MA32297B1 - Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique - Google Patents
Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxyliqueInfo
- Publication number
- MA32297B1 MA32297B1 MA33338A MA33338A MA32297B1 MA 32297 B1 MA32297 B1 MA 32297B1 MA 33338 A MA33338 A MA 33338A MA 33338 A MA33338 A MA 33338A MA 32297 B1 MA32297 B1 MA 32297B1
- Authority
- MA
- Morocco
- Prior art keywords
- halobiphenyl
- preparation
- carboxylic acid
- acid derivatives
- cyclopropane carboxylic
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
- C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
- C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08158022A EP2133322A1 (en) | 2008-06-11 | 2008-06-11 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
| PCT/EP2009/003288 WO2009149797A1 (en) | 2008-06-11 | 2009-05-08 | Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA32297B1 true MA32297B1 (fr) | 2011-05-02 |
Family
ID=40120119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA33338A MA32297B1 (fr) | 2008-06-11 | 2010-11-11 | Procede de preparation de derives d'acide 1-(2-halobiphenyl-4-yl)-cyclopropane carboxylique |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US8076505B2 (enExample) |
| EP (2) | EP2133322A1 (enExample) |
| JP (1) | JP5642067B2 (enExample) |
| KR (1) | KR101257217B1 (enExample) |
| CN (1) | CN102046576B (enExample) |
| AT (1) | ATE552230T1 (enExample) |
| AU (1) | AU2009256959B2 (enExample) |
| BR (1) | BRPI0909560A2 (enExample) |
| CA (1) | CA2723878C (enExample) |
| CO (1) | CO6331461A2 (enExample) |
| DK (1) | DK2285765T3 (enExample) |
| ES (1) | ES2384368T3 (enExample) |
| GE (1) | GEP20135800B (enExample) |
| HR (1) | HRP20120517T1 (enExample) |
| IL (1) | IL209209A (enExample) |
| MA (1) | MA32297B1 (enExample) |
| ME (1) | ME01160B (enExample) |
| MX (1) | MX2010012285A (enExample) |
| MY (1) | MY150280A (enExample) |
| NZ (1) | NZ589087A (enExample) |
| PL (1) | PL2285765T3 (enExample) |
| PT (1) | PT2285765E (enExample) |
| RU (1) | RU2502721C2 (enExample) |
| SI (1) | SI2285765T1 (enExample) |
| UA (1) | UA101835C2 (enExample) |
| WO (1) | WO2009149797A1 (enExample) |
| ZA (1) | ZA201007977B (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE409176T1 (de) * | 2003-02-21 | 2008-10-15 | Chiesi Farma Spa | 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen |
| CN102596879B (zh) * | 2009-08-04 | 2015-01-28 | 奇斯药制品公司 | 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法 |
| KR20130036210A (ko) * | 2010-04-01 | 2013-04-11 | 키에시 파르마슈티시 엣스. 피. 에이. | 신규 다형체 및 염 |
| ES2526522T3 (es) * | 2010-04-21 | 2015-01-13 | Chiesi Farmaceutici S.P.A. | Derivados del ácido 1-(2-fluorobifenil-4-il)alquil carboxílico para la terapia de la amiloidosis transtiretina |
| CN102905701A (zh) | 2010-06-04 | 2013-01-30 | 奇斯药制品公司 | 用于治疗朊病毒病的1-(2-氟联苯-4-基)-环丙烷羧酸衍生物 |
| US9592210B2 (en) | 2011-12-22 | 2017-03-14 | Chiesi Farmaceutici S.P.A. | 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment |
| EP2834214A1 (en) | 2012-04-04 | 2015-02-11 | Chiesi Farmaceutici S.p.A. | Derivatives of 1-(2-halo-biphenyl-4-yl)- alkanecarboxylic acids for the treatment of neurodegenerative diseases |
| EP2818460A1 (en) | 2013-06-24 | 2014-12-31 | ZaCh System S.p.A. | Cyclopropanation of substituted phenylacetonitriles or phenyl acetates |
| CA2915773A1 (en) | 2013-06-24 | 2014-12-31 | Chiesi Farmaceutici S.P.A. | Improved process for the preparation of derivatives of 1-(2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid |
