HRP20000609B1 - Process for the synthesis of hiv protease inhibitors - Google Patents
Process for the synthesis of hiv protease inhibitorsInfo
- Publication number
- HRP20000609B1 HRP20000609B1 HR20000609A HRP20000609A HRP20000609B1 HR P20000609 B1 HRP20000609 B1 HR P20000609B1 HR 20000609 A HR20000609 A HR 20000609A HR P20000609 A HRP20000609 A HR P20000609A HR P20000609 B1 HRP20000609 B1 HR P20000609B1
- Authority
- HR
- Croatia
- Prior art keywords
- compound
- reacting
- synthesis
- protease inhibitors
- hiv protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Postupak za dobivanje spoja formule (I) naznačen time, što sadrži: i) reakciju p-nitrofenilsulfonilskupine sa spojem formule (A) gdje P je amino-zaštitna skupina; ii) uklanjanje zaštite sa spoja dobivenog u koraku i); iii) reakciju spoja dobivenog u koraku ii) sa tetrahidrofuriloksi karbonil skupinom; ili reakciju spoja dobivenog u koraku ii) sa fosgenom, ili ekvivalentom, i reakciju dobivenog međuprodukta sa (S)-tetrahidro-3-furanolom; iiv) redukciju spoja dobivenog u koraku iii), da nastane spoj formule (I). Patent sadrži još 11 patentnih zahtjeva.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9805898.5A GB9805898D0 (en) | 1998-03-20 | 1998-03-20 | Process for the sythesis of hiv protease inhibitors |
| PCT/GB1999/000852 WO1999048885A1 (en) | 1998-03-20 | 1999-03-18 | Process for the synthesis of hiv protease inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20000609A2 HRP20000609A2 (en) | 2001-04-30 |
| HRP20000609B1 true HRP20000609B1 (en) | 2006-05-31 |
Family
ID=10828884
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000609A HRP20000609B1 (en) | 1998-03-20 | 2000-09-15 | Process for the synthesis of hiv protease inhibitors |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6281367B1 (hr) |
| EP (1) | EP1066276B1 (hr) |
| JP (1) | JP3363439B2 (hr) |
| KR (1) | KR100555278B1 (hr) |
| CN (1) | CN1308319C (hr) |
| AP (1) | AP1226A (hr) |
| AT (1) | ATE242772T1 (hr) |
| AU (1) | AU751534B2 (hr) |
| BR (1) | BR9908970A (hr) |
| CA (1) | CA2324217C (hr) |
| CZ (1) | CZ299193B6 (hr) |
| DE (1) | DE69908761T2 (hr) |
| DK (1) | DK1066276T3 (hr) |
| EA (1) | EA003022B1 (hr) |
| EE (1) | EE04750B1 (hr) |
| ES (1) | ES2203090T3 (hr) |
| GB (1) | GB9805898D0 (hr) |
| HK (1) | HK1032047A1 (hr) |
| HR (1) | HRP20000609B1 (hr) |
| HU (1) | HUP0105439A3 (hr) |
| ID (1) | ID26587A (hr) |
| IL (1) | IL138127A (hr) |
| IS (1) | IS2273B (hr) |
| NO (1) | NO317648B1 (hr) |
| NZ (1) | NZ506563A (hr) |
| PL (1) | PL201810B1 (hr) |
| PT (1) | PT1066276E (hr) |
| RS (1) | RS49954B (hr) |
| SK (1) | SK283939B6 (hr) |
| TR (1) | TR200002698T2 (hr) |
| WO (1) | WO1999048885A1 (hr) |
| ZA (1) | ZA200004482B (hr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2123065T3 (es) | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| EP1244610B1 (en) * | 1999-12-23 | 2008-07-16 | Ampac Fine Chemicals LLC | Improved preparation of 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| US6548706B2 (en) * | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| DK2767539T3 (en) * | 2002-05-16 | 2017-09-11 | Janssen Sciences Ireland Uc | Pseudopolymorphic forms of an HIV protease inhibitor |
| US7772411B2 (en) | 2003-12-23 | 2010-08-10 | Tibotec Pharmaceuticals Ltd. | Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate |
| TWI482775B (zh) | 2008-09-01 | 2015-05-01 | Tibotec Pharm Ltd | 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法 |
| KR20170078868A (ko) | 2010-01-27 | 2017-07-07 | 비이브 헬쓰케어 컴퍼니 | 항바이러스 치료 |
| EP2614055A2 (en) | 2010-09-10 | 2013-07-17 | Lupin Limited | Process for preparation of substantially pure fosamprenavir calcium and its intermediates |
| CN111233794A (zh) * | 2020-03-27 | 2020-06-05 | 江巨东 | 一种安普那韦的精制方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071930A (zh) * | 1991-07-10 | 1993-05-12 | 伊莱利利公司 | 用作治疗艾滋病的人免疫缺陷病毒蛋白酶的抑制剂 |
| ES2123065T3 (es) * | 1992-08-25 | 1999-01-01 | Searle & Co | Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas. |
| IS2334B (is) * | 1992-09-08 | 2008-02-15 | Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) | Aspartyl próteasi hemjari af nýjum flokki súlfonamíða |
| US5723490A (en) * | 1992-09-08 | 1998-03-03 | Vertex Pharmaceuticals Incorporated | THF-containing sulfonamide inhibitors of aspartyl protease |
-
1998
- 1998-03-20 GB GBGB9805898.5A patent/GB9805898D0/en not_active Ceased
-
1999
- 1999-03-18 SK SK1373-2000A patent/SK283939B6/sk not_active IP Right Cessation
