HRP20020455A2 - 2-arylquinoline derivatives, preparation and therapeutic use thereof - Google Patents

2-arylquinoline derivatives, preparation and therapeutic use thereof Download PDF

Info

Publication number
HRP20020455A2
HRP20020455A2 HR20020455A HRP20020455A HRP20020455A2 HR P20020455 A2 HRP20020455 A2 HR P20020455A2 HR 20020455 A HR20020455 A HR 20020455A HR P20020455 A HRP20020455 A HR P20020455A HR P20020455 A2 HRP20020455 A2 HR P20020455A2
Authority
HR
Croatia
Prior art keywords
group
alkyl
phenyl
formula
compound
Prior art date
Application number
HR20020455A
Other languages
English (en)
Croatian (hr)
Inventor
Philippe R Bovy
Alain Braun
Christophe Philippo
Original Assignee
Sanofi Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of HRP20020455A2 publication Critical patent/HRP20020455A2/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/08—Hydrogen atoms or radicals containing only hydrogen and carbon atoms
    • C07D333/10—Thiophene
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
HR20020455A 1999-11-25 2000-11-21 2-arylquinoline derivatives, preparation and therapeutic use thereof HRP20020455A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9914817A FR2801589A1 (fr) 1999-11-25 1999-11-25 Derives de 2-arylquinoleine, leur preparation et leur application en therapeutique
PCT/FR2000/003224 WO2001038310A1 (fr) 1999-11-25 2000-11-21 Derives de 2-arylquinoleine, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
HRP20020455A2 true HRP20020455A2 (en) 2003-08-31

Family

ID=9552515

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020455A HRP20020455A2 (en) 1999-11-25 2000-11-21 2-arylquinoline derivatives, preparation and therapeutic use thereof

Country Status (24)

Country Link
US (1) US6617336B1 (cs)
EP (1) EP1240146A1 (cs)
JP (1) JP2003526633A (cs)
KR (1) KR20020058036A (cs)
CN (1) CN1413196A (cs)
AU (1) AU2521501A (cs)
BG (1) BG106737A (cs)
BR (1) BR0015787A (cs)
CA (1) CA2392149A1 (cs)
CZ (1) CZ20021786A3 (cs)
EA (1) EA200200462A1 (cs)
EE (1) EE200200266A (cs)
FR (1) FR2801589A1 (cs)
HR (1) HRP20020455A2 (cs)
HU (1) HUP0203455A3 (cs)
IL (1) IL149653A0 (cs)
IS (1) IS6391A (cs)
MX (1) MXPA02005019A (cs)
NO (1) NO20022482L (cs)
PL (1) PL356159A1 (cs)
SK (1) SK7162002A3 (cs)
TR (1) TR200201352T2 (cs)
WO (1) WO2001038310A1 (cs)
ZA (1) ZA200204064B (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5147204B2 (ja) * 2006-07-27 2013-02-20 大塚製薬株式会社 カルボスチリル誘導体の製造方法
TW200823182A (en) * 2006-08-01 2008-06-01 Praecis Pharm Inc Chemical compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2731708B1 (fr) * 1995-03-13 1997-04-30 Synthelabo Derives de piperidine, leur procede de preparation et leur application en therapeutique
US6063810A (en) 1996-03-08 2000-05-16 Synthelabo 2-aminoethyl-benzofuran derivatives, preparation thereof and therapeutical use thereof
FR2752839B1 (fr) * 1996-08-29 1998-10-09 Synthelabo Derives de benzofurane, leur preparation et leur application en therapeutique
FR2752840A1 (fr) * 1996-08-29 1998-03-06 Synthelabo Derives de benzothiophene, leur preparation et leur application en therapeutique
FR2756564B1 (fr) * 1996-12-04 2004-05-14 Synthelabo Derives d'acide quinoleine-8-carboxylique, leur preparation et leur application en therapeutique
FR2783247B1 (fr) * 1998-09-10 2000-11-17 Synthelabo Derives de 2-aminoethyl-quinoleine, leur preparation et leur application en therapeutique
FR2785903B1 (fr) * 1998-11-17 2002-10-25 Synthelabo Derives de 1-aminoethylquinoleine, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
NO20022482D0 (no) 2002-05-24
JP2003526633A (ja) 2003-09-09
AU2521501A (en) 2001-06-04
EP1240146A1 (fr) 2002-09-18
FR2801589A1 (fr) 2001-06-01
BG106737A (bg) 2003-04-30
HUP0203455A3 (en) 2003-12-29
IS6391A (is) 2002-05-21
EE200200266A (et) 2003-06-16
CN1413196A (zh) 2003-04-23
KR20020058036A (ko) 2002-07-12
WO2001038310A1 (fr) 2001-05-31
US6617336B1 (en) 2003-09-09
SK7162002A3 (en) 2002-11-06
EA200200462A1 (ru) 2002-10-31
MXPA02005019A (es) 2003-01-28
TR200201352T2 (tr) 2003-02-21
NO20022482L (no) 2002-07-24
CZ20021786A3 (cs) 2002-08-14
ZA200204064B (en) 2003-07-30
CA2392149A1 (en) 2001-05-31
PL356159A1 (en) 2004-06-14
IL149653A0 (en) 2002-11-10
BR0015787A (pt) 2002-08-13
HUP0203455A2 (hu) 2003-02-28

