KR100771491B1 - 5-β-사포게닌 및 유사 사포게닌 유도체 및 치매치료에서의 이들의 사용법 - Google Patents

5-β-사포게닌 및 유사 사포게닌 유도체 및 치매치료에서의 이들의 사용법 Download PDF

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KR100771491B1
KR100771491B1 KR1020027003973A KR20027003973A KR100771491B1 KR 100771491 B1 KR100771491 B1 KR 100771491B1 KR 1020027003973 A KR1020027003973 A KR 1020027003973A KR 20027003973 A KR20027003973 A KR 20027003973A KR 100771491 B1 KR100771491 B1 KR 100771491B1
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alkyl
substituted
carbamoyl
compound
hydrogen
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KR20020092914A (ko
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바라클로우바울
한슨짐
구닝필
리스다일
시아종친
후야얼
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파이토팜 피엘씨
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
KR1020027003973A 1999-09-29 2000-09-29 5-β-사포게닌 및 유사 사포게닌 유도체 및 치매치료에서의 이들의 사용법 Expired - Fee Related KR100771491B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9923076.5A GB9923076D0 (en) 1999-09-29 1999-09-29 Sapogenin derivatives and their use
GB9923076.5 1999-09-29

Publications (2)

Publication Number Publication Date
KR20020092914A KR20020092914A (ko) 2002-12-12
KR100771491B1 true KR100771491B1 (ko) 2007-10-30

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US (2) US7138427B2 (enExample)
EP (2) EP1724279A2 (enExample)
JP (1) JP2003510332A (enExample)
KR (1) KR100771491B1 (enExample)
CN (2) CN100445295C (enExample)
AT (1) ATE325808T1 (enExample)
AU (1) AU778294C (enExample)
BR (1) BR0014381A (enExample)
CA (2) CA2385402C (enExample)
CY (1) CY1105225T1 (enExample)
CZ (1) CZ300150B6 (enExample)
DE (1) DE60027913T2 (enExample)
DK (1) DK1224205T3 (enExample)
ES (1) ES2260055T3 (enExample)
GB (1) GB9923076D0 (enExample)
HK (1) HK1045525B (enExample)
HR (2) HRP20020255A2 (enExample)
IL (2) IL148920A0 (enExample)
MX (1) MXPA02003305A (enExample)
NO (1) NO324959B1 (enExample)
NZ (1) NZ518596A (enExample)
PT (1) PT1224205E (enExample)
RU (1) RU2325396C2 (enExample)
TR (1) TR200200821T2 (enExample)
UA (1) UA82978C2 (enExample)
WO (1) WO2001023406A1 (enExample)
ZA (1) ZA200202382B (enExample)

Families Citing this family (27)

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Publication number Priority date Publication date Assignee Title
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
GB0107822D0 (en) * 2001-03-28 2001-05-23 Phytopharm Plc Sapogenin derivatives their synthesis and use methods based upon their use
HRP20041009A2 (en) * 2002-03-27 2004-12-31 Phytopharm Plc Theraputic methods and uses of sapogenins and their derivatives
EP1490071B1 (en) * 2002-03-27 2009-03-04 Phytopharm Plc Therapeutic uses of sapogenins
NZ547344A (en) * 2002-03-27 2007-11-30 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
US7718792B2 (en) 2002-10-28 2010-05-18 Phytopharm Plc Stereospecific reduction of sapogen-3-ones
GB0513881D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors III
GB0329667D0 (en) * 2003-12-22 2004-01-28 King S College London Core 2 GlcNAc-T inhibitor
US20080182801A1 (en) * 2003-12-22 2008-07-31 Btg International Limited Core 2 glcnac-t inhibitors
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
GB0512726D0 (en) * 2005-06-22 2005-07-27 Btg Int Ltd Multiple sclerosis therapy and diagnosis
GB0513888D0 (en) 2005-07-06 2005-08-10 Btg Int Ltd Core 2 GLCNAC-T Inhibitors II
GB0513883D0 (en) * 2005-07-06 2005-08-10 Btg Int Ltd Diagnosis of Atherosclerosis
WO2010084356A1 (en) 2009-01-24 2010-07-29 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
CN101768202B (zh) * 2009-02-18 2013-10-30 沈阳药科大学 知母中菝葜皂苷元及其衍生物的制备方法及其医药新用途
MX2013000760A (es) 2010-07-20 2013-10-28 Phytopharm Plc Tratamiento de trastornos inducidos por l-dopa, agonista de la dopamina y/o potenciador de dopamina.
CU20110244A7 (es) * 2011-12-27 2013-08-29 Ct De Investigación Y Desarrollo De Medicamentos Cidem Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios
US11319338B2 (en) 2012-04-03 2022-05-03 Goldporp Pharma Limited Timosaponin compounds
CN102924559B (zh) * 2012-11-16 2015-10-28 沈阳药科大学 菝葜皂苷元衍生物及其制备和应用
GB201305708D0 (en) * 2013-03-28 2013-05-15 Clasado Inc Novel use
CN103232520A (zh) * 2013-05-13 2013-08-07 中国药科大学 一种螺甾类化合物、其制备方法及医药用途
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
WO2017075313A1 (en) * 2015-10-29 2017-05-04 Emmyon, Inc. Furostan-3-ol derivatives as skeletal muscle hypertrophic agents
CN106977581B (zh) * 2017-04-17 2021-01-01 华东理工大学 知母皂苷元结构修饰的衍生物的应用以及药物组合物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016786A1 (fr) * 1997-09-26 1999-04-08 Institute Of Radiation Medicine, Academy Of Military Medical Sciences Of The Pla Utilisation de composes de saponine et de steroides pour prevenir la senilite et nouveaux composes de saponine steroide

