ZA201007977B - Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid - Google Patents

Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Info

Publication number
ZA201007977B
ZA201007977B ZA2010/07977A ZA201007977A ZA201007977B ZA 201007977 B ZA201007977 B ZA 201007977B ZA 2010/07977 A ZA2010/07977 A ZA 2010/07977A ZA 201007977 A ZA201007977 A ZA 201007977A ZA 201007977 B ZA201007977 B ZA 201007977B
Authority
ZA
South Africa
Prior art keywords
halobiphenyl
cyclopropanecarboxylic acid
preparing derivatives
preparing
derivatives
Prior art date
Application number
ZA2010/07977A
Other languages
English (en)
Inventor
Benoit Folleas
Hubert Bottle
Thomas Delacroix
Fausto Pivetti
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of ZA201007977B publication Critical patent/ZA201007977B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/263—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by condensation reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/10—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms
    • C07C17/14—Preparation of halogenated hydrocarbons by replacement by halogens of hydrogen atoms in the side-chain of aromatic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/14—Preparation of carboxylic acid nitriles by reaction of cyanides with halogen-containing compounds with replacement of halogen atoms by cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA2010/07977A 2008-06-11 2010-11-08 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid ZA201007977B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08158022A EP2133322A1 (en) 2008-06-11 2008-06-11 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
PCT/EP2009/003288 WO2009149797A1 (en) 2008-06-11 2009-05-08 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Publications (1)

Publication Number Publication Date
ZA201007977B true ZA201007977B (en) 2012-02-29

Family

ID=40120119

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2010/07977A ZA201007977B (en) 2008-06-11 2010-11-08 Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid

Country Status (27)

Country Link
US (1) US8076505B2 (enExample)
EP (2) EP2133322A1 (enExample)
JP (1) JP5642067B2 (enExample)
KR (1) KR101257217B1 (enExample)
CN (1) CN102046576B (enExample)
AT (1) ATE552230T1 (enExample)
AU (1) AU2009256959B2 (enExample)
BR (1) BRPI0909560A2 (enExample)
CA (1) CA2723878C (enExample)
CO (1) CO6331461A2 (enExample)
DK (1) DK2285765T3 (enExample)
ES (1) ES2384368T3 (enExample)
GE (1) GEP20135800B (enExample)
HR (1) HRP20120517T1 (enExample)
IL (1) IL209209A (enExample)
MA (1) MA32297B1 (enExample)
ME (1) ME01160B (enExample)
MX (1) MX2010012285A (enExample)
MY (1) MY150280A (enExample)
NZ (1) NZ589087A (enExample)
PL (1) PL2285765T3 (enExample)
PT (1) PT2285765E (enExample)
RU (1) RU2502721C2 (enExample)
SI (1) SI2285765T1 (enExample)
UA (1) UA101835C2 (enExample)
WO (1) WO2009149797A1 (enExample)
ZA (1) ZA201007977B (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101152448B1 (ko) * 2003-02-21 2012-07-02 키에시 파르마슈티시 엣스. 피. 에이. 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산 추출물의 제조방법
HRP20140032T1 (hr) * 2009-08-04 2014-02-14 Chiesi Farmaceutici S.P.A. Postupak priprave derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline
WO2011120778A1 (en) * 2010-04-01 2011-10-06 Chiesi Farmaceutici S.P.A. Novel polymorphs and salts
EP2560942B1 (en) * 2010-04-21 2014-11-26 Chiesi Farmaceutici S.p.A. 1-(2-fluorobiphenyl-4-yl)-alkyl carboxylic acid derivatives for the therapy of transthyretin amyloidosis
CA2801449A1 (en) 2010-06-04 2011-12-08 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the therapy of prion diseases
US9592210B2 (en) 2011-12-22 2017-03-14 Chiesi Farmaceutici S.P.A. 1-phenylalkanecarboxylic acid derivatives for the treatment of cognitive impairment
US8835494B2 (en) 2012-04-04 2014-09-16 Chiesi Farmaceutici S.P.A. Derivatives of 1-(2-halo-biphenyl-4-yl)-Alkanecarboxylic for the treatment of neurodegenerative diseases
KR20160021772A (ko) * 2013-06-24 2016-02-26 키에시 파르마슈티시 엣스. 피. 에이. 1-(2-플루오로［1,1′-비페닐］-4-일)-시클로프로판카복실산의 유도체의 개선된 제조 방법
EP2818460A1 (en) 2013-06-24 2014-12-31 ZaCh System S.p.A. Cyclopropanation of substituted phenylacetonitriles or phenyl acetates
WO2015181094A1 (en) 2014-05-26 2015-12-03 Chiesi Farmaceutici S.P.A. 1-(2-fluorobiphenyl-4-yl)-cyclopropanecarboxylic acid derivatives for the treatment of down's syndrome
CN107698462A (zh) * 2017-10-10 2018-02-16 重庆科脉生物化工有限公司 一种1‑氨基‑1‑环丙腈盐酸盐的制备方法
US12226408B2 (en) 2021-08-31 2025-02-18 Cerespir Incorporated Co-crystals

