IS7268A - Efnafræðilega breytt samtengd mennsk vaxtarhormón - Google Patents
Efnafræðilega breytt samtengd mennsk vaxtarhormónInfo
- Publication number
- IS7268A IS7268A IS7268A IS7268A IS7268A IS 7268 A IS7268 A IS 7268A IS 7268 A IS7268 A IS 7268A IS 7268 A IS7268 A IS 7268A IS 7268 A IS7268 A IS 7268A
- Authority
- IS
- Iceland
- Prior art keywords
- growth hormone
- human growth
- chemically altered
- synthetic human
- altered synthetic
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title 1
- 108010000521 Human Growth Hormone Proteins 0.000 title 1
- 239000000854 Human Growth Hormone Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33190701P | 2001-11-20 | 2001-11-20 | |
| PCT/US2002/037270 WO2003044056A2 (en) | 2001-11-20 | 2002-11-20 | Chemically-modified human growth hormone conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IS7268A true IS7268A (is) | 2004-05-17 |
Family
ID=23295870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IS7268A IS7268A (is) | 2001-11-20 | 2004-05-17 | Efnafræðilega breytt samtengd mennsk vaxtarhormón |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1453859A2 (is) |
| JP (2) | JP2005525302A (is) |
| KR (2) | KR20050044858A (is) |
| CN (1) | CN1608079A (is) |
| AP (1) | AP2004003050A0 (is) |
| AU (1) | AU2002356990A1 (is) |
| BR (1) | BR0214451A (is) |
| CA (1) | CA2467731A1 (is) |
| CO (1) | CO5580794A2 (is) |
| EA (2) | EA008505B1 (is) |
| EC (1) | ECSP045114A (is) |
| GE (1) | GEP20063860B (is) |
| HR (1) | HRP20040448A2 (is) |
| HU (1) | HUP0500997A2 (is) |
| IL (1) | IL162031A0 (is) |
| IS (1) | IS7268A (is) |
| MA (1) | MA27544A1 (is) |
| MX (1) | MXPA04004809A (is) |
| NO (1) | NO20042182L (is) |
| OA (1) | OA13063A (is) |
| PL (1) | PL374354A1 (is) |
| RS (1) | RS53104A (is) |
| TN (1) | TNSN04090A1 (is) |
| WO (1) | WO2003044056A2 (is) |
| ZA (1) | ZA200403907B (is) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| AU2002357806A1 (en) * | 2001-12-11 | 2003-06-23 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
| US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| CN101700401B (zh) * | 2002-01-18 | 2013-08-14 | 比奥根艾迪克Ma公司 | 具有用于共轭生物活性化合物的部分的聚亚烷基二醇 |
| EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
| KR100974843B1 (ko) | 2002-09-09 | 2010-08-11 | 넥타르 테라퓨틱스 | 수용성 중합체 알카날 |
| US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
| US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
| US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| CN100580087C (zh) * | 2003-10-10 | 2010-01-13 | 诺和诺德医疗保健公司 | 肽的缀合 |
| ATE550041T1 (de) * | 2004-01-21 | 2012-04-15 | Novo Nordisk Healthcare Ag | Transglutaminase-vermittelte konjugation von peptiden |
| WO2006024953A2 (en) * | 2004-08-31 | 2006-03-09 | Pharmacia & Upjohn Company Llc | Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof |
| JP2008525032A (ja) * | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
| KR20070090023A (ko) | 2004-12-22 | 2007-09-04 | 암브룩스, 인코포레이티드 | 변형 인간 성장 호르몬 |
| WO2006069246A2 (en) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| JP2008531482A (ja) | 2005-02-10 | 2008-08-14 | ノボ ノルディスク アクティーゼルスカブ | Ｃ末端がｐｅｇ化された成長ホルモン |
| RU2412199C2 (ru) | 2005-04-18 | 2011-02-20 | Ново Нордиск А/С | Варианты ил-21 |
| KR20080038391A (ko) * | 2005-08-30 | 2008-05-06 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 페그화 성장 호르몬의 액체 제제 |
| ATE500215T1 (de) | 2005-11-08 | 2011-03-15 | Ambrx Inc | Beschleuniger für die modifikation nichtnatürlicher aminosäuren und nichtnatürlicher aminosäurepolypeptide |
| KR101423898B1 (ko) | 2005-12-14 | 2014-07-28 | 암브룩스, 인코포레이티드 | 비-천연 아미노산 및 폴리펩티드를 함유하는 조성물, 비-천연 아미노산 및 폴리펩티드를 포함하는 방법, 및 비-천연 아미노산 및 폴리펩티드의 용도 |
| US9175061B2 (en) | 2006-07-07 | 2015-11-03 | Novo Nordisk Health Care Ag | Protein conjugates and methods for their preparation |
| CN101108895B (zh) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
| WO2008049920A2 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | Il-21 variants |
| CL2008002399A1 (es) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
| CN101809038B (zh) * | 2008-04-03 | 2013-10-30 | 厦门伯赛基因转录技术有限公司 | 双链聚乙二醇修饰的生长激素及其制备方法和应用 |
| KR101104574B1 (ko) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도 |
| US8273343B2 (en) * | 2008-07-31 | 2012-09-25 | Pharmaessentia Corp. | Protein-polymer conjugates |
| BRPI0917000A2 (pt) | 2008-08-06 | 2016-02-16 | Novo Nordisk Healthcare Ag | proteínas conjugadas com eficácia in vivo prolongada |
| RU2409669C9 (ru) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
| JP5766118B2 (ja) * | 2008-09-11 | 2015-08-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | ポリマー性アルファ−ヒドロキシアルデヒドおよびケトン反応剤ならびに抱合方法 |
| EP2389389B1 (en) | 2009-01-22 | 2015-04-15 | Novo Nordisk Health Care AG | Stable growth hormone compounds |
| US8841249B2 (en) | 2009-08-06 | 2014-09-23 | Novo Nordisk A/S | Growth hormones with prolonged in-vivo efficacy |
| AU2010332958B2 (en) | 2009-12-15 | 2014-09-18 | Ascendis Pharma Endocrinology Division A/S | Dry growth hormone composition transiently linked to a polymer carrier |
| MX345736B (es) | 2010-01-22 | 2017-02-14 | Novo Nordisk Healthcare Ag | Hormonas de crecimiento con eficacia in vivo prolongada. |
| CA2787895A1 (en) | 2010-01-22 | 2011-07-28 | Novo Nordisk Health Care Ag | Stable growth hormone compounds |
| KR20130115086A (ko) * | 2010-05-17 | 2013-10-21 | 세빅스 인코포레이티드 | 페길화된 c-펩티드 |
| EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
| EA019967B1 (ru) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Ковалентный конъюгат полиэтиленгликоля с гормоном роста человека |
| JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
| KR20230079520A (ko) | 2014-11-06 | 2023-06-07 | 파마에센시아 코퍼레이션 | Peg화된 인터페론의 투약 요법 |
| EP3285799A4 (en) * | 2015-03-11 | 2018-08-08 | Nektar Therapeutics | Conjugates of an il-7 moiety and an polymer |
| KR102152437B1 (ko) | 2015-09-18 | 2020-09-07 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 장시간 작용형 아드레노메둘린 유도체 |
| CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| EP0458064B1 (en) * | 1990-05-04 | 1998-02-25 | American Cyanamid Company | Stabilization of somatotropins by modification of cysteine residues |
| JPH06506217A (ja) * | 1991-03-18 | 1994-07-14 | エンゾン，インコーポレーテッド | ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体 |
| AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
| NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| DE69635026T2 (de) * | 1995-09-21 | 2006-05-24 | Genentech Inc., San Francisco | Varianten des menschlichen wachstumshormons |
| WO2000042175A1 (en) * | 1999-01-14 | 2000-07-20 | Bolder Biotechnology Inc. | Methods for making proteins containing free cysteine residues |
| IL133974A0 (en) * | 1997-07-14 | 2001-04-30 | Bolder Biotechnology Inc | Derivatives of growth hormone and related proteins |
| EA200400067A1 (ru) * | 1999-01-29 | 2004-04-29 | Эмджен Инк. | Конъюгаты гксф |
| WO2001076639A2 (en) * | 2000-04-06 | 2001-10-18 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
| JP2004524020A (ja) * | 2001-01-11 | 2004-08-12 | マキシゲン・エイピーエス | 改良された成長ホルモン分子 |
-
2002
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 RS YU53104A patent/RS53104A/sr unknown
- 2002-11-20 EA EA200400565A patent/EA008505B1/ru unknown
- 2002-11-20 EA EA200700431A patent/EA200700431A1/ru unknown
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/en not_active Application Discontinuation
- 2002-11-20 IL IL16203102A patent/IL162031A0/xx unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/en not_active Abandoned
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/ja active Pending
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/es not_active Application Discontinuation
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/ko active IP Right Grant
- 2002-11-20 EP EP02803695A patent/EP1453859A2/en not_active Withdrawn
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/pt not_active IP Right Cessation
- 2002-11-20 CN CNA028259289A patent/CN1608079A/zh active Pending
- 2002-11-20 PL PL02374354A patent/PL374354A1/xx unknown
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/ko not_active Application Discontinuation
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/hu unknown
-
2004
- 2004-05-17 IS IS7268A patent/IS7268A/is unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/fr unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/es unknown
- 2004-05-20 CO CO04046633A patent/CO5580794A2/es not_active Application Discontinuation
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/fr unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/hr not_active Application Discontinuation
- 2004-05-26 NO NO20042182A patent/NO20042182L/no not_active Application Discontinuation
-
2006
- 2006-07-14 JP JP2006193577A patent/JP2006321808A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20050044858A (ko) | 2005-05-13 |
| CA2467731A1 (en) | 2003-05-30 |
| BR0214451A (pt) | 2006-05-30 |
| JP2005525302A (ja) | 2005-08-25 |
| OA13063A (en) | 2006-11-10 |
| MXPA04004809A (es) | 2004-08-11 |
| AP2004003050A0 (en) | 2004-06-30 |
| EA200400565A1 (ru) | 2005-06-30 |
| MA27544A1 (fr) | 2005-10-03 |
| EA200700431A1 (ru) | 2008-02-28 |
| NO20042182L (no) | 2004-08-11 |
| ZA200403907B (en) | 2007-12-27 |
| IL162031A0 (en) | 2005-11-20 |
| HUP0500997A2 (en) | 2007-11-28 |
| AU2002356990A1 (en) | 2003-06-10 |
| EA008505B1 (ru) | 2007-06-29 |
| JP2006321808A (ja) | 2006-11-30 |
| KR20070072924A (ko) | 2007-07-06 |
| CO5580794A2 (es) | 2005-11-30 |
| TNSN04090A1 (fr) | 2006-06-01 |
| HRP20040448A2 (en) | 2006-02-28 |
| GEP20063860B (en) | 2006-06-26 |
| CN1608079A (zh) | 2005-04-20 |
| PL374354A1 (en) | 2005-10-17 |
| WO2003044056A2 (en) | 2003-05-30 |
| RS53104A (en) | 2006-10-27 |
| ECSP045114A (es) | 2004-07-23 |
| EP1453859A2 (en) | 2004-09-08 |
| WO2003044056A3 (en) | 2003-08-21 |
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| FR2815535B1 (fr) | Implant pediculaire | |
| DK1333853T3 (da) | Vækstfaktorkompleks | |
| NO20024890L (no) | Implantat | |
| DE60131102D1 (de) | Monofilamentband | |
| DE60238111D1 (de) | Viszeralfettmesser mit tonometer | |
| FR2810231B1 (fr) | Cornee synthetique | |
| DE60232967D1 (de) | Okulares tränen wachstumsfaktor-ähnliches protein | |
| DE50209070D1 (de) | Sämaschine | |
| FR2806309B1 (fr) | Implant | |
| ATE392808T1 (de) | Mähdrescher | |
| HUP0402334A3 (en) | Modified human growth hormone | |
| FR2825281B1 (fr) | Drain et son applicateur | |
| IS5999A (is) | Beinvaxtarörvandi þáttur | |
| FR2825911B1 (fr) | Implant cotyloidien | |
| NO20026215D0 (no) | Nytt hormonpreparat |