HRP20050612A2 - 4-substituted benzimidazoles and their use as inhibitors of gastric secretion - Google Patents
4-substituted benzimidazoles and their use as inhibitors of gastric secretionInfo
- Publication number
- HRP20050612A2 HRP20050612A2 HR20050612A HRP20050612A HRP20050612A2 HR P20050612 A2 HRP20050612 A2 HR P20050612A2 HR 20050612 A HR20050612 A HR 20050612A HR P20050612 A HRP20050612 A HR P20050612A HR P20050612 A2 HRP20050612 A2 HR P20050612A2
- Authority
- HR
- Croatia
- Prior art keywords
- inhibitors
- substituted benzimidazoles
- gastric secretion
- chr8
- formula
- Prior art date
Links
- 230000002496 gastric effect Effects 0.000 title abstract 3
- -1 4-substituted benzimidazoles Chemical class 0.000 title abstract 2
- 230000028327 secretion Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 230000001681 protective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02027874 | 2002-12-13 | ||
| EP03021348 | 2003-09-20 | ||
| PCT/EP2003/014069 WO2004054984A1 (en) | 2002-12-13 | 2003-12-11 | 4-substituted benzimidazoles and their use as inhibitors of gastric secretion |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20050612A2 true HRP20050612A2 (en) | 2006-08-31 |
Family
ID=32598782
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20050612A HRP20050612A2 (en) | 2002-12-13 | 2005-07-01 | 4-substituted benzimidazoles and their use as inhibitors of gastric secretion |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20060194969A1 (es) |
| EP (1) | EP1575924A1 (es) |
| JP (1) | JP2006511600A (es) |
| KR (1) | KR20050084170A (es) |
| AR (1) | AR043063A1 (es) |
| AU (1) | AU2003294831A1 (es) |
| BR (1) | BR0317041A (es) |
| CA (1) | CA2508838A1 (es) |
| CO (1) | CO5580786A2 (es) |
| EA (1) | EA008779B1 (es) |
| HR (1) | HRP20050612A2 (es) |
| IS (1) | IS7926A (es) |
| MX (1) | MXPA05006052A (es) |
| NO (1) | NO20053242L (es) |
| NZ (1) | NZ540862A (es) |
| PL (1) | PL375820A1 (es) |
| RS (1) | RS20050435A (es) |
| TW (1) | TW200504031A (es) |
| WO (1) | WO2004054984A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004226180A1 (en) | 2003-04-04 | 2004-10-14 | Altana Pharma Ag | Cyclic benzimidazoles |
| AR049168A1 (es) * | 2004-05-18 | 2006-07-05 | Altana Pharma Ag | Derivados de benzimidazol |
| CA2589448A1 (en) * | 2004-12-09 | 2006-06-15 | Altana Pharma Ag | Substituted imidazo[4,5-b]pyridines as inhibitors of gastric acid secretion |
| JP2008534475A (ja) * | 2005-03-24 | 2008-08-28 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | ６−チアミド置換されたベンゾイミダゾール |
| ES2332534T3 (es) | 2005-06-14 | 2010-02-08 | Raqualia Pharma Inc | Derivados de bencimidazol sustituidos con cromano como antagonistas de la bomba de acidos. |
| AR057061A1 (es) * | 2005-06-16 | 2007-11-14 | Altana Pharma Ag | Espiro-bencimidazoles farmaceuticamente activos y su uso en la fabricacion de medicamentos |
| CA2619518A1 (en) * | 2005-08-22 | 2007-03-01 | Nycomed Gmbh | Isotopically substituted benzimidazole derivatives |
| WO2007031860A1 (en) * | 2005-09-15 | 2007-03-22 | Pfizer Japan Inc. | Indane substituted benzimidazoles and their use as acid pump inhibitors |
| WO2007072146A1 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Chromane substituted benzimidazoles and their use as acid pump inhibitors |
| WO2007072142A2 (en) * | 2005-12-19 | 2007-06-28 | Pfizer Japan Inc. | Benzimidazole-5-carboxamide derivatives |
| WO2008017466A1 (en) * | 2006-08-08 | 2008-02-14 | Nycomed Gmbh | Pharmaceutically active tetrahydroisoquinoline-substituted benzimidazole derivatives |
| RU2412188C2 (ru) | 2006-09-21 | 2011-02-20 | Раквалиа Фарма Инк. | Производные бензимидазола в качестве селективных ингибиторов кислотной помпы |