- 1999-03-18 NZ NZ506563A patent/NZ506563A/en unknown
- 1999-03-18 CZ CZ20003457A patent/CZ299193B6/cs not_active IP Right Cessation
- 1999-03-18 AU AU29475/99A patent/AU751534B2/en not_active Ceased
- 1999-03-18 US US09/646,277 patent/US6281367B1/en not_active Expired - Lifetime
- 1999-03-18 EA EA200000859A patent/EA003022B1/ru unknown
- 1999-03-18 IL IL13812799A patent/IL138127A/xx not_active IP Right Cessation
- 1999-03-18 AP APAP/P/2000/001911A patent/AP1226A/en active
- 1999-03-18 ES ES99910543T patent/ES2203090T3/es not_active Expired - Lifetime
- 1999-03-18 HU HU0105439A patent/HUP0105439A3/hu unknown
- 1999-03-18 WO PCT/GB1999/000852 patent/WO1999048885A1/en active IP Right Grant
- 1999-03-18 BR BR9908970-0A patent/BR9908970A/pt not_active Application Discontinuation
- 1999-03-18 JP JP2000537868A patent/JP3363439B2/ja not_active Expired - Lifetime
- 1999-03-18 AT AT99910543T patent/ATE242772T1/de not_active IP Right Cessation
- 1999-03-18 CA CA002324217A patent/CA2324217C/en not_active Expired - Fee Related
- 1999-03-18 DK DK99910543T patent/DK1066276T3/da active
- 1999-03-18 DE DE69908761T patent/DE69908761T2/de not_active Expired - Lifetime
- 1999-03-18 EE EEP200000568A patent/EE04750B1/xx not_active IP Right Cessation
- 1999-03-18 PT PT99910543T patent/PT1066276E/pt unknown
- 1999-03-18 PL PL342602A patent/PL201810B1/pl not_active IP Right Cessation
- 1999-03-18 RS YUP-559/00A patent/RS49954B/sr unknown
- 1999-03-18 ID IDW20001857A patent/ID26587A/id unknown
- 1999-03-18 TR TR2000/02698T patent/TR200002698T2/xx unknown
- 1999-03-18 CN CNB998042242A patent/CN1308319C/zh not_active Expired - Fee Related
- 1999-03-18 EP EP99910543A patent/EP1066276B1/en not_active Expired - Lifetime
- 1999-03-18 KR KR1020007010359A patent/KR100555278B1/ko not_active IP Right Cessation
-
2000
- 2000-08-29 ZA ZA200004482A patent/ZA200004482B/en unknown
- 2000-08-29 IS IS5605A patent/IS2273B/is unknown
- 2000-09-15 HR HR20000609A patent/HRP20000609B1/xx not_active IP Right Cessation
- 2000-09-19 NO NO20004664A patent/NO317648B1/no not_active IP Right Cessation
-
2001
- 2001-03-30 HK HK01102333A patent/HK1032047A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AP2002002637A0 (en) | Novel piperazine | |
| NO992617D0 (no) | Sulfinsyrederivater, deres fremstilling og anvendelse | |
| TW349940B (en) | Phenylacetic acid derivatives, processes for their preparation, and their uses as fungicides and pesticides | |
| NO20034291D0 (no) | 2-aminopropanolderivater | |
| DK0944643T3 (da) | Oxyiminopregnancarbolactoner. | |
| RS50140B (sr) | Postupak za dobijanje perkihinina i njegova upotreba | |
| RS65604A (en) | Novel fluorene carboxylic acid esters, methods for the production thereof, and use of the same as pharmaceuticals | |
| YU94103A (sh) | Novi derivati sulfonske kiseline | |
| SE9802206D0 (sv) | Novel compounds | |
| ATE368645T1 (de) | Aminosäurederivate als hiv-protease-inhibitoren | |
| HRP20000609B1 (en) | Process for the synthesis of hiv protease inhibitors | |
| ATE341541T1 (de) | Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy- pyran-2-one | |
| MXPA03009548A (es) | Arilsulfonamidas como agentes antivirales. | |
| BR9408392A (pt) | Derivados de ácidos arilacéticos e sua utilização como fungicidas | |
| ATE239716T1 (de) | Synthese von 3,6-dialkyl-5,6-dihydro-4-hydroxy-2h-pyran-2-on | |
| ES2178765T3 (es) | Nuevos derivados de 1,7,7-trimetil-biciclo (2.2.1) heptano. | |
| HRP20010798B1 (hr) | Postupci priprave pesticidnih međuprodukata | |
| TR199800210T2 (xx) | Didepsipeptid temelli endoparazitisid kompozisyonlar, yeni didepsipeptidler ve bunlar�n �retimi i�in i�lemler. | |
| HUP0000726A2 (hu) | Eljárás flukonazol előállítására | |
| IT1251202B (it) | 6-amminochinoloni, sintesi ed impiego come antibatterici | |
| ES2128031T3 (es) | Forma cristalina y polimorfica de (s,s,s)-n-(1-(2-carboxi-3-(n2-mesilisilamino)propil)-1-ciclopentilcarbonil)tirosina. | |
| PT1194398E (pt) | Sintese de aminocarnitina (s) e (r) e dos seus derivados, a partir de acido aspartico l e d | |
| HRP940443B1 (en) | Process for the preparation of 1-nitro-2,2-diaminoethylene derivatives | |
| PT1296983E (pt) | Novo processo para a preparacao de pirazolopirimidinonas | |
| MXPA03003466A (es) | Derivados de piranosido. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| B1PR | Patent granted | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20081230 Year of fee payment: 11 |
|
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20100319 |