HRP20000611A2 - Bicyclo[2.2.1]heptanes and related compounds - Google Patents
Bicyclo[2.2.1]heptanes and related compounds Download PDFInfo
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- HRP20000611A2 HRP20000611A2 HR20000611A HRP20000611A HRP20000611A2 HR P20000611 A2 HRP20000611 A2 HR P20000611A2 HR 20000611 A HR20000611 A HR 20000611A HR P20000611 A HRP20000611 A HR P20000611A HR P20000611 A2 HRP20000611 A2 HR P20000611A2
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- 238000000825 ultraviolet detection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/42—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing seven carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7834698P | 1998-03-17 | 1998-03-17 | |
| PCT/IB1999/000376 WO1999047490A1 (en) | 1998-03-17 | 1999-03-04 | Bicyclo[2.2.1]heptanes and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000611A2 true HRP20000611A2 (en) | 2001-04-30 |
Family
ID=22143450
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000611A HRP20000611A2 (en) | 1998-03-17 | 2000-09-15 | Bicyclo[2.2.1]heptanes and related compounds |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6136861A (xx) |
| EP (1) | EP1064256B1 (xx) |
| JP (1) | JP3665567B2 (xx) |
| KR (1) | KR100372981B1 (xx) |
| CN (1) | CN1231461C (xx) |
| AP (1) | AP1116A (xx) |
| AR (1) | AR017236A1 (xx) |
| AT (1) | ATE272608T1 (xx) |
| AU (1) | AU753422B2 (xx) |
| BG (1) | BG104837A (xx) |
| BR (1) | BR9908850A (xx) |
| CA (1) | CA2321639C (xx) |
| CO (1) | CO5090835A1 (xx) |
| CZ (1) | CZ20003355A3 (xx) |
| DE (1) | DE69919142T2 (xx) |
| DZ (1) | DZ2745A1 (xx) |
| EA (1) | EA003946B1 (xx) |
| ES (1) | ES2224604T3 (xx) |
| GT (1) | GT199900040A (xx) |
| HR (1) | HRP20000611A2 (xx) |
| HU (1) | HUP0101031A3 (xx) |
| ID (1) | ID25651A (xx) |
| IL (1) | IL138342A0 (xx) |
| IS (1) | IS5592A (xx) |
| MA (1) | MA26614A1 (xx) |
| MY (1) | MY121047A (xx) |
| NO (1) | NO20004626L (xx) |
| NZ (1) | NZ506227A (xx) |
| OA (1) | OA11488A (xx) |
| PE (1) | PE20000339A1 (xx) |
| PL (1) | PL343278A1 (xx) |
| PT (1) | PT1064256E (xx) |
| SK (1) | SK13532000A3 (xx) |
| TN (1) | TNSN99039A1 (xx) |
| TR (1) | TR200002671T2 (xx) |
| TW (1) | TW509667B (xx) |
| UA (1) | UA53781C2 (xx) |
| WO (1) | WO1999047490A1 (xx) |
| YU (1) | YU53700A (xx) |
| ZA (1) | ZA992094B (xx) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6555564B1 (en) * | 1999-03-04 | 2003-04-29 | The Board Of Trustees Of The University Of Illinois | Neuropharmacological treatments of sleep-related breathing disorders |
| US6313159B1 (en) | 1999-08-20 | 2001-11-06 | Guilford Pharmaceuticals Inc. | Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors |
| UA73981C2 (en) * | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| EP1372620A2 (en) * | 2001-03-15 | 2004-01-02 | Saegis Pharmaceuticals | Methods for restoring cognitive function following systemic stress |
| US6689904B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine |
| US6750364B2 (en) * | 2001-06-29 | 2004-06-15 | Wyeth | Bridged tricyclic analogs of 2-(carboxycyclopropyl)glycine as inhibitors of glutamate transport |
| US6689905B2 (en) | 2001-06-29 | 2004-02-10 | Wyeth | Stereoisomers of 3-aminotricyclo[2.2.1.0(2.6)]heptane-1,3-dicarboxylic acid |
| CA2458375A1 (en) * | 2001-08-24 | 2003-03-06 | Pharmacia & Upjohn Company | Substituted-heteroaryl-7-aza¬2.2.1|bicycloheptanes for the treatment of disease |
