HUP0500997A2 - Chemically-modified human growth hormone conjugates - Google Patents
Chemically-modified human growth hormone conjugatesInfo
- Publication number
- HUP0500997A2 HUP0500997A2 HU0500997A HUP0500997A HUP0500997A2 HU P0500997 A2 HUP0500997 A2 HU P0500997A2 HU 0500997 A HU0500997 A HU 0500997A HU P0500997 A HUP0500997 A HU P0500997A HU P0500997 A2 HUP0500997 A2 HU P0500997A2
- Authority
- HU
- Hungary
- Prior art keywords
- chemically
- growth hormone
- human growth
- modified human
- hormone conjugates
- Prior art date
Links
- 102000002265 Human Growth Hormone Human genes 0.000 title 1
- 108010000521 Human Growth Hormone Proteins 0.000 title 1
- 239000000854 Human Growth Hormone Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33190701P | 2001-11-20 | 2001-11-20 | |
| PCT/US2002/037270 WO2003044056A2 (en) | 2001-11-20 | 2002-11-20 | Chemically-modified human growth hormone conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0500997A2 true HUP0500997A2 (en) | 2007-11-28 |
Family
ID=23295870
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0500997A HUP0500997A2 (en) | 2001-11-20 | 2002-11-20 | Chemically-modified human growth hormone conjugates |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1453859A2 (en) |
| JP (2) | JP2005525302A (en) |
| KR (2) | KR20050044858A (en) |
| CN (1) | CN1608079A (en) |
| AP (1) | AP2004003050A0 (en) |
| AU (1) | AU2002356990A1 (en) |
| BR (1) | BR0214451A (en) |
| CA (1) | CA2467731A1 (en) |
| CO (1) | CO5580794A2 (en) |
| EA (2) | EA200700431A1 (en) |
| EC (1) | ECSP045114A (en) |
| GE (1) | GEP20063860B (en) |
| HR (1) | HRP20040448A2 (en) |
| HU (1) | HUP0500997A2 (en) |
| IL (1) | IL162031A0 (en) |
| IS (1) | IS7268A (en) |
| MA (1) | MA27544A1 (en) |
| MX (1) | MXPA04004809A (en) |
| NO (1) | NO20042182L (en) |
| OA (1) | OA13063A (en) |
| PL (1) | PL374354A1 (en) |
| RS (1) | RS53104A (en) |
| TN (1) | TNSN04090A1 (en) |
| WO (1) | WO2003044056A2 (en) |
| ZA (1) | ZA200403907B (en) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030171285A1 (en) * | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
| US7041855B2 (en) | 2001-12-11 | 2006-05-09 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| EP1507755A4 (en) * | 2001-12-11 | 2006-05-17 | Sun Bio Inc | Novel monofunctional polyethylene glycol aldehydes |
| US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
| EP3669887A1 (en) * | 2002-01-18 | 2020-06-24 | Biogen MA Inc. | Polyalkylene polymer compounds and uses thereof |
| MXPA05002620A (en) | 2002-09-09 | 2005-05-05 | Nektar Therapeutics Al Corp | Water-soluble polymer alkanals. |
| EP1591467A1 (en) * | 2002-09-09 | 2005-11-02 | Nektar Therapeutics Al, Corporation | Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone |
| US20040142870A1 (en) * | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
| US20050281778A1 (en) * | 2003-03-28 | 2005-12-22 | Myung-Ok Park | Human growth hormone conjugated with biocompatible polymer |
| US7524813B2 (en) | 2003-10-10 | 2009-04-28 | Novo Nordisk Health Care Ag | Selectively conjugated peptides and methods of making the same |
