HRP20120124T1 - Benzilamini, postupak za njihovu proizvodnju i njihova uporaba kao protu-upalnih sredstava - Google Patents
Benzilamini, postupak za njihovu proizvodnju i njihova uporaba kao protu-upalnih sredstava Download PDFInfo
- Publication number
- HRP20120124T1 HRP20120124T1 HR20120124T HRP20120124T HRP20120124T1 HR P20120124 T1 HRP20120124 T1 HR P20120124T1 HR 20120124 T HR20120124 T HR 20120124T HR P20120124 T HRP20120124 T HR P20120124T HR P20120124 T1 HRP20120124 T1 HR P20120124T1
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- Croatia
- Prior art keywords
- group
- alkyl
- general formula
- hydroxy
- cyano
- Prior art date
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- 238000000034 method Methods 0.000 title claims 13
- 229940121363 anti-inflammatory agent Drugs 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 150000003939 benzylamines Chemical class 0.000 title 1
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims abstract 27
- 125000004093 cyano group Chemical group *C#N 0.000 claims abstract 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 25
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 18
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 17
- 239000001257 hydrogen Substances 0.000 claims abstract 17
- 229910052736 halogen Inorganic materials 0.000 claims abstract 15
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims abstract 14
- 150000002367 halogens Chemical class 0.000 claims abstract 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 13
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 13
- 125000003118 aryl group Chemical group 0.000 claims abstract 12
- 229910052801 chlorine Inorganic materials 0.000 claims abstract 9
- 239000000460 chlorine Substances 0.000 claims abstract 9
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract 9
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims abstract 9
- 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims abstract 8
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims abstract 8
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract 8
- 125000005843 halogen group Chemical group 0.000 claims abstract 8
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 8
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 7
- 229910052731 fluorine Inorganic materials 0.000 claims abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 6
- 125000006833 (C1-C5) alkylene group Chemical group 0.000 claims abstract 4
- 125000006715 (C1-C5) alkylthio group Chemical group 0.000 claims abstract 4
- 125000006375 C2-C10 alkynyl group Chemical class 0.000 claims abstract 4
- 125000002619 bicyclic group Chemical group 0.000 claims abstract 4
- 125000005842 heteroatom Chemical group 0.000 claims abstract 4
- 125000006574 non-aromatic ring group Chemical group 0.000 claims abstract 4
- 125000001424 substituent group Chemical group 0.000 claims abstract 4
- 125000004434 sulfur atom Chemical group 0.000 claims abstract 4
- 125000004122 cyclic group Chemical group 0.000 claims abstract 3
- -1 hydroxy, methoxy Chemical group 0.000 claims 65
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 8
- 150000002431 hydrogen Chemical class 0.000 claims 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 229910052740 iodine Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 150000003254 radicals Chemical class 0.000 claims 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 125000005997 bromomethyl group Chemical group 0.000 claims 4
- 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 claims 4
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 claims 4
- 125000005745 ethoxymethyl group Chemical group [H]C([H])([H])C([H])([H])OC([H])([H])* 0.000 claims 4
- 150000002466 imines Chemical class 0.000 claims 4
- 239000000543 intermediate Substances 0.000 claims 4
- 125000004592 phthalazinyl group Chemical group C1(=NN=CC2=CC=CC=C12)* 0.000 claims 4
