CN101258154B - 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 - Google Patents

作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 Download PDF

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Publication number
CN101258154B
CN101258154B CN2006800322776A CN200680032277A CN101258154B CN 101258154 B CN101258154 B CN 101258154B CN 2006800322776 A CN2006800322776 A CN 2006800322776A CN 200680032277 A CN200680032277 A CN 200680032277A CN 101258154 B CN101258154 B CN 101258154B
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CN
China
Prior art keywords
alkyl
azepine
phenyl
heteroaryl
aryl
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Expired - Fee Related
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CN2006800322776A
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English (en)
Chinese (zh)
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CN101258154A (zh
Inventor
马克·J·班福德
戴维·M·威尔逊
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of CN101258154A publication Critical patent/CN101258154A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN2006800322776A 2005-07-06 2006-07-04 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物 Expired - Fee Related CN101258154B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0513886.2 2005-07-06
GBGB0513886.2A GB0513886D0 (en) 2005-07-06 2005-07-06 Novel compounds
PCT/EP2006/006613 WO2007025596A1 (en) 2005-07-06 2006-07-04 Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists

Publications (2)

Publication Number Publication Date
CN101258154A CN101258154A (zh) 2008-09-03
CN101258154B true CN101258154B (zh) 2011-01-19

Family

ID=34856781

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2006800322776A Expired - Fee Related CN101258154B (zh) 2005-07-06 2006-07-04 作为组胺h3拮抗剂的吡唑并[3,4-d]氮杂䓬衍生物

Country Status (27)

Country Link
US (1) US7888347B2 (OSRAM)
EP (1) EP1899350B1 (OSRAM)
JP (1) JP5145218B2 (OSRAM)
KR (1) KR20080037651A (OSRAM)
CN (1) CN101258154B (OSRAM)
AT (1) ATE467636T1 (OSRAM)
AU (1) AU2006286897A1 (OSRAM)
BR (1) BRPI0612719A2 (OSRAM)
CA (1) CA2614232A1 (OSRAM)
CR (1) CR9622A (OSRAM)
CY (1) CY1110711T1 (OSRAM)
DE (1) DE602006014273D1 (OSRAM)
DK (1) DK1899350T3 (OSRAM)
EA (1) EA013600B1 (OSRAM)
ES (1) ES2345841T3 (OSRAM)
GB (1) GB0513886D0 (OSRAM)
HR (1) HRP20100401T1 (OSRAM)
IL (1) IL188184A0 (OSRAM)
MA (1) MA29623B1 (OSRAM)
MX (1) MX2008000383A (OSRAM)
NO (1) NO20080563L (OSRAM)
PL (1) PL1899350T3 (OSRAM)
PT (1) PT1899350E (OSRAM)
SI (1) SI1899350T1 (OSRAM)
UA (1) UA93047C2 (OSRAM)
WO (1) WO2007025596A1 (OSRAM)
ZA (1) ZA200710798B (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0712823A2 (pt) 2006-06-23 2012-07-24 Abbott Lab derivados de ciclopropil amina como moduladores de receptor de histamina h3
US9108948B2 (en) 2006-06-23 2015-08-18 Abbvie Inc. Cyclopropyl amine derivatives
MX2010002938A (es) 2007-09-24 2010-04-01 Comentis Inc Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer.
US9186353B2 (en) * 2009-04-27 2015-11-17 Abbvie Inc. Treatment of osteoarthritis pain
US8853390B2 (en) 2010-09-16 2014-10-07 Abbvie Inc. Processes for preparing 1,2-substituted cyclopropyl derivatives
CN102952139B (zh) * 2011-08-30 2016-08-10 上海药明康德新药开发有限公司 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法
WO2013151982A1 (en) 2012-04-03 2013-10-10 Arena Pharmaceuticals, Inc. Methods and compounds useful in treating pruritus, and methods for identifying such compounds
EP2647377A1 (en) 2012-04-06 2013-10-09 Sanofi Use of an h3 receptor antagonist for the treatment of alzheimer's disease
JO3407B1 (ar) 2012-05-31 2019-10-20 Eisai R&D Man Co Ltd مركبات رباعي هيدرو بيرازولو بيريميدين
US9910887B2 (en) * 2013-04-25 2018-03-06 Facebook, Inc. Variable search query vertical access
SG11201810292YA (en) * 2016-05-25 2018-12-28 Akarna Therapeutics Ltd Fused bicyclic compounds for the treatment of disease

