HRP20000609B1 - Process for the synthesis of hiv protease inhibitors - Google Patents

Process for the synthesis of hiv protease inhibitors

Info

Publication number
HRP20000609B1
HRP20000609B1 HR20000609A HRP20000609A HRP20000609B1 HR P20000609 B1 HRP20000609 B1 HR P20000609B1 HR 20000609 A HR20000609 A HR 20000609A HR P20000609 A HRP20000609 A HR P20000609A HR P20000609 B1 HRP20000609 B1 HR P20000609B1
Authority
HR
Croatia
Prior art keywords
compound
reacting
synthesis
protease inhibitors
hiv protease
Prior art date
Application number
HR20000609A
Other languages
English (en)
Croatian (hr)
Inventor
Al-Farhan Emile
D. Deininger David
Mcghie Stephen
O'callaghan John
Stuart Robertson Mark
Rodgers Keith
Rout Stephen
Singh Hardev
Dennis Tung Roger
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HRP20000609A2 publication Critical patent/HRP20000609A2/hr
Publication of HRP20000609B1 publication Critical patent/HRP20000609B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HR20000609A 1998-03-20 2000-09-15 Process for the synthesis of hiv protease inhibitors HRP20000609B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9805898.5A GB9805898D0 (en) 1998-03-20 1998-03-20 Process for the sythesis of hiv protease inhibitors
PCT/GB1999/000852 WO1999048885A1 (en) 1998-03-20 1999-03-18 Process for the synthesis of hiv protease inhibitors

Publications (2)

Publication Number Publication Date
HRP20000609A2 HRP20000609A2 (en) 2001-04-30
HRP20000609B1 true HRP20000609B1 (en) 2006-05-31

Family

ID=10828884

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20000609A HRP20000609B1 (en) 1998-03-20 2000-09-15 Process for the synthesis of hiv protease inhibitors

Country Status (32)

Country Link
US (1) US6281367B1 (ru)
EP (1) EP1066276B1 (ru)
JP (1) JP3363439B2 (ru)
KR (1) KR100555278B1 (ru)
CN (1) CN1308319C (ru)
AP (1) AP1226A (ru)
AT (1) ATE242772T1 (ru)
AU (1) AU751534B2 (ru)
BR (1) BR9908970A (ru)
CA (1) CA2324217C (ru)
CZ (1) CZ299193B6 (ru)
DE (1) DE69908761T2 (ru)
DK (1) DK1066276T3 (ru)
EA (1) EA003022B1 (ru)
EE (1) EE04750B1 (ru)
ES (1) ES2203090T3 (ru)
GB (1) GB9805898D0 (ru)
HK (1) HK1032047A1 (ru)
HR (1) HRP20000609B1 (ru)
HU (1) HUP0105439A3 (ru)
ID (1) ID26587A (ru)
IL (1) IL138127A (ru)
IS (1) IS2273B (ru)
NO (1) NO317648B1 (ru)
NZ (1) NZ506563A (ru)
PL (1) PL201810B1 (ru)
PT (1) PT1066276E (ru)
RS (1) RS49954B (ru)
SK (1) SK283939B6 (ru)
TR (1) TR200002698T2 (ru)
WO (1) WO1999048885A1 (ru)
ZA (1) ZA200004482B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE218541T1 (de) 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
US6548706B2 (en) * 1999-12-23 2003-04-15 Aerojet Fine Chemicals Llc Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
ATE401298T1 (de) * 1999-12-23 2008-08-15 Ampac Fine Chemicals Llc Verbessertes verfahren zur herstellung von 2s,3s- n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)- - nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin
US7700645B2 (en) * 2002-05-16 2010-04-20 Tibotec Pharmaceuticals Ltd. Pseudopolymorphic forms of a HIV protease inhibitor
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
TR201807704T4 (tr) 2010-01-27 2018-06-21 Viiv Healthcare Co Anti-viral tedavi.
EP2614055A2 (en) 2010-09-10 2013-07-17 Lupin Limited Process for preparation of substantially pure fosamprenavir calcium and its intermediates
CN111233794A (zh) * 2020-03-27 2020-06-05 江巨东 一种安普那韦的精制方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1071930A (zh) * 1991-07-10 1993-05-12 伊莱利利公司 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂
ATE218541T1 (de) * 1992-08-25 2002-06-15 Searle & Co Hydroxyethylaminosulfonamide verwendbar als inhibitoren retroviraler proteasen
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease

Also Published As

Publication number Publication date
IS5605A (is) 2000-08-29
HUP0105439A3 (en) 2002-08-28
IL138127A0 (en) 2001-10-31
PL342602A1 (en) 2001-06-18
BR9908970A (pt) 2000-11-28
AP1226A (en) 2003-11-21
YU55900A (sh) 2003-02-28
ATE242772T1 (de) 2003-06-15
IL138127A (en) 2003-10-31
JP3363439B2 (ja) 2003-01-08
CZ299193B6 (cs) 2008-05-14
AP2000001911A0 (en) 2000-09-30
NO317648B1 (no) 2004-11-29
GB9805898D0 (en) 1998-05-13
EP1066276A1 (en) 2001-01-10
ZA200004482B (en) 2001-11-28
ID26587A (id) 2001-01-18
JP2002507609A (ja) 2002-03-12
SK13732000A3 (sk) 2001-08-06
WO1999048885A1 (en) 1999-09-30
NO20004664D0 (no) 2000-09-19
AU2947599A (en) 1999-10-18
HK1032047A1 (en) 2001-07-06
ES2203090T3 (es) 2004-04-01
DE69908761D1 (de) 2003-07-17
CZ20003457A3 (cs) 2001-04-11
KR20010042022A (ko) 2001-05-25
SK283939B6 (sk) 2004-05-04
NZ506563A (en) 2003-05-30
EP1066276B1 (en) 2003-06-11
IS2273B (is) 2007-07-15
EA003022B1 (ru) 2002-12-26
TR200002698T2 (tr) 2000-12-21
KR100555278B1 (ko) 2006-03-03
US6281367B1 (en) 2001-08-28
CA2324217C (en) 2008-02-19
DE69908761T2 (de) 2004-02-19
RS49954B (sr) 2008-09-29
PT1066276E (pt) 2003-10-31
PL201810B1 (pl) 2009-05-29
EA200000859A1 (ru) 2001-04-23
HUP0105439A2 (en) 2002-06-29
CA2324217A1 (en) 1999-09-30
AU751534B2 (en) 2002-08-22
EE200000568A (et) 2002-02-15
CN1308319C (zh) 2007-04-04
DK1066276T3 (da) 2003-10-06
NO20004664L (no) 2000-09-19
EE04750B1 (et) 2006-12-15
HRP20000609A2 (en) 2001-04-30
CN1293668A (zh) 2001-05-02

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Legal Events

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A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
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Payment date: 20081230

Year of fee payment: 11

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Effective date: 20100319