HRP20070132T3 - Pirido-7-pirimidin-7-oni supstituirani sa hidroksialkilom - Google Patents
Pirido-7-pirimidin-7-oni supstituirani sa hidroksialkilomInfo
- Publication number
- HRP20070132T3 HRP20070132T3 HR20070132T HRP20070132T HRP20070132T3 HR P20070132 T3 HRP20070132 T3 HR P20070132T3 HR 20070132 T HR20070132 T HR 20070132T HR P20070132 T HRP20070132 T HR P20070132T HR P20070132 T3 HRP20070132 T3 HR P20070132T3
- Authority
- HR
- Croatia
- Prior art keywords
- pyrimidin
- ones
- hydroxyalkyl substituted
- substituted pyrido
- hydroxyalkyl
- Prior art date
Links
- 125000002768 hydroxyalkyl group Chemical group 0.000 title abstract 3
- 125000005350 hydroxycycloalkyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000005188 oxoalkyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Spoj formule 1,naznačen time, da jeX1 O, C=O ili S(O)n, gdje je n 0, 1 ili 2; Ar1 je aril ili heteroaril; R1 je alkoksialkil, alkil, cikloalkil, cikloalkilalkil, heterociklil, hidroksialkil ili hidroksicikloalkil; iR2 je hidroksialkil, oksoalkil ilihidroksicikloalkil. Patent sadrži još 8 patentnihzahtjeva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51978903P | 2003-11-13 | 2003-11-13 | |
PCT/EP2004/012475 WO2005047284A1 (en) | 2003-11-13 | 2004-11-04 | Hydroxyalkyl substituted pyrido-7-pyrimidin-7-ones |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20070132T3 true HRP20070132T3 (hr) | 2007-05-31 |
Family
ID=34590444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20070132T HRP20070132T3 (hr) | 2003-11-13 | 2007-03-30 | Pirido-7-pirimidin-7-oni supstituirani sa hidroksialkilom |
Country Status (27)
Country | Link |
---|---|
US (2) | US7348331B2 (hr) |
EP (1) | EP1685131B1 (hr) |
JP (1) | JP4616839B2 (hr) |
KR (1) | KR100816321B1 (hr) |
CN (1) | CN100455582C (hr) |
AR (1) | AR046705A1 (hr) |
AT (1) | ATE356124T1 (hr) |
AU (1) | AU2004289428B2 (hr) |
BR (1) | BRPI0416030A (hr) |
CA (1) | CA2544247A1 (hr) |
CO (1) | CO5690600A2 (hr) |
DE (1) | DE602004005238T2 (hr) |
DK (1) | DK1685131T3 (hr) |
ES (1) | ES2281843T3 (hr) |
HK (1) | HK1099021A1 (hr) |
HR (1) | HRP20070132T3 (hr) |
IL (1) | IL175284A0 (hr) |
MY (1) | MY141011A (hr) |
NO (1) | NO20062256L (hr) |
NZ (1) | NZ546634A (hr) |
PL (1) | PL1685131T3 (hr) |
PT (1) | PT1685131E (hr) |
RU (1) | RU2348632C2 (hr) |
SI (1) | SI1685131T1 (hr) |
TW (1) | TWI349670B (hr) |
WO (1) | WO2005047284A1 (hr) |
ZA (1) | ZA200603829B (hr) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2656507C (en) | 2006-07-17 | 2012-03-20 | Amgen Inc. | Quinazoline and pyridopyrimidine derivatives as p38 kinase inhibitors |
WO2008077799A2 (en) * | 2006-12-22 | 2008-07-03 | F. Hoffmann-La Roche Ag | Compounds and methods for amino-alkylenediol synthesis |
JP2010529973A (ja) * | 2007-06-15 | 2010-09-02 | エフ.ホフマン−ラ ロシュ アーゲー | 3−アミノ−ペンタン−1,5−ジオールの新規製造方法 |
US8889696B2 (en) * | 2009-12-18 | 2014-11-18 | Temple University—Of the Commonwealth System of Higher Education | Substituted pyrido[2,3-d]pyrimidin-7(8H)-ones and therapeutic uses thereof |
CA2937746C (en) | 2014-02-07 | 2020-09-01 | Principia Biopharma, Inc. | Quinolone derivatives as fibroblast growth factor receptor inhibitors |
