CN101108895B - 聚乙二醇乙醛衍生物及其与药物的结合物 - Google Patents
聚乙二醇乙醛衍生物及其与药物的结合物 Download PDFInfo
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- CN101108895B CN101108895B CN2006100990810A CN200610099081A CN101108895B CN 101108895 B CN101108895 B CN 101108895B CN 2006100990810 A CN2006100990810 A CN 2006100990810A CN 200610099081 A CN200610099081 A CN 200610099081A CN 101108895 B CN101108895 B CN 101108895B
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CN2006100990810A CN101108895B (zh) | 2006-07-19 | 2006-07-19 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
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CN2006100990810A CN101108895B (zh) | 2006-07-19 | 2006-07-19 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
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CN101108895A CN101108895A (zh) | 2008-01-23 |
CN101108895B true CN101108895B (zh) | 2011-10-26 |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170049864A1 (en) * | 2013-12-30 | 2017-02-23 | Zonhon Biopharma Institute Inc. | Pegylated tissue kallikrein, and preparation method therefor and uses thereof |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
WO2015081831A1 (zh) * | 2013-12-02 | 2015-06-11 | 天津键凯科技有限公司 | 多臂聚乙二醇-叠氮衍生物 |
EA037151B1 (ru) | 2014-11-06 | 2021-02-11 | Фармаэссентия Корпорейшн | Способ лечения с использованием пегилированного интерферона |
CN104926920B (zh) * | 2015-06-15 | 2019-08-09 | 浙江医药高等专科学校 | 蛋白多肽类药物n端定点聚乙二醇修饰的方法 |
CN107469089B (zh) * | 2016-06-07 | 2022-01-07 | 北京键凯科技股份有限公司 | 一种peg连接子及配基药物偶联物 |
CN108530636B (zh) * | 2017-03-05 | 2021-05-28 | 厦门赛诺邦格生物科技股份有限公司 | 一种单一官能化支化聚乙二醇 |
CN113845583B (zh) * | 2020-06-28 | 2023-08-11 | 江苏中新医药有限公司 | 一种修饰的重组人神经生长因子及其制备方法 |
CN115838478B (zh) * | 2022-01-14 | 2023-09-05 | 天津键凯科技有限公司 | 一种透明质酸衍生物或其盐及其制备方法和应用 |
CN114479059B (zh) * | 2022-02-28 | 2024-03-12 | 中国科学院长春应用化学研究所 | 一种丙醛功能化的聚乙二醇衍生物及其制备方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1608079A (zh) * | 2001-11-20 | 2005-04-20 | 法玛西雅公司 | 化学修饰的人生长激素缀合物 |
CN1611524A (zh) * | 2003-10-28 | 2005-05-04 | 北京键凯科技有限公司 | 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶 |
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Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN1608079A (zh) * | 2001-11-20 | 2005-04-20 | 法玛西雅公司 | 化学修饰的人生长激素缀合物 |
CN1611524A (zh) * | 2003-10-28 | 2005-05-04 | 北京键凯科技有限公司 | 聚乙二醇氨基酸n-内环羰酐活性衍生物及其药物键合物和凝胶 |
Non-Patent Citations (1)
Title |
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Filip Vandoorne et al.Functionalization of α-hydrogen-ω-methoxypoly (oxyethylene), l A new method for the conversion of hydroxyl end groups into aldehyde groups.《Makromol. Chem., Rapid Commun.》.1989,第10卷271-275. * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20170049864A1 (en) * | 2013-12-30 | 2017-02-23 | Zonhon Biopharma Institute Inc. | Pegylated tissue kallikrein, and preparation method therefor and uses thereof |
US10052368B2 (en) * | 2013-12-30 | 2018-08-21 | Zonhon Biopharma Institute Inc. | Pegylated tissue kallikrein, and preparation method therefor and uses thereof |
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CN101108895A (zh) | 2008-01-23 |
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Application publication date: 20080123 Assignee: American health Assignor: Tianjin JenKem Technology Co., Ltd. Contract record no.: 2015990000211 Denomination of invention: Polyglycol ethanal derivant and combo of medicament and the same Granted publication date: 20111026 License type: Exclusive License Record date: 20150427 |
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