DE60316047D1 - Verfahren zur Herstellung von Olanzapine und ein Zwischenprodukt dafür - Google Patents

Verfahren zur Herstellung von Olanzapine und ein Zwischenprodukt dafür

Info

Publication number
DE60316047D1
DE60316047D1 DE60316047T DE60316047T DE60316047D1 DE 60316047 D1 DE60316047 D1 DE 60316047D1 DE 60316047 T DE60316047 T DE 60316047T DE 60316047 T DE60316047 T DE 60316047T DE 60316047 D1 DE60316047 D1 DE 60316047D1
Authority
DE
Germany
Prior art keywords
preparation
olanzapines
intermediate therefor
therefor
olanzapine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60316047T
Other languages
English (en)
Other versions
DE60316047T2 (de
Inventor
Zbigniew Majka
Tomasz Stawinski
Justyna Rechnio
Maciej Wieczorek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adamed Sp zoo
Original Assignee
Adamed Sp zoo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29997625&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60316047(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adamed Sp zoo filed Critical Adamed Sp zoo
Application granted granted Critical
Publication of DE60316047D1 publication Critical patent/DE60316047D1/de
Publication of DE60316047T2 publication Critical patent/DE60316047T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60316047T 2002-06-20 2003-06-10 Verfahren zur Herstellung von Olanzapine und ein Zwischenprodukt dafür Expired - Fee Related DE60316047T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL354642A PL199016B1 (pl) 2002-06-20 2002-06-20 Sposób wytwarzania olanzapiny
PL35464202 2002-06-20

Publications (2)

Publication Number Publication Date
DE60316047D1 true DE60316047D1 (de) 2007-10-11
DE60316047T2 DE60316047T2 (de) 2008-05-21

Family

ID=29997625

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60316439T Expired - Lifetime DE60316439T3 (de) 2002-06-20 2003-06-10 Verfahren zur herstellung von olanzapin und ein zwischenprodukt dafür
DE60316047T Expired - Fee Related DE60316047T2 (de) 2002-06-20 2003-06-10 Verfahren zur Herstellung von Olanzapine und ein Zwischenprodukt dafür

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60316439T Expired - Lifetime DE60316439T3 (de) 2002-06-20 2003-06-10 Verfahren zur herstellung von olanzapin und ein zwischenprodukt dafür

Country Status (17)

Country Link
EP (2) EP1513845B2 (de)
CN (1) CN100338069C (de)
AT (2) ATE371660T1 (de)
AU (1) AU2003240167A1 (de)
BR (1) BR0305100A (de)
DE (2) DE60316439T3 (de)
ES (2) ES2291644T5 (de)
HR (1) HRP20041075B1 (de)
MX (1) MXPA04012200A (de)
NO (1) NO328873B1 (de)
PL (1) PL199016B1 (de)
PT (2) PT1513845E (de)
RU (1) RU2005101324A (de)
SI (2) SI1669359T1 (de)
TN (1) TNSN04226A1 (de)
UA (1) UA76616C2 (de)
WO (1) WO2004000847A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058773A1 (en) 2002-12-24 2004-07-15 Teva Pharmaceutical Industries Ltd. Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms
AR047460A1 (es) * 2004-01-27 2006-01-18 Synthon Bv Proceso para la fabricacion de acetato de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (acetato de olanzapina)
WO2005070938A1 (en) 2004-01-27 2005-08-04 Synthon B.V. Stable salts of olanzapine
AR048272A1 (es) * 2004-03-18 2006-04-12 Lek Pharmaceuticals Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales.
ES2427048T3 (es) 2004-07-14 2013-10-28 Jubilant Life Sciences Limited Un procedimiento para producir una forma pura de 2-metil-4-(4-metil-1-piperazinil)-10H-tieno[2,3-B][1,5]benzodiazepina
PL198589B1 (pl) 2004-11-22 2008-06-30 Adamed Sp Z Oo Sposób wytwarzania N-demetyloolanzapiny
CN100383144C (zh) * 2006-09-11 2008-04-23 杭州盛美医药科技开发有限公司 一种奥氮平的中间体及其制备与应用
EP2292624A1 (de) 2009-07-20 2011-03-09 LEK Pharmaceuticals d.d. Olanzapinreinigungsverfahren
CN102234285B (zh) * 2010-04-19 2013-06-12 江苏豪森药业股份有限公司 奥氮平的制备方法
CN102924470B (zh) * 2011-08-31 2014-12-03 江苏豪森药业股份有限公司 新颖的奥氮平的制备方法
CN102942573B (zh) * 2011-10-09 2015-03-25 连云港恒运医药科技有限公司 奥氮平的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7306069A (de) † 1973-05-02 1974-11-05
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US4115568A (en) † 1974-11-26 1978-09-19 Lilly Industries Limited Thieno[3,2-b]-[1,5]benzodiazepines
US5239071A (en) † 1989-11-21 1993-08-24 The B. F. Goodrich Company Process for methylating a hindered nitrogen atom in an inert non-aqueous solvent
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
DK55192D0 (da) † 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
US6348455B1 (en) 1998-11-23 2002-02-19 Sepracor Inc. Desmetylolanzapine compositions and methods

Also Published As

Publication number Publication date
AU2003240167A1 (en) 2004-01-06
DE60316047T2 (de) 2008-05-21
EP1513845A1 (de) 2005-03-16
CN1662543A (zh) 2005-08-31
ATE371660T1 (de) 2007-09-15
DE60316439D1 (de) 2007-10-31
DE60316439T2 (de) 2008-07-31
EP1669359B1 (de) 2007-08-29
ES2291644T3 (es) 2008-03-01
ATE373664T1 (de) 2007-10-15
BR0305100A (pt) 2004-09-28
HRP20041075B1 (en) 2008-05-31
HRP20041075A2 (en) 2005-02-28
ES2289730T3 (es) 2008-02-01
NO328873B1 (no) 2010-06-07
ES2291644T5 (es) 2011-02-15
EP1513845B2 (de) 2010-11-03
SI1513845T1 (sl) 2007-12-31
PT1669359E (pt) 2007-10-16
RU2005101324A (ru) 2005-08-10
CN100338069C (zh) 2007-09-19
SI1513845T2 (sl) 2011-01-31
SI1669359T1 (sl) 2007-12-31
PT1513845E (pt) 2007-11-21
PL199016B1 (pl) 2008-08-29
DE60316439T3 (de) 2011-05-05
NO20040658L (no) 2004-02-13
EP1669359A1 (de) 2006-06-14
EP1513845B1 (de) 2007-09-19
WO2004000847A1 (en) 2003-12-31
MXPA04012200A (es) 2005-08-26
TNSN04226A1 (en) 2007-03-12
PL354642A1 (en) 2003-12-29
UA76616C2 (en) 2006-08-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee