ATE412000T1 - Verfahren zur herstellung von n-demethylolanzapin - Google Patents
Verfahren zur herstellung von n-demethylolanzapinInfo
- Publication number
- ATE412000T1 ATE412000T1 AT05810971T AT05810971T ATE412000T1 AT E412000 T1 ATE412000 T1 AT E412000T1 AT 05810971 T AT05810971 T AT 05810971T AT 05810971 T AT05810971 T AT 05810971T AT E412000 T1 ATE412000 T1 AT E412000T1
- Authority
- AT
- Austria
- Prior art keywords
- demethylolanzapine
- olanzapine
- producing
- piperazine
- benzodiazepine
- Prior art date
Links
- FHPIXVHJEIZKJW-UHFFFAOYSA-N 4'-N-desmethylolanzapine Chemical compound S1C(C)=CC2=C1NC1=CC=CC=C1N=C2N1CCNCC1 FHPIXVHJEIZKJW-UHFFFAOYSA-N 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 abstract 2
- 229960005017 olanzapine Drugs 0.000 abstract 2
- 230000000561 anti-psychotic effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Hydrogenated Pyridines (AREA)
- Cephalosporin Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL371307A PL198589B1 (pl) | 2004-11-22 | 2004-11-22 | Sposób wytwarzania N-demetyloolanzapiny |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE412000T1 true ATE412000T1 (de) | 2008-11-15 |
Family
ID=35645631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05810971T ATE412000T1 (de) | 2004-11-22 | 2005-11-15 | Verfahren zur herstellung von n-demethylolanzapin |
Country Status (10)
| Country | Link |
|---|---|
| EP (2) | EP1988092B1 (de) |
| CN (1) | CN101061124B (de) |
| AT (1) | ATE412000T1 (de) |
| DE (1) | DE602005010606D1 (de) |
| ES (1) | ES2315928T3 (de) |
| NO (1) | NO20073165L (de) |
| PL (1) | PL198589B1 (de) |
| PT (1) | PT1814886E (de) |
| SI (1) | SI1814886T1 (de) |
| WO (1) | WO2006053870A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL395468A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Zwiazki amidoalkilopiperazynylowe do leczenia chorób osrodkowego ukladu nerwowego |
| CN102924470B (zh) * | 2011-08-31 | 2014-12-03 | 江苏豪森药业股份有限公司 | 新颖的奥氮平的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9009229D0 (en) | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
| ATE286398T1 (de) | 1998-11-23 | 2005-01-15 | Sepracor Inc | Desmethylolanzapine enthaltende zusammensetzungen und verfahren |
| CN1420117A (zh) * | 2001-11-16 | 2003-05-28 | 连云港豪森制药有限公司 | 一种制备奥氮平的方法 |
| PL199016B1 (pl) | 2002-06-20 | 2008-08-29 | Adamed Sp Z Oo | Sposób wytwarzania olanzapiny |
| WO2004094390A1 (en) * | 2003-03-20 | 2004-11-04 | Watson Pharmaceuticals, Inc. | 2-methyl-thieno-benzodiazepine process |
-
2004
- 2004-11-22 PL PL371307A patent/PL198589B1/pl unknown
-
2005
- 2005-11-15 EP EP08161324.2A patent/EP1988092B1/de not_active Ceased
- 2005-11-15 WO PCT/EP2005/055981 patent/WO2006053870A1/en not_active Ceased
- 2005-11-15 ES ES05810971T patent/ES2315928T3/es not_active Expired - Lifetime
- 2005-11-15 PT PT05810971T patent/PT1814886E/pt unknown
- 2005-11-15 AT AT05810971T patent/ATE412000T1/de not_active IP Right Cessation
- 2005-11-15 CN CN2005800399627A patent/CN101061124B/zh not_active Expired - Fee Related
- 2005-11-15 EP EP05810971A patent/EP1814886B1/de not_active Expired - Lifetime
- 2005-11-15 DE DE602005010606T patent/DE602005010606D1/de not_active Expired - Lifetime
- 2005-11-15 SI SI200530530T patent/SI1814886T1/sl unknown
-
2007
- 2007-06-22 NO NO20073165A patent/NO20073165L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006053870A1 (en) | 2006-05-26 |
| PT1814886E (pt) | 2008-11-04 |
| EP1988092B1 (de) | 2013-11-27 |
| ES2315928T3 (es) | 2009-04-01 |
| CN101061124A (zh) | 2007-10-24 |
| DE602005010606D1 (de) | 2008-12-04 |
| EP1814886B1 (de) | 2008-10-22 |
| CN101061124B (zh) | 2010-07-28 |
| EP1988092A1 (de) | 2008-11-05 |
| PL371307A1 (pl) | 2006-05-29 |
| SI1814886T1 (sl) | 2009-04-30 |
| PL198589B1 (pl) | 2008-06-30 |
| NO20073165L (no) | 2007-06-22 |
| EP1814886A1 (de) | 2007-08-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |