HRP20020028B1 - Hydroxylation of compactin to pravastatin by micro - Google Patents

Hydroxylation of compactin to pravastatin by micro

Info

Publication number
HRP20020028B1
HRP20020028B1 HR20020028A HRP20020028A HRP20020028B1 HR P20020028 B1 HRP20020028 B1 HR P20020028B1 HR 20020028 A HR20020028 A HR 20020028A HR P20020028 A HRP20020028 A HR P20020028A HR P20020028 B1 HRP20020028 B1 HR P20020028B1
Authority
HR
Croatia
Prior art keywords
compactin
pravastatin
hydroxylation
micro
Prior art date
Application number
HR20020028A
Other languages
English (en)
Inventor
Jekkel Antonia
Nagy Zsuzsanna
Horvath Gyula
Mozes Julia
Barta Istvan
Somogyi Gyoergy
Ambrus Gabor
Ilkoy Eva
Horvath Ildiko
Konya Attila
Mihaly Szabo Istvan
Salat Janos
Boros Sandor
Original Assignee
Gyogyszerkutato Intezet Kft.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gyogyszerkutato Intezet Kft. filed Critical Gyogyszerkutato Intezet Kft.
Publication of HRP20020028A2 publication Critical patent/HRP20020028A2/hr
Publication of HRP20020028B1 publication Critical patent/HRP20020028B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/29—Micromonospora
HR20020028A 1999-07-12 2002-01-10 Hydroxylation of compactin to pravastatin by micro HRP20020028B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902352A HUP9902352A1 (hu) 1999-07-12 1999-07-12 Eljárás pravasztatin mikrobiológiai előállítására
PCT/HU2000/000066 WO2001004340A1 (en) 1999-07-12 2000-06-29 Hydroxylation of compactin to pravastatin by micromonospora

Publications (2)

Publication Number Publication Date
HRP20020028A2 HRP20020028A2 (en) 2003-06-30
HRP20020028B1 true HRP20020028B1 (en) 2005-04-30

Family

ID=89998701

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20020028A HRP20020028B1 (en) 1999-07-12 2002-01-10 Hydroxylation of compactin to pravastatin by micro

Country Status (32)

Country Link
US (2) US6905851B1 (hu)
EP (3) EP1327689A1 (hu)
JP (2) JP4531315B2 (hu)
KR (2) KR100479837B1 (hu)
CN (2) CN1590555A (hu)
AP (1) AP1405A (hu)
AT (1) ATE243262T1 (hu)
AU (2) AU773633B2 (hu)
BG (1) BG65109B1 (hu)
BR (1) BR0013156A (hu)
CA (2) CA2379015A1 (hu)
CZ (2) CZ297009B6 (hu)
DE (1) DE60003424T2 (hu)
DK (1) DK1190087T3 (hu)
ES (1) ES2200891T3 (hu)
HR (1) HRP20020028B1 (hu)
HU (1) HUP9902352A1 (hu)
IL (2) IL147583A0 (hu)
IS (1) IS2138B (hu)
MX (1) MXPA02000356A (hu)
NO (1) NO20020119L (hu)
NZ (1) NZ516563A (hu)
OA (1) OA12150A (hu)
PL (2) PL353493A1 (hu)
PT (1) PT1190087E (hu)
RU (2) RU2235780C2 (hu)
SK (2) SK285726B6 (hu)
TR (1) TR200200726T2 (hu)
UA (1) UA67854C2 (hu)
WO (2) WO2001004340A1 (hu)
YU (1) YU2002A (hu)
ZA (1) ZA200200273B (hu)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
CN1754872A (zh) 1999-11-30 2006-04-05 特瓦药厂有限公司 从发酵肉汤中回收抑素化合物的方法
CA2394200C (en) 1999-12-14 2006-10-03 Biogal Gyogyszergyar Rt. Novel forms of pravastatin sodium
NZ525631A (en) * 2000-10-05 2005-05-27 Biogal Gyogyszergyar Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same
JP3236282B1 (ja) * 2000-10-16 2001-12-10 三共株式会社 プラバスタチンを精製する方法
CN1273608C (zh) * 2001-02-09 2006-09-06 荷兰联合利华有限公司 通过发酵制备一种或多种抑制素的方法
JP2003026634A (ja) * 2001-07-17 2003-01-29 Mercian Corp プラバスタチンナトリウム塩の製造方法
US6716615B2 (en) 2002-02-27 2004-04-06 Yung Shin Pharmaceutical Ind. Co., Ltd. Strains of saccharaothrix, process for producing pravastatin using the strains and isolation process of (HMG)-CoA reductase
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
DE04811862T1 (de) 2003-11-24 2006-03-02 Teva Gyogyszergyar Reszvenytarsasag Verfahren zur Reinigung von Pravastatin
MY161108A (en) * 2008-02-06 2017-04-14 Biocon Ltd Fermentation medias and processes thereof
RU2522806C1 (ru) * 2012-11-27 2014-07-20 Федеральное государственное бюджетное учреждение науки Центр "Биоинженерия" Российской академии наук Усовершенствованный способ очистки правастатина
JP6441599B2 (ja) * 2014-07-14 2018-12-19 合同酒精株式会社 プラバスタチンの製造法
CN114031496A (zh) * 2021-11-30 2022-02-11 广东蓝宝制药有限公司 一种高纯度普伐他汀1,1,3,3-四甲基丁胺的制备方法
CN114133331A (zh) * 2021-12-10 2022-03-04 广东蓝宝制药有限公司 一种回收获得高纯度普伐他汀酯的方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5810572A (ja) 1981-07-07 1983-01-21 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体およびその製造法
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JPS59175450A (ja) * 1983-03-24 1984-10-04 Sankyo Co Ltd Ｍｌ−２３６ｂ誘導体
US5179013A (en) * 1987-02-02 1993-01-12 Sankyo Company, Limited Cytochrome P-450 enzymes
JPH06253853A (ja) * 1993-03-09 1994-09-13 Asahi Chem Ind Co Ltd マクロライド抗生物質生合成遺伝子を含有するｄｎａ
US6043064A (en) * 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
JPH08149986A (ja) * 1994-09-28 1996-06-11 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
JPH0889277A (ja) * 1994-09-28 1996-04-09 Taisho Pharmaceut Co Ltd １２−ヒドロキシ−６−ｏ−アルキルエリスロマイシン及びその類縁体の製造方法
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
SI20072A (sl) * 1998-09-18 2000-04-30 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
HUP9902352A1 (hu) * 1999-07-12 2000-09-28 Gyógyszerkutató Intézet Kft. Eljárás pravasztatin mikrobiológiai előállítására
IN191580B (hu) * 1999-12-17 2003-12-06 Ranbaxy Lab Ltd

