HRP20110404T1 - Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina - Google Patents
Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina Download PDFInfo
- Publication number
- HRP20110404T1 HRP20110404T1 HR20110404T HRP20110404T HRP20110404T1 HR P20110404 T1 HRP20110404 T1 HR P20110404T1 HR 20110404 T HR20110404 T HR 20110404T HR P20110404 T HRP20110404 T HR P20110404T HR P20110404 T1 HRP20110404 T1 HR P20110404T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkylene
- substituted
- alkyl
- group
- substituted alkylene
- Prior art date
Links
- 150000001413 amino acids Chemical class 0.000 title claims abstract 19
- 229920001184 polypeptide Polymers 0.000 title claims abstract 10
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 10
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 10
- 230000004048 modification Effects 0.000 title 1
- 238000012986 modification Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract 17
- 239000011541 reaction mixture Substances 0.000 claims abstract 8
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims abstract 5
- 150000002923 oximes Chemical class 0.000 claims abstract 4
- 238000000034 method Methods 0.000 claims 15
- 125000002947 alkylene group Chemical group 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 10
- 150000004982 aromatic amines Chemical class 0.000 claims 8
- 230000001588 bifunctional effect Effects 0.000 claims 8
- 125000004450 alkenylene group Chemical group 0.000 claims 6
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 239000011347 resin Substances 0.000 claims 6
- 229920005989 resin Polymers 0.000 claims 6
- 239000003153 chemical reaction reagent Substances 0.000 claims 4
- 150000008365 aromatic ketones Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 150000002148 esters Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 3
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 2
- -1 oxoamine derivatives Chemical class 0.000 claims 2
- 101100025412 Arabidopsis thaliana XI-A gene Proteins 0.000 claims 1
- 238000009795 derivation Methods 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73458905P | 2005-11-08 | 2005-11-08 | |
PCT/US2006/043472 WO2007056448A2 (en) | 2005-11-08 | 2006-11-08 | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20110404T1 true HRP20110404T1 (hr) | 2011-08-31 |
Family
ID=38023955
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20110404T HRP20110404T1 (hr) | 2005-11-08 | 2011-05-31 | Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina |
Country Status (21)
Country | Link |
---|---|
US (5) | US20090137736A1 (sl) |
EP (1) | EP1954710B1 (sl) |
JP (1) | JP5508716B2 (sl) |
KR (1) | KR101379071B1 (sl) |
CN (2) | CN104710503B (sl) |
AT (1) | ATE500215T1 (sl) |
AU (1) | AU2006311568B2 (sl) |
CA (1) | CA2625540C (sl) |
CY (1) | CY1111506T1 (sl) |
DE (1) | DE602006020480D1 (sl) |
DK (1) | DK1954710T3 (sl) |
ES (1) | ES2362373T3 (sl) |
HK (1) | HK1123310A1 (sl) |
HR (1) | HRP20110404T1 (sl) |
IL (1) | IL190694A (sl) |
NZ (1) | NZ567234A (sl) |
PL (1) | PL1954710T3 (sl) |
PT (1) | PT1954710E (sl) |
RS (1) | RS51998B (sl) |
SI (1) | SI1954710T1 (sl) |
WO (1) | WO2007056448A2 (sl) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1828224T3 (en) * | 2004-12-22 | 2016-07-18 | Ambrx Inc | Compositions containing, methods including, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES |
DE602006020480D1 (de) * | 2005-11-08 | 2011-04-14 | Ambrx Inc | Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide |
EP1968635B1 (en) | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
US20090286968A1 (en) * | 2008-04-25 | 2009-11-19 | Auburn University | 2-Quinoxalinol Salen Compounds and Uses Thereof |
KR100995413B1 (ko) | 2008-08-01 | 2010-11-18 | 삼성에스디아이 주식회사 | 리튬 이온 이차 전지용 전해액 및 이를 포함하는 리튬 이온이차 전지 |
WO2010096394A2 (en) | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
