HRP20040448A2 - Method for detecting cells with numerical chromosomal abnormalities - Google Patents
Method for detecting cells with numerical chromosomal abnormalities Download PDFInfo
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- HRP20040448A2 HRP20040448A2 HR20040448A HRP20040448A HRP20040448A2 HR P20040448 A2 HRP20040448 A2 HR P20040448A2 HR 20040448 A HR20040448 A HR 20040448A HR P20040448 A HRP20040448 A HR P20040448A HR P20040448 A2 HRP20040448 A2 HR P20040448A2
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Classifications
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
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- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33190701P | 2001-11-20 | 2001-11-20 | |
PCT/US2002/037270 WO2003044056A2 (en) | 2001-11-20 | 2002-11-20 | Chemically-modified human growth hormone conjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
HRP20040448A2 true HRP20040448A2 (en) | 2006-02-28 |
Family
ID=23295870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HR20040448A HRP20040448A2 (en) | 2001-11-20 | 2004-05-20 | Method for detecting cells with numerical chromosomal abnormalities |
Country Status (25)
Country | Link |
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EP (1) | EP1453859A2 (is) |
JP (2) | JP2005525302A (is) |
KR (2) | KR20050044858A (is) |
CN (1) | CN1608079A (is) |
AP (1) | AP2004003050A0 (is) |
AU (1) | AU2002356990A1 (is) |
BR (1) | BR0214451A (is) |
CA (1) | CA2467731A1 (is) |
CO (1) | CO5580794A2 (is) |
EA (2) | EA008505B1 (is) |
EC (1) | ECSP045114A (is) |
GE (1) | GEP20063860B (is) |
HR (1) | HRP20040448A2 (is) |
HU (1) | HUP0500997A2 (is) |
IL (1) | IL162031A0 (is) |
IS (1) | IS7268A (is) |
MA (1) | MA27544A1 (is) |
MX (1) | MXPA04004809A (is) |
NO (1) | NO20042182L (is) |
OA (1) | OA13063A (is) |
PL (1) | PL374354A1 (is) |
RS (1) | RS53104A (is) |
TN (1) | TNSN04090A1 (is) |
WO (1) | WO2003044056A2 (is) |
ZA (1) | ZA200403907B (is) |
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CN1630530A (zh) * | 2002-01-18 | 2005-06-22 | 比奥根艾迪克Ma公司 | 聚亚烷基聚合物及其用途 |
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EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
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US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
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MX2007002441A (es) * | 2004-08-31 | 2007-05-04 | Pharmacia & Upjohn Co Llc | Conjugados de hormona del crecimiento humana y polietilenglicol ramificado con glicerol, proceso para su preparacion y metodos de uso de los mismos. |
AU2005323106B2 (en) * | 2004-12-22 | 2010-07-29 | Ambrx, Inc. | Methods for expression and purification of recombinant human growth hormone |
EP2399893B1 (en) | 2004-12-22 | 2018-08-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
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KR20080013878A (ko) | 2005-04-18 | 2008-02-13 | 노보 노르디스크 에이/에스 | Il-21 변이체 |
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KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
US9175061B2 (en) * | 2006-07-07 | 2015-11-03 | Novo Nordisk Health Care Ag | Protein conjugates and methods for their preparation |
CN101108895B (zh) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
WO2008049920A2 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | Il-21 variants |
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
PT2272875E (pt) * | 2008-04-03 | 2014-04-28 | Biosteed Gene Expression Tech Co Ltd | Hormona de crescimento modificada com polietilenoglicol de cadeia dupla, método de preparação e aplicação deste |
KR101104574B1 (ko) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도 |
MX2011001167A (es) * | 2008-07-31 | 2011-04-12 | Pharmaessentia Corp | Conjugados peptido-polimero. |
CN102112157B (zh) | 2008-08-06 | 2013-05-29 | 诺沃-诺迪斯克保健股份有限公司 | 具有延长的体内效能的缀合蛋白 |
RU2409669C9 (ru) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
EP2331139B1 (en) * | 2008-09-11 | 2019-04-17 | Nektar Therapeutics | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method |
TWI504405B (zh) | 2009-01-22 | 2015-10-21 | Novo Nordisk Healthcare Ag | 穩定的生長激素化合物 |
US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
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CN102834109B (zh) | 2010-01-22 | 2016-01-20 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
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EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
EA019967B1 (ru) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Ковалентный конъюгат полиэтиленгликоля с гормоном роста человека |
JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
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HUE056849T2 (hu) | 2014-11-21 | 2022-03-28 | Ascendis Pharma Endocrinology Div A/S | Hosszú hatástartalmú növekedési hormon adagolási formák |
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2002
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/ja active Pending
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/en not_active Abandoned
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/pt not_active IP Right Cessation
- 2002-11-20 CN CNA028259289A patent/CN1608079A/zh active Pending
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/en not_active Application Discontinuation
- 2002-11-20 PL PL02374354A patent/PL374354A1/xx unknown
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- 2002-11-20 IL IL16203102A patent/IL162031A0/xx unknown
- 2002-11-20 RS YU53104A patent/RS53104A/sr unknown
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/ko active IP Right Grant
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/hu unknown
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 EP EP02803695A patent/EP1453859A2/en not_active Withdrawn
- 2002-11-20 EA EA200700431A patent/EA200700431A1/ru unknown
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/ko not_active Application Discontinuation
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/es not_active Application Discontinuation
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2004
- 2004-05-17 IS IS7268A patent/IS7268A/is unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/fr unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/hr not_active Application Discontinuation
- 2004-05-20 CO CO04046633A patent/CO5580794A2/es not_active Application Discontinuation
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/es unknown
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/fr unknown
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-26 NO NO20042182A patent/NO20042182L/no not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
RS53104A (en) | 2006-10-27 |
NO20042182L (no) | 2004-08-11 |
IL162031A0 (en) | 2005-11-20 |
MA27544A1 (fr) | 2005-10-03 |
KR20050044858A (ko) | 2005-05-13 |
JP2005525302A (ja) | 2005-08-25 |
BR0214451A (pt) | 2006-05-30 |
WO2003044056A2 (en) | 2003-05-30 |
IS7268A (is) | 2004-05-17 |
CA2467731A1 (en) | 2003-05-30 |
EA200400565A1 (ru) | 2005-06-30 |
ECSP045114A (es) | 2004-07-23 |
CN1608079A (zh) | 2005-04-20 |
TNSN04090A1 (fr) | 2006-06-01 |
WO2003044056A3 (en) | 2003-08-21 |
JP2006321808A (ja) | 2006-11-30 |
ZA200403907B (en) | 2007-12-27 |
GEP20063860B (en) | 2006-06-26 |
AU2002356990A1 (en) | 2003-06-10 |
HUP0500997A2 (en) | 2007-11-28 |
CO5580794A2 (es) | 2005-11-30 |
EA008505B1 (ru) | 2007-06-29 |
AP2004003050A0 (en) | 2004-06-30 |
MXPA04004809A (es) | 2004-08-11 |
EP1453859A2 (en) | 2004-09-08 |
EA200700431A1 (ru) | 2008-02-28 |
KR20070072924A (ko) | 2007-07-06 |
OA13063A (en) | 2006-11-10 |
PL374354A1 (en) | 2005-10-17 |
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