NO20060539L - Fremgangsmate for fremstilling av 4-amino-3-kinolinkarbonitriler - Google Patents
Fremgangsmate for fremstilling av 4-amino-3-kinolinkarbonitrilerInfo
- Publication number
- NO20060539L NO20060539L NO20060539A NO20060539A NO20060539L NO 20060539 L NO20060539 L NO 20060539L NO 20060539 A NO20060539 A NO 20060539A NO 20060539 A NO20060539 A NO 20060539A NO 20060539 L NO20060539 L NO 20060539L
- Authority
- NO
- Norway
- Prior art keywords
- amino
- cyanoacetamide
- give
- cyanoacrylamide
- combining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Materials Engineering (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Quinoline Compounds (AREA)
Abstract
Foreliggende oppfinnelse beskriver en fremgangsmåte for fremstiUing av et 4-amino-3- kinolinkarbonitril omfattende kombinering av en aminforbindelse med en cyanoeddiksyre og en syrekatalysator, hvilket gir et cyanoacetamid; kondensering av cyanoacetamid med en eventuelt opp-til tetia-substituert anilin i et alkohohsk løsningsmiddel og et trialkylortoformat, hvilket gir et 2-amino-2- cyanoakrylamid; kombinering av 3-amino-2-cyanoakrylamid med fosforoksyklorid i acetonitril, butyronitril, toluen eller xylen, eventuelt i nærvær av en katalysator, hvilket gir en 4-amino-3- kinolinkarbonitril og den beskriver også en fremgangsmåte for fremstilling av en 7-amino-tieno[3,2- b]pyridin-6-karbonitril omfattende kombinering av en 3-amino tiofen med et cyanoacetamid og trialkylortoformat i et alkohohsk løsningsmiddel for å oppnå et 3-amino-2-cyanoakrylamid; og kombinering av 3-amino-2-cyanoakrylamid med fosforoksyklorid og acetonitril, butyronitiil, toluen eller xylen, eventuelt i nærvær av en katalysator, hvilket gir en 7-amino-tieno[3,2-b]pyridin-6- karbonitril og den beskriver også en fremgangsmåte for fremstilling av et 4 amino-3-kinolinkarbonitiil omfattende: kombinering av en aminforbindelse med cyanoeddiksyre og et peptidkoblingsreagens for å oppnå en suspensjon; filtiering av suspensjonen; hvilket gir cyanoacetamid; kondensering av cyanoacetamid med et eventuelt opptil tetia-substituert anilin med et alkohohsk løsningsmiddel, hvilket gir et 4-amino-3-kinolinkarbonitril og oppfinnelsen beskriver også en fremgangsmåte for å oppnå et cyanoacetamid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49619103P | 2003-08-19 | 2003-08-19 | |
| PCT/US2004/026329 WO2005019201A2 (en) | 2003-08-19 | 2004-08-13 | Process for the preparation of 4-amino-3-quinolinecarbonitriles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NO20060539L true NO20060539L (no) | 2006-02-13 |
Family
ID=34215972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20060539A NO20060539L (no) | 2003-08-19 | 2006-02-02 | Fremgangsmate for fremstilling av 4-amino-3-kinolinkarbonitriler |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US7297795B2 (no) |
| EP (1) | EP1660453A2 (no) |
| JP (1) | JP2007502819A (no) |
| KR (1) | KR20060066733A (no) |
| CN (1) | CN1835923A (no) |
| AR (1) | AR045277A1 (no) |
| AU (1) | AU2004267061A1 (no) |
| BR (1) | BRPI0413667A (no) |
| CA (1) | CA2535385A1 (no) |
| CO (1) | CO5670369A2 (no) |
| CR (1) | CR8226A (no) |
| EC (1) | ECSP066384A (no) |
| GT (1) | GT200400165A (no) |
| IL (1) | IL173456A0 (no) |
| MX (1) | MXPA06001590A (no) |
| MY (1) | MY140542A (no) |
| NO (1) | NO20060539L (no) |
| PA (1) | PA8609301A1 (no) |
| PE (1) | PE20050344A1 (no) |
| RU (1) | RU2345069C2 (no) |
| SA (1) | SA04250258B1 (no) |
| SG (1) | SG145744A1 (no) |
| SV (1) | SV2005001855A (no) |
| TW (1) | TW200517378A (no) |
