PT2272875E - Hormona de crescimento modificada com polietilenoglicol de cadeia dupla, método de preparação e aplicação deste - Google Patents
Hormona de crescimento modificada com polietilenoglicol de cadeia dupla, método de preparação e aplicação deste Download PDFInfo
- Publication number
- PT2272875E PT2272875E PT87338885T PT08733888T PT2272875E PT 2272875 E PT2272875 E PT 2272875E PT 87338885 T PT87338885 T PT 87338885T PT 08733888 T PT08733888 T PT 08733888T PT 2272875 E PT2272875 E PT 2272875E
- Authority
- PT
- Portugal
- Prior art keywords
- double
- preparation
- application
- polyethylene glycol
- growth hormone
- Prior art date
Links
- 102000018997 Growth Hormone Human genes 0.000 title 1
- 108010051696 Growth Hormone Proteins 0.000 title 1
- 239000002202 Polyethylene glycol Substances 0.000 title 1
- 239000000122 growth hormone Substances 0.000 title 1
- 229920001223 polyethylene glycol Polymers 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2008/000674 WO2009121210A1 (zh) | 2008-04-03 | 2008-04-03 | 双链聚乙二醇修饰的生长激素及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2272875E true PT2272875E (pt) | 2014-04-28 |
Family
ID=41134798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT87338885T PT2272875E (pt) | 2008-04-03 | 2008-04-03 | Hormona de crescimento modificada com polietilenoglicol de cadeia dupla, método de preparação e aplicação deste |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9840546B2 (pt) |
| EP (1) | EP2272875B1 (pt) |
| JP (1) | JP5458416B2 (pt) |
| KR (1) | KR101521674B1 (pt) |
| CN (1) | CN101809038B (pt) |
| AU (1) | AU2008353850B2 (pt) |
| BR (1) | BRPI0822530B1 (pt) |
| CA (1) | CA2720306C (pt) |
| DK (1) | DK2272875T3 (pt) |
| ES (1) | ES2453946T3 (pt) |
| MX (1) | MX2010010953A (pt) |
| PL (1) | PL2272875T3 (pt) |
| PT (1) | PT2272875E (pt) |
| RU (1) | RU2488598C2 (pt) |
| WO (1) | WO2009121210A1 (pt) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2272875T3 (da) | 2008-04-03 | 2014-03-31 | Biosteed Gene Expression Tech Co Ltd | Dobbeltstrenget polyethylenglycolmodificeret væksthormon, fremstillingsmetode samt anvendelse deraf |
| US10047623B2 (en) * | 2014-12-17 | 2018-08-14 | United Technologies Corporation | Compliant seal assembly and method of operating |
| CN107446908A (zh) * | 2016-06-01 | 2017-12-08 | 湖南华腾制药有限公司 | 分支型聚乙二醇修饰的l‑门冬酰胺酶及其制备方法 |
| CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
| CN114740108B (zh) * | 2022-03-28 | 2023-07-14 | 天津键凯科技有限公司 | 一种聚合物修饰抗体类药物的修饰度的测定方法 |
| CN115845079B (zh) * | 2022-11-24 | 2023-07-18 | 武汉禾元生物科技股份有限公司 | 一种重组人血清白蛋白与重组人生长激素的偶联物及其制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5382657A (en) | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| RU2158603C2 (ru) * | 1994-05-31 | 2000-11-10 | Амген Инк. | Способы и препараты для стимулирования роста и дифференцировки мегакариоцитов |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| TW517067B (en) | 1996-05-31 | 2003-01-11 | Hoffmann La Roche | Interferon conjugates |
| MX9605082A (es) * | 1996-10-24 | 1998-04-30 | Univ Autonoma De Nuevo Leon | Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano. |
| US7691367B2 (en) * | 1999-12-24 | 2010-04-06 | Kyowa Hakko Kirin Co., Ltd. | Branched polyalkylene glycols |