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB852847A (en) 1958-03-04 1960-11-02 British Drug Houses Ltd Improvements in or relating to 6-methyl steroid compounds
US3575810A (en) 1967-07-19 1971-04-20 Takashi Matsushima Method for removal of side chain of sapogenins
BE794362A (fr) 1972-01-22 1973-07-23 Merck Patent Gmbh Sulfates hydrosolubles de sterine
US3929769A (en) 1972-05-19 1975-12-30 Ciba Geigy Corp Process for the manufacture of steroid epoxides
CA985172A (en) 1972-10-06 1976-03-09 Dushan M. Dvornik Compositions and methods for reducing blood cholesterol
DE2416978A1 (de) 1974-04-08 1975-10-09 Degussa Arzneimittel mit dem hauptsapogenin der helleborus-arten als wirkstoff
LU81256A1 (fr) 1979-05-15 1980-12-16 Oreal Composition cosmetique capillaire notamment pour le lavage et/ou le demelage des cheveux,a base d'un extrait de plantes contenant des saponosides
IT1144136B (it) 1980-03-05 1986-10-29 Zenyaku Kogyo Kk Glucosidi di condurango agenti antitumorali che li comprendono e procedimento per la loro preparazione
GB2097672A (en) 1981-05-01 1982-11-10 Pattni Ramesh Damji Devji Process for extraction of crude sapogenins from Agave Leaves
JPS5855500A (ja) 1981-09-25 1983-04-01 Tokiwa Yakuhin Kogyo Kk １６−デヒドロプレグネノロンの製造法
US4602003A (en) 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia
US4602005A (en) 1982-05-17 1986-07-22 Medical Research Foundation Of Oregon Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis
US4562250A (en) 1982-09-13 1985-12-31 Regents Of The University Of Minnesota Steroidal glycosides produced by Yucca tissue culture
US4546097A (en) 1983-11-04 1985-10-08 The United States Of America As Represented By The Department Of Health And Human Services Saponin-based polyether polyols, pharmaceutical compositions and a method of using same
US4680289A (en) 1985-06-05 1987-07-14 Progenics, Inc. Treatment of obesity and diabetes using sapogenins
JPS62234025A (ja) 1986-04-03 1987-10-14 Asahi Chem Ind Co Ltd 老人性痴呆者用食品
US5017562A (en) 1987-02-11 1991-05-21 Regents Of The University Of Minnesota Crystalline saponin-containing complex
DE3838716A1 (de) 1988-11-15 1990-05-17 Kanoldt Arzneimittel Gmbh Arzneimittelzubereitung aus esterderivaten des hecogenins und dessen verwendung zur behandlung von benigner prostatahyperplasie
JPH02188528A (ja) 1989-01-13 1990-07-24 Tsurataka Tashiro 痴呆症治療薬
AU654474B2 (en) 1990-01-18 1994-11-10 Cura Nominees Pty Ltd Glycoalkaloids
SE9100342D0 (sv) 1991-02-04 1991-02-04 Astra Ab Novel steroid esters
US5252729A (en) 1991-10-23 1993-10-12 Schering Corporation Extraction of compounds from plant materials using supercritical fluids
US5244887A (en) 1992-02-14 1993-09-14 Straub Carl D Stanols to reduce cholesterol absorption from foods and methods of preparation and use thereof
JPH05246866A (ja) * 1992-03-06 1993-09-24 Ruibosuteii Japan:Kk 脳代謝促進・脳機能改善剤
EP0647234A1 (en) 1992-06-26 1995-04-12 Pfizer Inc. Steroidal glycosides for treating hypercholesterolemia
DE4303214A1 (de) * 1993-02-04 1994-08-11 Wolfgang Marks Behandlung von Erkrankungen viraler, viroidaler oder onkogener Genese durch Steroid-Saponine oder deren Aglykone
AU6274394A (en) 1993-02-23 1994-09-14 Pharmakon Usa, Inc. Therapeutic herbal composition
CN1052636C (zh) 1993-03-29 2000-05-24 中国科学院沈阳应用生态研究所 文冠果子的醇提取物在制备治疗智力低下的药物中的应用
CN1092992A (zh) 1993-03-29 1994-10-05 中国科学院沈阳应用生态研究所 提高脑功能的药物及其制备方法
JPH06305952A (ja) 1993-04-27 1994-11-01 Sumitomo Pharmaceut Co Ltd スレオ−３−（３，４−ジヒドロキシフェニル）セリン経鼻投与製剤
US5760009A (en) 1993-04-28 1998-06-02 Pfizer Inc. Spirostanyl glycosidal crystalline monohydrate
CN1033754C (zh) * 1993-05-31 1997-01-08 上海第二医科大学 知母皂甙元作为制备β肾上腺素和M胆碱受体双向调节药的用途及其制法
CN1102186A (zh) 1993-10-29 1995-05-03 沈阳医学院 中药薤白新成分的鉴定及用途
US5589182A (en) 1993-12-06 1996-12-31 Tashiro; Renki Compositions and method of treating cardio-, cerebro-vascular and alzheimer's diseases and depression
JPH09500906A (ja) 1993-12-28 1997-01-28 ファイザー・インク． 血中コレステロール低下薬
EP0737203A1 (en) 1993-12-28 1996-10-16 Pfizer Inc. Steroidal glycosides
IL109614A (en) 1994-05-10 1998-06-15 Yissum Res Dev Co Comestible products containing saponins
US5563131A (en) 1994-08-04 1996-10-08 Pherin Corporation Pregnane steroids as neurochemical initiators of change in human hypothalamic function and related pharmaceutical compositions and methods
US5840740A (en) 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds and a method of treating infection using the aminosterol compounds
US5856535A (en) 1994-08-18 1999-01-05 Magainin Pharmaceuticals, Inc. Aminosterol ester compounds
