HRP20120254T1 - Pripravak za produljenu lokalnu anesteziju koji sadrži saib - Google Patents
Pripravak za produljenu lokalnu anesteziju koji sadrži saib Download PDFInfo
- Publication number
- HRP20120254T1 HRP20120254T1 HR20120254T HRP20120254T HRP20120254T1 HR P20120254 T1 HRP20120254 T1 HR P20120254T1 HR 20120254 T HR20120254 T HR 20120254T HR P20120254 T HRP20120254 T HR P20120254T HR P20120254 T1 HRP20120254 T1 HR P20120254T1
- Authority
- HR
- Croatia
- Prior art keywords
- preparation
- weight
- bupivacaine
- use according
- subject
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 230000002459 sustained effect Effects 0.000 title abstract 2
- 239000003589 local anesthetic agent Substances 0.000 title 1
- 230000003444 anaesthetic effect Effects 0.000 claims abstract 3
- 239000007788 liquid Substances 0.000 claims abstract 3
- 239000002904 solvent Substances 0.000 claims abstract 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 9
- LEBVLXFERQHONN-UHFFFAOYSA-N 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide Chemical compound CCCCN1CCCCC1C(=O)NC1=C(C)C=CC=C1C LEBVLXFERQHONN-UHFFFAOYSA-N 0.000 claims 5
- 229960003150 bupivacaine Drugs 0.000 claims 5
- 235000019445 benzyl alcohol Nutrition 0.000 claims 3
- UVGUPMLLGBCFEJ-SWTLDUCYSA-N sucrose acetate isobutyrate Chemical compound CC(C)C(=O)O[C@H]1[C@H](OC(=O)C(C)C)[C@@H](COC(=O)C(C)C)O[C@@]1(COC(C)=O)O[C@@H]1[C@H](OC(=O)C(C)C)[C@@H](OC(=O)C(C)C)[C@H](OC(=O)C(C)C)[C@@H](COC(C)=O)O1 UVGUPMLLGBCFEJ-SWTLDUCYSA-N 0.000 claims 3
- 235000010983 sucrose acetate isobutyrate Nutrition 0.000 claims 3
- 239000001797 sucrose acetate isobutyrate Substances 0.000 claims 3
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 238000002690 local anesthesia Methods 0.000 claims 2
- 230000002035 prolonged effect Effects 0.000 claims 2
- 208000029836 Inguinal Hernia Diseases 0.000 claims 1
- 208000002847 Surgical Wound Diseases 0.000 claims 1
- 206010052428 Wound Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 238000007486 appendectomy Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 206010002091 Anaesthesia Diseases 0.000 abstract 1
- 230000037005 anaesthesia Effects 0.000 abstract 1
- 238000001949 anaesthesia Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
- A61P23/02—Local anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Dispersion Chemistry (AREA)
- Anesthesiology (AREA)
- Surgery (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Optical Communication System (AREA)
- Amplifiers (AREA)
- Detergent Compositions (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Selective Calling Equipment (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61079704P | 2004-09-17 | 2004-09-17 | |
US69139505P | 2005-06-17 | 2005-06-17 | |
PCT/US2005/032863 WO2006033948A2 (en) | 2004-09-17 | 2005-09-15 | Sustained local anesthetic composition containing preferably a sugar ester such as saib |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120254T1 true HRP20120254T1 (hr) | 2012-04-30 |
Family
ID=35949130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120254T HRP20120254T1 (hr) | 2004-09-17 | 2012-03-20 | Pripravak za produljenu lokalnu anesteziju koji sadrži saib |
Country Status (26)
Country | Link |
---|---|
US (9) | US8753665B2 (de) |
EP (4) | EP2415484B1 (de) |
JP (2) | JP5285275B2 (de) |
KR (2) | KR101351771B1 (de) |
AT (1) | ATE537844T1 (de) |
AU (1) | AU2005287175B2 (de) |
BR (1) | BRPI0515372B8 (de) |
CA (1) | CA2581287C (de) |
CY (2) | CY1112625T1 (de) |
DK (3) | DK2767292T3 (de) |
EA (2) | EA201001885A1 (de) |
ES (3) | ES2602273T3 (de) |
GE (1) | GEP20094831B (de) |
HK (1) | HK1201437A1 (de) |
HR (1) | HRP20120254T1 (de) |
HU (1) | HUE032040T2 (de) |
IL (1) | IL181474A (de) |
LT (1) | LT2767292T (de) |
MX (1) | MX2007002962A (de) |
NO (1) | NO342596B1 (de) |
NZ (1) | NZ553369A (de) |
PL (2) | PL1809329T3 (de) |
PT (3) | PT2415484E (de) |
RS (1) | RS52198B (de) |
SI (2) | SI2415484T1 (de) |
WO (1) | WO2006033948A2 (de) |
Families Citing this family (38)
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US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
EA201001885A1 (ru) | 2004-09-17 | 2011-12-30 | Дьюрект Корпорейшн | Система контролируемой доставки |
MX344532B (es) * | 2004-10-01 | 2016-12-19 | Ramscor Inc | Composiciones de farmaco de liberacion sostenida convenientemente implantables. |