| WO2008071765A1 (en) * | 2006-12-14 | 2008-06-19 | Nycomed Gmbh | Pharmaceutically active spiro-substituted benzimidazole derivatives |
| WO2008084067A2 (en) * | 2007-01-12 | 2008-07-17 | Nycomed Gmbh | Pharmaceutically active dihydrobenzofurane-substituted benzimidazole derivatives |
| WO2008151927A2 (en) * | 2007-06-15 | 2008-12-18 | Nycomed Gmbh | 6-n-substituted benz imidazole derivatives as acid pump antagonists |
| CN101801189B (zh) | 2007-08-27 | 2015-08-26 | 基内塔第四有限责任公司 | 用于治疗沙粒病毒感染的抗病毒药 |
| WO2010081670A2 (en) * | 2009-01-14 | 2010-07-22 | Lonza Ltd | Process for the preparation of benzimidazoles |
| CN102470126A (zh) | 2009-07-09 | 2012-05-23 | 拉夸里亚创药株式会社 | 用于治疗与异常肠胃运动有关的疾病的酸泵拮抗剂 |
| WO2012081036A2 (en) * | 2010-12-13 | 2012-06-21 | Sequent Scientific Limited | A process for preparation of 4,4'-(1-methyl-1,2-ethandiyl)-bis-(2,6-piperazinedione) |
| RU2506259C1 (ru) * | 2012-12-04 | 2014-02-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Ярославский государственный университет им. П.Г. Демидова" | Способ получения 4-{4-амино-2-хлоро-5-[(5-хлоро-2-метил-1н-бензимидазол-6-ил)амино]фенокси}бензойной кислоты |
| EP2953950B1 (en) | 2013-02-11 | 2021-01-13 | The Regents of The University of California | Compositions and methods for treating neurodegenerative diseases |
| BR112015031073B1 (pt) | 2013-06-21 | 2022-11-29 | Zenith Epigenetics Ltd | Compostos inibidores bicíclicos de bromodomínio e composição farmacêutica contendo os referidos compostos |
| US9636328B2 (en) | 2013-06-21 | 2017-05-02 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
| KR101472686B1 (ko) | 2013-07-09 | 2014-12-16 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
| KR20160038008A (ko) | 2013-07-31 | 2016-04-06 | 제니쓰 에피제네틱스 코포레이션 | 브로모도메인 억제제로서 신규 퀴나졸리논 |
| US10710992B2 (en) | 2014-12-01 | 2020-07-14 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
| WO2016092375A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Corp. | Substituted heterocycles as bromodomain inhibitors |
| US10231953B2 (en) | 2014-12-17 | 2019-03-19 | Zenith Epigenetics Ltd. | Inhibitors of bromodomains |
| KR101684053B1 (ko) | 2015-01-20 | 2016-12-08 | 씨제이헬스케어 주식회사 | 벤즈이미다졸 유도체의 신규 결정형 및 이의 제조방법 |
| EP3305291B1 (en) * | 2015-06-08 | 2021-05-19 | HK inno.N Corporation | Uses of benzimidazole derivative for nocturnal acid breakthrough |
| CA3067695A1 (en) | 2017-06-21 | 2018-12-27 | Mitokinin, Inc. | Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease |
| CN113527272B (zh) * | 2021-08-06 | 2023-07-21 | 西安淳甄新材料有限公司 | 一种特戈拉赞的合成方法 |
| KR20230099093A (ko) | 2021-12-27 | 2023-07-04 | 에이치케이이노엔 주식회사 | 벤즈이미다졸 유도체의 제조방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8604566D0 (sv) * | 1986-10-27 | 1986-10-27 | Haessle Ab | Novel compunds |
| IL108520A (en) * | 1993-02-15 | 1997-09-30 | Byk Gulden Lomberg Chem Fab | 2, 3, 8-TRISUBSTITUTED IMIDAZO £1, 2-a| PYRIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| SE9602286D0 (sv) * | 1996-06-10 | 1996-06-10 | Astra Ab | New compounds |
-
2003
- 2003-12-10 AR ARP030104544A patent/AR043063A1/es unknown
- 2003-12-11 JP JP2005502432A patent/JP2006511600A/ja active Pending
- 2003-12-11 PL PL03375820A patent/PL375820A1/xx not_active Application Discontinuation
- 2003-12-11 WO PCT/EP2003/014069 patent/WO2004054984A1/en active Application Filing
- 2003-12-11 EA EA200500895A patent/EA008779B1/ru not_active IP Right Cessation
- 2003-12-11 EP EP03785790A patent/EP1575924A1/en not_active Withdrawn
- 2003-12-11 NZ NZ540862A patent/NZ540862A/en unknown