JPH09510735A (ja) 1994-08-30 1997-10-28 フアイザー・インコーポレイテツド スピロスタニルグリコシド性結晶
WO1996009827A2 (en) 1994-09-20 1996-04-04 Pfizer Inc. Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor
WO1996038466A1 (en) 1995-05-29 1996-12-05 Pfizer Inc. Steroidal glycosides
US5847172A (en) 1995-06-07 1998-12-08 Magainin Pharmaceuticals Inc. Certain aminosterol compounds and pharmaceutical compositions including these compounds
US6143738A (en) 1995-06-07 2000-11-07 Magainin Pharmaceuticals, Inc. Therapeutic uses for an aminosterol compound
US5840936A (en) 1995-06-07 1998-11-24 Magainin Pharmaceuticals Inc. Aminosterol compounds useful as inhibitors of the sodium/proton exchanger (NHE)
US5763430A (en) 1995-06-07 1998-06-09 Magainin Pharmaceuticals Inc. Method of treating a viral infection by administering a steroid compound
US5795885A (en) 1995-06-07 1998-08-18 Magainin Pharmaceuticals Inc. Method of inhibiting profileration of cells by administering an aminosterol compound
US5792635A (en) 1995-06-07 1998-08-11 Magainin Pharmaceuticals, Inc. Method of inhibiting the sodium/proton exchanger NHE3 and method of inhibiting growth by administering squalamine
JPH09100295A (ja) 1995-06-13 1997-04-15 Toray Ind Inc 新規トリテルペノイドサポニン類およびそれを有効成分とする神経突起伸展作用を有する治療剤
CU22860A1 (es) 1995-10-12 2003-05-26 Univ La Habana Espirostanonas con funciones oxigenadas en el anillo a. como reguladores del crecimiento vegetal y su procedimiento de obtención
DE69615214T2 (de) 1995-10-13 2002-06-27 Banyu Pharmaceutical Co., Ltd. Substituierte heteroaromatische derivate
FR2743561B1 (fr) 1996-01-15 1998-02-20 Fournier Sca Lab Derives de steroides, procede de preparation et utilisation en therapeutique
KR0169536B1 (ko) 1996-02-27 1999-01-15 손경식 신규한 인삼 사포닌, 그의 제조방법 및 이를 유효성분으로 하는 항종양제
US5726179A (en) 1996-04-01 1998-03-10 The University Of Toledo Muscarinic agonists
JP4228116B2 (ja) 1996-05-09 2009-02-25 ゼニス・オペレイションズ・プロプライエタリー・リミテッド 喘息および気道の疾患の治療
ES2229376T5 (es) 1996-07-22 2010-10-25 Renovo Limited Uso de compuestos que promueven la actividad estrogenica para acelerar la cicatrizacion de las heridas de la piel.
US5804239A (en) 1996-07-26 1998-09-08 Nouveau Technologies, Inc. Method and composition for food flavoring
JP4386470B2 (ja) 1997-05-15 2009-12-16 ユニバーシティ・オブ・ワシントン アルツハイマー病および他のアミロイド症のための組成物および方法
WO1998058543A1 (en) 1997-06-20 1998-12-30 Gubarev Michael J Method to enhance innate immunity defense mechanisms by treatment with plant-derived alkaloids
WO1999009837A1 (en) 1997-08-28 1999-03-04 Cv Technologies Inc. Chemical and pharmacological standardization of herbal extracts
JP3906948B2 (ja) * 1997-09-13 2007-04-18 本田技研工業株式会社 電動式変速装置の変速制御装置
CA2217088A1 (en) 1997-09-30 1999-03-30 Universite De Sherbrooke New mandevilla velutina derivatives as steady-state r-type ca2+ channel blockers, method of making and use thereof
JP3873097B2 (ja) 1997-11-06 2007-01-24 独立行政法人理化学研究所 抗肥満剤及び脂質代謝改善剤
GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
HUP0101693A3 (en) 1998-03-26 2002-08-28 Phytopharm Plc Godmanchester Use of steroidal sapogenins and their derivatives for producing pharmaceutical compositions for the treatment of alzheimeirs disease
GB9905275D0 (en) 1999-03-08 1999-04-28 Phytopharm Ltd Treatment of conditions associated with membrane-bound receptors and their function
KR100292406B1 (ko) 1998-06-11 2001-07-12 윤종용 감광성중합체,용해억제제및이들을포함하는화학증폭형포토레지스트조성물
GB2347676A (en) 1999-03-08 2000-09-13 Phytopharm Plc Screening method
GB9923078D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
AUPP968699A0 (en) 1999-04-09 1999-05-06 Cura Nominees Pty Ltd Therapeutic compositions and method for their preparation
US6544566B1 (en) 1999-04-23 2003-04-08 Protein Technologies International, Inc. Composition containing plant sterol, soy protein and isoflavone for reducing LDL cholesterol
GB9923077D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
BR0001794A (pt) 2000-05-15 2001-12-26 Laboratorios Biosintetica Ltda Aplicação de fitosteróides (e seus isÈmeros), ácidofólico, cianocobalamina e piridoxina em fibrasdietéticas (alimentares)
US20050130948A1 (en) 2002-03-27 2005-06-16 Daryl Rees Therapeutic methods and uses of sapogenins and their derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016786A1 (fr) * 1997-09-26 1999-04-08 Institute Of Radiation Medicine, Academy Of Military Medical Sciences Of The Pla Utilisation de composes de saponine et de steroides pour prevenir la senilite et nouveaux composes de saponine steroide

