EA200700431A1 - CONJUGATES OF CHEMICALLY MODIFIED HUMAN GROWTH HORMONE - Google Patents
CONJUGATES OF CHEMICALLY MODIFIED HUMAN GROWTH HORMONEInfo
- Publication number
- EA200700431A1 EA200700431A1 EA200700431A EA200700431A EA200700431A1 EA 200700431 A1 EA200700431 A1 EA 200700431A1 EA 200700431 A EA200700431 A EA 200700431A EA 200700431 A EA200700431 A EA 200700431A EA 200700431 A1 EA200700431 A1 EA 200700431A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- chemically modified
- growth hormone
- human growth
- conjugates
- modified human
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Abstract
Согласно настоящему изобретению предложен химически модифицированный гормон роста человека (hGH), полученный путем связывания водорастворимого полимера с белком. Химически модифицированный белок по настоящему изобретению может иметь намного более продолжительную активность hGH, чем активность немодифицированного hGH, что дает возможность снизить дозу и создать благоприятные условия режима введения.According to the present invention, a chemically modified human growth hormone (hGH), obtained by binding a water-soluble polymer to a protein, is proposed. The chemically modified protein of the present invention can have a much longer activity of hGH than the activity of unmodified hGH, which makes it possible to reduce the dose and create favorable conditions for the administration regimen.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33190701P | 2001-11-20 | 2001-11-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200700431A1 true EA200700431A1 (en) | 2008-02-28 |
Family
ID=23295870
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400565A EA008505B1 (en) | 2001-11-20 | 2002-11-20 | Chemically modified human growth hormone conjugates |
EA200700431A EA200700431A1 (en) | 2001-11-20 | 2002-11-20 | CONJUGATES OF CHEMICALLY MODIFIED HUMAN GROWTH HORMONE |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200400565A EA008505B1 (en) | 2001-11-20 | 2002-11-20 | Chemically modified human growth hormone conjugates |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1453859A2 (en) |
JP (2) | JP2005525302A (en) |
KR (2) | KR20050044858A (en) |
CN (1) | CN1608079A (en) |
AP (1) | AP2004003050A0 (en) |
AU (1) | AU2002356990A1 (en) |
BR (1) | BR0214451A (en) |
CA (1) | CA2467731A1 (en) |
CO (1) | CO5580794A2 (en) |
EA (2) | EA008505B1 (en) |
EC (1) | ECSP045114A (en) |
GE (1) | GEP20063860B (en) |
HR (1) | HRP20040448A2 (en) |
HU (1) | HUP0500997A2 (en) |
IL (1) | IL162031A0 (en) |
IS (1) | IS7268A (en) |
MA (1) | MA27544A1 (en) |
MX (1) | MXPA04004809A (en) |
NO (1) | NO20042182L (en) |
OA (1) | OA13063A (en) |
PL (1) | PL374354A1 (en) |
RS (1) | RS53104A (en) |
TN (1) | TNSN04090A1 (en) |
WO (1) | WO2003044056A2 (en) |
ZA (1) | ZA200403907B (en) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
AU2002357806A1 (en) * | 2001-12-11 | 2003-06-23 | Sun Bio, Inc. | Novel monofunctional polyethylene glycol aldehydes |
US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
KR100964411B1 (en) * | 2002-01-18 | 2010-06-15 | 바이오겐 아이덱 엠에이 인코포레이티드 | Polyalkylene glycol with moiety for conjugating biologically active compound |
EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
US7157546B2 (en) | 2002-09-09 | 2007-01-02 | Nektar Therapeutics Al, Corporation | Water-soluble polymer alkanals |
US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
ES2349743T3 (en) * | 2003-10-10 | 2011-01-11 | Novo Nordisk A/S | DERIVATIVES OF IL-21. |
US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
RU2385879C2 (en) * | 2004-01-21 | 2010-04-10 | Ново Нордиск Хелс Кеа Аг | Method of conjugating peptides, mediated by transglutaminase |
AP2007003919A0 (en) * | 2004-08-31 | 2007-02-28 | Pharmacia & Upjohn Co Llc | Glycerol branched polyethylene glycol human growthhormone conjugates, process for their prepation a nd methods of use thereof |