WO2011109326A2 (en) * | 2010-03-02 | 2011-09-09 | Yumei Huang | Crosslinking reagents, methods, and compositions for studying protein-protein interactions |
BR112013003522B1 (pt) | 2010-08-17 | 2021-05-25 | Ambrx, Inc. | polipeptídeos relaxina modificados compreendendo um aminoácido não codificado naturalmente, seu método de preparação e seu uso, bem como ácido nucleico e célula hospedeira |
US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
RU2606016C2 (ru) | 2011-01-14 | 2017-01-10 | Редвуд Байосайнс, Инк. | Меченые альдегидом полипептиды иммуноглобулина и способы их применения |
CA2837586C (en) * | 2011-05-27 | 2018-12-11 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
WO2012166559A1 (en) * | 2011-05-27 | 2012-12-06 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
WO2014083505A1 (en) | 2012-11-30 | 2014-06-05 | Novartis Ag | Methods for making conjugates from disulfide-containing proteins |
CA2923160A1 (en) | 2013-09-09 | 2015-03-12 | Canimguide Therapeutics Ab | Immune system modulators |
CA2978617A1 (en) | 2015-03-06 | 2016-09-15 | Canimguide Therapeutics Ab | Immune system modulators and compositions |
DK3283508T3 (en) | 2015-04-17 | 2021-05-31 | Alpine Immune Sciences Inc | Immunomodulatory Proteins with Tunable Affinities |
ES2827776T3 (es) | 2015-11-23 | 2021-05-24 | Bristol Myers Squibb Co | Sistemas de aditivos para uso en la PEGilación de proteínas |
CN109071634A (zh) | 2016-04-26 | 2018-12-21 | R.P.谢勒技术有限责任公司 | 抗体偶联物及其制备和使用方法 |
CN110637027A (zh) | 2017-02-08 | 2019-12-31 | 百时美施贵宝公司 | 包含药代动力学增强子的修饰的松弛素多肽及其用途 |
US20220056093A1 (en) * | 2018-09-11 | 2022-02-24 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and their uses |
CN113788890B (zh) * | 2021-09-01 | 2022-11-08 | 浙江新码生物医药有限公司 | 一种人白细胞介素2-聚乙二醇偶联物及其应用 |
Family Cites Families (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2009A (en) * | 1841-03-18 | Improvement in machines for boring war-rockets | ||
US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
US3773919A (en) * | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
GB1366554A (en) * | 1972-03-06 | 1974-09-11 | Science Union & Cie | Phenylalanine derivatives and a process for their preparation |
JPS4924452A (sl) * | 1972-06-28 | 1974-03-04 | ||
US4289872A (en) * | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
JPS5665867A (en) * | 1979-11-02 | 1981-06-03 | Nippon Soda Co Ltd | Oxime and its preparation |
FR2504010B1 (fr) * | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
US4551433A (en) * | 1981-05-18 | 1985-11-05 | Genentech, Inc. | Microbial hybrid promoters |
JPS57206622A (en) * | 1981-06-10 | 1982-12-18 | Ajinomoto Co Inc | Blood substitute |
US4485045A (en) * | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
EP0088046B1 (de) * | 1982-02-17 | 1987-12-09 | Ciba-Geigy Ag | Lipide in wässriger Phase |
US4671958A (en) * | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US5089398A (en) * | 1983-02-22 | 1992-02-18 | Chiron Corporation | Enhanced yeast transcription employing hybrid GAPDH promoter region constructs |
US4876197A (en) * | 1983-02-22 | 1989-10-24 | Chiron Corporation | Eukaryotic regulatable transcription |
US4859600A (en) * | 1983-04-25 | 1989-08-22 | Genentech, Inc. | Recombinant procaryotic cell containing correctly processed human growth hormone |
US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
US4544545A (en) * | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US4689406A (en) * | 1983-08-10 | 1987-08-25 | Amgen | Enhancement of microbial expression of polypeptides |
EP0142641B1 (de) * | 1983-09-26 | 1991-01-16 | Udo Dr. Ehrenfeld | Mittel und Erzeugnis für die Diagnose und Therapie von Tumoren sowie zur Behandlung von Schwächen der zelligen und humoralen Immunabwehr |
US4880734A (en) * | 1984-05-11 | 1989-11-14 | Chiron Corporation | Eukaryotic regulatable transcription |
