DK1188747T3 - Phenoxypropylaminforbindelser - Google Patents

Phenoxypropylaminforbindelser

Info

Publication number
DK1188747T3
DK1188747T3 DK00927844T DK00927844T DK1188747T3 DK 1188747 T3 DK1188747 T3 DK 1188747T3 DK 00927844 T DK00927844 T DK 00927844T DK 00927844 T DK00927844 T DK 00927844T DK 1188747 T3 DK1188747 T3 DK 1188747T3
Authority
DK
Denmark
Prior art keywords
phenoxypropylamine
compound
antidepressants
hydrates
expressing
Prior art date
Application number
DK00927844T
Other languages
English (en)
Inventor
Akira Nishiyama
Masahiro Bougauchi
Takanobu Kuroita
Masanori Minoguchi
Yasunori Morio
Kouji Kanzaki
Original Assignee
Mitsubishi Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Pharma Corp filed Critical Mitsubishi Pharma Corp
Application granted granted Critical
Publication of DK1188747T3 publication Critical patent/DK1188747T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK00927844T 1999-05-24 2000-05-22 Phenoxypropylaminforbindelser DK1188747T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP14275099 1999-05-24
JP16616099 1999-06-14
JP27738499 1999-09-29
JP2000018080 2000-01-25

Publications (1)

Publication Number Publication Date
DK1188747T3 true DK1188747T3 (da) 2006-01-23

Family

ID=27472476

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00927844T DK1188747T3 (da) 1999-05-24 2000-05-22 Phenoxypropylaminforbindelser

Country Status (17)

Country Link
US (2) US6720320B2 (da)
EP (1) EP1188747B1 (da)
JP (1) JP3893878B2 (da)
KR (2) KR100882544B1 (da)
CN (1) CN1164574C (da)
AT (1) ATE303987T1 (da)
AU (1) AU777594B2 (da)
BR (1) BR0011542A (da)
CA (2) CA2716369C (da)
DE (1) DE60022504T2 (da)
DK (1) DK1188747T3 (da)
EA (1) EA004704B1 (da)
ES (1) ES2244438T3 (da)
IL (2) IL146564A0 (da)
MX (1) MXPA01012046A (da)
NZ (1) NZ516111A (da)
WO (1) WO2000071517A1 (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046177A1 (en) * 1999-12-20 2001-06-28 Eli Lilly And Company Benzofuran derivatives
EP1242411B1 (en) 1999-12-20 2006-03-08 Eli Lilly And Company Indole derivatives for the treatment of depression and anxiety
JP4042566B2 (ja) * 2000-11-27 2008-02-06 田辺三菱製薬株式会社 ピペリジン化合物およびその医薬用途
JP2006503846A (ja) * 2002-09-26 2006-02-02 ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー 精神分裂病の治療のためのヘテロ環式置換ピペラジン類
SE0303280D0 (sv) * 2003-12-05 2003-12-05 Astrazeneca Ab Novel compounds
EP1697334A1 (en) * 2003-12-08 2006-09-06 Warner-Lambert Company LLC Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia
GB0407025D0 (en) * 2004-03-29 2004-04-28 Glaxo Group Ltd Novel compounds
US7674822B2 (en) 2004-11-24 2010-03-09 Wyeth PTP1b inhibitors
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
MX2007013977A (es) 2005-05-10 2008-02-05 Incyte Corp Moduladores de 2,3-dioxigenasa indolamina y metodos de uso de los mismos.
TWI329641B (en) 2005-08-31 2010-09-01 Otsuka Pharma Co Ltd (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same
EP1963268B1 (en) * 2005-12-07 2010-12-01 NSAB, Filial af NeuroSearch Sweden AB, Sverige Disubstituted phenylpiperidines as modulators of cortical catecholaminergic neurotransmission
CA2634198C (en) 2005-12-20 2014-06-03 Incyte Corporation N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
JP5229567B2 (ja) * 2005-12-30 2013-07-03 メルク・シャープ・アンド・ドーム・コーポレーション Ｃｅｔｐ阻害剤
US9249407B2 (en) 2006-02-03 2016-02-02 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
US7649098B2 (en) * 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
CL2007002650A1 (es) 2006-09-19 2008-02-08 Incyte Corp Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
ES2444574T3 (es) 2006-09-19 2014-02-25 Incyte Corporation N-hidroxiamidinoheterociclos como moduladores de la indolamina 2,3-dioxigenasa
JP2008195654A (ja) * 2007-02-14 2008-08-28 Mitsubishi Tanabe Pharma Corp ベンゾ［ｂ］フラン化合物の新規結晶形
US20090270496A1 (en) * 2007-05-03 2009-10-29 Courchesne William E Antifungal compounds
TW200920355A (en) * 2007-09-06 2009-05-16 Lexicon Pharmaceuticals Inc Compositions and methods for treating immunological and inflammatory diseases and disorders
IE20070928A1 (en) * 2007-12-21 2009-09-30 Giuliani Int Ltd Multi target ligands
KR101847107B1 (ko) 2008-07-08 2018-04-10 인사이트 홀딩스 코포레이션 인돌아민 ２,３-디옥시게나아제의 억제제로서의 １,２,５-옥사디아졸
DK2398775T3 (da) 2009-02-18 2019-06-03 Univ Cornell Koblet genkendelses-/detekteringssystem til anvendelse in vivo og in vitro
US8324250B2 (en) 2009-03-19 2012-12-04 Hoffmann-La Roche Inc. Piperidine derivatives as NK3 receptor antagonists
US8476309B2 (en) * 2009-08-20 2013-07-02 The University Of Tennessee Research Foundation Benzofuran cannabinoid compounds and related methods of use
US11453646B2 (en) 2011-07-27 2022-09-27 Cornell University Methods for RNA detection and quantification
CA3150231A1 (en) 2013-01-24 2014-07-31 Minerva Neurosciences, Inc. Methods of use of phenoxypropylamine compounds to treat depression
KR101665301B1 (ko) 2013-08-07 2016-10-11 카딜라 핼쓰캐어 리미티드 야누스 키나제의 억제제로서 n-시아노메틸아미드
US9664676B2 (en) 2013-09-06 2017-05-30 Cornell University RNA sequences that induce fluorescence of small molecule fluorophores
US20150158926A1 (en) 2013-10-21 2015-06-11 Opko Biologics, Ltd. Long-acting polypeptides and methods of producing and administering same
TWI696618B (zh) 2013-11-08 2020-06-21 美商英塞特控股公司 用於合成吲哚胺2,3-雙加氧酶抑制劑之方法
US10590086B2 (en) * 2014-11-03 2020-03-17 Iomet Pharma Ltd. Pharmaceutical compound
CN106243088B (zh) 2015-06-03 2019-01-04 广东东阳光药业有限公司 取代的哌嗪化合物及其使用方法和用途
AU2016280867B2 (en) 2015-06-19 2020-02-27 Opko Biologics Ltd. Long-acting coagulation factors and methods of producing same
SG10202011471XA (en) * 2016-05-25 2021-01-28 Mitsubishi Tanabe Pharma Corp (2s)-1-[4-(3,4-dichlorophenyl)piperidin-l-yl]-3-[2-(5-methyl-l,3,4-oxadiazol-2-yl)benzo[b]furan-4-yloxy]propan-2-ol or its metabolite for treating anxiety disorders
MX2019000554A (es) 2016-07-11 2019-09-19 Opko Biologics Ltd Factor vii de coagulación de acción prolongada y métodos para producir el mismo.
GB2591937B (en) * 2018-09-04 2023-06-07 Minerva Neurosciences Inc Methods of using a phenoxypropylamine compound to treat pain

