DK1899350T3 - Pyrazolo [3,4-D]azepinderivater som histamin-H3-antagonister - Google Patents
Pyrazolo [3,4-D]azepinderivater som histamin-H3-antagonisterInfo
- Publication number
- DK1899350T3 DK1899350T3 DK06818218.7T DK06818218T DK1899350T3 DK 1899350 T3 DK1899350 T3 DK 1899350T3 DK 06818218 T DK06818218 T DK 06818218T DK 1899350 T3 DK1899350 T3 DK 1899350T3
- Authority
- DK
- Denmark
- Prior art keywords
- antagonists
- pyrazolo
- histamine
- azepine derivatives
- derivatives
- Prior art date
Links
- 239000003395 histamine H3 receptor antagonist Substances 0.000 title 1
- RMUDBHOUKWNOLH-UHFFFAOYSA-N pyrazolo[3,4-d]azepine Chemical class C1=CN=CC=C2C=NN=C21 RMUDBHOUKWNOLH-UHFFFAOYSA-N 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000926 neurological effect Effects 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0513886.2A GB0513886D0 (en) | 2005-07-06 | 2005-07-06 | Novel compounds |
| PCT/EP2006/006613 WO2007025596A1 (en) | 2005-07-06 | 2006-07-04 | Pyrazolo [3 , 4-d] azepine derivatives as histamine h3 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1899350T3 true DK1899350T3 (da) | 2010-09-06 |
Family
ID=34856781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06818218.7T DK1899350T3 (da) | 2005-07-06 | 2006-07-04 | Pyrazolo [3,4-D]azepinderivater som histamin-H3-antagonister |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7888347B2 (OSRAM) |
| EP (1) | EP1899350B1 (OSRAM) |
| JP (1) | JP5145218B2 (OSRAM) |
| KR (1) | KR20080037651A (OSRAM) |
| CN (1) | CN101258154B (OSRAM) |
| AT (1) | ATE467636T1 (OSRAM) |
| AU (1) | AU2006286897A1 (OSRAM) |
| BR (1) | BRPI0612719A2 (OSRAM) |
| CA (1) | CA2614232A1 (OSRAM) |
| CR (1) | CR9622A (OSRAM) |
| CY (1) | CY1110711T1 (OSRAM) |
| DE (1) | DE602006014273D1 (OSRAM) |
| DK (1) | DK1899350T3 (OSRAM) |
| EA (1) | EA013600B1 (OSRAM) |
| ES (1) | ES2345841T3 (OSRAM) |
| GB (1) | GB0513886D0 (OSRAM) |
| HR (1) | HRP20100401T1 (OSRAM) |
| IL (1) | IL188184A0 (OSRAM) |
| MA (1) | MA29623B1 (OSRAM) |
| MX (1) | MX2008000383A (OSRAM) |
| NO (1) | NO20080563L (OSRAM) |
| PL (1) | PL1899350T3 (OSRAM) |
| PT (1) | PT1899350E (OSRAM) |
| SI (1) | SI1899350T1 (OSRAM) |
| UA (1) | UA93047C2 (OSRAM) |
| WO (1) | WO2007025596A1 (OSRAM) |
| ZA (1) | ZA200710798B (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0712823A2 (pt) | 2006-06-23 | 2012-07-24 | Abbott Lab | derivados de ciclopropil amina como moduladores de receptor de histamina h3 |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| MX2010002938A (es) | 2007-09-24 | 2010-04-01 | Comentis Inc | Derivados de (3-hidroxi-4-amino-butan-2-il)-3-(2-tiazol-2-il-pirro lidin-1-carbonil)benzamida y compuestos relacionados como inhibidores de beta-secretasa para tratar enfermedad de alzheimer. |
| US9186353B2 (en) * | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| US8853390B2 (en) | 2010-09-16 | 2014-10-07 | Abbvie Inc. | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| CN102952139B (zh) * | 2011-08-30 | 2016-08-10 | 上海药明康德新药开发有限公司 | 反式-3a-氟吡咯烷[3,4-C]并环化合物及其制备方法 |