US4542225A (en) * | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4738921A (en) * | 1984-09-27 | 1988-04-19 | Eli Lilly And Company | Derivative of the tryptophan operon for expression of fused gene products |
US4659839A (en) * | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
US4837148A (en) * | 1984-10-30 | 1989-06-06 | Phillips Petroleum Company | Autonomous replication sequences for yeast strains of the genus pichia |
JPS61243018A (ja) | 1985-04-18 | 1986-10-29 | Taisho Pharmaceut Co Ltd | 真菌症治療剤 |
DE3675588D1 (de) * | 1985-06-19 | 1990-12-20 | Ajinomoto Kk | Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist. |
US4680338A (en) * | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
US5186933A (en) * | 1986-12-30 | 1993-02-16 | Baylor College Of Medicine | Synthesis and immunogenicity of rotavirus genes using a baculovirus expression system |
US5229490A (en) * | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
US5080891A (en) * | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US4929555A (en) * | 1987-10-19 | 1990-05-29 | Phillips Petroleum Company | Pichia transformation |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
CA1340772C (en) * | 1987-12-30 | 1999-09-28 | Patricia Tekamp-Olson | Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences |
CA1324969C (en) * | 1988-05-06 | 1993-12-07 | Jeffrey R. Shuster | High level expression of proteins in yeast |
US5674706A (en) * | 1988-05-06 | 1997-10-07 | Chiron Corporation | High level expression of proteins in yeast |
FR2631974B1 (fr) * | 1988-05-31 | 1992-12-11 | Agronomique Inst Nat Rech | Baculovirus modifie, son procede de preparation et son application en tant que vecteur d'expression de genes |
CA2001774C (en) * | 1988-10-28 | 2001-10-16 | James A. Wells | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
US5750373A (en) * | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
US6780613B1 (en) * | 1988-10-28 | 2004-08-24 | Genentech, Inc. | Growth hormone variants |
AU649217B2 (en) | 1988-11-18 | 1994-05-19 | Regents Of The University Of California, The | Method for site-specifically incorporating unnatural amino acids into proteins |
ATE135370T1 (de) * | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US4902502A (en) * | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
US5324844A (en) * | 1989-04-19 | 1994-06-28 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5122614A (en) * | 1989-04-19 | 1992-06-16 | Enzon, Inc. | Active carbonates of polyalkylene oxides for modification of polypeptides |
US5162601A (en) * | 1989-11-22 | 1992-11-10 | The Upjohn Company | Plant potyvirus expression vector with a gene for protease |
US5364840A (en) | 1989-12-05 | 1994-11-15 | Vical, Inc. | Synthetic calcitonin peptides |
US5219564A (en) * | 1990-07-06 | 1993-06-15 | Enzon, Inc. | Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon |
CA2018801C (en) | 1990-06-12 | 2000-08-22 | Pierre Louis Beaulieu | Antiherpes peptide derivatives having a 1,4-dioxo c n-terminus |
FR2664905B1 (fr) * | 1990-07-18 | 1994-08-12 | Agronomique Inst Nat Rech | Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus. |
WO1992001800A1 (en) * | 1990-07-20 | 1992-02-06 | Chiron Corporation | Method for integrative transformation of yeast using dispersed repetitive elements |
CA2090969C (en) * | 1990-09-04 | 2001-08-21 | Russell Arthur Brierley | Production of insulin-like growth factor-1 in methylotrophic yeast cells |
WO1992008790A1 (en) * | 1990-11-14 | 1992-05-29 | Cargill, Incorporated | Conjugates of poly(vinylsaccharide) with proteins for the stabilization of proteins |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
US5231178A (en) * | 1991-01-16 | 1993-07-27 | The Salk Institute Biotechnology/Industrial Associates, Inc. | Method for the purification of intact, correctly-folded insulin-like growth factor-1 |