Similar Documents

Publication Publication Date Title
EP1133474B1 (en) 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators
KR940000828B1 (ko) 항혈전성 강심제 이미다조 퀴놀린의 제조방법
FI100969B (fi) Menetelmä valmistaa terapeuttisesti aktiivista pyratsolo£1,5-a|pyridii niyhdistettä
JP3847786B2 (ja) 三環性化合物
JP3238397B2 (ja) 新規のスルホニル化合物
PL119501B1 (en) Process for manufacturing novel,condensed pyrimidine derivatives pirimidina
KR870000275B1 (ko) 3-메틸플라본-8-카르복실산 에스테르류의 제조방법
HRP20020455A2 (en) 2-arylquinoline derivatives, preparation and therapeutic use thereof
EP0538477B1 (en) Novel cyclic aminophenylacetic acid derivative, production thereof, and immune response modulator containing the same as active ingredient
US6331549B1 (en) 1-aminoethylquinoline derivatives for treating urinary incontinence
JP3782445B2 (ja) 尿失禁を処置するためのキノロン誘導体
US20030097000A1 (en) 2-Phenyl-quinoline derivatives, preparation method and therapeutic use thereof
US6060508A (en) Benzylamine derivatives, their preparation and their application in therapeutics
JPH07119188B2 (ja) カルコン誘導体
US4612317A (en) Tetrahydro-β-carboline dithioic acid derivatives and treatment of liver diseases
US4628115A (en) Substituted 4-acetyl-3-hydroxyphenoxy alkanoic acids
HU198296B (en) Process for producing new 2-pyridyl acetic acid derivatives and pharmaceutical compositions comprising same
US5112836A (en) Cyclic anthranililc acid carboxylic acid derivatives and medical therapeutic use thereof
US4425351A (en) Therapeutically useful oxygen derivatives of 3,7a-diazacyclohepta[j,k]fluorenes
FR2526020A1 (fr) Nouveaux derives cycloaliphatiques condenses de pyrido(1,2-a)pyrimidines substituees utiles notamment comme medicaments anti-allergiques, anti-inflammatoires et dans la prevention ou le traitement des ulceres gastro-intestinaux et procede pour leur preparation
FR2783247A1 (fr) Derives de 2-aminoethyl-quinoleine, leur preparation et leur application en therapeutique
JPH089593B2 (ja) 環状エノ−ル誘導体およびその製造法
FR2758820A1 (fr) Derives de alpha-azacyclomethyl-benzofurane, leur preparation et leur application en therapeutique
FR2486801A1 (fr) Compositions pharmaceutiques a base de pyridoindoles
PL162009B1 (pl) Sposób wytwarzania nowych pochodnych etanoloaminy

Legal Events

Date Code Title Description
A1OB Publication of a patent application
OBST Application withdrawn