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2042054A1 (de) * 1970-08-25 1972-03-02 Agfa Gevaert Ag Photographisches Trockenkopierverfahren
DE2106577C2 (de) * 1971-02-11 1982-07-08 Agfa-Gevaert Ag, 5090 Leverkusen Aufzeichnungsmaterial für das photographische Trockenkopierverfahren und photographisches Verfahren zur Herstellung von Bildern
JPS4718538U (da) 1971-03-31 1972-11-01
DE2337461A1 (de) * 1973-07-24 1975-02-06 Boehringer Mannheim Gmbh Neue indolderivate und verfahren zu deren herstellung
DE2702919A1 (de) * 1976-01-26 1977-07-28 Canon Kk Durch erwaermung entwickelbares, lichtempfindliches aufzeichnungsmaterial
JPS5292610A (en) 1976-01-26 1977-08-04 Canon Kk Electrostatic printing master
JPS5290307A (en) 1976-01-26 1977-07-29 Canon Kk Thermoodeveloping photoosensitive material for electrostatic printing master
DE2623314C2 (de) 1976-05-25 1984-08-02 Hoechst Ag, 6230 Frankfurt 1-Aryloxy-2-Hydroxy-3-aminopropane, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
JPS55100361A (en) 1979-01-18 1980-07-31 Sandoz Ag 33aminopropoxyaryl derivative
JPS58121214A (ja) * 1982-01-09 1983-07-19 Kanegafuchi Chem Ind Co Ltd 血小板凝集阻害剤
JPS60202872A (ja) * 1984-03-27 1985-10-14 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体、その製法およびそれを有効成分とする降圧剤
DE3427985A1 (de) * 1984-07-28 1986-01-30 Boehringer Mannheim Gmbh, 6800 Mannheim Neue 2h-l-benzopyran-2-on-derivate, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPS6157572A (ja) * 1984-08-28 1986-03-24 Kanegafuchi Chem Ind Co Ltd 新規α−ベンジリデン−γ−ブチロラクトン誘導体
JPS61218582A (ja) * 1985-03-23 1986-09-29 Kaken Pharmaceut Co Ltd ベンゾフラン誘導体、その製法およびそれを有効成分とする降圧剤
HU209759B (en) * 1986-07-17 1994-10-28 Hem Res Inc Method for the preparation of synergistic pharmaceutical composition containing lymphokines and mismatched double-stranded rnas
US4861897A (en) * 1987-06-22 1989-08-29 Ortho Pharmaceutical Corporation 2-Aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles
HU209753B (en) 1990-12-13 1995-02-28 Richter Gedeon Vegyeszeti Gyar Rt. Process for producing of 3-(4-nitrophenoxy)-propylamine derivatives and pharmaceutical compositions comprising them
JPH06506937A (ja) * 1991-04-09 1994-08-04 ジ・アップジョン・カンパニー 多剤耐性細胞に感受性を付与するアミンの使用
US5281624A (en) 1991-09-27 1994-01-25 Eli Lilly And Company N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof
ES2152310T3 (es) * 1993-03-29 2001-02-01 Basf Ag Derivados de 1-amino-3-fenoxipropano como moduladores de la resistencia a multiples a farmacos.
US5500431A (en) * 1993-04-14 1996-03-19 Eli Lilly And Company Tetrahydro-β-carbolines
EP0620222A3 (en) 1993-04-14 1995-04-12 Lilly Co Eli Tetrahydro-beta-carbolines.
JPH0717952A (ja) * 1993-06-29 1995-01-20 Nissan Chem Ind Ltd ベンジリデン誘導体
CA2185236A1 (en) * 1994-03-11 1995-09-14 James Edmund Audia Method for treating 5ht2b receptor related conditions
US5576321A (en) * 1995-01-17 1996-11-19 Eli Lilly And Company Compounds having effects on serotonin-related systems
US5789402A (en) 1995-01-17 1998-08-04 Eli Lilly Company Compounds having effects on serotonin-related systems
JPH09136877A (ja) * 1995-06-16 1997-05-27 Takeda Chem Ind Ltd 複素環化合物、その製造法及び用途
US5912256A (en) * 1996-06-20 1999-06-15 Eli Lilly And Company Compounds having effects on serotonin-related systems
JP4246822B2 (ja) 1997-09-26 2009-04-02 興和株式会社 テトラゾール誘導体
DE69805033T2 (de) * 1997-09-26 2002-11-14 Kowa Co Tetrazolderivate als LTD4 und H1 Antagonisten
WO1999055672A2 (en) * 1998-04-29 1999-11-04 American Home Products Corporation Antipsychotic indolyl derivatives
JP2000086603A (ja) * 1998-07-15 2000-03-28 Yoshitomi Pharmaceut Ind Ltd 桂皮酸アミド誘導体および３―フェニルプロピオン酸アミド誘導体
ATE264855T1 (de) * 1998-12-18 2004-05-15 Basilea Pharmaceutica Ag 4-(aminoalkoxy)benzofurane als n- myristoyltransferasehemmer
JP4042566B2 (ja) * 2000-11-27 2008-02-06 田辺三菱製薬株式会社 ピペリジン化合物およびその医薬用途