| MXPA04004336A (es) * | 2001-11-07 | 2005-05-16 | Nektar Therapeutics Al Corp | Polimeros ramificados y sus conjugados. |
| HUP0500997A2 (en) * | 2001-11-20 | 2007-11-28 | Pharmacia Corp | Chemically-modified human growth hormone conjugates |
| ES2291620T3 (es) * | 2002-03-13 | 2008-03-01 | Beijing Jiankai Technology Co., Ltd. | Derivado de polimeros hidrfilicos con rama tipo y y metodo de preparacion de compuesto metodo que comprende el compuesto anterior. |
| CN1477126A (zh) | 2002-07-22 | 2004-02-25 | 长春金赛药业有限责任公司 | 长效生长激素及药物组合物 |
| PL376883A1 (pl) | 2002-11-15 | 2006-01-09 | F. Hoffmann-La Roche Ag | Izomery podstawienia PEG IFN alfa 2a |
| US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
| US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
| WO2006094530A1 (en) * | 2005-03-11 | 2006-09-14 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
| WO2006102659A2 (en) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | CONJUGATES OF AN hGH MOIETY AND A POLYMER |
| CA2710841C (en) * | 2007-12-29 | 2018-01-23 | Biosteed Gene Expression Tech. Co., Ltd. | Y-shaped polyethylene glycol modified g-csf, the preparation and use thereof |
| DK2272875T3 (da) | 2008-04-03 | 2014-03-31 | Biosteed Gene Expression Tech Co Ltd | Dobbeltstrenget polyethylenglycolmodificeret væksthormon, fremstillingsmetode samt anvendelse deraf |
-
2008
- 2008-04-03 DK DK08733888.5T patent/DK2272875T3/da active
- 2008-04-03 KR KR1020107022013A patent/KR101521674B1/ko active IP Right Grant
- 2008-04-03 EP EP08733888.5A patent/EP2272875B1/en active Active
- 2008-04-03 RU RU2010136327/10A patent/RU2488598C2/ru active
- 2008-04-03 JP JP2011502208A patent/JP5458416B2/ja active Active
- 2008-04-03 PT PT87338885T patent/PT2272875E/pt unknown
- 2008-04-03 CA CA2720306A patent/CA2720306C/en active Active
- 2008-04-03 PL PL08733888T patent/PL2272875T3/pl unknown
- 2008-04-03 ES ES08733888.5T patent/ES2453946T3/es active Active
- 2008-04-03 CN CN200880009718XA patent/CN101809038B/zh active Active
- 2008-04-03 MX MX2010010953A patent/MX2010010953A/es active IP Right Grant
- 2008-04-03 WO PCT/CN2008/000674 patent/WO2009121210A1/zh active Application Filing
- 2008-04-03 AU AU2008353850A patent/AU2008353850B2/en active Active
- 2008-04-03 US US12/936,164 patent/US9840546B2/en active Active
- 2008-04-03 BR BRPI0822530-3A patent/BRPI0822530B1/pt active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010010953A (es) | 2011-04-21 |
| PL2272875T3 (pl) | 2014-06-30 |
| CA2720306C (en) | 2016-03-15 |
| US9840546B2 (en) | 2017-12-12 |
| RU2488598C2 (ru) | 2013-07-27 |
| AU2008353850B2 (en) | 2014-08-21 |
| AU2008353850A1 (en) | 2009-10-08 |
| CA2720306A1 (en) | 2009-10-08 |
| BRPI0822530B1 (pt) | 2022-03-22 |
| KR101521674B1 (ko) | 2015-05-19 |
| US20110028388A1 (en) | 2011-02-03 |
| WO2009121210A1 (zh) | 2009-10-08 |
| CN101809038A (zh) | 2010-08-18 |
| DK2272875T3 (da) | 2014-03-31 |
| CN101809038B (zh) | 2013-10-30 |
| ES2453946T3 (es) | 2014-04-09 |
| RU2010136327A (ru) | 2012-05-10 |
| EP2272875B1 (en) | 2014-01-15 |
| EP2272875A4 (en) | 2011-08-31 |
| KR20110014564A (ko) | 2011-02-11 |
| BRPI0822530A2 (pt) | 2020-08-18 |
| EP2272875A1 (en) | 2011-01-12 |
| JP2011516429A (ja) | 2011-05-26 |
| JP5458416B2 (ja) | 2014-04-02 |
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