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CA2640998A1 (en) 2001-04-05
PT1224205E (pt) 2006-08-31
AU7537500A (en) 2001-04-30
NO20021541D0 (no) 2002-03-27
CZ300150B6 (cs) 2009-02-25
RU2325396C2 (ru) 2008-05-27
NO324959B1 (no) 2008-01-14
IL180972A0 (en) 2007-07-04
DE60027913T2 (de) 2007-01-11
HK1045525A1 (en) 2002-11-29
PL357370A1 (en) 2004-07-26
NO20021541L (no) 2002-05-28
HRP20020255A2 (en) 2003-08-31
KR20020092914A (ko) 2002-12-12
US20030004147A1 (en) 2003-01-02
GB9923076D0 (en) 1999-12-01
CY1105225T1 (el) 2010-03-03
US20060100184A9 (en) 2006-05-11
US7138427B2 (en) 2006-11-21
EP1724279A2 (en) 2006-11-22
CN100445295C (zh) 2008-12-24
MXPA02003305A (es) 2002-10-04
CA2385402A1 (en) 2001-04-05
BR0014381A (pt) 2002-06-25
EP1224205A1 (en) 2002-07-24
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ATE325808T1 (de) 2006-06-15
IL148920A0 (en) 2002-09-12
DK1224205T3 (da) 2006-06-12
UA82978C2 (ru) 2008-06-10
US20060276415A1 (en) 2006-12-07
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JP2003510332A (ja) 2003-03-18
ZA200202382B (en) 2003-09-23
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US7507720B2 (en) 2009-03-24
AU778294C (en) 2005-08-04
WO2001023406A1 (en) 2001-04-05
ES2260055T3 (es) 2006-11-01
NZ518596A (en) 2004-07-30
CN101411712A (zh) 2009-04-22
TR200200821T2 (tr) 2002-06-21
CN1377368A (zh) 2002-10-30
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HK1045525B (en) 2006-08-04

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