HRP20020876B1 - Method for synthesis of perindopril and its pharmaceutically acceotable salts - Google Patents

Method for synthesis of perindopril and its pharmaceutically acceotable salts

Info

Publication number
HRP20020876B1
HRP20020876B1 HR20020876A HRP20020876A HRP20020876B1 HR P20020876 B1 HRP20020876 B1 HR P20020876B1 HR 20020876 A HR20020876 A HR 20020876A HR P20020876 A HRP20020876 A HR P20020876A HR P20020876 B1 HRP20020876 B1 HR P20020876B1
Authority
HR
Croatia
Prior art keywords
formula
compound
perindopril
synthesis
salts
Prior art date
Application number
HR20020876A
Other languages
English (en)
Croatian (hr)
Inventor
Langlois Pascal
Turbe Hugues
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8848925&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20020876(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of HRP20020876A2 publication Critical patent/HRP20020876A2/hr
Publication of HRP20020876B1 publication Critical patent/HRP20020876B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HR20020876A 2000-04-06 2002-11-06 Method for synthesis of perindopril and its pharmaceutically acceotable salts HRP20020876B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0004379A FR2807431B1 (fr) 2000-04-06 2000-04-06 Nouveau procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables
PCT/FR2001/001026 WO2001058868A1 (fr) 2000-04-06 2001-04-05 Procede de synthese du perindopril et de ses sels pharmaceutiquement acceptables

Publications (2)

Publication Number Publication Date
HRP20020876A2 HRP20020876A2 (en) 2004-02-29
HRP20020876B1 true HRP20020876B1 (en) 2010-10-31

Family

ID=8848925

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020876A HRP20020876B1 (en) 2000-04-06 2002-11-06 Method for synthesis of perindopril and its pharmaceutically acceotable salts

Country Status (35)