| WO2013151982A1 (en) | 2012-04-03 | 2013-10-10 | Arena Pharmaceuticals, Inc. | Methods and compounds useful in treating pruritus, and methods for identifying such compounds |
| EP2647377A1 (en) | 2012-04-06 | 2013-10-09 | Sanofi | Use of an h3 receptor antagonist for the treatment of alzheimer's disease |
| JO3407B1 (ar) | 2012-05-31 | 2019-10-20 | Eisai R&D Man Co Ltd | مركبات رباعي هيدرو بيرازولو بيريميدين |
| US9910887B2 (en) * | 2013-04-25 | 2018-03-06 | Facebook, Inc. | Variable search query vertical access |
| SG11201810292YA (en) * | 2016-05-25 | 2018-12-28 | Akarna Therapeutics Ltd | Fused bicyclic compounds for the treatment of disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6573218B1 (en) * | 1998-09-09 | 2003-06-03 | Ishihara Sangyo Kaisha, Ltd. | Fused-benzene derivatives useful as herbicides |
| EP1173438A1 (en) * | 1999-04-16 | 2002-01-23 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
| JP2001220390A (ja) | 2000-02-09 | 2001-08-14 | Yamanouchi Pharmaceut Co Ltd | 縮合ピラゾール誘導体 |
| WO2003104235A1 (en) * | 2002-06-06 | 2003-12-18 | Novo Nordisk A/S | Substituted hexahydropyrrolo[1,2-a]pyrazines, octahydropyrido[1,2-a]pyrazines and decahydropyrazino[1,2-a]azepines |
| US6770597B2 (en) | 2002-07-17 | 2004-08-03 | Ishihara Sangyo Kaisha, Ltd. | Benzohydrazide derivatives as herbicides and desiccant compositions containing them |
| JP2005537290A (ja) | 2002-07-25 | 2005-12-08 | ファルマシア・イタリア・エス・ピー・エー | キナーゼ阻害剤として活性なビシクロピラゾール類、その製造方法、およびそれを含有する薬学的組成物 |
| JP2006500376A (ja) * | 2002-08-20 | 2006-01-05 | イーライ・リリー・アンド・カンパニー | ヒスタミンｈ３受容体アンタゴニストとしての置換アゼピン、製造および治療上の使用 |
| GB0224083D0 (en) | 2002-10-16 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
| ES2333008T3 (es) | 2002-12-20 | 2010-02-16 | Glaxo Group Limited | Derivados de benzo(d)azepina para el tratamiento de trastornos neurologicos. |
| US7402680B2 (en) * | 2003-09-17 | 2008-07-22 | Janssen Pharmaceutica, N.V. | Fused heterocyclic compounds |
| GB0329214D0 (en) | 2003-12-17 | 2004-01-21 | Glaxo Group Ltd | Novel compounds |
| GB0405628D0 (en) | 2004-03-12 | 2004-04-21 | Glaxo Group Ltd | Novel compounds |
| GB0408083D0 (en) | 2004-04-08 | 2004-05-12 | Glaxo Group Ltd | Novel compounds |
| JP2008502644A (ja) | 2004-06-18 | 2008-01-31 | グラクソ グループ リミテッド | ヒスタミンｈ３アンタゴニストとしての３−シクロアルキルベンズアゼピン |
| GB0418267D0 (en) | 2004-08-16 | 2004-09-15 | Glaxo Group Ltd | Novel compounds |
| RU2007125648A (ru) | 2004-12-07 | 2009-01-20 | Глэксо Груп Лимитед (GB) | Инденильные производные и их применение для лечения неврологических расстройств |
| ATE420091T1 (de) | 2005-03-14 | 2009-01-15 | Glaxo Group Ltd | Kondensierte thiazolderivate mit affinität für den histamin-h3-rezeptor |
-
2005
- 2005-07-06 GB GBGB0513886.2A patent/GB0513886D0/en not_active Ceased
-
2006
- 2006-07-04 DE DE602006014273T patent/DE602006014273D1/de active Active
