EA200700431A1 - Конъюгаты химически модифицированного гормона роста человека - Google Patents
Конъюгаты химически модифицированного гормона роста человекаInfo
- Publication number
- EA200700431A1 EA200700431A1 EA200700431A EA200700431A EA200700431A1 EA 200700431 A1 EA200700431 A1 EA 200700431A1 EA 200700431 A EA200700431 A EA 200700431A EA 200700431 A EA200700431 A EA 200700431A EA 200700431 A1 EA200700431 A1 EA 200700431A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chemically modified
- growth hormone
- human growth
- conjugates
- modified human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Abstract
Согласно настоящему изобретению предложен химически модифицированный гормон роста человека (hGH), полученный путем связывания водорастворимого полимера с белком. Химически модифицированный белок по настоящему изобретению может иметь намного более продолжительную активность hGH, чем активность немодифицированного hGH, что дает возможность снизить дозу и создать благоприятные условия режима введения.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33190701P | 2001-11-20 | 2001-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200700431A1 true EA200700431A1 (ru) | 2008-02-28 |
Family
ID=23295870
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400565A EA008505B1 (ru) | 2001-11-20 | 2002-11-20 | Конъюгаты химически модифицированного гормона роста человека |
EA200700431A EA200700431A1 (ru) | 2001-11-20 | 2002-11-20 | Конъюгаты химически модифицированного гормона роста человека |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400565A EA008505B1 (ru) | 2001-11-20 | 2002-11-20 | Конъюгаты химически модифицированного гормона роста человека |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1453859A2 (ru) |
JP (2) | JP2005525302A (ru) |
KR (2) | KR20050044858A (ru) |
CN (1) | CN1608079A (ru) |
AP (1) | AP2004003050A0 (ru) |
AU (1) | AU2002356990A1 (ru) |
BR (1) | BR0214451A (ru) |
CA (1) | CA2467731A1 (ru) |
CO (1) | CO5580794A2 (ru) |
EA (2) | EA008505B1 (ru) |
EC (1) | ECSP045114A (ru) |
GE (1) | GEP20063860B (ru) |
HR (1) | HRP20040448A2 (ru) |
HU (1) | HUP0500997A2 (ru) |
IL (1) | IL162031A0 (ru) |
IS (1) | IS7268A (ru) |
MA (1) | MA27544A1 (ru) |
MX (1) | MXPA04004809A (ru) |
NO (1) | NO20042182L (ru) |
OA (1) | OA13063A (ru) |
PL (1) | PL374354A1 (ru) |
RS (1) | RS53104A (ru) |
TN (1) | TNSN04090A1 (ru) |
WO (1) | WO2003044056A2 (ru) |
ZA (1) | ZA200403907B (ru) |
Families Citing this family (45)
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US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
EP1507755A4 (en) * | 2001-12-11 | 2006-05-17 | Sun Bio Inc | NOVEL MONOFUNCTIONAL POLYETHYLENE GLYCOL ALDEHYDES |
US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
PL213322B1 (pl) * | 2002-01-18 | 2013-02-28 | Biogen Idec Inc | Kompozycja farmaceutyczna zawierajaca polimer glikolu polialkilenowego skoniugowany z biologicznie aktywnym zwiazkiem lub jego prekursorem oraz jej zastosowania |
RS20050202A (en) | 2002-09-09 | 2007-08-03 | Nektar Therapeuticals Al.Corporation, | Water-soluble polymer alkanals |
EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
CN100580087C (zh) * | 2003-10-10 | 2010-01-13 | 诺和诺德医疗保健公司 | 肽的缀合 |
US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
ES2642214T3 (es) * | 2004-01-21 | 2017-11-15 | Novo Nordisk Health Care Ag | Conjugación de péptidos mediante transglutaminasa |
AP2007003919A0 (en) * | 2004-08-31 | 2007-02-28 | Pharmacia & Upjohn Co Llc | Glycerol branched polyethylene glycol human growthhormone conjugates, process for their prepation a nd methods of use thereof |