Country Link
US (1) US6835843B2 (ko)
EP (1) EP1268424B1 (ko)
JP (1) JP3939553B2 (ko)
KR (1) KR100507616B1 (ko)
CN (1) CN1296355C (ko)
AP (1) AP1385A (ko)
AT (1) ATE369338T1 (ko)
AU (2) AU4847001A (ko)
BG (1) BG65984B1 (ko)
BR (1) BRPI0109836B1 (ko)
CA (1) CA2405486C (ko)
CY (1) CY1108522T1 (ko)
CZ (1) CZ302575B6 (ko)
DE (1) DE60129800T2 (ko)
DK (1) DK1268424T3 (ko)
EA (1) EA005079B1 (ko)
EE (1) EE05032B1 (ko)
ES (1) ES2291307T3 (ko)
FR (1) FR2807431B1 (ko)
GE (1) GEP20063797B (ko)
HK (1) HK1053309A1 (ko)
HR (1) HRP20020876B1 (ko)
HU (1) HU227674B1 (ko)
ME (1) ME00441B (ko)
MX (1) MXPA02009706A (ko)
NO (1) NO324174B1 (ko)
NZ (1) NZ521454A (ko)
OA (1) OA12242A (ko)
PL (1) PL204471B1 (ko)
PT (1) PT1268424E (ko)
RS (1) RS50808B (ko)
SK (1) SK286921B6 (ko)
UA (1) UA75070C2 (ko)
WO (1) WO2001058868A1 (ko)
ZA (1) ZA200207419B (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2827860B1 (fr) 2001-07-24 2004-12-10 Servier Lab Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril
DE60220877T2 (de) 2002-01-30 2008-04-10 Les Laboratoires Servier Verfahren zur Herstellung von hochreinem Perindopril und Zwischenverbindungen nützlich in der Synthese
JP2005256847A (ja) * 2002-02-28 2005-09-22 Nsk Ltd 車輪用軸受ユニット
GB2395195A (en) 2002-11-18 2004-05-19 Cipla Ltd Preparation of perindopril from carboxy-protected precursor, & perindopril monohydrates for use as angiotensin converting enzyme (ACE) inhibitors
DE60301774T2 (de) * 2003-02-28 2006-07-20 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
EP1338591B1 (fr) * 2003-02-28 2005-10-26 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2S, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application à la synthèse du perindopril
SI1603558T1 (sl) 2003-02-28 2008-12-31 Servier S A Lab Postopek za pripravo perindoprila in njegovih soli
ATE307139T1 (de) 2003-02-28 2005-11-15 Servier Lab Verfahren für die synthese von perindopril und seiner pharmazeutisch annehmbaren salze
ES2231759T3 (es) * 2003-03-12 2005-05-16 Les Laboratoires Servier Procedimiento para la sintesis de derivados de acido (2s,3as,7as)-1-(s)-alanil)-octahidro-1h-indol-2-carboxilico y su utilizacion en la sintesis de perindopril.
ES2231760T3 (es) * 2003-03-12 2005-05-16 Les Laboratoires Servier Nuevo procedimiento de sintesis del acido(2s, 3as,7as)perhidroindol-2-carboxilico y de sus esteres, y su aplicacion a la sintesis de perindopril.
EP1321471B1 (fr) * 2003-03-12 2005-05-04 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
WO2004099138A2 (en) * 2003-05-12 2004-11-18 Cipla Limited Process for the preparation of perindopril
DK1636185T3 (da) 2003-06-24 2012-05-07 Servier Lab Nye krystalformer af Perindopril erbumin
EP1367063B1 (fr) * 2003-07-31 2006-08-23 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
DK1367062T3 (da) * 2003-07-31 2007-01-02 Servier Lab Ny fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
WO2005037788A1 (en) * 2003-10-21 2005-04-28 Lupin Ltd. Novel method for preparation of crystalline perindopril erbumine
EP1420029B9 (fr) * 2003-12-10 2008-11-12 Les Laboratoires Servier Procédé de synthèse du perindopril et ses sels pharmaceutiquement acceptables
ES2603856T3 (es) * 2004-03-29 2017-03-01 Les Laboratoires Servier Procedimiento para preparar una composición farmacéutica sólida
GB2413128A (en) 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
SI21800A (sl) 2004-05-14 2005-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Nov postopek sinteze perindoprila
ES2255872B1 (es) * 2004-12-31 2007-08-16 Quimica Sintetica, S.A. Procedimiento para la preparacion de perindopril erbumina.
EP1679072B9 (en) * 2005-01-06 2009-09-02 IPCA Laboratories Limited Process for for synthesis of (2S,3aS,7aS)-1-(S)-alanyl-octahydro-1H-indole-2- carboxylic acid derivatives and use in the synthesis of perindopril
US7291745B2 (en) * 2005-03-21 2007-11-06 Glenmark Pharmaceuticals Limited Process for the preparation of perindopril
JP2006290825A (ja) * 2005-04-13 2006-10-26 Shiono Chemical Co Ltd アルファ型ペリンドプリルエルブミンの製造法
DE102005058166A1 (de) * 2005-12-05 2007-06-06 Hexal Ag Matrixkontrolliertes transdermales System mit Amin-Salzen der ACE-Hemmer-Dicarbonsäuren
WO2007085933A2 (en) * 2006-01-25 2007-08-02 Glenmark Pharmaceuticals Limited Process for the preparation of n-[1-(s)-ethoxycarbonyl-1-butyl]-(s)-alanine-dmt complex and its use in the preparation of perindopril
WO2008114270A1 (en) * 2007-03-22 2008-09-25 Aarti Healthcare Limited Process for the preparation of perindopril erbumine salt and novel polymorph (s) thereof
FR2961105B1 (fr) * 2010-06-15 2013-02-08 Servier Lab Utilisation de l'association d'un inhibiteur du courant if sinusal et d'un inhibiteur de l'enzyme de conversion de l'angiotensine pour le traitement de l'insuffisance cardiaque
WO2014057404A1 (en) * 2012-10-10 2014-04-17 Piramal Enterprises Limited An improved process for preparation of perindopril intermediate
WO2016178591A2 (en) 2015-05-05 2016-11-10 Gene Predit, Sa Genetic markers and treatment of male obesity
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN107098949B (zh) * 2017-04-20 2021-03-16 上药东英（江苏）药业有限公司 一种制备培哚普利叔丁胺盐的绿色合成新工艺