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 150000002118 epoxides Chemical class 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 150000002576 ketones Chemical class 0.000 claims 3
- 125000002950 monocyclic group Chemical group 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 238000006555 catalytic reaction Methods 0.000 claims 2
- 239000011737 fluorine Chemical group 0.000 claims 2
- 125000001041 indolyl group Chemical group 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 125000000654 isopropylidene group Chemical group C(C)(C)=* 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-SCSAIBSYSA-N D-Proline Chemical compound OC(=O)[C@H]1CCCN1 ONIBWKKTOPOVIA-SCSAIBSYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 238000005808 aromatic amination reaction Methods 0.000 claims 1
- 150000003935 benzaldehydes Chemical class 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 239000003054 catalyst Substances 0.000 claims 1
- 230000003197 catalytic effect Effects 0.000 claims 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001070 dihydroindolyl group Chemical group N1(CCC2=CC=CC=C12)* 0.000 claims 1
- 125000004611 dihydroisoindolyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 claims 1
- 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims 1
- 125000005044 dihydroquinolinyl group Chemical group N1(CC=CC2=CC=CC=C12)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 125000003151 isocoumarinyl group Chemical group C1(=O)OC(=CC2=CC=CC=C12)* 0.000 claims 1
- 125000000493 isoindolonyl group Chemical group C1(N=C(C2=CC=CC=C12)*)=O 0.000 claims 1
- 125000000904 isoindolyl group Chemical group C=1(NC=C2C=CC=CC12)* 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- ZCSHNCUQKCANBX-UHFFFAOYSA-N lithium diisopropylamide Chemical compound [Li+].CC(C)[N-]C(C)C ZCSHNCUQKCANBX-UHFFFAOYSA-N 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 125000001979 organolithium group Chemical group 0.000 claims 1
- 239000008177 pharmaceutical agent Substances 0.000 claims 1
- 125000005633 phthalidyl group Chemical group 0.000 claims 1
- DNAJDTIOMGISDS-UHFFFAOYSA-N prop-2-enylsilane Chemical compound [SiH3]CC=C DNAJDTIOMGISDS-UHFFFAOYSA-N 0.000 claims 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 1
- 125000001567 quinoxalinyl group Chemical group N1=C(C=NC2=CC=CC=C12)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 150000003573 thiols Chemical class 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
- UKRDPEFKFJNXQM-UHFFFAOYSA-N vinylsilane Chemical compound [SiH3]C=C UKRDPEFKFJNXQM-UHFFFAOYSA-N 0.000 claims 1
Classifications
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- C07—ORGANIC CHEMISTRY
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- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
- C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
- C07C215/16—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
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- A—HUMAN NECESSITIES
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- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US83067106P | 2006-07-14 | 2006-07-14 | |
EP06014665A EP1878717A1 (en) | 2006-07-14 | 2006-07-14 | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
PCT/EP2007/006472 WO2008006627A1 (en) | 2006-07-14 | 2007-07-16 | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20120124T1 true HRP20120124T1 (hr) | 2012-03-31 |
Family
ID=37842984
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20120124T HRP20120124T1 (hr) | 2006-07-14 | 2012-02-06 | Benzilamini, postupak za njihovu proizvodnju i njihova uporaba kao protu-upalnih sredstava |
Country Status (38)
Country | Link |
---|---|
US (3) | US7999108B2 (ko) |
EP (2) | EP1878717A1 (ko) |
JP (1) | JP5313892B2 (ko) |
KR (1) | KR101389817B1 (ko) |
CN (2) | CN101636377B (ko) |
AR (1) | AR061993A1 (ko) |
AT (1) | ATE535510T1 (ko) |
AU (1) | AU2007271920B2 (ko) |
BR (1) | BRPI0714415A2 (ko) |
CA (1) | CA2657006C (ko) |
CL (1) | CL2007002047A1 (ko) |
CO (1) | CO6150135A2 (ko) |
CR (1) | CR10557A (ko) |