| CN100580087C (en) * | 2003-10-10 | 2010-01-13 | 诺和诺德医疗保健公司 | Conjugation of peptides |
| ATE550041T1 (en) * | 2004-01-21 | 2012-04-15 | Novo Nordisk Healthcare Ag | TRANSGLUTAMINASE-MEDIATED CONJUGATION OF PEPTIDES |
| KR20070042567A (en) * | 2004-08-31 | 2007-04-23 | 파마시아 앤드 업존 캄파니 엘엘씨 | Glycerol branched polyethylene glycol human growth hormone conjugates, process for their preparation, and methods of use thereof |
| MX2007007580A (en) | 2004-12-22 | 2007-12-11 | Ambrx Inc | Modified human growth hormone. |
| US7385028B2 (en) | 2004-12-22 | 2008-06-10 | Ambrx, Inc | Derivatization of non-natural amino acids and polypeptides |
| US8080391B2 (en) * | 2004-12-22 | 2011-12-20 | Ambrx, Inc. | Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer |
| JP2008531482A (en) | 2005-02-10 | 2008-08-14 | ノボ ノルディスク アクティーゼルスカブ | Growth hormone with PEGylated C-terminus |
| JP2008538290A (en) | 2005-04-18 | 2008-10-23 | ノボ ノルディスク アクティーゼルスカブ | IL-21 mutant |
| AU2006286486A1 (en) * | 2005-08-30 | 2007-03-08 | Novo Nordisk Health Care Ag | Liquid formulations of pegylated growth hormone |
| CN104710503B (en) | 2005-11-08 | 2023-04-25 | Ambrx 公司 | Promoters for modification of unnatural amino acids and unnatural amino acid polypeptides |
| SG170116A1 (en) | 2005-12-14 | 2011-04-29 | Ambrx Inc | Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides |
| CN101495155A (en) | 2006-07-07 | 2009-07-29 | 诺沃-诺迪斯克保健股份有限公司 | New protein conjugates and methods for their preparation |
| CN101108895B (en) * | 2006-07-19 | 2011-10-26 | 北京键凯科技有限公司 | Polyglycol ethanal derivant and combo of medicament and the same |
| JP2010507382A (en) | 2006-10-26 | 2010-03-11 | ノヴォ ノルディスク アクティーゼルスカブ | IL-21 mutant |
| CL2008002399A1 (en) * | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Substantially pure conjugate having a polymeric portion, a protein portion (interferon alpha 2b) and an aliphatic binder of 1 to 10 carbon atoms, useful in the treatment of hepatitis b or c. |
| PL2272875T3 (en) | 2008-04-03 | 2014-06-30 | Biosteed Gene Expression Tech Co Ltd | Double-stranded polyethylene glycol modified growth hormone, preparation method and application thereof |
| KR101104574B1 (en) * | 2008-05-14 | 2012-01-11 | 성균관대학교산학협력단 | Human growth hormone derivative linked with polyethyleneglycol, method for the preparation thereof and pharmaceutical composition comprising the same |
| JP5639585B2 (en) * | 2008-07-31 | 2014-12-10 | ファーマエッセンティア コーポレイション | Peptide-polymer conjugate |
| MX2011000847A (en) | 2008-08-06 | 2011-02-25 | Novo Nordisk Healthcare Ag | Conjugated proteins with prolonged in vivo efficacy. |
| RU2409669C9 (en) * | 2008-08-18 | 2012-05-27 | ООО "Саентифик Фьючер Менеджмент" ("Scientific Future Management", "SFM") | Method for immobilising biologically active substance (bas) on carrier (versions) and bas-carrier conjugate produced by such methods |
| US8492503B2 (en) * | 2008-09-11 | 2013-07-23 | Nektar Therapeutics | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method |
| AU2010207725B2 (en) | 2009-01-22 | 2015-06-11 | Novo Nordisk Health Care Ag | Stable growth hormone compounds |
