HRP20080602T3 - Amidomethyl-substituted 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromium-6-yl-derivatives and drugs containing said compounds - Google Patents
Amidomethyl-substituted 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromium-6-yl-derivatives and drugs containing said compoundsInfo
- Publication number
- HRP20080602T3 HRP20080602T3 HR20080602T HRP20080602T HRP20080602T3 HR P20080602 T3 HRP20080602 T3 HR P20080602T3 HR 20080602 T HR20080602 T HR 20080602T HR P20080602 T HRP20080602 T HR P20080602T HR P20080602 T3 HRP20080602 T3 HR P20080602T3
- Authority
- HR
- Croatia
- Prior art keywords
- alkyl
- substituted
- phenyl
- sulfonilamino
- hidroxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10348298A DE10348298A1 (de) | 2003-10-17 | 2003-10-17 | Amidomethyl-substituierte 2-(4-Sulfonylamino)-3-hydroxy-3,4-dihydro-2H-chromen-6-ylderivade, Verfahren und Zwischenprodukte zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| PCT/EP2004/052539 WO2005037780A2 (de) | 2003-10-17 | 2004-10-14 | Amidomethyl-substituierte 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromen-6-yl-derivate, verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20080602T3 true HRP20080602T3 (en) | 2008-12-31 |
Family
ID=34442032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20080602T HRP20080602T3 (en) | 2003-10-17 | 2008-11-20 | Amidomethyl-substituted 2-(4-sulfonilamino)-3-hidroxy-3,4-dihydro-2h-chromium-6-yl-derivatives and drugs containing said compounds |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1678130B1 (ja) |
| JP (1) | JP4791968B2 (ja) |
| KR (1) | KR20060129170A (ja) |
| CN (1) | CN100532375C (ja) |
| AR (1) | AR046106A1 (ja) |
| AT (1) | ATE405547T1 (ja) |
| AU (1) | AU2004281195B2 (ja) |
| BR (1) | BRPI0415523A (ja) |
| CA (1) | CA2542813C (ja) |
| DE (3) | DE10348298A1 (ja) |
| DK (1) | DK1678130T3 (ja) |
| ES (1) | ES2313126T3 (ja) |
| HK (1) | HK1096960A1 (ja) |
| HR (1) | HRP20080602T3 (ja) |
| IL (1) | IL174950A (ja) |
| MX (1) | MXPA06003958A (ja) |
| NO (1) | NO20062202L (ja) |
| PL (1) | PL1678130T3 (ja) |
| PT (1) | PT1678130E (ja) |
| RU (1) | RU2355685C2 (ja) |
| SI (1) | SI1678130T1 (ja) |
| TW (1) | TWI321564B (ja) |
| UA (1) | UA82907C2 (ja) |
| WO (1) | WO2005037780A2 (ja) |
| ZA (1) | ZA200602788B (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4971304B2 (ja) * | 2005-04-12 | 2012-07-11 | ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | アミノアルキル−アミドメチル置換２−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体およびそのカリウムチャンネル遮断薬としての使用 |
| US7714150B2 (en) | 2005-04-12 | 2010-05-11 | Solvay Pharmaceuticals Gmbh | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2H-chroman-6-yl derivatives |
| WO2007015775A2 (en) * | 2005-07-22 | 2007-02-08 | Merck & Co., Inc. | Potassium channel inhibitors |
| GB0525164D0 (en) | 2005-12-09 | 2006-01-18 | Xention Discovery Ltd | Compounds |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| NO3175985T3 (ja) | 2011-07-01 | 2018-04-28 | ||
| NZ627942A (en) | 2012-01-27 | 2016-03-31 | Gilead Sciences Inc | Combination therapies using late sodium ion channel blockers and potassium ion channel blockers |
| WO2014134419A1 (en) | 2013-03-01 | 2014-09-04 | Gilead Sciences, Inc. | Use of ikach blockers for the treatment of cardiac diseases |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK281507B6 (sk) * | 1992-11-30 | 2001-04-09 | Smithkline Beecham Plc | Použitie benzopyránových analógov, benzopyránové analógy, spôsob ich prípravy a farmaceutický prostriedok s ich obsahom |
| DE19546736A1 (de) * | 1995-12-14 | 1997-06-19 | Hoechst Ag | Substituierte Chromanylsulfonyl(thio)harnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung pharmazeutischer Präparate |
| WO2000012077A1 (en) * | 1998-09-01 | 2000-03-09 | Bristol-Myers Squibb Company | Potassium channel inhibitors and method |
| JP2000336085A (ja) * | 1999-03-25 | 2000-12-05 | Nissan Chem Ind Ltd | クロマン誘導体 |
| AU2830800A (en) * | 1999-03-25 | 2000-10-16 | Nissan Chemical Industries Ltd. | Chroman derivatives |
| EP1240147A1 (en) * | 1999-12-21 | 2002-09-18 | Icagen, Inc. | Potassium channel inhibitors |
-
2003
- 2003-10-17 DE DE10348298A patent/DE10348298A1/de not_active Withdrawn
-
2004
- 2004-10-13 AR ARP040103705A patent/AR046106A1/es not_active Application Discontinuation
- 2004-10-13 TW TW093130943A patent/TWI321564B/zh not_active IP Right Cessation
- 2004-10-14 DE DE112004001659T patent/DE112004001659D2/de not_active Expired - Fee Related
- 2004-10-14 ZA ZA200602788A patent/ZA200602788B/xx unknown
- 2004-10-14 KR KR1020067006939A patent/KR20060129170A/ko not_active Application Discontinuation
- 2004-10-14 SI SI200430848T patent/SI1678130T1/sl unknown
- 2004-10-14 EP EP04817204A patent/EP1678130B1/de active Active
- 2004-10-14 ES ES04817204T patent/ES2313126T3/es active Active
- 2004-10-14 WO PCT/EP2004/052539 patent/WO2005037780A2/de active IP Right Grant
- 2004-10-14 RU RU2006116629/04A patent/RU2355685C2/ru not_active IP Right Cessation
- 2004-10-14 DK DK04817204T patent/DK1678130T3/da active
- 2004-10-14 AU AU2004281195A patent/AU2004281195B2/en not_active Ceased
- 2004-10-14 AT AT04817204T patent/ATE405547T1/de active
- 2004-10-14 CN CNB2004800283503A patent/CN100532375C/zh not_active Expired - Fee Related
- 2004-10-14 CA CA2542813A patent/CA2542813C/en not_active Expired - Fee Related
- 2004-10-14 JP JP2006534762A patent/JP4791968B2/ja not_active Expired - Fee Related
- 2004-10-14 PL PL04817204T patent/PL1678130T3/pl unknown
- 2004-10-14 MX MXPA06003958A patent/MXPA06003958A/es active IP Right Grant
- 2004-10-14 PT PT04817204T patent/PT1678130E/pt unknown
- 2004-10-14 DE DE502004007916T patent/DE502004007916D1/de active Active
- 2004-10-14 BR BRPI0415523-8A patent/BRPI0415523A/pt not_active IP Right Cessation
- 2004-10-14 UA UAA200605330A patent/UA82907C2/uk unknown
-
2006
- 2006-04-11 IL IL174950A patent/IL174950A/en not_active IP Right Cessation
- 2006-05-16 NO NO20062202A patent/NO20062202L/no not_active Application Discontinuation
-
2007
- 2007-02-23 HK HK07102051.5A patent/HK1096960A1/xx not_active IP Right Cessation
-
2008
- 2008-11-20 HR HR20080602T patent/HRP20080602T3/xx unknown
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