US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
PT2117521E (pt) | 2006-11-03 | 2012-09-10 | Durect Corp | Sistemas de administração transdérmica que compreendem bupivacaína |
EP3085363B1 (de) * | 2007-03-28 | 2019-03-20 | Innocoll Pharmaceuticals Limited | Arzneiabgabevorrichtung zur bereitstellung von lokalanalgesie, lokalnarkose oder nervenblockade |
CA2714514C (en) * | 2008-02-08 | 2016-08-16 | Qps Llc | Non-polymeric compositions for controlled drug delivery |
US20100143437A1 (en) * | 2008-12-09 | 2010-06-10 | Morris Edward J | Implantable analgesic |
WO2010132673A1 (en) | 2009-05-13 | 2010-11-18 | Keraplast Technologies, Ltd. | Biopolymer materials |
KR20140015266A (ko) * | 2010-11-24 | 2014-02-06 | 듀렉트 코퍼레이션 | 생분해성 약물 전달 조성물 |
DK2849724T3 (en) * | 2012-05-16 | 2018-10-15 | Orexa B V | MEDIUM TO PROMOTE FOOD INTAKE AND FOOD RETENTION |
AU2014228313B2 (en) * | 2013-03-15 | 2019-01-17 | Heron Therapeutics, Inc. | Compositions of a polyorthoester and an aprotic solvent |
RU2703303C2 (ru) * | 2013-05-24 | 2019-10-16 | Данмаркс Текниске Университет | Состав геля для лучевой терапии под визуальным контролем |
JP6564369B2 (ja) | 2013-12-09 | 2019-08-21 | デュレクト コーポレイション | 薬学的活性剤複合体、ポリマー複合体、ならびにこれらを伴う組成物及び方法 |
WO2015123734A1 (en) * | 2014-02-21 | 2015-08-27 | The University Of Sydney | Liquid carrier materials |
EP3509601A1 (de) | 2014-04-21 | 2019-07-17 | Heron Therapeutics, Inc. | Pharmazeutische zusammensetzung mit einem abgabesystem, einem amidartigen lokalanesthetikum und meloxicam |
US10213510B2 (en) | 2014-04-21 | 2019-02-26 | Heron Therapeutics, Inc. | Long-acting polymeric delivery systems |
GB201505527D0 (en) | 2015-03-31 | 2015-05-13 | Jmedtech Pte Ltd | Composition |
KR20170025011A (ko) | 2015-08-27 | 2017-03-08 | 고려대학교 산학협력단 | 통증완화약물의 지속성 방출을 위한 약학적 조성물 및 그 투여를 위한 투여 장치 |
JP2019514976A (ja) * | 2016-05-05 | 2019-06-06 | リクイディア・テクノロジーズ・インコーポレーテッド | 負荷と放出が正確に制御された術後疼痛用粒子 |
US10682340B2 (en) | 2016-06-30 | 2020-06-16 | Durect Corporation | Depot formulations |
EP3478285A4 (de) * | 2016-06-30 | 2020-07-22 | Durect Corporation | Depotformulierungen |
CA3048485C (en) * | 2016-12-26 | 2022-07-19 | Cellix Bio Private Limited | Compositions and methods for the treatment of chronic pain |
PT3486233T (pt) * | 2017-03-27 | 2021-03-18 | Fruithy Holdings Ltd | Complexo pouco solúvel ou um seu solvato, composição farmacêutica e sua aplicação |
AU2018345844B2 (en) | 2017-10-06 | 2024-03-07 | Foundry Therapeutics, Inc. | Implantable depots for the controlled release of therapeutic agents |
RU2674025C1 (ru) * | 2017-10-25 | 2018-12-04 | Общество с ограниченной ответственностью "Научно-производственная фирма "ЭЛЕСТ" (ООО "НПФ "ЭЛЕСТ") | Лекарственное средство на основе порфиринового фотосенсибилизатора копропорфирина для лечения рака кожи методом фотодинамической терапии |
EP4087540A4 (de) * | 2020-01-06 | 2024-01-10 | Pacira Pharmaceuticals, Inc. | Behandlung von schmerzen in verbindung mit einem kaiserschnitt mit zusammensetzung aus liposomalen anästhetika mit verzögerter freisetzung |
CN115297854A (zh) | 2020-01-10 | 2022-11-04 | 帕西拉制药股份有限公司 | 通过蛛网膜下腔给予缓释脂质体麻醉组合物治疗疼痛 |
WO2021141959A1 (en) | 2020-01-10 | 2021-07-15 | Pacira Pharmaceuticals, Inc. | Treatment of pain by administration of sustained-release liposomal anesthetic compositions |
EP4090353A4 (de) | 2020-01-13 | 2023-08-09 | Durect Corporation | Arzneimittelabgabesysteme mit verzögerter freisetzung mit reduzierten verunreinigungen und verwandte verfahren |
BR112022016914A2 (pt) * | 2020-02-25 | 2022-10-25 | Univ North Carolina Chapel Hill | Composições anestésicas de base eutética e suas aplicações |
CN116997338A (zh) | 2021-01-11 | 2023-11-03 | 帕西拉制药股份有限公司 | 用缓释脂质体麻醉剂组合物治疗髋部疼痛 |
CN115068414B (zh) * | 2021-03-16 | 2023-07-21 | 湖南慧泽生物医药科技有限公司 | 供注射用罗哌卡因长效溶液制剂及其制备方法 |
US11931459B2 (en) | 2021-03-19 | 2024-03-19 | Pacira Pharmaceuticals, Inc. | Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions |
CN115414324A (zh) * | 2021-05-31 | 2022-12-02 | 中国科学院过程工程研究所 | 一种载局部麻醉药的乳剂及其制备方法 |
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US11918565B1 (en) | 2022-11-03 | 2024-03-05 | Pacira Pharmaceuticals, Inc. | Treatment of post-operative pain via sciatic nerve block with sustained-release liposomal anesthetic compositions |
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