US10538518B2 (en) | 2015-08-11 | 2020-01-21 | Principia Biopharma, Inc. | Processes for preparing an FGFR inhibitor |
CN105418609B (zh) * | 2015-12-31 | 2017-06-23 | 山东大学 | 4‑(1,2,3‑三氮唑取代苯胺基)‑吡啶骈嘧啶酮衍生物及其制备方法与应用 |
WO2017151409A1 (en) | 2016-02-29 | 2017-09-08 | University Of Florida Research Foundation, Incorporated | Chemotherapeutic methods |
PL3464318T3 (pl) | 2016-06-02 | 2021-11-08 | Abbvie Inc. | Agonista receptora glukokortykoidowego i jego immunokoniugaty |
ES2866883T3 (es) | 2016-06-08 | 2021-10-20 | Support Venture Gmbh | Combinaciones farmacéuticas para el tratamiento del cáncer |
KR20190039142A (ko) | 2016-08-17 | 2019-04-10 | 서포트-벤처 게엠베하 | 청력 손실(hearing loss)의 예방 또는 치료 방법 |
EP3606514A1 (en) | 2017-04-04 | 2020-02-12 | Strekin AG | Methods of preventing or treating ophthalmic diseases |
US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
SG10202110259QA (en) | 2017-10-05 | 2021-10-28 | Fulcrum Therapeutics Inc | Use of p38 inhibitors to reduce expression of dux4 |
US10772970B2 (en) | 2017-12-01 | 2020-09-15 | Abbvie Inc. | Glucocorticoid receptor agonist and immunoconjugates thereof |
CN112469719B (zh) | 2018-05-21 | 2024-01-23 | 内尔维亚诺医疗科学公司 | 杂缩合的吡啶酮化合物及其作为idh抑制剂的用途 |
KR20210031909A (ko) | 2018-07-13 | 2021-03-23 | 키나루스 아게 | 섬유증 질환을 예방 또는 치료하기 위한 ppar 효능제 및 p38 키나제 억제제의 조합물 |
JP2022554364A (ja) | 2019-11-08 | 2022-12-28 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | gem-二置換複素環式化合物及びIDH阻害剤としてのその使用 |
EP4196120A1 (en) | 2020-08-11 | 2023-06-21 | Kinarus AG | Methods of preventing or treating covid-19 and related viral diseases or disorders |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4215216A (en) | 1979-04-18 | 1980-07-29 | American Home Products Corporation | 7,8-Dihydro-2,5,8-trisubstituted-7-oxo-pyrido[2,3-d]pyrimidine-6-carboxylic acid derivatives |
US5037826A (en) | 1986-10-15 | 1991-08-06 | Schering Corporation | 1-substituted naphthyridine and pyridopyrazine derivatives |
AU598093B2 (en) | 1987-02-07 | 1990-06-14 | Wellcome Foundation Limited, The | Pyridopyrimidines, methods for their preparation and pharmaceutical formulations thereof |
WO1993017682A1 (en) | 1992-03-04 | 1993-09-16 | Abbott Laboratories | Angiotensin ii receptor antagonists |
IL115256A0 (en) | 1994-11-14 | 1995-12-31 | Warner Lambert Co | 6-Aryl pyrido (2,3-d) pyrimidines and naphthyridines and their use |
DK0790997T3 (da) | 1994-11-14 | 2000-08-21 | Warner Lambert Co | 6-Aryl-pyrido[2,3-d]pyrimidiner og napthyridiner til hæmning af protein-tyrosin-kinase-fremkaldt celleproliferation |
IL117923A (en) | 1995-05-03 | 2000-06-01 | Warner Lambert Co | Anti-cancer pharmaceutical compositions containing polysubstituted pyrido¬2,3-d¾pyrimidine derivatives and certain such novel compounds |
US5620981A (en) | 1995-05-03 | 1997-04-15 | Warner-Lambert Company | Pyrido [2,3-D]pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation |
ES2301194T3 (es) | 1997-02-05 | 2008-06-16 | Warner-Lambert Company Llc | Pirido 2,3-d pirimidinas y 4-aminopirimidinas como inhibidores de la proliferacion celular. |
US5945422A (en) | 1997-02-05 | 1999-08-31 | Warner-Lambert Company | N-oxides of amino containing pyrido 2,3-D! pyrimidines |
