NO953332L - Nye forbindelser - Google Patents

Nye forbindelser

Info

Publication number
NO953332L
NO953332L NO953332A NO953332A NO953332L NO 953332 L NO953332 L NO 953332L NO 953332 A NO953332 A NO 953332A NO 953332 A NO953332 A NO 953332A NO 953332 L NO953332 L NO 953332L
Authority
NO
Norway
Prior art keywords
pct
alkyl
date
fluoroalkyl
cyano
Prior art date
Application number
NO953332A
Other languages
English (en)
Other versions
NO953332D0 (no
Inventor
Susanna Karin Maria Bjork
Kristina Birgitta Gotthammar
Mats Torbjorn Linderberg
Per Johan Luthman
Kerstin Margareta Irma Persson
Robert Schwarcz
Original Assignee
Astra Ab
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab, Univ Maryland filed Critical Astra Ab
Publication of NO953332D0 publication Critical patent/NO953332D0/no
Publication of NO953332L publication Critical patent/NO953332L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/59—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
    • C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
    • C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/64—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/68—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
    • C07C229/70—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/59—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nye derivater av 3-hydroksyantranilsyre, 3-HANA, som har den generelle formel (I) COOH hvor Ri og R2 er like eller forskjellige og valgt fra H og alkyl; X er valgt fra alkyltio, aryltio, aryloksy, halogen og cyano; R3, R4 er like eller forskjellige og valgt fra halogen, metyl, fluoralkyl, cyano og Z-R5 hvor Z er valgt fra CHn, NHm, O, S. SC>2 og CO hvor n = l eller 2; m = O eller l og R5 er valgt fra alkyl. aryl og fluoralkyl; eller R3 og R4 danner sammen et mettet eller umettet ringsystem Y-V-Z hvor Y og Z, uavhengig av hverandre er som definert for Z ovenfor og V er valgt fra Ci-C3 alkylen eller alkenylen, -N = , -N=N- og -N-R7 hvor Ry = H eller alkyl; eller et farmasøytisk akseptabelt salt derav, fremgangsmåter og mellom- produkter for deres fremstilling, nye farmasøytiske preparater og anvendelse derav for inhibering av enzymet 3-hydroksyantranilatoksygenase, 3-HAO, som er ansvarlig for produksjonen av det endogene neurotoksinet kinolinsyre, QUIN.
NO953332A 1993-02-26 1995-08-24 Nye forbindelser NO953332L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9300657A SE9300657D0 (sv) 1993-02-26 1993-02-26 New compounds
PCT/SE1994/000152 WO1994019315A1 (en) 1993-02-26 1994-02-24 New compounds

Publications (2)

Publication Number Publication Date
NO953332D0 NO953332D0 (no) 1995-08-24
NO953332L true NO953332L (no) 1995-08-24

Family

ID=20389053

Family Applications (1)

Application Number Title Priority Date Filing Date
NO953332A NO953332L (no) 1993-02-26 1995-08-24 Nye forbindelser

Country Status (16)

Country Link
US (2) US5661183A (no)
EP (1) EP0686144B1 (no)
JP (1) JPH08507294A (no)
CN (1) CN1121344A (no)
AT (1) ATE191908T1 (no)
AU (1) AU6159994A (no)
CZ (1) CZ213995A3 (no)
DE (1) DE69424039D1 (no)
FI (1) FI954016A (no)
HU (1) HUT72992A (no)
IS (1) IS4133A (no)
NO (1) NO953332L (no)
PL (1) PL310398A1 (no)
SE (1) SE9300657D0 (no)
SK (1) SK96995A3 (no)
WO (1) WO1994019315A1 (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2509413C (en) 2002-12-20 2012-05-01 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
AR059898A1 (es) 2006-03-15 2008-05-07 Janssen Pharmaceutica Nv Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
TW200845978A (en) 2007-03-07 2008-12-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
BRPI0816767B8 (pt) 2007-09-14 2021-05-25 Addex Pharmaceuticals Sa composto 4-fenil-3,4,5,6-tetra-hidro-2h,1'h-[1,4']bipiridi¬nil-2'-onas 1',3'-dissubstituídas, composição farmacêutica e uso dos mesmos
WO2010011871A2 (en) * 2008-07-23 2010-01-28 The Regents Of The University Of California Methods and compositions for providing salicylic acid-independent pathogen resistance in plants
AU2009289784B2 (en) 2008-09-02 2012-03-22 Addex Pharma S.A. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
WO2010060589A1 (en) 2008-11-28 2010-06-03 Ortho-Mcneil-Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
MY161325A (en) 2009-05-12 2017-04-14 Janssen Pharmaceuticals Inc 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
US8946205B2 (en) 2009-05-12 2015-02-03 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
PL2649069T3 (pl) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc Pochodne 1,2,4-triazolo[4,3-a]pirydyny i ich zastosowanie jako dodatnich allosterycznych modulatorów receptorów mGluR2
CN103261195B (zh) 2010-11-08 2015-09-02 杨森制药公司 1,2,4-三唑并[4,3-a]吡啶衍生物及其作为MGLUR2受体的正变构调节剂的用途
AU2011328203B2 (en) 2010-11-08 2015-03-19 Janssen Pharmaceuticals, Inc. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
JO3368B1 (ar) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2
JO3367B1 (ar) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2
UA121965C2 (uk) 2014-01-21 2020-08-25 Янссен Фармацевтика Нв Комбінації, які містять позитивні алостеричні модулятори або ортостеричні агоністи метаботропного глутаматергічного рецептора 2 підтипу, та їх застосування
KR102461134B1 (ko) 2014-01-21 2022-10-28 얀센 파마슈티카 엔.브이. 대사 조절형 글루탐산 작동성 수용체 제2아형의 양성 알로스테릭 조절제 또는 오르토스테릭 작동제를 포함하는 조합 및 그 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0621083B2 (ja) * 1986-12-22 1994-03-23 株式会社三光開発科学研究所 ジ（アリ−ルオキシ）アルカンの製造方法