| WO (1) | WO2005019201A2 (no) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7479561B2 (en) | 2004-08-16 | 2009-01-20 | Wyeth | 4-(2,4-dichloro-5-methoxyphenyl)amino-6-methoxy-7-{[5-substituted-amino)methyl]-3-furyl}-3-quinolinecarbonitriles as kinase inhibitors |
| DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
| JP2008540656A (ja) * | 2005-05-18 | 2008-11-20 | ワイス | Ｔｐｌ２キナーゼの３−シアノキノリン阻害物質ならびにそれを製造および使用する方法 |
| RU2007139544A (ru) * | 2005-05-25 | 2009-06-27 | Вайет (Us) | Способ получения 3-цианохинолинов и промежуточные соединения, полученные согласно данному способу |
| KR20080016671A (ko) * | 2005-05-25 | 2008-02-21 | 와이어쓰 | 치환된 3-시아노퀴놀린 및 그것의 중간체를 합성하는 방법 |
| WO2006127203A2 (en) * | 2005-05-25 | 2006-11-30 | Wyeth | Methods of synthesizing 6-alkylaminoquinoline derivatives |
| CN101248047A (zh) | 2005-07-01 | 2008-08-20 | 惠氏公司 | 4-[(2,4-二氯-5-甲氧基苯基)氨基]-6-甲氧基-7-[3-(4-甲基-1-哌嗪基)丙氧基]-3-喹啉甲腈的晶型及其制备方法 |
| RU2451524C2 (ru) | 2005-11-04 | 2012-05-27 | Вайет | Противоопухолевые комбинации с ингибиторами mtor, герцептином и/или hki-272 |
| WO2007092153A2 (en) * | 2006-02-08 | 2007-08-16 | Wyeth | Preparation of 7-alkenyl-3 quinolinecarbonitriles via a palladium mediated coupling reaction |
| CN101195578B (zh) * | 2006-12-08 | 2012-04-25 | 上海睿智化学研究有限公司 | 1-(卤烷氧基)-2-烷氧基-5-硝基苯类化合物的合成方法 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| EP2310011B1 (en) | 2008-06-17 | 2013-07-24 | Wyeth LLC | Antineoplastic combinations containing hki-272 and vinorelbine |
| KR101434009B1 (ko) | 2008-08-04 | 2014-08-25 | 와이어쓰 엘엘씨 | 4-아닐리노-3-사이아노퀴놀린과 카페시타빈의 항신생물성 조합물 |
| US20100069340A1 (en) * | 2008-09-11 | 2010-03-18 | Wyeth | Pharmaceutical compositions of an src kinase inhibitor and an aromatase inhibitor |
| PT3000467T (pt) | 2009-04-06 | 2023-03-30 | Wyeth Llc | Regime de tratamento utilizando neratinib para o cancro de mama |
| SG177309A1 (en) | 2009-07-02 | 2012-02-28 | Wyeth Llc | 3-cyanoquinoline tablet formulations and uses thereof |
| CN101792416B (zh) * | 2010-01-15 | 2011-10-05 | 南京医科大学 | 一种博舒替尼的制备工艺 |
| CN105061438B (zh) * | 2010-06-23 | 2017-07-04 | 韩美科学株式会社 | 用于抑制酪氨酸激酶活性的稠合嘧啶衍生物 |
| WO2013187967A1 (en) | 2012-06-15 | 2013-12-19 | Institute For Cancer Research D/B/A The Research Institute Of Fox Case Cancer Center ("Fox Chase Cancer Center") | Sensitization of cancer cells to dna damage by inhibiting kinases essential for dna damage checkpoint control |
| CN102952037A (zh) * | 2012-11-18 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种2-氰基-n-(2,4-二氯-5-甲氧苯基)乙酰胺的合成方法 |
| WO2015123758A1 (en) * | 2014-02-20 | 2015-08-27 | Apotex Inc. | Bosutinib forms and preparation methods thereof |
| CN104876865A (zh) * | 2014-02-27 | 2015-09-02 | 南京正荣医药化学有限公司 | 一种博舒替尼的制备工艺 |
| NZ738538A (en) | 2015-07-06 | 2019-06-28 | Gilead Sciences Inc | 6-amino-quinoline-3-carbonitrils as cot modulators |
| CN114380799A (zh) | 2015-07-06 | 2022-04-22 | 吉利德科学公司 | Cot调节剂及其使用方法 |
| CN105085398A (zh) * | 2015-09-06 | 2015-11-25 | 合肥华方医药科技有限公司 | 一种博舒替尼异构体杂质的制备方法 |
| CN105646345A (zh) * | 2016-03-16 | 2016-06-08 | 浙江海正药业股份有限公司 | 博舒替尼的新晶型及其制备方法 |
| WO2018005435A1 (en) | 2016-06-30 | 2018-01-04 | Gilead Sciences, Inc. | 4,6-diaminoquinazolines as cot modulators and methods of use thereof |
| MX2020004034A (es) | 2017-10-18 | 2020-08-13 | Jiangsu Hengrui Medicine Co | Metodo de preparacion para un inhibidor de tirosina cinasa e intermediario del mismo. |
| CN108084085B (zh) * | 2017-12-28 | 2019-11-26 | 山东铂源药业有限公司 | 一种n-(3-氯-4-(2-吡啶甲氧基)苯基)-2-氰基乙酰胺的制备方法 |
| WO2019186429A1 (en) * | 2018-03-30 | 2019-10-03 | Sun Pharmaceutical Industries Limited | A process for the preparation of bosutinib |
| CN109180578B (zh) * | 2018-10-19 | 2020-06-26 | 山东创新药物研发有限公司 | 一种博舒替尼的制备方法 |
| CN111646955B (zh) * | 2019-03-04 | 2024-05-24 | 鲁南制药集团股份有限公司 | 一种制备博舒替尼中间体的方法 |
