | 2018-02-16 | 重庆科脉生物化工有限公司 | 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法 |
| JP2024534268A (ja) | 2021-08-31 | 2024-09-18 | セレスピア インコーポレイテッド | 共結晶 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4507294B2 (ja) * | 1999-05-27 | 2010-07-21 | チッソ株式会社 | ビアリール誘導体の製造方法 |
| JP4502293B2 (ja) * | 1999-06-04 | 2010-07-14 | 長瀬産業株式会社 | 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用 |
| JP2004091342A (ja) * | 2002-08-29 | 2004-03-25 | Matsushita Electric Ind Co Ltd | 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子 |
| CA2514384C (en) * | 2003-02-21 | 2012-04-10 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of neurodegenerative diseases |
| ITMI20030311A1 (it) * | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| US20090291988A1 (en) * | 2005-06-14 | 2009-11-26 | Renata Oballa | Reversible Inhibitors of Monoamine Oxidase A and B |
| JP5272345B2 (ja) * | 2006-08-28 | 2013-08-28 | 東ソー株式会社 | ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法 |
| WO2011015287A2 (en) * | 2009-08-04 | 2011-02-10 | Chiesi Farmaceutici S.P.A. | Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
-
2008
- 2008-06-11 EP EP08158022A patent/EP2133322A1/en not_active Withdrawn
-
2009
- 2009-05-08 NZ NZ589087A patent/NZ589087A/en not_active IP Right Cessation
- 2009-05-08 JP JP2011512846A patent/JP5642067B2/ja not_active Expired - Fee Related
- 2009-05-08 ME MEP-2010-200A patent/ME01160B/me unknown
- 2009-05-08 SI SI200930272T patent/SI2285765T1/sl unknown
- 2009-05-08 GE GEAP200911997A patent/GEP20135800B/en unknown
- 2009-05-08 CN CN2009801196647A patent/CN102046576B/zh not_active Expired - Fee Related
- 2009-05-08 KR KR1020107027903A patent/KR101257217B1/ko not_active Expired - Fee Related
- 2009-05-08 DK DK09761360.8T patent/DK2285765T3/da active
- 2009-05-08 MY MYPI2010005220A patent/MY150280A/en unknown
- 2009-05-08 HR HRP20120517AT patent/HRP20120517T1/hr unknown
- 2009-05-08 BR BRPI0909560A patent/BRPI0909560A2/pt not_active IP Right Cessation
- 2009-05-08 ES ES09761360T patent/ES2384368T3/es active Active
- 2009-05-08 CA CA2723878A patent/CA2723878C/en active Active
- 2009-05-08 PL PL09761360T patent/PL2285765T3/pl unknown
- 2009-05-08 AU AU2009256959A patent/AU2009256959B2/en not_active Ceased
- 2009-05-08 MX MX2010012285A patent/MX2010012285A/es active IP Right Grant
- 2009-05-08 WO PCT/EP2009/003288 patent/WO2009149797A1/en not_active Ceased
- 2009-05-08 AT AT09761360T patent/ATE552230T1/de active
- 2009-05-08 EP EP09761360A patent/EP2285765B1/en active Active
- 2009-05-08 PT PT09761360T patent/PT2285765E/pt unknown
- 2009-05-08 UA UAA201013287A patent/UA101835C2/uk unknown
- 2009-05-08 RU RU2010146299/04A patent/RU2502721C2/ru not_active IP Right Cessation
- 2009-05-15 US US12/466,660 patent/US8076505B2/en active Active
-
2010
- 2010-11-08 ZA ZA2010/07977A patent/ZA201007977B/en unknown
- 2010-11-09 IL IL209209A patent/IL209209A/en not_active IP Right Cessation
- 2010-11-11 MA MA33338A patent/MA32297B1/fr unknown
- 2010-11-16 CO CO10143043A patent/CO6331461A2/es active IP Right Grant
Also Published As
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