SG161210A1 (en) * | 2004-12-22 | 2010-05-27 | Ambrx Inc | Methods for expression and purification of recombinant human growth hormone |
KR20070090023A (en) * | 2004-12-22 | 2007-09-04 | 암브룩스, 인코포레이티드 | Modified human growth hormone |
DK2399893T3 (en) * | 2004-12-22 | 2018-10-08 | Ambrx Inc | COMPOSITIONS CONTAINING, INVOLVING PROCEDURES, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES |
WO2006084888A2 (en) | 2005-02-10 | 2006-08-17 | Novo Nordisk A/S | C-terminally pegylated growth hormones |
EP1877439B1 (en) | 2005-04-18 | 2011-02-09 | Novo Nordisk A/S | Il-21 variants |
AU2006286486A1 (en) | 2005-08-30 | 2007-03-08 | Novo Nordisk Health Care Ag | Liquid formulations of pegylated growth hormone |
RS51998B (en) * | 2005-11-08 | 2012-04-30 | Ambrx Inc. | Accelerants for the modification of non-natural amino acids and non-natural amino acid polypeptides |
EP1968635B1 (en) | 2005-12-14 | 2014-09-17 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
AU2007271150A1 (en) | 2006-07-07 | 2008-01-10 | Novo Nordisk Health Care Ag | New protein conjugates and methods for their preparation |
CN101108895B (en) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | Polyglycol ethanal derivant and combo of medicament and the same |
AU2007310777A1 (en) | 2006-10-26 | 2008-05-02 | Novo Nordisk A/S | IL-21 variants |
CL2008002399A1 (en) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Substantially pure conjugate having a polymeric portion, a protein portion (interferon alpha 2b) and an aliphatic binder of 1 to 10 carbon atoms, useful in the treatment of hepatitis b or c. |
ES2453946T3 (en) | 2008-04-03 | 2014-04-09 | Biosteed Gene Expression Tech. Co., Ltd. | Growth hormone modified with double stranded polyethylene glycol, method of preparation and application of this |
KR101104574B1 (en) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | Human growth hormone derivative linked with polyethyleneglycol, method for the preparation thereof and pharmaceutical composition comprising the same |
JP5639585B2 (en) * | 2008-07-31 | 2014-12-10 | ファーマエッセンティア コーポレイション | Peptide-polymer conjugate |
MX2011000847A (en) | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Conjugated proteins with prolonged in vivo efficacy. |
RU2409669C9 (en) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Method for immobilising biologically active substance (bas) on carrier (versions) and bas-carrier conjugate produced by such methods |
JP5766118B2 (en) * | 2008-09-11 | 2015-08-19 | ウェルズ ファーゴ バンク ナショナル アソシエイション | Polymeric alpha-hydroxyaldehyde and ketone reagents and conjugation methods |
US8513192B2 (en) | 2009-01-22 | 2013-08-20 | Novo Nordisk A/S | Stable growth hormone compounds resistant to proteolytic degradation |
JP6086528B2 (en) | 2009-08-06 | 2017-03-01 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | Growth hormone with long-term in vivo efficacy |
SG181648A1 (en) | 2009-12-15 | 2012-07-30 | Ascendis Pharma As | Dry growth hormone composition transiently linked to a polymer carrier |
RU2012134974A (en) | 2010-01-22 | 2014-02-27 | Ново Нордиск Хелс Кеа Аг | STABILIZED GROWTH HORMONE COMPOUND |
TWI508737B (en) | 2010-01-22 | 2015-11-21 | 諾佛 儂迪克股份有限公司 | Growth hormones with prolonged in-vivo efficacy |
NZ603399A (en) * | 2010-05-17 | 2014-09-26 | Cebix Inc | Pegylated c-peptide |
EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
EA019967B1 (en) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Polyethyleneglycol covalent conjugate with human growth hormone |
ES2841123T3 (en) | 2013-04-05 | 2021-07-07 | Formulacion Del Compuesto De La Hormona De Crecimiento | Growth hormone compound formulation |
EP4282485A3 (en) | 2014-11-06 | 2024-01-17 | PharmaEssentia Corporation | Dosage regimen for pegylated interferon |
IL254389B2 (en) * | 2015-03-11 | 2023-03-01 | Nektar Therapeutics | Conjugates of an il-7 moiety and an polymer |
SG11201802180TA (en) | 2015-09-18 | 2018-04-27 | Univ Miyazaki | Long-acting adrenomedullin derivative |