Also Published As

Publication number Publication date
US6720320B2 (en) 2004-04-13
DE60022504D1 (de) 2005-10-13
CA2375008A1 (en) 2000-11-30
CN1378533A (zh) 2002-11-06
KR20020012235A (ko) 2002-02-15
IL146564A (en) 2006-12-31
US20040138227A1 (en) 2004-07-15
KR100799134B1 (ko) 2008-01-29
DE60022504T2 (de) 2006-06-29
CA2716369A1 (en) 2000-11-30
EP1188747A1 (en) 2002-03-20
MXPA01012046A (es) 2003-09-04
EA200101232A1 (ru) 2002-06-27
AU777594B2 (en) 2004-10-21
CN1164574C (zh) 2004-09-01
US7196199B2 (en) 2007-03-27
WO2000071517A1 (fr) 2000-11-30
NZ516111A (en) 2003-05-30
BR0011542A (pt) 2002-03-05
JP3893878B2 (ja) 2007-03-14
EA004704B1 (ru) 2004-06-24
US20020111358A1 (en) 2002-08-15
KR20070118193A (ko) 2007-12-13
ATE303987T1 (de) 2005-09-15
IL146564A0 (en) 2002-07-25
AU4616000A (en) 2000-12-12
ES2244438T3 (es) 2005-12-16
EP1188747B1 (en) 2005-09-07
CA2716369C (en) 2013-05-14
EP1188747A4 (en) 2002-10-09
CA2375008C (en) 2011-01-04
KR100882544B1 (ko) 2009-02-12

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