CU (1) | CU23757B7 (ko) |
CY (1) | CY1112520T1 (ko) |
DK (1) | DK2041069T3 (ko) |
EA (1) | EA015258B1 (ko) |
EC (1) | ECSP099070A (ko) |
ES (1) | ES2377465T3 (ko) |
GT (1) | GT200900009A (ko) |
HK (2) | HK1204471A1 (ko) |
HR (1) | HRP20120124T1 (ko) |
IL (1) | IL195527A (ko) |
MX (1) | MX2009000480A (ko) |
MY (1) | MY146084A (ko) |
NO (1) | NO20090724L (ko) |
NZ (1) | NZ573063A (ko) |
PE (1) | PE20080547A1 (ko) |
PL (1) | PL2041069T3 (ko) |
PT (1) | PT2041069E (ko) |
RS (1) | RS52125B (ko) |
SI (1) | SI2041069T1 (ko) |
SV (1) | SV2009003153A (ko) |
TW (1) | TWI408127B (ko) |
UA (1) | UA97806C2 (ko) |
UY (1) | UY30488A1 (ko) |
WO (1) | WO2008006627A1 (ko) |
ZA (1) | ZA200901050B (ko) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1878717A1 (en) | 2006-07-14 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
EP2062880A1 (en) * | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents |
EP2231678B1 (en) * | 2008-01-11 | 2013-07-24 | Dow AgroSciences LLC | Process for the selective deprotonation and functionalization of 1-fluoro-2-substituted-3-chlorobenzenes |
US20100016338A1 (en) * | 2008-07-21 | 2010-01-21 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents |
EP2149558A1 (en) * | 2008-07-21 | 2010-02-03 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino-1-arylquinolin-2-ones, a process for their production and their use as anti-inflammatory agents |
WO2010049073A1 (en) * | 2008-10-30 | 2010-05-06 | Bayer Schering Pharma Aktiengesellschaft | 1,1,1-trifluoro-3-amino-3-heteroaryl-2-propanoles, a process for their production and their use as anti-inflammatory agents |
US11356340B2 (en) * | 2014-09-29 | 2022-06-07 | Hewlett Packard Enterprise Development Lp | Provisioning a service |
WO2017161518A1 (en) | 2016-03-23 | 2017-09-28 | Astrazeneca Ab | New physical form |
WO2018046684A1 (en) | 2016-09-08 | 2018-03-15 | Bayer Pharma Aktiengesellschaft | Process for the preparation of substituted 5-{[2-(alkoxymethyl)-3,3,3-trifluoro-2-hydroxy-1-phenylpropyl]amino}quinolin-2(1h)-ones |
WO2021233752A1 (en) * | 2020-05-19 | 2021-11-25 | Bayer Aktiengesellschaft | Trpa1 antagonists for the treatment of diseases associated with pain and inflammation |
CN112608252A (zh) * | 2020-12-15 | 2021-04-06 | 广西师范大学 | 一种4-硝基苯胺衍生物及其合成方法和应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1045180A (en) * | 1963-09-20 | 1966-10-12 | Parke Davis & Co | Quinazoline derivatives |
US3849450A (en) * | 1973-02-02 | 1974-11-19 | Us Navy | Bis(trifluoromethyl)epoxides |
US4197209A (en) * | 1977-03-10 | 1980-04-08 | Ciba-Geigy Corporation | Lubricant compositions containing sulfur-containing esters of phosphoric acid |
JPH06172321A (ja) * | 1992-10-08 | 1994-06-21 | Agro Kanesho Co Ltd | 置換アミノピリミジン誘導体、その製造法及びそれを有効成分とする有害生物駆除剤 |
UA57002C2 (uk) | 1995-10-13 | 2003-06-16 | Мерк Фросст Кенада Енд Ко./Мерк Фросст Кенада Енд Сі. | Похідне (метилсульфоніл)феніл-2-(5н)-фуранону, фармацевтична композиція та спосіб лікування |
AU5682299A (en) * | 1998-08-21 | 2000-03-14 | Scripps Research Institute, The | Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles |
DE10038639A1 (de) * | 2000-07-28 | 2002-02-21 | Schering Ag | Nichtsteroidale Entzündungshemmer |
WO2003082787A1 (en) | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
MXPA06000169A (es) * | 2003-07-01 | 2006-04-27 | Schering Ag | Derivados de pentanol heterociclicamente sustituidos, procedimiento para su preparacion y su uso como anti-inflamatorios. |
US20050090559A1 (en) * | 2003-07-01 | 2005-04-28 | Markus Berger | Heterocyclically-substituted pentanol derivatives, process for their production and their use as anti-inflammatory agents |
US20050009109A1 (en) | 2003-07-08 | 2005-01-13 | Stanford University | Fluorophore compounds and their use in biological systems |
DE10347385A1 (de) * | 2003-10-08 | 2005-05-12 | Schering Ag | Umgelagerte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer |
KR101179382B1 (ko) * | 2004-06-09 | 2012-09-03 | 에릭 엠. 카레이라 | 모노포스핀 화합물, 그의 전이 금속 착체 및 상기 착체를비대칭 촉매로서 사용하는 광학 활성 화합물의 제조 방법 |