| US7232798B2 (en) * | 2001-11-13 | 2007-06-19 | Tran Loi H | Neuroprotection and neuroegenisis by administering cyclic prolyl glycine |
| FR2872045B1 (fr) * | 2004-06-28 | 2006-09-29 | Centre Nat Rech Scient Cnrse | Medicaments pour le traitement specifique de symptomes de la maladie de parkinson |
| AR059898A1 (es) | 2006-03-15 | 2008-05-07 | Janssen Pharmaceutica Nv | Derivados de 3-ciano-piridona 1,4-disustituida y su uso como moduladores alostericos de los receptores mglur2 |
| TW200845978A (en) * | 2007-03-07 | 2008-12-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
| TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
| EP2200997B9 (en) | 2007-09-13 | 2016-01-13 | Concert Pharmaceuticals Inc. | Synthesis of deuterated benzodioxoles |
| JP5133416B2 (ja) | 2007-09-14 | 2013-01-30 | オルソー−マクニール−ジャンセン ファーマシューティカルズ， インコーポレイテッド． | １’，３’−二置換−４−フェニル−３，４，５，６−テトラヒドロ−２ｈ，１’ｈ−［１，４’］ビピリジニル−２’−オン |
| EP2205565B1 (en) * | 2007-09-14 | 2013-04-17 | Janssen Pharmaceuticals, Inc. | 1,3-disubstituted-4-phenyl-1 h-pyridin-2-ones |
| ATE516272T1 (de) | 2007-09-14 | 2011-07-15 | Ortho Mcneil Janssen Pharm | 1,3-disubstituierte 4-(aryl-x-phenyl)-1h-pyridin- 2-one |
| EP2220083B1 (en) * | 2007-11-14 | 2017-07-19 | Janssen Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| US8691849B2 (en) | 2008-09-02 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
| CA2738849C (en) | 2008-10-16 | 2016-06-28 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
| CN102232074B (zh) | 2008-11-28 | 2014-12-03 | 奥梅-杨森制药有限公司 | 作为代谢性谷氨酸盐受体调节剂的吲哚和苯并噁嗪衍生物 |
| MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| MY161325A (en) | 2009-05-12 | 2017-04-14 | Janssen Pharmaceuticals Inc | 1, 2, 4-triazolo[4,3-a]pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
| ES2409006T3 (es) | 2009-05-12 | 2013-06-24 | Janssen Pharmaceuticals Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de los receptores mGluR2 |
| JP5852665B2 (ja) | 2010-11-08 | 2016-02-03 | ジヤンセン・フアーマシユーチカルズ・インコーポレーテツド | １，２，４−トリアゾロ［４，３−ａ］ピリジン誘導体およびｍＧｌｕＲ２受容体のポジティブアロステリックモジュレーターとしてのそれらの使用 |
| CA2815002C (en) | 2010-11-08 | 2019-10-22 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
| ES2552455T3 (es) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | Derivados de 1,2,4-triazolo[4,3-a]piridina y su uso como moduladores alostéricos positivos de receptores mGluR2 |
| TWI520935B (zh) | 2010-11-18 | 2016-02-11 | 美國禮來大藥廠 | 作為ｍＧｌｕＲ２／３拮抗劑之４－經取代－３－苯基磺醯基甲基－雙環［３.１.０］己烷化合物 |
| MX2013005623A (es) | 2010-11-18 | 2013-07-05 | Lilly Co Eli | Compuestos de 3-benciloxi-biciclico [3.1.0] hexano 4-sustituidos como antagonistas de mglur 2/3. |
| AR095036A1 (es) | 2013-03-14 | 2015-09-16 | Kalyra Pharmaceuticals Inc | Compuestos analgésicos bicíclicos |
| JO3368B1 (ar) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 6، 7- ثاني هيدرو بيرازولو [5،1-a] بيرازين- 4 (5 يد)- اون واستخدامها بصفة منظمات تفارغية سلبية لمستقبلات ميجلور 2 |
| JO3367B1 (ar) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | مركبات 2،1، 4- ثلاثي زولو [3،4-a] بيريدين واستخدامها بصفة منظمات تفارغية موجبة لمستقبلات ميجلور 2 |
| CN105814013A (zh) | 2013-12-12 | 2016-07-27 | 卡利拉制药公司 | 双环烷基化合物及合成 |
| BR112016016390B1 (pt) | 2014-01-21 | 2023-04-11 | Janssen Pharmaceutica Nv | Produto compreendendo modulador alostérico positivo do receptor glutamatérgico metabotrópico do subtipo 2 e ligante da proteína de vesícula sináptica 2a |
| ES2860298T3 (es) | 2014-01-21 | 2021-10-04 | Janssen Pharmaceutica Nv | Combinaciones que comprenden moduladores alostéricos positivos del receptor glutamatérgico metabotrópico de subtipo 2 y su uso |
