HRP20020322B1 - Methods of preparing substituted tetracyclines with transition metal-based chemistries - Google Patents

Methods of preparing substituted tetracyclines with transition metal-based chemistries

Info

Publication number
HRP20020322B1
HRP20020322B1 HR20020322A HRP20020322A HRP20020322B1 HR P20020322 B1 HRP20020322 B1 HR P20020322B1 HR 20020322 A HR20020322 A HR 20020322A HR P20020322 A HRP20020322 A HR P20020322A HR P20020322 B1 HRP20020322 B1 HR P20020322B1
Authority
HR
Croatia
Prior art keywords
transition metal
methods
reactive
preparing substituted
tetracycline
Prior art date
Application number
HR20020322A
Other languages
English (en)
Croatian (hr)
Inventor
L. Nelson Mark
Rennie Glen
J. Koza Darell
Original Assignee
Trustees Of Tufts College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Trustees Of Tufts College filed Critical Trustees Of Tufts College
Publication of HRP20020322A2 publication Critical patent/HRP20020322A2/hr
Publication of HRP20020322B1 publication Critical patent/HRP20020322B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20020322A 1999-09-14 2002-04-12 Methods of preparing substituted tetracyclines with transition metal-based chemistries HRP20020322B1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15470199P 1999-09-14 1999-09-14
US23209100P 2000-09-12 2000-09-12
PCT/US2000/025040 WO2001019784A1 (en) 1999-09-14 2000-09-13 Methods of preparing substituted tetracyclines with transition metal-based chemistries

Publications (2)

Publication Number Publication Date
HRP20020322A2 HRP20020322A2 (en) 2004-02-29
HRP20020322B1 true HRP20020322B1 (en) 2009-04-30

Family

ID=26851695

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020322A HRP20020322B1 (en) 1999-09-14 2002-04-12 Methods of preparing substituted tetracyclines with transition metal-based chemistries

Country Status (21)

Country Link
US (3) US6617318B1 (hu)
EP (5) EP1666453A1 (hu)
JP (2) JP5093953B2 (hu)
KR (1) KR100764992B1 (hu)
CN (2) CN1399627A (hu)
AT (2) ATE323671T1 (hu)
AU (3) AU781439C (hu)
BR (1) BR0013993A (hu)
CA (2) CA2383364C (hu)
CY (1) CY1105094T1 (hu)
CZ (1) CZ301835B6 (hu)
DE (1) DE60027465T2 (hu)
DK (1) DK1240133T3 (hu)
EA (3) EA012203B1 (hu)
ES (1) ES2260051T3 (hu)
HR (1) HRP20020322B1 (hu)
HU (1) HUP0202798A3 (hu)
IL (4) IL148482A0 (hu)
MX (1) MXPA02002595A (hu)
PT (1) PT1240133E (hu)
WO (1) WO2001019784A1 (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
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HRP20030091B1 (en) * 2000-07-07 2011-10-31 Trustees Of Tufts College 9-substituted minocycline compounds

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US6756365B2 (en) * 1991-11-06 2004-06-29 Trustees Of Tufts College Reducing tetracycline resistance in living cells
JP2002501026A (ja) * 1998-01-23 2002-01-15 トルスティーズ オブ トゥフツ カレッジ 薬学的に活性の化合物及びその利用法
EP1666453A1 (en) * 1999-09-14 2006-06-07 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US6849615B2 (en) 1999-09-14 2005-02-01 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US6500812B2 (en) 1999-09-14 2002-12-31 Paratek Pharmaceuticals, Inc. 13-substituted methacycline compounds
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
WO2001052858A1 (en) * 2000-01-24 2001-07-26 Trustees Of Tufts College Tetracycline compounds for treatment of cryptosporidium parvum related disorders
US6818634B2 (en) * 2000-03-31 2004-11-16 Paratek Pharmaceuticals, Inc. 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds
EP1286954B1 (en) * 2000-05-15 2004-04-14 Paratek Pharmaceuticals, Inc. 7-substituted fused ring tetracycline compounds
US20040224927A1 (en) * 2000-06-16 2004-11-11 Trustees Of Tufts College 7-N-substituted phenyl tetracycline compounds
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
US20020128238A1 (en) * 2000-06-16 2002-09-12 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
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WO2002004405A2 (en) * 2000-07-07 2002-01-17 Trustees Of Tufts College 13-substituted methacycline compounds
US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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US7553828B2 (en) * 2001-03-13 2009-06-30 Paratek Pharmaceuticals, Inc. 9-aminomethyl substituted minocycline compounds
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WO2003079983A2 (en) * 2002-03-21 2003-10-02 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
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MXPA02002595A (es) 2003-07-21
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CA2672722A1 (en) 2001-03-22
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