| CN102612376A (en) | 2009-08-06 | 2012-07-25 | 诺沃-诺迪斯克保健股份有限公司 | Growth hormones with prolonged in-vivo efficacy |
| WO2011073234A2 (en) | 2009-12-15 | 2011-06-23 | Ascendis Pharma As | Growth hormone composition |
| CN103002918B (en) | 2010-01-22 | 2016-05-04 | 诺沃—诺迪斯克保健股份有限公司 | The growth hormone that in body, effect extends |
| MX338357B (en) | 2010-01-22 | 2016-04-13 | Novo Nordisk Healthcare Ag | Stable growth hormone compounds. |
| EP2571896A4 (en) * | 2010-05-17 | 2014-01-08 | Cebix Inc | Pegylated c-peptide |
| EP2446898A1 (en) | 2010-09-30 | 2012-05-02 | Laboratorios Del. Dr. Esteve, S.A. | Use of growth hormone to enhance the immune response in immunosuppressed patients |
| EA019967B1 (en) * | 2011-12-21 | 2014-07-30 | Общество С Ограниченной Ответственностью "Форт" (Ооо "Форт") | Polyethyleneglycol covalent conjugate with human growth hormone |
| WO2014166836A1 (en) | 2013-04-05 | 2014-10-16 | Novo Nordisk A/S | Growth hormone compound formulation |
| CA2964390A1 (en) | 2014-11-06 | 2016-05-12 | Pharmaessentia Corporation | Dosage regimen for pegylated interferon |
| WO2016079302A1 (en) | 2014-11-21 | 2016-05-26 | Ascendis Pharma Growth Disorders Division A/S | Long-acting growth hormone dosage forms |
| WO2016145388A1 (en) * | 2015-03-11 | 2016-09-15 | Nektar Therapeutics | Conjugates of an il-7 moiety and an polymer |
| EP3351561A4 (en) | 2015-09-18 | 2019-05-15 | University of Miyazaki | Long-acting adrenomedullin derivative |
| CN114539384B (en) * | 2020-11-19 | 2024-09-06 | 江苏众红生物工程创药研究院有限公司 | Pegylated long-acting growth hormone, preparation method and medical application thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4904584A (en) * | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| ES2113354T3 (en) * | 1990-05-04 | 1998-05-01 | American Cyanamid Co | STABILIZATION OF SOMATOTROPINS AND OTHER PROTEINS BY MODIFICATION OF CYSTEINE WASTE. |
| EP0576589A4 (en) * | 1991-03-18 | 1994-07-27 | Enzon Inc | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| WO1993000109A1 (en) * | 1991-06-28 | 1993-01-07 | Genentech, Inc. | Method of stimulating immune response using growth hormone |
| NZ250375A (en) * | 1992-12-09 | 1995-07-26 | Ortho Pharma Corp | Peg hydrazone and peg oxime linkage forming reagents and protein derivatives |
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| ES2190388T3 (en) * | 1995-09-21 | 2006-04-01 | Genentech, Inc. | VARIANTS OF HUMAN GROWTH HORMONE. |
| CN1269805A (en) * | 1997-07-14 | 2000-10-11 | 博尔德生物技术公司 | Derivatives of growth hormone and related proteins |
| BR0008759B1 (en) * | 1999-01-14 | 2014-03-11 | Bolder Biotechnology Inc | Methods for the production of protein containing free cysteine residues |
| CZ300546B6 (en) * | 1999-01-29 | 2009-06-10 | Amgen, Inc. | Physiologically active conjugate, composition and process for preparing thereof |
| AU2001289307A1 (en) * | 2000-04-06 | 2001-10-23 | Pharmacia Corporation | Chemically-modified myelopoietin conjugates |
| WO2002055532A2 (en) * | 2001-01-11 | 2002-07-18 | Maxygen Aps | Variant growth hormone molecules conjugated with macromolecular compounds |
