HRP20020579B1 - A process for the preparation of quetiapine and intermediates thereof - Google Patents

A process for the preparation of quetiapine and intermediates thereof

Info

Publication number
HRP20020579B1
HRP20020579B1 HR20020579A HRP20020579A HRP20020579B1 HR P20020579 B1 HRP20020579 B1 HR P20020579B1 HR 20020579 A HR20020579 A HR 20020579A HR P20020579 A HRP20020579 A HR P20020579A HR P20020579 B1 HRP20020579 B1 HR P20020579B1
Authority
HR
Croatia
Prior art keywords
quetiapine
preparation
intermediates
formula
thiazepine
Prior art date
Application number
HR20020579A
Other languages
English (en)
Inventor
B�zsing D�niel
Kov�nyin� Lax Gy�rgyi
Simig Gyula
R�k�czy Gy�rgyn�
T�mpe P�ter
Krasznai Gy�rgy
Vereczkeyn� Don�th Gy�rgyi
Nagy K�lm�n
Original Assignee
Egis Gy�gyszergy�r RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gy�gyszergy�r RT filed Critical Egis Gy�gyszergy�r RT
Publication of HRP20020579A2 publication Critical patent/HRP20020579A2/hr
Publication of HRP20020579B1 publication Critical patent/HRP20020579B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Steroid Compounds (AREA)
HR20020579A 2000-01-25 2002-07-05 A process for the preparation of quetiapine and intermediates thereof HRP20020579B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0000283A HU227039B1 (en) 2000-01-25 2000-01-25 New process for the production of quetiapine and intermediates therefor
PCT/HU2001/000010 WO2001055125A1 (en) 2000-01-25 2001-01-24 A process for the preparation of quetiapine and intermediates therefor

Publications (2)

Publication Number Publication Date
HRP20020579A2 HRP20020579A2 (en) 2004-08-31
HRP20020579B1 true HRP20020579B1 (en) 2005-08-31

Family

ID=89978038

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020579A HRP20020579B1 (en) 2000-01-25 2002-07-05 A process for the preparation of quetiapine and intermediates thereof

Country Status (16)