CA2594557C (en) | 2004-12-22 | 2016-04-26 | Ambrx, Inc. | Modified human growth hormone |
WO2006069246A2 (en) | 2004-12-22 | 2006-06-29 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
JP2008525032A (ja) * | 2004-12-22 | 2008-07-17 | アンブレツクス・インコーポレイテツド | 組換えヒト成長ホルモンを発現及び精製するための方法 |
WO2006084888A2 (en) | 2005-02-10 | 2006-08-17 | Novo Nordisk A/S | C-terminally pegylated growth hormones |
JP2008538290A (ja) | 2005-04-18 | 2008-10-23 | ノボ ノルディスク アクティーゼルスカブ | Il−21変異体 |
EP1928906A2 (en) | 2005-08-30 | 2008-06-11 | Novo Nordisk Health Care AG | Liquid formulations of pegylated growth hormone |
WO2007056448A2 (en) * | 2005-11-08 | 2007-05-18 | Ambrx, Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
JP2009519942A (ja) * | 2005-12-14 | 2009-05-21 | アンブルックス,インコーポレイテッド | 非天然アミノ酸およびポリペプチドを含んでいる組成物、それらに関する方法、ならびに、それらの使用 |
EP2040757A2 (en) | 2006-07-07 | 2009-04-01 | Novo Nordisk Health Care AG | New protein conjugates and methods for their preparation |
CN101108895B (zh) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | 聚乙二醇乙醛衍生物及其与药物的结合物 |
EP2091968A2 (en) | 2006-10-26 | 2009-08-26 | Novo Nordisk A/S | Il-21 variants |
CL2008002399A1 (es) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
WO2009121210A1 (zh) * | 2008-04-03 | 2009-10-08 | 厦门伯赛基因转录技术有限公司 | 双链聚乙二醇修饰的生长激素及其制备方法和应用 |
KR101104574B1 (ko) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | 폴리에틸렌글리콜로 화학적으로 수식된 인간 성장 호르몬, 이의 제조방법 및 용도 |
CN102131844B (zh) * | 2008-07-31 | 2016-03-02 | 药华医药股份有限公司 | 肽-聚合物缀合物 |
KR20110039348A (ko) | 2008-08-06 | 2011-04-15 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 연장된 생체내 효능을 가지는 콘쥬게이트된 단백질 |
RU2409669C9 (ru) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Способ иммобилизации биологически активного вещества (бав) на носитель (варианты) и конъюгат бав-носитель, полученный данными способами |
WO2010030366A2 (en) * | 2008-09-11 | 2010-03-18 | Nektar Therapeutics | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method |
KR20110122100A (ko) | 2009-01-22 | 2011-11-09 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 안정한 성장 호르몬 화합물 |
EP2461831B1 (en) | 2009-08-06 | 2018-11-21 | Novo Nordisk Health Care AG | Growth hormones with prolonged in-vivo efficacy |
BR112012014721B1 (pt) | 2009-12-15 | 2022-06-28 | Ascendis Pharma Endocrinology Division A/S | Composições de hormônio do crescimento, seus métodos de fabricação, recipiente e kit |
JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
CN102834109B (zh) | 2010-01-22 | 2016-01-20 | 诺沃—诺迪斯克保健股份有限公司 | 稳定的生长激素化合物 |
JP2013533217A (ja) * | 2010-05-17 | 2013-08-22 | セビックス・インコーポレイテッド | Peg化c−ペプチド |
EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
EA019967B1 (ru) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Ковалентный конъюгат полиэтиленгликоля с гормоном роста человека |
JP6464145B2 (ja) | 2013-04-05 | 2019-02-06 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 成長ホルモン化合物製剤 |
EP3215193B1 (en) | 2014-11-06 | 2023-10-04 | PharmaEssentia Corporation | Dosage regimen for pegylated interferon |
AU2016228555B2 (en) * | 2015-03-11 | 2021-12-23 | Nektar Therapeutics | Conjugates of an IL-7 moiety and a polymer |
RU2020111229A (ru) * | 2015-09-18 | 2020-06-08 | Юниверсити Оф Миязаки | Длительно действующее производное адреномедуллина |
CN114539384A (zh) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化长效生长激素及其制备方法和医药应用 |
