IL188184A0 - Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonists - Google Patents
Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonistsInfo
- Publication number
- IL188184A0 IL188184A0 IL188184A IL18818407A IL188184A0 IL 188184 A0 IL188184 A0 IL 188184A0 IL 188184 A IL188184 A IL 188184A IL 18818407 A IL18818407 A IL 18818407A IL 188184 A0 IL188184 A0 IL 188184A0
- Authority
- IL
- Israel
- Prior art keywords
- antagonists
- pyrazolo
- histamine
- azepine derivatives
- derivatives
- Prior art date
Links
- 239000003395 histamine H3 receptor antagonist Substances 0.000 title 1
- RMUDBHOUKWNOLH-UHFFFAOYSA-N pyrazolo[3,4-d]azepine Chemical class C1=CN=CC=C2C=NN=C21 RMUDBHOUKWNOLH-UHFFFAOYSA-N 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
| PCT/EP2006/006613 WO2007025596A1 (en) | 2005-07-06 | 2006-07-04 | Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL188184A0 true IL188184A0 (en) | 2008-03-20 |
Family
ID=34856781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL188184A IL188184A0 (en) | 2005-07-06 | 2007-12-17 | Pyrazolo [3,4-d] azepine derivatives as histamine h3 antagonists |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7888347B2 (OSRAM) |
| EP (1) | EP1899350B1 (OSRAM) |
| JP (1) | JP5145218B2 (OSRAM) |
| KR (1) | KR20080037651A (OSRAM) |
| CN (1) | CN101258154B (OSRAM) |
| AT (1) | ATE467636T1 (OSRAM) |
| AU (1) | AU2006286897A1 (OSRAM) |
| BR (1) | BRPI0612719A2 (OSRAM) |
| CA (1) | CA2614232A1 (OSRAM) |
| CR (1) | CR9622A (OSRAM) |
| CY (1) | CY1110711T1 (OSRAM) |
| DE (1) | DE602006014273D1 (OSRAM) |
| DK (1) | DK1899350T3 (OSRAM) |
| EA (1) | EA013600B1 (OSRAM) |
| ES (1) | ES2345841T3 (OSRAM) |
| GB (1) | GB0513886D0 (OSRAM) |
| HR (1) | HRP20100401T1 (OSRAM) |
| IL (1) | IL188184A0 (OSRAM) |
| MA (1) | MA29623B1 (OSRAM) |
| MX (1) | MX2008000383A (OSRAM) |
| NO (1) | NO20080563L (OSRAM) |
| PL (1) | PL1899350T3 (OSRAM) |
| PT (1) | PT1899350E (OSRAM) |
| SI (1) | SI1899350T1 (OSRAM) |
| UA (1) | UA93047C2 (OSRAM) |
| WO (1) | WO2007025596A1 (OSRAM) |
| ZA (1) | ZA200710798B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| KR20090024811A (ko) | 2006-06-23 | 2009-03-09 | 아보트 러보러터리즈 | 히스타민 ｈ3 수용체 조절제로서의 사이클로프로필 아민 유도체 |
| US8299267B2 (en) | 2007-09-24 | 2012-10-30 | Comentis, Inc. | (3-hydroxy-4-amino-butan-2-yl) -3- (2-thiazol-2-yl-pyrrolidine-1-carbonyl) benzamide derivatives and related compounds as beta-secretase inhibitors for treating |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
| KR20190040140A (ko) * | 2016-05-25 | 2019-04-17 | 아카나 테라퓨틱스, 엘티디. | 질환의 치료를 위한 융합된 비시클릭 화합물 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ID28692A (id) * | 1998-09-09 | 2001-06-28 | Ishihara Sangyo Kaisha | Turunan benzena dilebur yang berguna sebagai herbisida |
| AU3956900A (en) * | 1999-04-16 | 2000-11-02 | Boehringer Ingelheim International Gmbh | Substituted imidazoles, their preparation and use |
| JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
| JP2005529942A (ja) * | 2002-06-06 | 2005-10-06 | ノボ ノルディスク アクティーゼルスカブ | 置換ピラジン類および置換アゼピン類 |
| US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
| CA2493637A1 (en) | 2002-07-25 | 2004-02-12 | Manuela Villa | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
| US20060089347A1 (en) * | 2002-08-20 | 2006-04-27 | Eli Lilly And Company | Substituted azepines as histamine h3 receptor antagonists, preparation and therapeutic uses |
| GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| NZ540148A (en) | 2002-12-20 | 2007-11-30 | Glaxo Group Ltd | Benzazepine derivatives for the treatment of neurological disorders |
| JP5069907B2 (ja) * | 2003-09-17 | 2012-11-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 縮合複素環式化合物 |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| EP1756094A1 (en) | 2004-06-18 | 2007-02-28 | Glaxo Group Limited | 3-cycloalkylbenzazepines as histamine h3 antagonists |
| GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| EP1833796A1 (en) | 2004-12-07 | 2007-09-19 | Glaxo Group Limited | Indenyl derivatives and use thereof for the treatment of neurological disorders |
| AU2006224440A1 (en) | 2005-03-14 | 2006-09-21 | Glaxo Group Limited | Fused thiazole derivatives having affinity for the histamine H3 receptor |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en not_active Ceased
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Ceased
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200710798B (en) | 2008-11-26 |
| SI1899350T1 (sl) | 2010-09-30 |
| EA200800264A1 (ru) | 2008-06-30 |
| EA013600B1 (ru) | 2010-06-30 |
| ES2345841T3 (es) | 2010-10-04 |
| CA2614232A1 (en) | 2007-03-08 |
| DK1899350T3 (da) | 2010-09-06 |
| BRPI0612719A2 (pt) | 2010-11-30 |
| KR20080037651A (ko) | 2008-04-30 |
| CY1110711T1 (el) | 2015-06-10 |
| MA29623B1 (fr) | 2008-07-01 |
| HRP20100401T1 (hr) | 2010-09-30 |
| JP5145218B2 (ja) | 2013-02-13 |
| MX2008000383A (es) | 2008-03-07 |
| CN101258154A (zh) | 2008-09-03 |
| CN101258154B (zh) | 2011-01-19 |
| GB0513886D0 (en) | 2005-08-10 |
| UA93047C2 (ru) | 2011-01-10 |
| NO20080563L (no) | 2008-02-01 |
| PT1899350E (pt) | 2010-07-21 |
| EP1899350A1 (en) | 2008-03-19 |
| WO2007025596A1 (en) | 2007-03-08 |
| AU2006286897A1 (en) | 2007-03-08 |
| JP2009500366A (ja) | 2009-01-08 |
| CR9622A (es) | 2008-04-10 |
| US7888347B2 (en) | 2011-02-15 |
| PL1899350T3 (pl) | 2010-10-29 |
| EP1899350B1 (en) | 2010-05-12 |
| ATE467636T1 (de) | 2010-05-15 |
| US20080176832A1 (en) | 2008-07-24 |
| DE602006014273D1 (de) | 2010-06-24 |
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