ME01160B - Postupak za dobijanje derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline - Google Patents

Postupak za dobijanje derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline

Info

Publication number
ME01160B
ME01160B MEP-2010-200A MEP20010A ME01160B ME 01160 B ME01160 B ME 01160B ME P20010 A MEP20010 A ME P20010A ME 01160 B ME01160 B ME 01160B
Authority
ME
Montenegro
Prior art keywords
formula
compound
fluoro
dichloro
biphenyl
Prior art date
Application number
MEP-2010-200A
Other languages
English (en)
French (fr)
Unknown language (me)
Inventor
Fausto Pivetti
Benoit Folleas
Hubert Botte
Thomas Delacroix
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of ME01160B publication Critical patent/ME01160B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
MEP-2010-200A 2008-06-11 2009-05-08 Postupak za dobijanje derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline ME01160B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08158022A EP2133322A1 (en) 2008-06-11 2008-06-11 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
PCT/EP2009/003288 WO2009149797A1 (en) 2008-06-11 2009-05-08 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number Publication Date
ME01160B true ME01160B (me) 2013-03-20

Family

ID=40120119

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2010-200A ME01160B (me) 2008-06-11 2009-05-08 Postupak za dobijanje derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline

Country Status (27)

Country Link
US (1) US8076505B2 (enExample)
EP (2) EP2133322A1 (enExample)
JP (1) JP5642067B2 (enExample)
KR (1) KR101257217B1 (enExample)
CN (1) CN102046576B (enExample)
AT (1) ATE552230T1 (enExample)
AU (1) AU2009256959B2 (enExample)
BR (1) BRPI0909560A2 (enExample)
CA (1) CA2723878C (enExample)
CO (1) CO6331461A2 (enExample)
DK (1) DK2285765T3 (enExample)
ES (1) ES2384368T3 (enExample)
GE (1) GEP20135800B (enExample)
HR (1) HRP20120517T1 (enExample)
IL (1) IL209209A (enExample)
MA (1) MA32297B1 (enExample)
ME (1) ME01160B (enExample)
MX (1) MX2010012285A (enExample)
MY (1) MY150280A (enExample)
NZ (1) NZ589087A (enExample)
PL (1) PL2285765T3 (enExample)
PT (1) PT2285765E (enExample)
RU (1) RU2502721C2 (enExample)
SI (1) SI2285765T1 (enExample)
UA (1) UA101835C2 (enExample)
WO (1) WO2009149797A1 (enExample)
ZA (1) ZA201007977B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法
KR20130036210A (ko) * 2010-04-01 2013-04-11 키에시 파르마슈티시 엣스. 피. 에이. 신규 다형체 및 염
ES2526522T3 (es) * 2010-04-21 2015-01-13 Chiesi Farmaceutici S.P.A. Derivados del ácido 1-(2-fluorobifenil-4-il)alquil carboxílico para la terapia de la amiloidosis transtiretina
CN102905701A (zh) 2010-06-04 2013-01-30 奇斯药制品公司 用于治疗朊病毒病的1-(2-氟联苯-4-基)-环丙烷羧酸衍生物
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
EP2834214A1 (en) 2012-04-04 2015-02-11 Chiesi Farmaceutici S.p.A. Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases
EP2818460A1 (en) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
CA2915773A1 (en) 2013-06-24 2014-12-31 Chiesi Farmaceutici S.P.A. Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid
WO2015181094A1 (en) 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
CN107698462A (zh) * 2017-10-10 2018-02-16 重庆科脉生物化工有限公司 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法
AU2022338032A1 (en) 2021-08-31 2024-03-07 Cerespir Incorporated Co-crystals

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4507294B2 (ja) * 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP4502293B2 (ja) * 1999-06-04 2010-07-14 長瀬産業株式会社 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用
JP2004091342A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子
ATE409176T1 (de) * 2003-02-21 2008-10-15 Chiesi Farma Spa 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
WO2006133559A1 (en) * 2005-06-14 2006-12-21 Merck Frosst Canada Ltd. Reversible inhibitors of monoamine oxidase a and b
JP5272345B2 (ja) * 2006-08-28 2013-08-28 東ソー株式会社 ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法
CN102596879B (zh) * 2009-08-04 2015-01-28 奇斯药制品公司 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法

Also Published As

Publication number Publication date
MA32297B1 (fr) 2011-05-02
DK2285765T3 (da) 2012-06-04
EP2285765B1 (en) 2012-04-04
GEP20135800B (en) 2013-04-10
SI2285765T1 (sl) 2012-08-31
CN102046576B (zh) 2013-08-21
PT2285765E (pt) 2012-06-21
AU2009256959A1 (en) 2009-12-17
ZA201007977B (en) 2012-02-29
EP2285765A1 (en) 2011-02-23
NZ589087A (en) 2012-03-30
CA2723878C (en) 2016-06-28
BRPI0909560A2 (pt) 2015-09-22
HK1152292A1 (en) 2012-02-24
IL209209A (en) 2014-05-28
MY150280A (en) 2013-12-31
JP2011523953A (ja) 2011-08-25
KR101257217B1 (ko) 2013-04-22
CO6331461A2 (es) 2011-10-20
UA101835C2 (uk) 2013-05-13
AU2009256959B2 (en) 2014-03-27
RU2010146299A (ru) 2012-07-20
MX2010012285A (es) 2010-12-01
EP2133322A1 (en) 2009-12-16
JP5642067B2 (ja) 2014-12-17
KR20110010633A (ko) 2011-02-01
CN102046576A (zh) 2011-05-04
ES2384368T3 (es) 2012-07-04
ATE552230T1 (de) 2012-04-15
US20090312426A1 (en) 2009-12-17
RU2502721C2 (ru) 2013-12-27
IL209209A0 (en) 2011-01-31
HRP20120517T1 (hr) 2012-07-31
PL2285765T3 (pl) 2012-08-31
US8076505B2 (en) 2011-12-13
CA2723878A1 (en) 2009-12-17
WO2009149797A1 (en) 2009-12-17

Similar Documents

Publication Publication Date Title
ME01160B (me) Postupak za dobijanje derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline
Zafrani et al. Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor
JP6001112B2 (ja) １−（２−ハロビフェニル−４−イル）−シクロプロパンカルボン酸の誘導体の調製方法
Hu et al. Fluoro‐Hydroxylation of gem‐Difluoroalkenes: Synthesis of 18O‐labeled α‐CF3 Alcohols
CN101468936A (zh) 醇羟基氟代衍生物的合成方法
JP4374987B2 (ja) ２−ブロモシクロペンタノンの製造法
WO2018021517A1 (ja) ４－アルコキシ－３－トリフルオロメチルベンジルアルコールの製造方法
Cui et al. Direct Double Electrophilic Fluorination of Allenoic Acids and Tosylamides to Give 1, 1‐Difluoroallylic Heterocyclic Compounds
HK1168588B (en) Process for the preparation of derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
JP2012017313A (ja) フッ化スルホニルの製造法