CN1138778C (zh) | 1998-05-26 | 2004-02-18 | 沃尼尔·朗伯公司 | 用作细胞增殖抑制剂的二环嘧啶及二环3,4-二氢嘧啶化合物及用途 |
US7053070B2 (en) | 2000-01-25 | 2006-05-30 | Warner-Lambert Company | Pyrido[2,3-d]pyrimidine-2,7-diamine kinase inhibitors |
CA2394525A1 (en) | 2000-01-27 | 2001-08-02 | Warner-Lambert Company | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease |
AU2001233028A1 (en) | 2000-03-06 | 2001-10-03 | Warner-Lambert Company | 5-alkylpyrido(2,3-D)pyrimidines tyrosine kinase inhibitors |
US6518276B2 (en) | 2000-08-31 | 2003-02-11 | Syntex (U.S.A.) Llc | 7-oxo-pyridopyrimidines (II) |
AU9378401A (en) * | 2000-08-31 | 2002-03-13 | Hoffmann La Roche | 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation |
ATE305303T1 (de) * | 2001-02-12 | 2005-10-15 | Hoffmann La Roche | 6-substituierte pyridopyrimidine |
GEP20063909B (en) | 2002-01-22 | 2006-08-25 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d] PYRIMIDIN-7-ONES |
FR2897336B1 (fr) | 2006-02-10 | 2010-07-30 | Ranger France | Support d'aile pour vehicule automobile |
-
2004
- 2004-11-04 AU AU2004289428A patent/AU2004289428B2/en not_active Ceased
- 2004-11-04 DK DK04797601T patent/DK1685131T3/da active
- 2004-11-04 RU RU2006120486/04A patent/RU2348632C2/ru not_active IP Right Cessation
- 2004-11-04 AT AT04797601T patent/ATE356124T1/de active
- 2004-11-04 DE DE602004005238T patent/DE602004005238T2/de active Active
- 2004-11-04 WO PCT/EP2004/012475 patent/WO2005047284A1/en active IP Right Grant
- 2004-11-04 SI SI200430261T patent/SI1685131T1/sl unknown
- 2004-11-04 EP EP04797601A patent/EP1685131B1/en active Active
- 2004-11-04 CN CNB2004800337221A patent/CN100455582C/zh not_active Expired - Fee Related
- 2004-11-04 KR KR1020067009146A patent/KR100816321B1/ko not_active IP Right Cessation
- 2004-11-04 BR BRPI0416030-4A patent/BRPI0416030A/pt not_active IP Right Cessation
- 2004-11-04 PT PT04797601T patent/PT1685131E/pt unknown
- 2004-11-04 ES ES04797601T patent/ES2281843T3/es active Active
- 2004-11-04 JP JP2006538744A patent/JP4616839B2/ja not_active Expired - Fee Related
- 2004-11-04 PL PL04797601T patent/PL1685131T3/pl unknown
- 2004-11-04 NZ NZ546634A patent/NZ546634A/en not_active IP Right Cessation
- 2004-11-04 CA CA002544247A patent/CA2544247A1/en not_active Abandoned
- 2004-11-09 MY MYPI20044668A patent/MY141011A/en unknown
- 2004-11-10 TW TW093134375A patent/TWI349670B/zh not_active IP Right Cessation
- 2004-11-10 AR ARP040104138A patent/AR046705A1/es not_active Application Discontinuation
- 2004-11-12 US US10/987,656 patent/US7348331B2/en not_active Expired - Fee Related
-
2006
- 2006-04-27 IL IL175284A patent/IL175284A0/en unknown
- 2006-05-12 ZA ZA200603829A patent/ZA200603829B/en unknown
- 2006-05-12 CO CO06045585A patent/CO5690600A2/es not_active Application Discontinuation
- 2006-05-19 NO NO20062256A patent/NO20062256L/no not_active Application Discontinuation
-
2007
- 2007-03-30 HR HR20070132T patent/HRP20070132T3/hr unknown
- 2007-06-18 HK HK07106518.3A patent/HK1099021A1/xx not_active IP Right Cessation
- 2007-11-19 US US11/985,821 patent/US7750016B2/en not_active Expired - Fee Related
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