CY1110711T1 - Παραγωγα πυραζολο [3,4-d]αζεπινης ως ανταγωνιστες ισταμινης η3 - Google Patents
Παραγωγα πυραζολο [3,4-d]αζεπινης ως ανταγωνιστες ισταμινης η3Info
- Publication number
- CY1110711T1 CY1110711T1 CY20101100713T CY101100713T CY1110711T1 CY 1110711 T1 CY1110711 T1 CY 1110711T1 CY 20101100713 T CY20101100713 T CY 20101100713T CY 101100713 T CY101100713 T CY 101100713T CY 1110711 T1 CY1110711 T1 CY 1110711T1
- Authority
- CY
- Cyprus
- Prior art keywords
- azepinis
- anticine
- pyrazolo
- product
- components
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση αφορά νέα παράγωγα πυραζολίου του τύπου Ι που έχουν φαρμακολογική δραστικότητα ως ανταγωνιστές Η3, μέθοδος για την παρασκευή αυτών, συνθέσεις που περιέχουν αυτά και την χρήση αυτών στην θεραπεία νευρολογικών και ψυχιατρικών διαταραχών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
EP06818218A EP1899350B1 (en) | 2005-07-06 | 2006-07-04 | Pyrazolo [3 , 4-d]azepine derivatives as histamine h3 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1110711T1 true CY1110711T1 (el) | 2015-06-10 |
Family
ID=34856781
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20101100713T CY1110711T1 (el) | 2005-07-06 | 2010-07-29 | Παραγωγα πυραζολο [3,4-d]αζεπινης ως ανταγωνιστες ισταμινης η3 |
Country Status (27)
Country | Link |
---|---|
US (1) | US7888347B2 (el) |
EP (1) | EP1899350B1 (el) |
JP (1) | JP5145218B2 (el) |
KR (1) | KR20080037651A (el) |
CN (1) | CN101258154B (el) |
AT (1) | ATE467636T1 (el) |
AU (1) | AU2006286897A1 (el) |
BR (1) | BRPI0612719A2 (el) |
CA (1) | CA2614232A1 (el) |
CR (1) | CR9622A (el) |
CY (1) | CY1110711T1 (el) |
DE (1) | DE602006014273D1 (el) |
DK (1) | DK1899350T3 (el) |
EA (1) | EA013600B1 (el) |
ES (1) | ES2345841T3 (el) |
GB (1) | GB0513886D0 (el) |
HR (1) | HRP20100401T1 (el) |
IL (1) | IL188184A0 (el) |
MA (1) | MA29623B1 (el) |
MX (1) | MX2008000383A (el) |
NO (1) | NO20080563L (el) |
PL (1) | PL1899350T3 (el) |
PT (1) | PT1899350E (el) |
SI (1) | SI1899350T1 (el) |
UA (1) | UA93047C2 (el) |
WO (1) | WO2007025596A1 (el) |
ZA (1) | ZA200710798B (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA98772C2 (ru) | 2006-06-23 | 2012-06-25 | Эбботт Леборетриз | Производные циклопропиламина как модуляторы н3-гистаминового рецептора |
US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
JP5055432B2 (ja) | 2007-09-24 | 2012-10-24 | コメンティス,インコーポレーテッド | 治療のためのβ−セクレターゼ阻害剤としての(3−ヒドロキシ−4−アミノブタン−2−イル)−3−(2−チアゾール−2−イル−ピロリジン−1−カルボニル)ベンズアミド誘導体及び関連する化合物 |
US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
US20200325140A1 (en) * | 2016-05-25 | 2020-10-15 | Akarna Therapeutics, Ltd. | Fused bicyclic compounds for the treatment of disease |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20010079778A (ko) * | 1998-09-09 | 2001-08-22 | 이시하라 겐조 | 제초제로 유용한 융합-벤젠 유도체 |
EP1173438A1 (en) * | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
ES2283768T3 (es) * | 2002-06-06 | 2007-11-01 | Novo Nordisk A/S | Hexahidropirrolo(1,2-a)piracinas, octahidropirido(1,2-a)piracinas y decahidropiracino(1,2-a)acepinas sustituidas. |
US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
AU2003244649A1 (en) | 2002-07-25 | 2004-02-23 | Pharmacia Italia Spa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
EP1539704A1 (en) * | 2002-08-20 | 2005-06-15 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
ATE441417T1 (de) | 2002-12-20 | 2009-09-15 | Glaxo Group Ltd | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten |
WO2005040169A2 (en) * | 2003-09-17 | 2005-05-06 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds as serotonin receptor modulators |
GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
US20070232590A1 (en) | 2004-06-18 | 2007-10-04 | Glaxo Group Limited | 3-Cylcoalkylbenzazepines as Histamine H3 Antagonists |
GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
BRPI0518841A2 (pt) | 2004-12-07 | 2008-12-09 | Glaxo Group Ltd | derivados de indenila e uso destes para o tratamento de transtornos neurolàgicos |
AU2006224440A1 (en) | 2005-03-14 | 2006-09-21 | Glaxo Group Limited | Fused thiazole derivatives having affinity for the histamine H3 receptor |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Application Discontinuation
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en active Application Filing
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-20 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
IL188184A0 (en) | 2008-03-20 |
JP5145218B2 (ja) | 2013-02-13 |
CR9622A (es) | 2008-04-10 |
EA013600B1 (ru) | 2010-06-30 |
DK1899350T3 (da) | 2010-09-06 |
SI1899350T1 (sl) | 2010-09-30 |
MA29623B1 (fr) | 2008-07-01 |
HRP20100401T1 (hr) | 2010-09-30 |
WO2007025596A1 (en) | 2007-03-08 |
MX2008000383A (es) | 2008-03-07 |
ATE467636T1 (de) | 2010-05-15 |
ZA200710798B (en) | 2008-11-26 |
US7888347B2 (en) | 2011-02-15 |
EP1899350A1 (en) | 2008-03-19 |
PL1899350T3 (pl) | 2010-10-29 |
JP2009500366A (ja) | 2009-01-08 |
PT1899350E (pt) | 2010-07-21 |
DE602006014273D1 (de) | 2010-06-24 |
GB0513886D0 (en) | 2005-08-10 |
BRPI0612719A2 (pt) | 2010-11-30 |
AU2006286897A1 (en) | 2007-03-08 |
NO20080563L (no) | 2008-02-01 |
CN101258154A (zh) | 2008-09-03 |
US20080176832A1 (en) | 2008-07-24 |
ES2345841T3 (es) | 2010-10-04 |
EA200800264A1 (ru) | 2008-06-30 |
CN101258154B (zh) | 2011-01-19 |
EP1899350B1 (en) | 2010-05-12 |
KR20080037651A (ko) | 2008-04-30 |
CA2614232A1 (en) | 2007-03-08 |
UA93047C2 (ru) | 2011-01-10 |
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