HRP20020255A2 - 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia - Google Patents

5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia Download PDF

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Publication number
HRP20020255A2
HRP20020255A2 HR20020255A HRP20020255A HRP20020255A2 HR P20020255 A2 HRP20020255 A2 HR P20020255A2 HR 20020255 A HR20020255 A HR 20020255A HR P20020255 A HRP20020255 A HR P20020255A HR P20020255 A2 HRP20020255 A2 HR P20020255A2
Authority
HR
Croatia
Prior art keywords
preferably substituted
substituted alkyl
alkoxycarbonyl
carbamoyl
sapogenin
Prior art date
Application number
HR20020255A
Other languages
English (en)
Croatian (hr)
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of HRP20020255A2 publication Critical patent/HRP20020255A2/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
HR20020255A 1999-09-29 2000-09-29 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia HRP20020255A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923076.5A GB9923076D0 (en) 1999-09-29 1999-09-29 Sapogenin derivatives and their use
PCT/GB2000/003737 WO2001023406A1 (en) 1999-09-29 2000-09-29 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia

Publications (1)

Publication Number Publication Date
HRP20020255A2 true HRP20020255A2 (en) 2003-08-31

Family

ID=10861837

Family Applications (2)

Application Number Title Priority Date Filing Date
HR20080467A HRP20080467A2 (hr) 1999-09-29 2000-09-29 Derivati 5-beta-sapogenina i pseudosapogenina te njihova uporaba u liječenju demencije
HR20020255A HRP20020255A2 (en) 1999-09-29 2000-09-29 5-beta-sapogenin and pseudosapogenin derivatives and their use in the treatment of dementia

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HR20080467A HRP20080467A2 (hr) 1999-09-29 2000-09-29 Derivati 5-beta-sapogenina i pseudosapogenina te njihova uporaba u liječenju demencije

Country Status (27)

Country Link
US (2) US7138427B2 (enExample)
EP (2) EP1224205B1 (enExample)
JP (1) JP2003510332A (enExample)
KR (1) KR100771491B1 (enExample)
CN (2) CN101411712A (enExample)
AT (1) ATE325808T1 (enExample)
AU (1) AU778294C (enExample)
BR (1) BR0014381A (enExample)
CA (2) CA2385402C (enExample)
CY (1) CY1105225T1 (enExample)
CZ (1) CZ300150B6 (enExample)
DE (1) DE60027913T2 (enExample)
DK (1) DK1224205T3 (enExample)
ES (1) ES2260055T3 (enExample)
GB (1) GB9923076D0 (enExample)
HK (1) HK1045525B (enExample)
HR (2) HRP20080467A2 (enExample)
IL (2) IL148920A0 (enExample)
MX (1) MXPA02003305A (enExample)
NO (1) NO324959B1 (enExample)
NZ (1) NZ518596A (enExample)
PT (1) PT1224205E (enExample)
RU (1) RU2325396C2 (enExample)
TR (1) TR200200821T2 (enExample)
UA (1) UA82978C2 (enExample)
WO (1) WO2001023406A1 (enExample)
ZA (1) ZA200202382B (enExample)

Families Citing this family (27)

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GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
EP1490071B1 (en) * 2002-03-27 2009-03-04 Phytopharm Plc Therapeutic uses of sapogenins
DE60326437D1 (de) * 2002-03-27 2009-04-16 Phytopharm Plc Godmanchester Therapeutische verwendung von sapogeninen
ATE424211T1 (de) * 2002-03-27 2009-03-15 Phytopharm Plc Therapeutische verwendung von sapogeninen
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GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20080182801A1 (en) * 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
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AU2010207597A1 (en) 2009-01-24 2011-08-18 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
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JP2013543482A (ja) 2010-07-20 2013-12-05 ファイトファーム ピーエルシー Ｌ−ドーパ、ドーパミン作動薬及び／又はドーパミン賦活剤により誘発される疾患の処置
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CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
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CN103232520A (zh) * 2013-05-13 2013-08-07 中国药科大学 一种螺甾类化合物、其制备方法及医药用途
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
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Also Published As

Publication number Publication date
AU778294B2 (en) 2004-11-25
HK1045525B (en) 2006-08-04
WO2001023406A1 (en) 2001-04-05
DK1224205T3 (da) 2006-06-12
EP1724279A2 (en) 2006-11-22
NZ518596A (en) 2004-07-30
PT1224205E (pt) 2006-08-31
CN101411712A (zh) 2009-04-22
CZ300150B6 (cs) 2009-02-25
US20060100184A9 (en) 2006-05-11
US7138427B2 (en) 2006-11-21
CA2640998A1 (en) 2001-04-05
IL180972A0 (en) 2007-07-04
NO20021541D0 (no) 2002-03-27
AU778294C (en) 2005-08-04
KR100771491B1 (ko) 2007-10-30
CA2385402C (en) 2009-01-13
DE60027913D1 (de) 2006-06-14
ZA200202382B (en) 2003-09-23
TR200200821T2 (tr) 2002-06-21
NO20021541L (no) 2002-05-28
MXPA02003305A (es) 2002-10-04
US20060276415A1 (en) 2006-12-07
CA2385402A1 (en) 2001-04-05
DE60027913T2 (de) 2007-01-11
PL357370A1 (en) 2004-07-26
CN100445295C (zh) 2008-12-24
NO324959B1 (no) 2008-01-14
RU2325396C2 (ru) 2008-05-27
ES2260055T3 (es) 2006-11-01
CY1105225T1 (el) 2010-03-03
US7507720B2 (en) 2009-03-24
AU7537500A (en) 2001-04-30
IL148920A0 (en) 2002-09-12
UA82978C2 (ru) 2008-06-10
EP1224205A1 (en) 2002-07-24
BR0014381A (pt) 2002-06-25
US20030004147A1 (en) 2003-01-02
JP2003510332A (ja) 2003-03-18
EP1224205B1 (en) 2006-05-10
GB9923076D0 (en) 1999-12-01
ATE325808T1 (de) 2006-06-15
HRP20080467A2 (hr) 2008-11-30
HK1045525A1 (en) 2002-11-29
CN1377368A (zh) 2002-10-30
KR20020092914A (ko) 2002-12-12

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