CN114539384A (en) * | 2020-11-19 | 2022-05-27 | 江苏众红生物工程创药研究院有限公司 | Pegylated long-acting growth hormone, and preparation method and medical application thereof |
Family Cites Families (13)
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US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
DK0458064T3 (en) * | 1990-05-04 | 1998-04-27 | American Cyanamid Co | Stabilization of somatotropins by modifying cysteine residues |
CA2101918A1 (en) * | 1991-03-18 | 1992-09-19 | Samuel Zalipsky | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
DE69635026T2 (en) * | 1995-09-21 | 2006-05-24 | Genentech Inc., San Francisco | VARIANTS OF HUMAN GROWTH HORMONE |
DE69838552T2 (en) * | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | DERIVATIVES OF GROWTH HORMONE AND RELATED PROTEINS |
CA2359345A1 (en) * | 1999-01-14 | 2000-07-20 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
ES2204509T3 (en) * | 1999-01-29 | 2004-05-01 | F. Hoffmann-La Roche Ag | CONJUGATES OF GCSF. |
WO2001076639A2 (en) * | 2000-04-06 | 2001-10-18 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
WO2002055532A2 (en) * | 2001-01-11 | 2002-07-18 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
-
2002
- 2002-11-20 CN CNA028259289A patent/CN1608079A/en active Pending
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/en not_active Application Discontinuation
- 2002-11-20 RS YU53104A patent/RS53104A/en unknown
- 2002-11-20 IL IL16203102A patent/IL162031A0/en unknown
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/en active IP Right Grant
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/en not_active IP Right Cessation
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 EA EA200400565A patent/EA008505B1/en unknown
- 2002-11-20 EA EA200700431A patent/EA200700431A1/en unknown
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/en unknown
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/en not_active Application Discontinuation
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/en not_active Abandoned
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/en not_active Application Discontinuation
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/en active Pending
- 2002-11-20 PL PL02374354A patent/PL374354A1/en unknown
- 2002-11-20 EP EP02803695A patent/EP1453859A2/en not_active Withdrawn
-
2004
- 2004-05-17 IS IS7268A patent/IS7268A/en unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/en unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/en unknown
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/en unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/en not_active Application Discontinuation
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-20 CO CO04046633A patent/CO5580794A2/en not_active Application Discontinuation
- 2004-05-26 NO NO20042182A patent/NO20042182L/en not_active Application Discontinuation
-
2006
- 2006-07-14 JP JP2006193577A patent/JP2006321808A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
OA13063A (en) | 2006-11-10 |
KR20050044858A (en) | 2005-05-13 |
PL374354A1 (en) | 2005-10-17 |
MXPA04004809A (en) | 2004-08-11 |
EP1453859A2 (en) | 2004-09-08 |
HUP0500997A2 (en) | 2007-11-28 |
TNSN04090A1 (en) | 2006-06-01 |
JP2005525302A (en) | 2005-08-25 |
BR0214451A (en) | 2006-05-30 |
CN1608079A (en) | 2005-04-20 |
JP2006321808A (en) | 2006-11-30 |
HRP20040448A2 (en) | 2006-02-28 |
CO5580794A2 (en) | 2005-11-30 |
AU2002356990A1 (en) | 2003-06-10 |
IL162031A0 (en) | 2005-11-20 |
WO2003044056A2 (en) | 2003-05-30 |
ECSP045114A (en) | 2004-07-23 |
RS53104A (en) | 2006-10-27 |
IS7268A (en) | 2004-05-17 |
EA200400565A1 (en) | 2005-06-30 |
ZA200403907B (en) | 2007-12-27 |
CA2467731A1 (en) | 2003-05-30 |
AP2004003050A0 (en) | 2004-06-30 |
MA27544A1 (en) | 2005-10-03 |
NO20042182L (en) | 2004-08-11 |
KR20070072924A (en) | 2007-07-06 |
WO2003044056A3 (en) | 2003-08-21 |
EA008505B1 (en) | 2007-06-29 |
GEP20063860B (en) | 2006-06-26 |
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