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4507294B2 (ja) * 1999-05-27 2010-07-21 チッソ株式会社 ビアリール誘導体の製造方法
JP4502293B2 (ja) * 1999-06-04 2010-07-14 長瀬産業株式会社 軸不斉を有する光学活性な４級アンモニウム塩、その製法およびα−アミノ酸誘導体の不斉合成への応用
JP2004091342A (ja) * 2002-08-29 2004-03-25 Matsushita Electric Ind Co Ltd 芳香族メチリデン化合物、それを製造するための化合物、それらの製造方法、及び芳香族メチリデン化合物を用いた有機電界発光素子
ITMI20030311A1 (it) * 2003-02-21 2004-08-22 Chiesi Farma Spa Acidi 2-fenil-2-dialchil-acetici per il trattamento della malattia di alzheimer.
KR101152448B1 (ko) * 2003-02-21 2012-07-02 키에시 파르마슈티시 엣스. 피. 에이. 신경 퇴행성 질환의 치료를 위한 1-페닐알캔카복실산 추출물의 제조방법
EP1650183A1 (en) * 2004-10-21 2006-04-26 Cellzome Ag (Benzyloxy-biphenyl) acetic acids and derivatives thereof and their use in therapy
US7524870B2 (en) * 2004-12-03 2009-04-28 Hoffmann-La Roche Inc. Biaryloxymethylarenecarboxylic acids as glycogen synthase activators
CA2610659A1 (en) * 2005-06-14 2006-12-21 Merck Frosst Canada Ltd. Reversible inhibitors of monoamine oxidase a and b
JP5272345B2 (ja) * 2006-08-28 2013-08-28 東ソー株式会社 ヘテロアセン誘導体、テトラハロターフェニル誘導体及びそれらの製造方法
HRP20140032T1 (hr) * 2009-08-04 2014-02-14 Chiesi Farmaceutici S.P.A. Postupak priprave derivata 1-(2-halobifenil-4-il)-ciklopropankarboksilne kiseline

Also Published As

Publication number Publication date
KR20110010633A (ko) 2011-02-01
CN102046576B (zh) 2013-08-21
CA2723878A1 (en) 2009-12-17
IL209209A (en) 2014-05-28
US20090312426A1 (en) 2009-12-17
US8076505B2 (en) 2011-12-13
PL2285765T3 (pl) 2012-08-31
DK2285765T3 (da) 2012-06-04
SI2285765T1 (sl) 2012-08-31
AU2009256959A1 (en) 2009-12-17
EP2285765A1 (en) 2011-02-23
JP2011523953A (ja) 2011-08-25
ME01160B (me) 2013-03-20
HK1152292A1 (en) 2012-02-24
ES2384368T3 (es) 2012-07-04
MX2010012285A (es) 2010-12-01
CN102046576A (zh) 2011-05-04
BRPI0909560A2 (pt) 2015-09-22
JP5642067B2 (ja) 2014-12-17
MA32297B1 (fr) 2011-05-02
RU2010146299A (ru) 2012-07-20
PT2285765E (pt) 2012-06-21
CO6331461A2 (es) 2011-10-20
WO2009149797A1 (en) 2009-12-17
NZ589087A (en) 2012-03-30
CA2723878C (en) 2016-06-28
KR101257217B1 (ko) 2013-04-22
AU2009256959B2 (en) 2014-03-27
HRP20120517T1 (hr) 2012-07-31
EP2133322A1 (en) 2009-12-16
UA101835C2 (uk) 2013-05-13
EP2285765B1 (en) 2012-04-04
MY150280A (en) 2013-12-31
IL209209A0 (en) 2011-01-31
RU2502721C2 (ru) 2013-12-27
ATE552230T1 (de) 2012-04-15
GEP20135800B (en) 2013-04-10

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