-
2002
- 2002-11-20 PL PL02374354A patent/PL374354A1/en unknown
- 2002-11-20 CA CA002467731A patent/CA2467731A1/en not_active Abandoned
- 2002-11-20 EA EA200700431A patent/EA200700431A1/en unknown
- 2002-11-20 HU HU0500997A patent/HUP0500997A2/en unknown
- 2002-11-20 OA OA1200400143A patent/OA13063A/en unknown
- 2002-11-20 KR KR1020047007708A patent/KR20050044858A/en active IP Right Grant
- 2002-11-20 GE GE5599A patent/GEP20063860B/en unknown
- 2002-11-20 JP JP2003545691A patent/JP2005525302A/en active Pending
- 2002-11-20 MX MXPA04004809A patent/MXPA04004809A/en not_active Application Discontinuation
- 2002-11-20 KR KR1020077011730A patent/KR20070072924A/en not_active Application Discontinuation
- 2002-11-20 BR BRPI0214451-4A patent/BR0214451A/en not_active IP Right Cessation
- 2002-11-20 CN CNA028259289A patent/CN1608079A/en active Pending
- 2002-11-20 EA EA200400565A patent/EA008505B1/en unknown
- 2002-11-20 AU AU2002356990A patent/AU2002356990A1/en not_active Abandoned
- 2002-11-20 WO PCT/US2002/037270 patent/WO2003044056A2/en not_active Application Discontinuation
- 2002-11-20 IL IL16203102A patent/IL162031A0/en unknown
- 2002-11-20 EP EP02803695A patent/EP1453859A2/en not_active Withdrawn
- 2002-11-20 AP APAP/P/2004/003050A patent/AP2004003050A0/en unknown
- 2002-11-20 RS YU53104A patent/RS53104A/en unknown
-
2004
- 2004-05-17 IS IS7268A patent/IS7268A/en unknown
- 2004-05-19 MA MA27686A patent/MA27544A1/en unknown
- 2004-05-20 CO CO04046633A patent/CO5580794A2/en not_active Application Discontinuation
- 2004-05-20 ZA ZA200403907A patent/ZA200403907B/en unknown
- 2004-05-20 TN TNP2004000090A patent/TNSN04090A1/en unknown
- 2004-05-20 EC EC2004005114A patent/ECSP045114A/en unknown
- 2004-05-20 HR HR20040448A patent/HRP20040448A2/en not_active Application Discontinuation
- 2004-05-26 NO NO20042182A patent/NO20042182L/en not_active Application Discontinuation
-
2006
- 2006-07-14 JP JP2006193577A patent/JP2006321808A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IS7268A (en) | 2004-05-17 |
| GEP20063860B (en) | 2006-06-26 |
| PL374354A1 (en) | 2005-10-17 |
| JP2005525302A (en) | 2005-08-25 |
| KR20050044858A (en) | 2005-05-13 |
| MA27544A1 (en) | 2005-10-03 |
| CO5580794A2 (en) | 2005-11-30 |
| ZA200403907B (en) | 2007-12-27 |
| JP2006321808A (en) | 2006-11-30 |
| AP2004003050A0 (en) | 2004-06-30 |
| NO20042182L (en) | 2004-08-11 |
| KR20070072924A (en) | 2007-07-06 |
| CA2467731A1 (en) | 2003-05-30 |
| WO2003044056A3 (en) | 2003-08-21 |
| ECSP045114A (en) | 2004-07-23 |
| HRP20040448A2 (en) | 2006-02-28 |
| EA008505B1 (en) | 2007-06-29 |
| EP1453859A2 (en) | 2004-09-08 |
| MXPA04004809A (en) | 2004-08-11 |
| OA13063A (en) | 2006-11-10 |
| EA200700431A1 (en) | 2008-02-28 |
| BR0214451A (en) | 2006-05-30 |
| TNSN04090A1 (en) | 2006-06-01 |
| IL162031A0 (en) | 2005-11-20 |
| CN1608079A (en) | 2005-04-20 |
| WO2003044056A2 (en) | 2003-05-30 |
| AU2002356990A1 (en) | 2003-06-10 |
| RS53104A (en) | 2006-10-27 |
| EA200400565A1 (en) | 2005-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD9A | Lapse of provisional protection due to non-payment of fees |