| WO2015181094A1 (en) | 2014-05-26 | 2015-12-03 | Chiesi Farmaceutici S.P.A. | 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome |
| CN107698462A (zh) * | 2017-10-10 | 2018-02-16 | 重庆科脉生物化工有限公司 | 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法 |
| AU2022338032A1 (en) | 2021-08-31 | 2024-03-07 | Cerespir Incorporated | Co-crystals |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4507294B2 (ja) * | 1999-05-27 | 2010-07-21 | チッソ株式会社 | ビアリール誘導体の製造方法 |
| JP4502293B2 (ja) * | 1999-06-04 | 2010-07-14 | 長瀬産業株式会社 | 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用 |
| JP2004091342A (ja) * | 2002-08-29 | 2004-03-25 | Matsushita Electric Ind Co Ltd | 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子 |
| ATE409176T1 (de) * | 2003-02-21 | 2008-10-15 | Chiesi Farma Spa | 1-phenylalkancarbonsäurederivate zur behandlung neurodegenerativer erkrankungen |
| ITMI20030311A1 (it) * | 2003-02-21 | 2004-08-22 | Chiesi Farma Spa | Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer. |
| EP1650183A1 (en) * | 2004-10-21 | 2006-04-26 | Cellzome Ag | (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy |
| US7524870B2 (en) * | 2004-12-03 | 2009-04-28 | Hoffmann-La Roche Inc. | Biaryloxymethylarenecarboxylic acids as glycogen synthase activators |
| WO2006133559A1 (en) * | 2005-06-14 | 2006-12-21 | Merck Frosst Canada Ltd. | Reversible inhibitors of monoamine oxidase a and b |
| JP5272345B2 (ja) * | 2006-08-28 | 2013-08-28 | 東ソー株式会社 | ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法 |
| CN102596879B (zh) * | 2009-08-04 | 2015-01-28 | 奇斯药制品公司 | 制备1-(2-卤代联苯-4-基)-环丙烷羧酸的衍生物的方法 |
-
2008
- 2008-06-11 EP EP08158022A patent/EP2133322A1/en not_active Withdrawn
-
2009
- 2009-05-08 KR KR1020107027903A patent/KR101257217B1/ko not_active Expired - Fee Related
- 2009-05-08 GE GEAP200911997A patent/GEP20135800B/en unknown
- 2009-05-08 DK DK09761360.8T patent/DK2285765T3/da active
- 2009-05-08 WO PCT/EP2009/003288 patent/WO2009149797A1/en not_active Ceased
- 2009-05-08 EP EP09761360A patent/EP2285765B1/en active Active
- 2009-05-08 JP JP2011512846A patent/JP5642067B2/ja not_active Expired - Fee Related
- 2009-05-08 NZ NZ589087A patent/NZ589087A/en not_active IP Right Cessation
- 2009-05-08 RU RU2010146299/04A patent/RU2502721C2/ru not_active IP Right Cessation
- 2009-05-08 AU AU2009256959A patent/AU2009256959B2/en not_active Ceased
- 2009-05-08 CA CA2723878A patent/CA2723878C/en active Active
- 2009-05-08 BR BRPI0909560A patent/BRPI0909560A2/pt not_active IP Right Cessation
- 2009-05-08 UA UAA201013287A patent/UA101835C2/uk unknown
- 2009-05-08 CN CN2009801196647A patent/CN102046576B/zh not_active Expired - Fee Related
- 2009-05-08 AT AT09761360T patent/ATE552230T1/de active
- 2009-05-08 HR HRP20120517AT patent/HRP20120517T1/hr unknown
- 2009-05-08 PT PT09761360T patent/PT2285765E/pt unknown
- 2009-05-08 ME MEP-2010-200A patent/ME01160B/me unknown
- 2009-05-08 ES ES09761360T patent/ES2384368T3/es active Active
- 2009-05-08 SI SI200930272T patent/SI2285765T1/sl unknown
- 2009-05-08 PL PL09761360T patent/PL2285765T3/pl unknown
- 2009-05-08 MX MX2010012285A patent/MX2010012285A/es active IP Right Grant
- 2009-05-08 MY MYPI2010005220A patent/MY150280A/en unknown
- 2009-05-15 US US12/466,660 patent/US8076505B2/en active Active
-
2010
- 2010-11-08 ZA ZA2010/07977A patent/ZA201007977B/en unknown
- 2010-11-09 IL IL209209A patent/IL209209A/en not_active IP Right Cessation
- 2010-11-11 MA MA33338A patent/MA32297B1/fr unknown
- 2010-11-16 CO CO10143043A patent/CO6331461A2/es active IP Right Grant
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