| CN113336653A (zh) | 2014-03-07 | 2021-09-03 | 里科瑞尔姆Ip控股有限责任公司 | 螺桨烷衍生物及合成 |
| CN106999451B (zh) | 2014-09-17 | 2021-04-02 | 里科瑞尔姆Ip控股有限责任公司 | 双环化合物 |
| WO2017160926A1 (en) * | 2016-03-16 | 2017-09-21 | Kalyra Pharmaceuticals, Inc. | Analgesic compounds |
| US11242327B2 (en) | 2017-05-15 | 2022-02-08 | Recurium Ip Holdings, Llc | Analgesic compounds |
| AU2019271189A1 (en) | 2018-05-15 | 2021-01-07 | Lloyd Hung Loi TRAN | Therapeutic agent composition and method of use, for treatment of mild cognitive impairment, depression, and psychological disorders |
| KR102157141B1 (ko) | 2018-11-27 | 2020-09-17 | 주식회사 파미니티 | 으아리 추출물을 유효 성분으로 포함하는 인지 기능 개선용 조성물 |
| KR102172916B1 (ko) | 2018-12-07 | 2020-11-02 | 주식회사 파미니티 | 실크 펩타이드 및 천연 추출물을 포함하는 인지 기능 개선용 조성물 |
| US10844380B1 (en) | 2019-06-17 | 2020-11-24 | Biorchestra Co., Ltd. | Uses for prevention or treatment of brain diseases using microrna |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
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| US5587398A (en) * | 1994-06-03 | 1996-12-24 | David R. Elmaleh | Meta substituted arylalkylamines and therapeutic and diagnostic uses therefor |
| PL182285B1 (pl) * | 1994-08-12 | 2001-12-31 | Lilly Co Eli | Syntetyczne aminokwasy oraz ich estry i srodki farmaceutyczne je zawierajace PL PL PL PL PL PL PL |
| GB9605429D0 (en) * | 1995-11-16 | 1996-05-15 | Lilly Co Eli | Excitatory amino acid receptor antagonists |
| AU703093B2 (en) * | 1995-11-16 | 1999-03-18 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
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1999
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- 1999-03-04 PT PT99905122T patent/PT1064256E/pt unknown
- 1999-03-04 EA EA200000842A patent/EA003946B1/ru not_active IP Right Cessation
- 1999-03-04 HU HU0101031A patent/HUP0101031A3/hu unknown
- 1999-03-04 ID IDW20001811A patent/ID25651A/id unknown
- 1999-03-04 PL PL99343278A patent/PL343278A1/xx unknown
- 1999-03-04 AT AT99905122T patent/ATE272608T1/de not_active IP Right Cessation
- 1999-03-04 TR TR2000/02671T patent/TR200002671T2/xx unknown
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- 1999-03-04 CN CNB998040401A patent/CN1231461C/zh not_active Expired - Fee Related
- 1999-03-04 JP JP2000536687A patent/JP3665567B2/ja not_active Expired - Fee Related
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- 1999-03-04 YU YU53700A patent/YU53700A/sh unknown
- 1999-03-04 NZ NZ506227A patent/NZ506227A/xx unknown
- 1999-03-04 ES ES99905122T patent/ES2224604T3/es not_active Expired - Lifetime
- 1999-03-04 CZ CZ20003355A patent/CZ20003355A3/cs unknown
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- 1999-03-04 SK SK1353-2000A patent/SK13532000A3/sk unknown
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- 1999-03-15 MY MYPI99000966A patent/MY121047A/en unknown
- 1999-03-15 AR ARP990101118A patent/AR017236A1/es unknown
- 1999-03-16 MA MA25498A patent/MA26614A1/fr unknown
- 1999-03-16 TN TNTNSN99039A patent/TNSN99039A1/fr unknown
- 1999-03-16 ZA ZA9902094A patent/ZA992094B/xx unknown
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- 1999-03-16 DZ DZ990046A patent/DZ2745A1/xx active
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- 1999-04-03 UA UA2000095327A patent/UA53781C2/uk unknown
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2000
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