US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
US6013433A (en) * | 1991-04-26 | 2000-01-11 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Baculovirus expression vectors and recombinant antigens for detecting type-specific antibodies to herpes simplex virus |
US5281698A (en) * | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
US5290686A (en) * | 1991-07-31 | 1994-03-01 | The United States Of America As Represented By The Department Of Health And Human Services | Expression of influenza a M2 protein in baculovirus |
US5516657A (en) * | 1992-05-11 | 1996-05-14 | Cambridge Biotech Corporation | Baculovirus vectors for expression of secretory and membrane-bound proteins |
ZA933926B (en) * | 1992-06-17 | 1994-01-03 | Amgen Inc | Polyoxymethylene-oxyethylene copolymers in conjuction with blomolecules |
US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
CA2110543A1 (en) | 1992-12-09 | 1994-06-10 | David E. Wright | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives thereof |
US5532142A (en) * | 1993-02-12 | 1996-07-02 | Board Of Regents, The University Of Texas System | Method of isolation and purification of fusion polypeptides |
IL104734A0 (en) * | 1993-02-15 | 1993-06-10 | Univ Bar Ilan | Bioactive conjugates of cellulose with amino compounds |
US5762939A (en) * | 1993-09-13 | 1998-06-09 | Mg-Pmc, Llc | Method for producing influenza hemagglutinin multivalent vaccines using baculovirus |
US5643575A (en) * | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5491076A (en) * | 1993-11-01 | 1996-02-13 | The Texas A&M University System | Expression of foreign genes using a replicating polyprotein producing virus vector |
US5605792A (en) * | 1993-11-04 | 1997-02-25 | The Ohio State University Research Foundation | Infectious bursal disease virus VP2 fusion protein expressed by baculovirus, use as diagnostic |
US5446090A (en) * | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
JP3090586B2 (ja) * | 1994-03-15 | 2000-09-25 | 片倉工業株式会社 | システインプロテアーゼ遺伝子欠損バキュロウイルスおよびその製造法並びにこれを利用する有用タンパク質の製造法 |
US5473034A (en) * | 1994-03-18 | 1995-12-05 | Hyogo Prefectural Government | Method for producing protein-synthetic polymer conjugate and said conjugate produced thereby |
US5629384A (en) * | 1994-05-17 | 1997-05-13 | Consiglio Nazionale Delle Ricerche | Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces |
US5650234A (en) * | 1994-09-09 | 1997-07-22 | Surface Engineering Technologies, Division Of Innerdyne, Inc. | Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
WO1996041813A2 (en) * | 1994-11-09 | 1996-12-27 | Offord Robin E | Functionalized polymers for site-specific attachment |
US5932462A (en) * | 1995-01-10 | 1999-08-03 | Shearwater Polymers, Inc. | Multiarmed, monofunctional, polymer for coupling to molecules and surfaces |
CA2223125A1 (en) * | 1995-02-17 | 1996-08-22 | Stichting Instituut Voor Dierhouderij En Diergezondheid | Production of biologically active recombinant bovine follicle stimulating hormone (recbfsh) in the baculovirus expression system |
FR2732035B1 (fr) * | 1995-03-23 | 1997-05-30 | Agronomique Inst Nat Rech | Procede de regulation de l'expression d'un gene dans un baculovirus, par un site de fixation d'un recepteur de l'acide retinoique, et vecteur pour la mise en oeuvre du dit procede |
NZ308772A (en) * | 1995-05-17 | 1999-04-29 | Du Pont | Recombinant baculovirus insecticides |
US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US5861279A (en) * | 1996-01-17 | 1999-01-19 | Schering Corporation | Baculovirus expression system for human interleukin 5 receptor and method of screening for interleukin 5 antagonists |
US5980948A (en) * | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
ES2306462T3 (es) * | 1996-12-13 | 2008-11-01 | Novartis Vaccines And Diagnostics, Inc. | Analisis y separacion de proteinas del factor de crecimiento derivadas de plaquetas. |