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325267A (zh) * 1998-09-09 2001-12-05 石原产业株式会社 用作除草剂的稠合的苯衍生物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1173438A1 (en) * 1999-04-16 2002-01-23 Novo Nordisk A/S Substituted imidazoles, their preparation and use
JP2001220390A (ja) 2000-02-09 2001-08-14 Yamanouchi Pharmaceut Co Ltd 縮合ピラゾール誘導体
WO2003104235A1 (en) * 2002-06-06 2003-12-18 Novo Nordisk A/S Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]pyrazines and decahydropyrazino[1,2-a]azepines
US6770597B2 (en) 2002-07-17 2004-08-03 Ishihara Sangyo Kaisha, Ltd. Benzohydrazide derivatives as herbicides and desiccant compositions containing them
JP2005537290A (ja) 2002-07-25 2005-12-08 ファルマシア・イタリア・エス・ピー・エー キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物
JP2006500376A (ja) * 2002-08-20 2006-01-05 イーライ・リリー・アンド・カンパニー ヒスタミンｈ３受容体アンタゴニストとしての置換アゼピン、製造および治療上の使用
GB0224083D0 (en) 2002-10-16 2002-11-27 Glaxo Group Ltd Novel compounds
GB0224557D0 (en) 2002-10-22 2002-11-27 Glaxo Group Ltd Novel compounds
ES2333008T3 (es) 2002-12-20 2010-02-16 Glaxo Group Limited Derivados de benzo(d)azepina para el tratamiento de trastornos neurologicos.
US7402680B2 (en) * 2003-09-17 2008-07-22 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds
GB0329214D0 (en) 2003-12-17 2004-01-21 Glaxo Group Ltd Novel compounds
GB0405628D0 (en) 2004-03-12 2004-04-21 Glaxo Group Ltd Novel compounds
GB0408083D0 (en) 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
JP2008502644A (ja) 2004-06-18 2008-01-31 グラクソ　グループ　リミテッド ヒスタミンｈ３アンタゴニストとしての３−シクロアルキルベンズアゼピン
GB0418267D0 (en) 2004-08-16 2004-09-15 Glaxo Group Ltd Novel compounds
RU2007125648A (ru) 2004-12-07 2009-01-20 Глэксо Груп Лимитед (GB) Инденильные производные и их применение для лечения неврологических расстройств
ATE420091T1 (de) 2005-03-14 2009-01-15 Glaxo Group Ltd Kondensierte thiazolderivate mit affinität für den histamin-h3-rezeptor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1325267A (zh) * 1998-09-09 2001-12-05 石原产业株式会社 用作除草剂的稠合的苯衍生物

Also Published As

Publication number Publication date
WO2007025596A1 (en) 2007-03-08
DK1899350T3 (da) 2010-09-06
CR9622A (es) 2008-04-10
HRP20100401T1 (hr) 2010-09-30
IL188184A0 (en) 2008-03-20
EA013600B1 (ru) 2010-06-30
CY1110711T1 (el) 2015-06-10
JP2009500366A (ja) 2009-01-08
JP5145218B2 (ja) 2013-02-13
DE602006014273D1 (de) 2010-06-24
PT1899350E (pt) 2010-07-21
AU2006286897A1 (en) 2007-03-08
CN101258154A (zh) 2008-09-03
CA2614232A1 (en) 2007-03-08
ZA200710798B (en) 2008-11-26
NO20080563L (no) 2008-02-01
GB0513886D0 (en) 2005-08-10
PL1899350T3 (pl) 2010-10-29
US20080176832A1 (en) 2008-07-24
BRPI0612719A2 (pt) 2010-11-30
US7888347B2 (en) 2011-02-15
EP1899350A1 (en) 2008-03-19
ATE467636T1 (de) 2010-05-15
MA29623B1 (fr) 2008-07-01
ES2345841T3 (es) 2010-10-04
KR20080037651A (ko) 2008-04-30
EA200800264A1 (ru) 2008-06-30
SI1899350T1 (sl) 2010-09-30
UA93047C2 (ru) 2011-01-10
EP1899350B1 (en) 2010-05-12
MX2008000383A (es) 2008-03-07

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Granted publication date: 20110119

Termination date: 20130704