HRP20100401T1 - DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI - Google Patents
DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI Download PDFInfo
- Publication number
- HRP20100401T1 HRP20100401T1 HR20100401T HRP20100401T HRP20100401T1 HR P20100401 T1 HRP20100401 T1 HR P20100401T1 HR 20100401 T HR20100401 T HR 20100401T HR P20100401 T HRP20100401 T HR P20100401T HR P20100401 T1 HRP20100401 T1 HR P20100401T1
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- tetrahydropyrazolo
- azepin
- compound
- phenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
| PCT/EP2006/006613 WO2007025596A1 (en) | 2005-07-06 | 2006-07-04 | Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20100401T1 true HRP20100401T1 (hr) | 2010-09-30 |
Family
ID=34856781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20100401T HRP20100401T1 (hr) | 2005-07-06 | 2006-07-04 | DERIVATI PIRAZOLO/3,4-d/AZEPINA KAO HISTAMINSKI H3 ANTAGONISTI |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7888347B2 (OSRAM) |
| EP (1) | EP1899350B1 (OSRAM) |
| JP (1) | JP5145218B2 (OSRAM) |
| KR (1) | KR20080037651A (OSRAM) |
| CN (1) | CN101258154B (OSRAM) |
| AT (1) | ATE467636T1 (OSRAM) |
| AU (1) | AU2006286897A1 (OSRAM) |
| BR (1) | BRPI0612719A2 (OSRAM) |
| CA (1) | CA2614232A1 (OSRAM) |
| CR (1) | CR9622A (OSRAM) |
| CY (1) | CY1110711T1 (OSRAM) |
| DE (1) | DE602006014273D1 (OSRAM) |
| DK (1) | DK1899350T3 (OSRAM) |
| EA (1) | EA013600B1 (OSRAM) |
| ES (1) | ES2345841T3 (OSRAM) |
| GB (1) | GB0513886D0 (OSRAM) |
| HR (1) | HRP20100401T1 (OSRAM) |
| IL (1) | IL188184A0 (OSRAM) |
| MA (1) | MA29623B1 (OSRAM) |
| MX (1) | MX2008000383A (OSRAM) |
| NO (1) | NO20080563L (OSRAM) |
| PL (1) | PL1899350T3 (OSRAM) |
| PT (1) | PT1899350E (OSRAM) |
| SI (1) | SI1899350T1 (OSRAM) |
| UA (1) | UA93047C2 (OSRAM) |
| WO (1) | WO2007025596A1 (OSRAM) |
| ZA (1) | ZA200710798B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US8829041B2 (en) | 2006-06-23 | 2014-09-09 | Abbvie Inc. | Cyclopropyl amine derivatives |
| MX2010002938A (es) | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
| BR112018074231A2 (pt) * | 2016-05-25 | 2019-03-06 | Akarna Therapeutics, Ltd. | compostos bicíclicos fundidos para o tratamento de doença |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573218B1 (en) * | 1998-09-09 | 2003-06-03 | Ishihara Sangyo Kaisha, Ltd. | Fused-benzene derivatives useful as herbicides |
| EP1173438A1 (en) * | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
| DE60312328T2 (de) * | 2002-06-06 | 2007-11-08 | Novo Nordisk A/S | Substituierte hexahydropyrrolo(1,2-a)pyrazine, octahydropyrido(1,2-a)pyrazine und decahydropyrazino(1,2-a)azepine |
| US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
| AU2003244649A1 (en) | 2002-07-25 | 2004-02-23 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| EP1539704A1 (en) * | 2002-08-20 | 2005-06-15 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| ATE441417T1 (de) | 2002-12-20 | 2009-09-15 | Glaxo Group Ltd | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten |
| AU2004283196B2 (en) * | 2003-09-17 | 2011-08-25 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| US20070232590A1 (en) | 2004-06-18 | 2007-10-04 | Glaxo Group Limited | 3-Cylcoalkylbenzazepines as Histamine H3 Antagonists |
| GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| AU2005313550A1 (en) | 2004-12-07 | 2006-06-15 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| EP1858900B1 (en) | 2005-03-14 | 2009-01-07 | Glaxo Group Limited | Fused thiazole derivatives having affinity for the histamine h3 receptor |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Ceased
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en not_active Ceased
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0612719A2 (pt) | 2010-11-30 |
| CR9622A (es) | 2008-04-10 |
| US7888347B2 (en) | 2011-02-15 |
| JP5145218B2 (ja) | 2013-02-13 |
| UA93047C2 (ru) | 2011-01-10 |
| WO2007025596A1 (en) | 2007-03-08 |
| ATE467636T1 (de) | 2010-05-15 |
| DE602006014273D1 (de) | 2010-06-24 |
| JP2009500366A (ja) | 2009-01-08 |
| EP1899350B1 (en) | 2010-05-12 |
| ZA200710798B (en) | 2008-11-26 |
| EA200800264A1 (ru) | 2008-06-30 |
| EP1899350A1 (en) | 2008-03-19 |
| SI1899350T1 (sl) | 2010-09-30 |
| CN101258154A (zh) | 2008-09-03 |
| US20080176832A1 (en) | 2008-07-24 |
| AU2006286897A1 (en) | 2007-03-08 |
| CA2614232A1 (en) | 2007-03-08 |
| IL188184A0 (en) | 2008-03-20 |
| KR20080037651A (ko) | 2008-04-30 |
| EA013600B1 (ru) | 2010-06-30 |
| GB0513886D0 (en) | 2005-08-10 |
| ES2345841T3 (es) | 2010-10-04 |
| CY1110711T1 (el) | 2015-06-10 |
| MA29623B1 (fr) | 2008-07-01 |
| NO20080563L (no) | 2008-02-01 |
| MX2008000383A (es) | 2008-03-07 |
| PL1899350T3 (pl) | 2010-10-29 |
| DK1899350T3 (da) | 2010-09-06 |
| PT1899350E (pt) | 2010-07-21 |
| CN101258154B (zh) | 2011-01-19 |
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