WO1998029376A1 (en) * | 1996-12-19 | 1998-07-09 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Process for the solid phase synthesis of aldehydes, ketones, oximes, amines and hydroxamic acid compounds |
US5990237A (en) * | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
US5965393A (en) * | 1997-07-01 | 1999-10-12 | National Institute Of Immunology | Method for enhancing foreign gene expression in baculovirus expression vector system |
US6455550B1 (en) | 1997-08-22 | 2002-09-24 | Hoffmann-La Roche Inc. | N-alkanoylphenylalanine derivatives |
US5989868A (en) * | 1997-09-12 | 1999-11-23 | The Board Of Regents Of The University Of Oklahoma | Fusion protein systems designed to increase soluble cytoplasmic expression of heterologous proteins in esherichia coli |
WO1999016318A1 (en) * | 1997-09-26 | 1999-04-08 | Uab Research Foundation | Reduced antigenic cells and uses therefor |
US6449281B1 (en) | 1997-09-30 | 2002-09-10 | Intel Corporation | Interface control of communication between a control processor and a digital signal processor |
US6004573A (en) * | 1997-10-03 | 1999-12-21 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
HUP0101467A3 (en) | 1998-03-11 | 2003-03-28 | G D Searle & Co Skokie | Halogenated amidino amino acid derivatives useful as nitric monoxide synthase inhibitors |
WO1999052539A1 (en) | 1998-04-10 | 1999-10-21 | Mayo Foundation For Medical Education And Research | Neo-tryptophan |
US6168932B1 (en) * | 1998-07-13 | 2001-01-02 | Parker Hughes Institute | Recombinant DTctGMCSF fusion toxin in a baculovirus expression vector system |
CA2365668C (en) | 1999-03-17 | 2014-05-20 | The Board Of Trustees Of The Leland Stanford Junior University | In vitro macromolecule biosynthesis methods using exogenous amino acids and a novel atp regeneration system |
US6994986B2 (en) | 1999-03-17 | 2006-02-07 | The Board Of Trustees Of The Leland Stanford University | In vitro synthesis of polypeptides by optimizing amino acid metabolism |
US6337191B1 (en) | 1999-03-22 | 2002-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Vitro protein synthesis using glycolytic intermediates as an energy source |
US6699997B2 (en) * | 2000-06-28 | 2004-03-02 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
US6448281B1 (en) | 2000-07-06 | 2002-09-10 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
CN1191215C (zh) * | 2000-08-18 | 2005-03-02 | 三菱化学株式会社 | 生产苯乙烯的方法 |
ES2314100T3 (es) | 2001-05-03 | 2009-03-16 | Monsanto Technology Llc | Derivados de piruvato. |
US6608196B2 (en) | 2001-05-03 | 2003-08-19 | Galileo Pharmaceuticals, Inc. | Process for solid supported synthesis of pyruvate-derived compounds |
EP1434576A4 (en) | 2001-09-13 | 2006-03-29 | Kenneth E Miller | METHOD FOR RELIEVING PAIN |
AU2002356990A1 (en) * | 2001-11-20 | 2003-06-10 | Pharmacia Corporation | Chemically-modified human growth hormone conjugates |
KR100934550B1 (ko) * | 2003-03-04 | 2009-12-29 | 삼성전자주식회사 | 금속필름 또는 패턴 형성용 유기금속 전구체 및 이를이용한 금속 필름 또는 패턴 형성방법 |
AU2005319099B2 (en) * | 2004-02-02 | 2010-09-16 | Ambrx, Inc. | Modified human growth hormone |
DK1828224T3 (en) | 2004-12-22 | 2016-07-18 | Ambrx Inc | Compositions containing, methods including, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES |
DE602006020480D1 (de) | 2005-11-08 | 2011-04-14 | Ambrx Inc | Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide |
EP1968635B1 (en) | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
CN102702105A (zh) | 2005-12-30 | 2012-10-03 | Ambrx公司 | 含有非天然氨基酸和多肽的组合物、涉及非天然氨基酸和多肽的方法以及非天然氨基酸和多肽的用途 |
US7639491B2 (en) * | 2006-03-29 | 2009-12-29 | Dell Products, L.P. | Method and apparatus for coupling an optical drive to a chassis |
-
2006
- 2006-11-08 DE DE602006020480T patent/DE602006020480D1/de active Active
- 2006-11-08 AT AT06837144T patent/ATE500215T1/de active