Also Published As

Publication number Publication date
IS4133A (is) 1994-08-27
DE69424039D1 (de) 2000-05-25
NO953332D0 (no) 1995-08-24
AU6159994A (en) 1994-09-14
FI954016A0 (fi) 1995-08-25
FI954016A (fi) 1995-08-25
CZ213995A3 (en) 1996-04-17
US5661183A (en) 1997-08-26
HU9502491D0 (en) 1995-10-30
EP0686144A1 (en) 1995-12-13
PL310398A1 (en) 1995-12-11
ATE191908T1 (de) 2000-05-15
US5688945A (en) 1997-11-18
HUT72992A (en) 1996-06-28
WO1994019315A1 (en) 1994-09-01
EP0686144B1 (en) 2000-04-19
JPH08507294A (ja) 1996-08-06
SK96995A3 (en) 1996-06-05
CN1121344A (zh) 1996-04-24
SE9300657D0 (sv) 1993-02-26

Similar Documents

Publication Publication Date Title
NO953332D0 (no) Nye forbindelser
DE69305322D1 (de) Salpetersäureester von 2-(2,6-dihalophenylamino)phenylessigsäurederivaten und verfahren zu ihrer herstellung
RU94019984A (ru) ПИРИДАЗИНЫ КАК ИНГИБИТОРЫ ИНТЕРЛЕЙКИН-1 β ПРЕОБРАЗУЮЩЕГО ФЕРМЕНТА, ФАРМКОМПОЗИЦИЯ НА ИХ ОСНОВЕ И ИХ ПРИМЕНЕНИЕ
HUP0301249A2 (hu) APO B termelődés gátló benzamid-vegyületek ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
ATE377010T1 (de) Caspase-inhibitoren und ihre verwendungen
DK0696287T3 (da) Ureido-derivater af naphthalenphosphonsyrer og fremgangsmåde til deres fremstilling
ATE260257T1 (de) Quinolinon derivate, verfahren zu ihrer herstellung und anti-allergisches wirkstoff
HUP0204347A2 (en) Compounds having antitumor activity: process for their preparation and pharmaceutical compositions containing them and their use
EA200100090A3 (ru) Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции
DE69129333D1 (de) Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane
EA200300044A1 (ru) Новые замещенные фталиды, способ их получения и содержащие их фармацевтические композиции
ATE141606T1 (de) Cephemverbindungen und verfahren zu ihrer herstellung
PT874841E (pt) Derivados da 1-benzenossulfonilpirrolidina como antagonistas do receptor da bradiquinina
DE69624582D1 (de) Ester und amide als pla2-inhibitoren
ATE184593T1 (de) Aminosäurederivate und ihre verwendung als phospholipase-a2-inhibitoren
DE69635057D1 (de) Verfahren zur herstellung von campothecinderivate
HUP0300177A2 (hu) Szívszélhűdés ellen alkalmazható piridazinil-fenil-hidrazon-származékok és ezeket tartalmazó gyógyszerkészítmények
SE8501988L (sv) Iminotiazolidinderivat
PE68299A1 (es) 1,2,3,4-tetrahidroisoquinolinas terapeuticas
CA2156079A1 (en) Novel derivatives of 3-hydroxy anthranilic acid, methods and intermediates for their preparation, novel pharmaceutial compositions and the use thereof
DE69422800D1 (de) Neue verbindungen
TH54292B (th) กรรมวิธีสำหรับการเตรียม n-แอริล-แอนธรานิลิคแอซิด และอนุพันธ์ของสารเหล่านั้น
JPS52254A (en) Process for preparation of secopenicilanic acid amide derivatives