Also Published As

Publication number Publication date
KR20020048927A (ko) 2002-06-24
DK1190087T3 (da) 2003-10-13
EP1327689A1 (en) 2003-07-16
MXPA02000356A (es) 2005-06-06
PT1190087E (pt) 2003-10-31
US6905851B1 (en) 2005-06-14
SK492002A3 (sk) 2005-03-04
CZ297009B6 (cs) 2006-08-16
BG106302A (en) 2002-10-31
CN1590555A (zh) 2005-03-09
EP1190087A1 (en) 2002-03-27
TR200200726T2 (tr) 2002-06-21
JP2003528576A (ja) 2003-09-30
HRP20020028A2 (en) 2003-06-30
PL364872A1 (en) 2004-12-27
CZ2002127A3 (cs) 2003-06-18
ES2200891T3 (es) 2004-03-16
DE60003424T2 (de) 2004-05-19
CZ2002119A3 (cs) 2003-02-12
EP1190087B1 (en) 2003-06-18
US20050124051A1 (en) 2005-06-09
NO20020119L (no) 2002-02-21
CN1399686A (zh) 2003-02-26
EP1198448A2 (en) 2002-04-24
CA2373544A1 (en) 2001-01-18
IL147588A0 (en) 2002-08-14
KR100479837B1 (ko) 2005-03-31
WO2001003647A2 (en) 2001-01-18
AP1405A (en) 2005-04-28
SK285726B6 (sk) 2007-07-06
NO20020119D0 (no) 2002-01-10
ATE243262T1 (de) 2003-07-15
HUP9902352A1 (hu) 2000-09-28
IS2138B (is) 2006-08-15
EP1198448A4 (en) 2003-05-28
RU2235780C2 (ru) 2004-09-10
BR0013156A (pt) 2002-04-02
CA2379015A1 (en) 2001-01-18
AU773633B2 (en) 2004-05-27
HU9902352D0 (en) 1999-09-28
WO2001004340A1 (en) 2001-01-18
WO2001003647A3 (en) 2001-06-28
IS6227A (is) 2002-01-11
YU2002A (sh) 2004-12-31
PL353493A1 (en) 2003-11-17
SK612002A3 (en) 2002-12-03
AP2002002404A0 (en) 2002-03-31
NZ516563A (en) 2002-11-26
UA67854C2 (en) 2004-07-15
JP2003504071A (ja) 2003-02-04
RU2004114667A (ru) 2005-10-27
OA12150A (en) 2006-05-05
BG65109B1 (bg) 2007-02-28
ZA200200273B (en) 2003-06-25
IL147583A0 (en) 2002-08-14
JP4531315B2 (ja) 2010-08-25
AU6349200A (en) 2001-01-30
AU5835500A (en) 2001-01-30
KR20020060150A (ko) 2002-07-16
DE60003424D1 (de) 2003-07-24

Similar Documents

Publication Publication Date Title
HRP20020028B1 (en) Hydroxylation of compactin to pravastatin by micro
EP0836642A4 (en) TRANSFORMATION OF COMPACTINE TO PRAVASTATIN USING ACTINOMADURA
EG24138A (en) Asymmetrics synthesis of pregabalin
PL359560A1 (en) Process for the isolation of lovastatin
IL150187A0 (en) Novel forms of pravastatin sodium
HUP0303106A3 (en) Method of purifying pravastatin
AU5586100A (en) Efficient synthesis of alkyl carbonates
HUP0202173A3 (en) Hydroxylation of compactin to pravastatin by micromonospora
AU2132002A (en) Synthesis of small particles
IL155158A0 (en) A method for purification of pravastatin
HK1037683A1 (en) Genes related to biosynthesis of ml-236B
AU3862500A (en) Synthesis of functionalized esters
TW507799U (en) Braking device of manhole cover
TW483322U (en) Structure of soap box
AU2001259381A1 (en) Synthesis of diphosphinoarenes
TW379709U (en) Brake structure of walker
GB2375246B (en) Frequency conversion of signals
GB0015568D0 (en) Ester synthesis
GB0017074D0 (en) Ester synthesis
AU2002339136A1 (en) A process for lactonization to produce highly pure simvastatin
TW441838U (en) Box structure of removable disk
AU2001238141A1 (en) Intermediates for and synthesis of 3-methylene cephams
TW478517U (en) Barrelhead structure of trash can
TW525448U (en) Novel structure of drawer
TW435238U (en) Structure of magnetically controlled brake for exercycle

Legal Events

Date Code Title Description
A1OB Publication of a patent application
AIPI Request for the grant of a patent on the basis of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20070621

Year of fee payment: 8

PBON Lapse due to non-payment of renewal fee

Effective date: 20080630