- 2006-11-08 CA CA2625540A patent/CA2625540C/en not_active Expired - Fee Related
- 2006-11-08 JP JP2008540156A patent/JP5508716B2/ja active Active
- 2006-11-08 WO PCT/US2006/043472 patent/WO2007056448A2/en active Application Filing
- 2006-11-08 PL PL06837144T patent/PL1954710T3/pl unknown
- 2006-11-08 CN CN201510093840.1A patent/CN104710503B/zh active Active
- 2006-11-08 US US12/092,265 patent/US20090137736A1/en not_active Abandoned
- 2006-11-08 KR KR1020087011067A patent/KR101379071B1/ko active IP Right Grant
- 2006-11-08 RS RS20110224A patent/RS51998B/en unknown
- 2006-11-08 SI SI200631022T patent/SI1954710T1/sl unknown
- 2006-11-08 PT PT06837144T patent/PT1954710E/pt unknown
- 2006-11-08 NZ NZ567234A patent/NZ567234A/en unknown
- 2006-11-08 ES ES06837144T patent/ES2362373T3/es active Active
- 2006-11-08 EP EP06837144A patent/EP1954710B1/en active Active
- 2006-11-08 DK DK06837144.2T patent/DK1954710T3/da active
- 2006-11-08 CN CNA200680041547XA patent/CN101400646A/zh active Pending
- 2006-11-08 AU AU2006311568A patent/AU2006311568B2/en active Active
-
2007
- 2007-10-19 US US11/875,761 patent/US7468458B2/en active Active
- 2007-10-19 US US11/875,741 patent/US20080139794A1/en not_active Abandoned
- 2007-10-26 US US11/925,711 patent/US7888533B2/en active Active
-
2008
- 2008-04-08 IL IL190694A patent/IL190694A/en active IP Right Grant
-
2009
- 2009-01-21 HK HK09100645.0A patent/HK1123310A1/xx unknown
-
2010
- 2010-11-12 US US12/945,599 patent/US8071809B2/en active Active
-
2011
- 2011-05-31 CY CY20111100522T patent/CY1111506T1/el unknown
- 2011-05-31 HR HR20110404T patent/HRP20110404T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20110404T1 (hr) | Ubrzivači za modifikaciju ne-prirodnih aminokiselina i polipeptida ne-prirodnih aminokiselina | |
ES2643689T3 (es) | Polímero para la unión metálica y compuestos y composiciones útiles para ello | |
HRP20170621T1 (hr) | Postupak za pripremanje derivata piperazinil i diazepanil benzamida | |
JP2005179360A5 (sl) | ||
NZ260338A (en) | Polyanhydroaspartic acid having substantially biodegradable hydrolysates, their preparation and use as detergent builders | |
MXPA04006581A (es) | Derivados de sulfonato y su empleo como acidos latentes. | |
NO20060539L (no) | Fremgangsmate for fremstilling av 4-amino-3-kinolinkarbonitriler | |
HRP20180976T1 (hr) | Inhibitori iap | |
WO2002090375A3 (en) | Liver x receptor agonists | |
KR930016389A (ko) | No 신타제 및 시클로옥시게나제의 이중 억제제, 이들의 제조방법 및 이들을 함유하는 치료 조성물 | |
ES2152747T3 (es) | Un procedimiento para preparar 5-(acetil(2,3-dihidroxipropil)amino)-n,n'-bis(2,3-dihidroxipropil)-2,4,6-triyodo-1,3-bencenodicarboxamida. | |
WO2001012233A3 (en) | Sustained release formulation of a peptide | |
BR0114522A (pt) | Processo de fabricação de poliamida | |
BR112020002147A2 (pt) | composição e método para melhorar a estabilidade de composições de espuma aquosas e resistentes ao álcool | |
BRPI0818472A2 (pt) | agente dispersante para sistemas hidraulicamente ligantes | |
FI61870C (fi) | Foerfarande foer framstaellning av aminokarboxylsyraestrar | |
SG160212A1 (en) | Process for the preparation of n-substituted 2-cyanopyrrolidines | |
HRP20100565T1 (hr) | Postupak priprave kontrastnih sredstava | |
CN105688741B (zh) | 氨基酸型Bola表面活性剂的制备方法 | |
BRPI0411195A (pt) | método para a preparação de uma oxazinona fundida e método para a preparação de um composto | |
WO2008068423A3 (fr) | Derives de pyrrole, leur preparation et leur utilisation en therapeutique. | |
AR023914A1 (es) | Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores | |
FI63403C (fi) | Foerfarande foer framstaellning av nya antiarytmiska n-bensyl-n'-bispidinderivat | |
CA2460782A1 (en) | Method of preparing phenoxy alkanoic, alkenoic, and alkynoic acids and salts thereof via a dicarboxylate intermediate | |
JP2009513679A5 (sl) |