- 2006-07-04 BR BRPI0612719-3A patent/BRPI0612719A2/pt not_active IP Right Cessation
- 2006-07-04 JP JP2008519862A patent/JP5145218B2/ja not_active Expired - Fee Related
- 2006-07-04 ES ES06818218T patent/ES2345841T3/es active Active
- 2006-07-04 PT PT06818218T patent/PT1899350E/pt unknown
- 2006-07-04 AT AT06818218T patent/ATE467636T1/de active
- 2006-07-04 UA UAA200800190A patent/UA93047C2/ru unknown
- 2006-07-04 CA CA002614232A patent/CA2614232A1/en not_active Abandoned
- 2006-07-04 HR HR20100401T patent/HRP20100401T1/hr unknown
- 2006-07-04 SI SI200630733T patent/SI1899350T1/sl unknown
- 2006-07-04 EA EA200800264A patent/EA013600B1/ru not_active IP Right Cessation
- 2006-07-04 KR KR1020087000265A patent/KR20080037651A/ko not_active Ceased
- 2006-07-04 AU AU2006286897A patent/AU2006286897A1/en not_active Abandoned
- 2006-07-04 DK DK06818218.7T patent/DK1899350T3/da active
- 2006-07-04 CN CN2006800322776A patent/CN101258154B/zh not_active Expired - Fee Related
- 2006-07-04 PL PL06818218T patent/PL1899350T3/pl unknown
- 2006-07-04 MX MX2008000383A patent/MX2008000383A/es active IP Right Grant
- 2006-07-04 WO PCT/EP2006/006613 patent/WO2007025596A1/en not_active Ceased
- 2006-07-04 EP EP06818218A patent/EP1899350B1/en active Active
- 2006-07-04 US US11/994,689 patent/US7888347B2/en not_active Expired - Fee Related
-
2007
- 2007-12-12 ZA ZA200710798A patent/ZA200710798B/xx unknown
- 2007-12-17 IL IL188184A patent/IL188184A0/en unknown
- 2007-12-20 CR CR9622A patent/CR9622A/es not_active Application Discontinuation
-
2008
- 2008-01-09 MA MA30562A patent/MA29623B1/fr unknown
- 2008-01-30 NO NO20080563A patent/NO20080563L/no not_active Application Discontinuation
-
2010
- 2010-07-29 CY CY20101100713T patent/CY1110711T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007025596A1 (en) | 2007-03-08 |
| CR9622A (es) | 2008-04-10 |
| HRP20100401T1 (hr) | 2010-09-30 |
| IL188184A0 (en) | 2008-03-20 |
| EA013600B1 (ru) | 2010-06-30 |
| CY1110711T1 (el) | 2015-06-10 |
| JP2009500366A (ja) | 2009-01-08 |
| JP5145218B2 (ja) | 2013-02-13 |
| DE602006014273D1 (de) | 2010-06-24 |
| PT1899350E (pt) | 2010-07-21 |
| AU2006286897A1 (en) | 2007-03-08 |
| CN101258154A (zh) | 2008-09-03 |
| CA2614232A1 (en) | 2007-03-08 |
| ZA200710798B (en) | 2008-11-26 |
| NO20080563L (no) | 2008-02-01 |
| GB0513886D0 (en) | 2005-08-10 |
| PL1899350T3 (pl) | 2010-10-29 |
| US20080176832A1 (en) | 2008-07-24 |
| BRPI0612719A2 (pt) | 2010-11-30 |
| US7888347B2 (en) | 2011-02-15 |
| EP1899350A1 (en) | 2008-03-19 |
| ATE467636T1 (de) | 2010-05-15 |
| CN101258154B (zh) | 2011-01-19 |
| MA29623B1 (fr) | 2008-07-01 |
| ES2345841T3 (es) | 2010-10-04 |
| KR20080037651A (ko) | 2008-04-30 |
| EA200800264A1 (ru) | 2008-06-30 |
| SI1899350T1 (sl) | 2010-09-30 |
| UA93047C2 (ru) | 2011-01-10 |
| EP1899350B1 (en) | 2010-05-12 |
| MX2008000383A (es) | 2008-03-07 |
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