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US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
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JPH06506217A (ja) * | 1991-03-18 | 1994-07-14 | エンゾン,インコーポレーテッド | ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体 |
AU2147192A (en) * | 1991-06-28 | 1993-01-25 | Genentech Inc. | Method of stimulating immune response using growth hormone |
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DK1157037T3 (da) * | 1999-01-29 | 2003-11-24 | Hoffmann La Roche | GCSF-konjugater |
AU2001289307A1 (en) * | 2000-04-06 | 2001-10-23 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
AU2002219021A1 (en) * | 2001-01-11 | 2002-07-24 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
-
2002
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 EA EA200400565A patent/EA008505B1/ru unknown
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/ko active IP Right Grant
- 2002-11-20 IL IL16203102A patent/IL162031A0/xx unknown
- 2002-11-20 RS YU53104A patent/RS53104A/sr unknown
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/hu unknown
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/en not_active Abandoned
- 2002-11-20 EA EA200700431A patent/EA200700431A1/ru unknown
- 2002-11-20 PL PL02374354A patent/PL374354A1/xx unknown
- 2002-11-20 CN CNA028259289A patent/CN1608079A/zh active Pending
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/pt not_active IP Right Cessation
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/ko not_active Application Discontinuation
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/es not_active Application Discontinuation
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/ja active Pending
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/en not_active Application Discontinuation
- 2002-11-20 EP EP02803695A patent/EP1453859A2/en not_active Withdrawn
-
2004
- 2004-05-17 IS IS7268A patent/IS7268A/is unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/fr unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/es unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/hr not_active Application Discontinuation
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/fr unknown
- 2004-05-20 CO CO04046633A patent/CO5580794A2/es not_active Application Discontinuation
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-26 NO NO20042182A patent/NO20042182L/no not_active Application Discontinuation
-
2006
- 2006-07-14 JP JP2006193577A patent/JP2006321808A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
TNSN04090A1 (fr) | 2006-06-01 |
MA27544A1 (fr) | 2005-10-03 |
IS7268A (is) | 2004-05-17 |
MXPA04004809A (es) | 2004-08-11 |
CO5580794A2 (es) | 2005-11-30 |
AU2002356990A1 (en) | 2003-06-10 |
JP2006321808A (ja) | 2006-11-30 |
WO2003044056A2 (en) | 2003-05-30 |
IL162031A0 (en) | 2005-11-20 |
EP1453859A2 (en) | 2004-09-08 |
KR20070072924A (ko) | 2007-07-06 |
BR0214451A (pt) | 2006-05-30 |
AP2004003050A0 (en) | 2004-06-30 |
CN1608079A (zh) | 2005-04-20 |
CA2467731A1 (en) | 2003-05-30 |
NO20042182L (no) | 2004-08-11 |
WO2003044056A3 (en) | 2003-08-21 |
EA008505B1 (ru) | 2007-06-29 |
HRP20040448A2 (en) | 2006-02-28 |
OA13063A (en) | 2006-11-10 |
PL374354A1 (en) | 2005-10-17 |
GEP20063860B (en) | 2006-06-26 |
HUP0500997A2 (en) | 2007-11-28 |
JP2005525302A (ja) | 2005-08-25 |
ECSP045114A (es) | 2004-07-23 |
EA200400565A1 (ru) | 2005-06-30 |
ZA200403907B (en) | 2007-12-27 |
KR20050044858A (ko) | 2005-05-13 |
RS53104A (en) | 2006-10-27 |
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