- 2003-12-11 AU AU2003294831A patent/AU2003294831A1/en not_active Abandoned
- 2003-12-11 KR KR1020057010166A patent/KR20050084170A/ko not_active Application Discontinuation
- 2003-12-11 RS YUP-2005/0435A patent/RS20050435A/sr unknown
- 2003-12-11 BR BR0317041-1A patent/BR0317041A/pt unknown
- 2003-12-11 MX MXPA05006052A patent/MXPA05006052A/es active IP Right Grant
- 2003-12-11 CA CA002508838A patent/CA2508838A1/en not_active Abandoned
- 2003-12-11 US US10/537,693 patent/US20060194969A1/en not_active Abandoned
- 2003-12-12 TW TW092135239A patent/TW200504031A/zh unknown
-
2005
- 2005-07-01 NO NO20053242A patent/NO20053242L/no not_active Application Discontinuation
- 2005-07-01 HR HR20050612A patent/HRP20050612A2/xx not_active Application Discontinuation
- 2005-07-01 IS IS7926A patent/IS7926A/is unknown
- 2005-07-11 CO CO05067806A patent/CO5580786A2/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ540862A (en) | 2008-07-31 |
| PL375820A1 (en) | 2005-12-12 |
| TW200504031A (en) | 2005-02-01 |
| AR043063A1 (es) | 2005-07-13 |
| NO20053242D0 (no) | 2005-07-01 |
| RS20050435A (en) | 2007-08-03 |
| KR20050084170A (ko) | 2005-08-26 |
| BR0317041A (pt) | 2005-10-25 |
| AU2003294831A1 (en) | 2004-07-09 |
| JP2006511600A (ja) | 2006-04-06 |
| EA008779B1 (ru) | 2007-08-31 |
| WO2004054984A1 (en) | 2004-07-01 |
| EA200500895A1 (ru) | 2005-12-29 |
| MXPA05006052A (es) | 2005-08-18 |
| NO20053242L (no) | 2005-07-01 |
| IS7926A (is) | 2005-07-01 |
| US20060194969A1 (en) | 2006-08-31 |
| CA2508838A1 (en) | 2004-07-01 |
| CO5580786A2 (es) | 2005-11-30 |
| EP1575924A1 (en) | 2005-09-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HRP20050612A2 (en) | 4-substituted benzimidazoles and their use as inhibitors of gastric secretion | |
| CY1111481T1 (el) | Υποκατεστημενα αρυλοκυκλοπροπυλακεταμιδια ως ενεργοποιητες γλυκοκινασης | |
| TW515798B (en) | Heterocyclic compounds for inhibition of gastric acid secretion, processes for their preparation and pharmaceutical compositions thereof | |
| SE9801526D0 (sv) | New compounds | |
| ATE423122T1 (de) | Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) | |
| SG151249A1 (en) | 6-substituted 2-quinolinones and 2-quinoxalinones as poly(adp-ribose) polymerase inhibitors | |
| RS51805B (en) | FUNGICIDE COMPOSITIONS | |
| BRPI0506817A (pt) | inibidores seletivos de quinase | |
| ES2178169T3 (es) | Compuestos para la inhibicion de la secrecion de acido gastrico. | |
| NO20055033L (no) | Cykliske benzimidazoler | |
| SE9602286D0 (sv) | New compounds | |
| MY134667A (en) | Herbicidal compositions | |
| DE60229420D1 (de) | Neue metallproteinaseinhibitoren | |
| PT1419163E (pt) | Imidazopiridinas triciclicas | |
| DE60336735D1 (de) | Neue biologischaktive molekü le | |
| NO20052857L (no) | 8-substituerte imidazopyridiner | |
| PT1427727E (pt) | Compostos que inibem a libertacao de citocinas inflamatorias | |
| NO20033959D0 (no) | Benzimidazoler som er nyttige i behandling av seksuell dysfunksjon | |
| SE0102808D0 (sv) | New compounds | |
| BR0305708A (pt) | Derivados de benzimidazol para o tratamento de disfunção sexual | |
| TW200600502A (en) | Novel 6-substituted benzimidazoles | |
| HRP20090011T3 (en) | 2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl-piperidines used as cgrp antagonists | |
| GB0215392D0 (en) | Chemical compounds | |
| JO2615B1 (en) | Benzimidazole compound | |
| DK1651596T3 (da) | Hidtil ukendte derivater af 4,4'-dithiobis-(3-aminobutan-1-sulfonater) og sammensætninger, der omfatter samme |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20081210 Year of fee payment: 6 |
|
| OBST | Application withdrawn |