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
EP0116842A2 (de) * 1983-01-22 1984-08-29 Boehringer Ingelheim Kg Aminosäure-Derivate, Verfahren zu ihrer Herstellung und Verwendung
EP0308341A1 (fr) * 1987-09-17 1989-03-22 Adir Et Compagnie Procédé de synthèse industrielle du périndopril et de ses principaux intermédiaires de synthèse
EP0309324A1 (fr) * 1987-09-17 1989-03-29 Adir Et Compagnie Procédé de synthèse d'alpha amino N alkyles et de leurs esters. Application à la synthèse de carboxyalkyl dipeptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049658A1 (fr) * 1980-10-02 1982-04-14 Adir Iminodiacides substitués, leur préparation et compositions pharmaceutiques les contenant
EP0116842A2 (de) * 1983-01-22 1984-08-29 Boehringer Ingelheim Kg Aminosäure-Derivate, Verfahren zu ihrer Herstellung und Verwendung
EP0308341A1 (fr) * 1987-09-17 1989-03-22 Adir Et Compagnie Procédé de synthèse industrielle du périndopril et de ses principaux intermédiaires de synthèse
EP0309324A1 (fr) * 1987-09-17 1989-03-29 Adir Et Compagnie Procédé de synthèse d'alpha amino N alkyles et de leurs esters. Application à la synthèse de carboxyalkyl dipeptides

Also Published As

Publication number Publication date
AU4847001A (en) 2001-08-20
KR100507616B1 (ko) 2005-08-10
PT1268424E (pt) 2007-10-16
EA200201057A1 (ru) 2003-06-26
HRP20020876A2 (en) 2004-02-29
CA2405486C (fr) 2008-07-29
HK1053309A1 (en) 2003-10-17
MXPA02009706A (es) 2004-09-06
WO2001058868A1 (fr) 2001-08-16
US20030069431A1 (en) 2003-04-10
DE60129800D1 (de) 2007-09-20
PL346555A1 (en) 2001-09-10
NO20024808D0 (no) 2002-10-04
BG65984B1 (bg) 2010-08-31
EP1268424A1 (fr) 2003-01-02
SK286921B6 (sk) 2009-07-06
US6835843B2 (en) 2004-12-28
NO20024808L (no) 2002-10-04
YU73802A (sh) 2006-01-16
BR0109836A (pt) 2003-06-24
DE60129800T2 (de) 2008-06-05
NO324174B1 (no) 2007-09-03
CZ302575B6 (cs) 2011-07-20
CN1296355C (zh) 2007-01-24
EE05032B1 (et) 2008-06-16
KR20030013381A (ko) 2003-02-14
HUP0101336A2 (hu) 2002-02-28
AP2002002630A0 (en) 2002-09-30
CY1108522T1 (el) 2014-04-09
JP3939553B2 (ja) 2007-07-04
BRPI0109836B1 (pt) 2015-08-04
JP2003531825A (ja) 2003-10-28
PL204471B1 (pl) 2010-01-29
ZA200207419B (en) 2003-09-16
NZ521454A (en) 2004-03-26
AU2001248470B2 (en) 2005-01-20
HU227674B1 (hu) 2011-11-28
DK1268424T3 (da) 2007-12-17
ATE369338T1 (de) 2007-08-15
CA2405486A1 (fr) 2001-08-16
FR2807431B1 (fr) 2002-07-19
BG107249A (bg) 2003-07-31
CN1420867A (zh) 2003-05-28
HUP0101336A3 (en) 2003-03-28
FR2807431A1 (fr) 2001-10-12
EP1268424B1 (fr) 2007-08-08
EA005079B1 (ru) 2004-10-28
EE200200575A (et) 2004-04-15
ES2291307T3 (es) 2008-03-01
HU0101336D0 (en) 2001-06-28
RS50808B (sr) 2010-08-31
CZ20023291A3 (cs) 2003-02-12
OA12242A (en) 2003-12-08
AP1385A (en) 2005-04-08
SK14182002A3 (sk) 2003-02-04
ME00441B (me) 2011-10-10
GEP20063797B (en) 2006-04-25
UA75070C2 (uk) 2006-03-15

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Payment date: 20180327

Year of fee payment: 18

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