| CN111646939A (zh) * | 2019-03-04 | 2020-09-11 | 鲁南制药集团股份有限公司 | 一种博舒替尼的制备方法 |
| TWI770527B (zh) | 2019-06-14 | 2022-07-11 | 美商基利科學股份有限公司 | Cot 調節劑及其使用方法 |
| WO2021202224A1 (en) | 2020-03-30 | 2021-10-07 | Gilead Sciences, Inc. | Solid forms of (s)-6-(((1-(bicyclo[1.1.1]pentan-1-yl)-1h-1,2,3-triazol-4-yl)2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)))amino)8-chloro-(neopentylamino)quinoline-3-carb onitrile a cot inhibitor compound |
| JP7446475B2 (ja) | 2020-04-02 | 2024-03-08 | ギリアード サイエンシーズ， インコーポレイテッド | Ｃｏｔ阻害剤化合物を調製するためのプロセス |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73073C2 (uk) * | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція |
-
2004
- 2004-08-13 AU AU2004267061A patent/AU2004267061A1/en not_active Abandoned
- 2004-08-13 KR KR1020067003360A patent/KR20060066733A/ko not_active Application Discontinuation
- 2004-08-13 RU RU2006108524/04A patent/RU2345069C2/ru not_active IP Right Cessation
- 2004-08-13 EP EP04781074A patent/EP1660453A2/en not_active Withdrawn
- 2004-08-13 CN CNA2004800236697A patent/CN1835923A/zh active Pending
- 2004-08-13 MX MXPA06001590A patent/MXPA06001590A/es active IP Right Grant
- 2004-08-13 SG SG200806052-7A patent/SG145744A1/en unknown
- 2004-08-13 WO PCT/US2004/026329 patent/WO2005019201A2/en active Application Filing
- 2004-08-13 JP JP2006523942A patent/JP2007502819A/ja not_active Withdrawn
- 2004-08-13 CA CA002535385A patent/CA2535385A1/en not_active Abandoned
- 2004-08-13 BR BRPI0413667-5A patent/BRPI0413667A/pt not_active IP Right Cessation
- 2004-08-16 US US10/918,947 patent/US7297795B2/en not_active Expired - Fee Related
- 2004-08-17 PE PE2004000794A patent/PE20050344A1/es not_active Application Discontinuation
- 2004-08-17 TW TW093124649A patent/TW200517378A/zh unknown
- 2004-08-18 AR ARP040102964A patent/AR045277A1/es unknown
- 2004-08-18 MY MYPI20043356A patent/MY140542A/en unknown
- 2004-08-19 GT GT200400165A patent/GT200400165A/es unknown
- 2004-08-19 PA PA20048609301A patent/PA8609301A1/es unknown
- 2004-08-19 SV SV2004001855A patent/SV2005001855A/es not_active Application Discontinuation
- 2004-08-21 SA SA04250258A patent/SA04250258B1/ar unknown
-
2006
- 2006-01-31 IL IL173456A patent/IL173456A0/en unknown
- 2006-02-02 CR CR8226A patent/CR8226A/es not_active Application Discontinuation
- 2006-02-02 NO NO20060539A patent/NO20060539L/no not_active Application Discontinuation
- 2006-02-15 CO CO06015094A patent/CO5670369A2/es unknown
- 2006-02-17 EC EC2006006384A patent/ECSP066384A/es unknown
-
2007
- 2007-10-05 US US11/973,259 patent/US20080033175A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050043537A1 (en) | 2005-02-24 |
| WO2005019201A3 (en) | 2005-08-04 |
| CR8226A (es) | 2008-08-21 |
| MY140542A (en) | 2009-12-31 |
| RU2345069C2 (ru) | 2009-01-27 |
| SG145744A1 (en) | 2008-09-29 |
| CA2535385A1 (en) | 2005-03-03 |
| WO2005019201A2 (en) | 2005-03-03 |
| PE20050344A1 (es) | 2005-06-19 |
| IL173456A0 (en) | 2006-06-11 |
| TW200517378A (en) | 2005-06-01 |
| MXPA06001590A (es) | 2006-05-19 |
| US20080033175A1 (en) | 2008-02-07 |
| CN1835923A (zh) | 2006-09-20 |
| BRPI0413667A (pt) | 2006-10-24 |
| CO5670369A2 (es) | 2006-08-31 |
| GT200400165A (es) | 2005-04-12 |
| RU2006108524A (ru) | 2007-09-27 |
| AU2004267061A1 (en) | 2005-03-03 |
| EP1660453A2 (en) | 2006-05-31 |
| AR045277A1 (es) | 2005-10-19 |
| JP2007502819A (ja) | 2007-02-15 |
| PA8609301A1 (es) | 2005-03-03 |
| SV2005001855A (es) | 2005-11-04 |
| KR20060066733A (ko) | 2006-06-16 |
| US7297795B2 (en) | 2007-11-20 |
| SA04250258B1 (ar) | 2009-01-07 |
| ECSP066384A (es) | 2006-08-30 |
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