EP1661915A1 (en) * | 2004-11-25 | 2006-05-31 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Preparation of antibodies against the human chitinase-like protein GL008 |
EP1878717A1 (en) * | 2006-07-14 | 2008-01-16 | Bayer Schering Pharma Aktiengesellschaft | Benzyl amines, a process for their production and their use as anti-inflammatory agents |
EP2062880A1 (en) | 2007-11-22 | 2009-05-27 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1H-quinolin-2-ones, a process for their production and their use as anti-inflammatory agents |
US20100016338A1 (en) | 2008-07-21 | 2010-01-21 | Bayer Schering Pharma Aktiengesellschaft | 5-[(3,3,3-Trifluoro-2-hydroxy-1-arylpropyl)amino]-1-arylquinolin-2-ones, a Process for their Production and their Use as Anti-inflammatory Agents |
-
2006
- 2006-07-14 EP EP06014665A patent/EP1878717A1/en not_active Withdrawn
-
2007
- 2007-07-13 US US11/777,411 patent/US7999108B2/en not_active Expired - Fee Related
- 2007-07-13 AR ARP070103119A patent/AR061993A1/es active IP Right Grant
- 2007-07-13 TW TW096125742A patent/TWI408127B/zh active
- 2007-07-13 UY UY30488A patent/UY30488A1/es not_active Application Discontinuation
- 2007-07-13 PE PE2007000904A patent/PE20080547A1/es not_active Application Discontinuation
- 2007-07-13 CL CL200702047A patent/CL2007002047A1/es unknown
- 2007-07-16 NZ NZ573063A patent/NZ573063A/en not_active IP Right Cessation
- 2007-07-16 EP EP07786221A patent/EP2041069B1/en active Active
- 2007-07-16 WO PCT/EP2007/006472 patent/WO2008006627A1/en active Application Filing
- 2007-07-16 MY MYPI20090155A patent/MY146084A/en unknown
- 2007-07-16 PL PL07786221T patent/PL2041069T3/pl unknown
- 2007-07-16 RS RS20120049A patent/RS52125B/en unknown
- 2007-07-16 JP JP2009519875A patent/JP5313892B2/ja not_active Expired - Fee Related
- 2007-07-16 EA EA200900090A patent/EA015258B1/ru not_active IP Right Cessation
- 2007-07-16 CA CA2657006A patent/CA2657006C/en not_active Expired - Fee Related
- 2007-07-16 DK DK07786221.7T patent/DK2041069T3/da active
- 2007-07-16 SI SI200730820T patent/SI2041069T1/sl unknown
- 2007-07-16 MX MX2009000480A patent/MX2009000480A/es active IP Right Grant
- 2007-07-16 BR BRPI0714415-6A patent/BRPI0714415A2/pt not_active Application Discontinuation
- 2007-07-16 CN CN200780026698.2A patent/CN101636377B/zh not_active Expired - Fee Related
- 2007-07-16 PT PT07786221T patent/PT2041069E/pt unknown
- 2007-07-16 AU AU2007271920A patent/AU2007271920B2/en not_active Ceased
- 2007-07-16 ES ES07786221T patent/ES2377465T3/es active Active
- 2007-07-16 AT AT07786221T patent/ATE535510T1/de active
- 2007-07-16 UA UAA200900882A patent/UA97806C2/ru unknown
- 2007-07-16 CN CN201410476588.8A patent/CN104356006B/zh not_active Expired - Fee Related
- 2007-07-16 KR KR1020097000713A patent/KR101389817B1/ko not_active IP Right Cessation
-
2008
- 2008-11-26 IL IL195527A patent/IL195527A/en active IP Right Grant
-
2009
- 2009-01-14 EC EC2009009070A patent/ECSP099070A/es unknown
- 2009-01-14 CU CU20090009A patent/CU23757B7/es active IP Right Grant
- 2009-01-14 SV SV2009003153A patent/SV2009003153A/es active IP Right Grant
- 2009-01-14 CR CR10557A patent/CR10557A/es unknown
- 2009-01-14 CO CO09002483A patent/CO6150135A2/es unknown
- 2009-01-14 GT GT200900009A patent/GT200900009A/es unknown
- 2009-02-13 ZA ZA2009/01050A patent/ZA200901050B/en unknown
- 2009-02-13 NO NO20090724A patent/NO20090724L/no not_active Application Discontinuation
-
2010
- 2010-07-16 HK HK15104994.1A patent/HK1204471A1/xx not_active IP Right Cessation
- 2010-07-16 HK HK10106915.7A patent/HK1140471A1/xx not_active IP Right Cessation
-
2011
- 2011-08-15 US US13/210,173 patent/US8173676B2/en not_active Expired - Fee Related
-
2012
- 2012-02-06 HR HR20120124T patent/HRP20120124T1/hr unknown
- 2012-02-28 CY CY20121100201T patent/CY1112520T1/el unknown
- 2012-05-07 US US13/465,746 patent/US8461346B2/en not_active Expired - Fee Related
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