Country Link
EP (1) EP1252151B1 (sl)
CN (2) CN1177839C (sl)
AT (1) ATE261949T1 (sl)
AU (1) AU3214601A (sl)
CZ (1) CZ301236B6 (sl)
DE (1) DE60102357T2 (sl)
DK (1) DK1252151T3 (sl)
ES (1) ES2217115T3 (sl)
HR (1) HRP20020579B1 (sl)
HU (1) HU227039B1 (sl)
PL (1) PL211338B1 (sl)
RU (1) RU2258067C2 (sl)
SI (1) SI1252151T1 (sl)
SK (1) SK287171B6 (sl)
UA (1) UA73547C2 (sl)
WO (1) WO2001055125A1 (sl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK12882001A3 (sk) 1999-03-15 2002-04-04 Axys Pharmaceuticals, Inc. Zlúčeniny a prípravky ako proteinázové inhibítory
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
US7064123B1 (en) 2000-12-22 2006-06-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
IL160819A0 (en) 2001-09-14 2004-08-31 Aventis Pharma Inc Novel compounds and compositions as cathepsin inhibitors
US6977256B2 (en) 2001-11-14 2005-12-20 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin S inhibitors
CN1777594A (zh) * 2003-02-22 2006-05-24 特瓦制药工业有限公司 喹迪平及其可药用盐的合成
ES2368737T3 (es) 2003-04-23 2011-11-21 Medarex, Inc. Anticuerpos humanizados contra el receptor de interferon alfa 1 (ifnar-1).
PL195728B1 (pl) * 2003-07-18 2007-10-31 Helm Ag Sposób wytwarzania 11-(1-piperazynylo)dibenzo[b,f][1,4]tiazepiny
ES2223294B2 (es) * 2003-08-08 2005-10-01 Vita Cientifica, S.L. Procedimiento de preparacion de un compuesto farmaceuticamente activo.
DE602004024798D1 (de) 2003-09-23 2010-02-04 Fermion Oy Herstellung von quetiapin
CA2538866A1 (en) * 2003-09-23 2005-03-31 Fermion Oy Preparation of quetiapine
KR101038389B1 (ko) * 2004-06-23 2011-06-01 에스케이바이오팜 주식회사 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법
WO2006035293A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Polymorphic forms of quetiapine hemifumarate
GB0425729D0 (en) * 2004-11-23 2004-12-22 Pliva Res & Dev Ltd Heterocyclic compounds
WO2006056772A2 (en) * 2004-11-23 2006-06-01 Pliva Hrvatska D.O.O. Salts of quetiapine
ES2234447B1 (es) * 2005-03-07 2006-03-01 Union Quimico-Farmaceutica S.A. Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina.
EP1869007A1 (en) 2005-04-14 2007-12-26 Teva Pharmaceutical Industries Ltd Process for preparing quetiapine fumarate
EP1928849A1 (en) 2005-09-30 2008-06-11 Fermion Oy New crystallization process of quetiapine hemifumarate
PL2262486T3 (pl) 2008-08-01 2013-06-28 Krka Tovarna Zdravil D D Novo Mesto Kompozycja kwetiapiny
CN101676275B (zh) * 2008-09-17 2014-05-07 北京德众万全药物技术开发有限公司 一种富马酸喹硫平的制备方法
JP2012519683A (ja) 2009-03-04 2012-08-30 ランバクシー ラボラトリーズ リミテッド フマル酸クエチアピンの調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH422793A (de) * 1961-07-20 1966-10-31 Wander Ag Dr A Verfahren zur Herstellung 11-basisch substituierter Dibenzo(b,f) (1,4)thiazepine
CH476743A (de) * 1962-06-08 1969-08-15 Wander Ag Dr A Verfahren zur Herstellung von Amidinen der Dibenzo (b,e) (1,4)-diazepin-Reihe
US3539573A (en) * 1967-03-22 1970-11-10 Jean Schmutz 11-basic substituted dibenzodiazepines and dibenzothiazepines
US3560622A (en) * 1967-10-13 1971-02-02 American Cyanamid Co Trifluoromethyl oxazepines,thiazepines and diazepines as anti-inflammatory agents

Also Published As

Publication number Publication date
EP1252151B1 (en) 2004-03-17
CN1537847A (zh) 2004-10-20
CZ301236B6 (cs) 2009-12-16
DE60102357T2 (de) 2005-01-13
SK10602002A3 (sk) 2002-11-06
ATE261949T1 (de) 2004-04-15
RU2002122723A (ru) 2004-01-10
CN1177839C (zh) 2004-12-01
HU227039B1 (en) 2010-05-28
RU2258067C2 (ru) 2005-08-10
CZ20022463A3 (cs) 2002-10-16
SI1252151T1 (sl) 2004-08-31
HUP0000283A3 (en) 2002-11-28
CN1239487C (zh) 2006-02-01
ES2217115T3 (es) 2004-11-01
AU3214601A (en) 2001-08-07
HUP0000283A2 (hu) 2002-04-29
PL211338B1 (pl) 2012-05-31
HU0000283D0 (en) 2000-03-28
UA73547C2 (uk) 2005-08-15
PL355726A1 (en) 2004-05-17
DK1252151T3 (da) 2004-07-12
SK287171B6 (sk) 2010-02-08
CN1396916A (zh) 2003-02-12
HRP20020579A2 (en) 2004-08-31
EP1252151A1 (en) 2002-10-30
DE60102357D1 (de) 2004-04-22
WO2001055125A1 (en) 2001-08-02

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Legal Events

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Payment date: 20151230

Year of fee payment: 16

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Effective date: 20170124