HK91989A - Cardioselective aryloxy-and arylthio-hydroxypropyl piperazinyl acetanilides which affect calcium entry - Google Patents
Cardioselective aryloxy-and arylthio-hydroxypropyl piperazinyl acetanilides which affect calcium entryInfo
- Publication number
- HK91989A HK91989A HK919/89A HK91989A HK91989A HK 91989 A HK91989 A HK 91989A HK 919/89 A HK919/89 A HK 919/89A HK 91989 A HK91989 A HK 91989A HK 91989 A HK91989 A HK 91989A
- Authority
- HK
- Hong Kong
- Prior art keywords
- lower alkyl
- cardioselective
- independently hydrogen
- together form
- calcium entry
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Pyridine Compounds (AREA)
- Cosmetics (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Polyesters Or Polycarbonates (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/495,904 US4567264A (en) | 1983-05-18 | 1983-05-18 | Cardioselective aryloxy- and arylthio- hydroxypropylene-piperazinyl acetanilides which affect calcium entry |
Publications (1)
Publication Number | Publication Date |
---|---|
HK91989A true HK91989A (en) | 1989-11-24 |
Family
ID=23970461
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK919/89A HK91989A (en) | 1983-05-18 | 1989-11-16 | Cardioselective aryloxy-and arylthio-hydroxypropyl piperazinyl acetanilides which affect calcium entry |
Country Status (26)
Country | Link |
---|---|
US (1) | US4567264A (sv) |
EP (1) | EP0126449B1 (sv) |
JP (1) | JPS59219271A (sv) |
KR (1) | KR890000020B1 (sv) |
AT (1) | ATE31533T1 (sv) |
AU (1) | AU566489B2 (sv) |
BR (1) | BR1100474A (sv) |
CA (1) | CA1256874A (sv) |
CS (1) | CS246080B2 (sv) |
DE (1) | DE3468215D1 (sv) |
DK (1) | DK168535B1 (sv) |
ES (1) | ES8601947A1 (sv) |
FI (1) | FI78479C (sv) |
HK (1) | HK91989A (sv) |
HU (1) | HU192404B (sv) |
IE (1) | IE57487B1 (sv) |
IL (1) | IL71863A (sv) |
MX (1) | MX9203001A (sv) |
NO (1) | NO163618C (sv) |
NZ (1) | NZ208188A (sv) |
PH (1) | PH20016A (sv) |
PL (2) | PL142760B1 (sv) |
PT (1) | PT78604B (sv) |
RU (2) | RU2071471C1 (sv) |
SG (1) | SG25086G (sv) |
ZA (1) | ZA843746B (sv) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5028610A (en) * | 1987-03-18 | 1991-07-02 | Sankyo Company Limited | N-benzhydryl-substituted heterocyclic derivatives, their preparation and their use |
US5359097A (en) * | 1988-12-26 | 1994-10-25 | Kowa Company Ltd. | Process for preparation of glycidyl ether |
ATE142497T1 (de) * | 1989-06-23 | 1996-09-15 | Syntex Inc | Ranolazin und verwandte piperazine zur behandlung von geweben, von physischen oder chemischen schäden betroffen |
HU209723B (en) * | 1990-10-31 | 1994-10-28 | Richter Gedeon Vegyeszet | Process for producing of piperazine derivatives |
US5455045A (en) * | 1993-05-13 | 1995-10-03 | Syntex (U.S.A.) Inc. | High dose formulations |
WO1996040664A2 (en) * | 1995-06-07 | 1996-12-19 | Dade Chemistry Systems Inc. | Preparation of immunogens and other conjugates of drugs |
US6303607B1 (en) * | 1998-09-10 | 2001-10-16 | Cv Therapeutics, Inc. | Method for administering a sustained release ranolanolazine formulation |
US6479496B1 (en) * | 1998-09-10 | 2002-11-12 | Cv Therapeutics, Inc. | Methods for treating angina with ranolazine |
BR0108452A (pt) * | 2000-02-18 | 2003-04-01 | Cv Therapeutics Inc | Inibidores da oxidação parcial de ácido graxo no tratamento de insuficiência cardìaca congestiva |
EP1259493A2 (en) * | 2000-02-22 | 2002-11-27 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
US6552023B2 (en) | 2000-02-22 | 2003-04-22 | Cv Therapeutics, Inc. | Aralkyl substituted piperazine compounds |
US6451798B2 (en) * | 2000-02-22 | 2002-09-17 | Cv Therapeutics, Inc. | Substituted alkyl piperazine derivatives |
WO2001062749A1 (en) * | 2000-02-22 | 2001-08-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
AU2001239827A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted alkylene diamine compounds |
US6677336B2 (en) * | 2000-02-22 | 2004-01-13 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
WO2002007716A2 (en) * | 2000-07-21 | 2002-01-31 | Cv Therapeutics, Inc. | Method for treating angina |
US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
US6573264B1 (en) * | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
CA2454059A1 (en) * | 2001-07-19 | 2003-01-30 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
US7001909B2 (en) * | 2001-07-19 | 2006-02-21 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
US20030220344A1 (en) * | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
US20080109040A1 (en) * | 2002-04-04 | 2008-05-08 | Luiz Belardinelli | Method of treating arrhythmias |
KR101030943B1 (ko) | 2002-05-21 | 2011-04-28 | 씨브이 쎄러퓨틱스, 인코포레이티드 | 당뇨병 치료를 위한 라놀라진 등의 부분적 지방산 산화저해제 투여 |
US8822473B2 (en) * | 2002-05-21 | 2014-09-02 | Gilead Sciences, Inc. | Method of treating diabetes |
DE60327765D1 (de) | 2002-06-24 | 2009-07-09 | Janssen Pharmaceutica Nv | Verfahren zur herstellung von n-(2,6-dimethylphenyl)-2-piperazin-1-ylacetamid |
US7056924B2 (en) * | 2002-07-18 | 2006-06-06 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
CA2508608A1 (en) * | 2002-12-05 | 2004-06-24 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
EP1806346B1 (en) * | 2002-12-05 | 2009-07-22 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
AU2003303676A1 (en) * | 2003-01-03 | 2004-08-10 | Gilead Palo Alto, Inc. | Substituted heterocyclic compounds |
JP2006515891A (ja) * | 2003-01-17 | 2006-06-08 | シーブイ・セラピューティクス・インコーポレイテッド | 循環器疾患の処置に有効な置換ヘテロ環化合物 |
JP2007518677A (ja) * | 2003-06-23 | 2007-07-12 | シーブイ・セラピューティクス・インコーポレイテッド | 脂肪酸酸化インヒビターとしてのピペラジンおよびピペリジンのウレア誘導体 |
AU2004303882A1 (en) | 2003-12-18 | 2005-07-07 | Gilead Palo Alto, Inc. | 1-akan-2-ol substituted piperazine and piperidine compounds |
WO2006008753A1 (en) * | 2004-07-19 | 2006-01-26 | Unichem Laboratories Limited | Crystalline and amorphous form of ranolazine and the process for manufacturing them |
WO2006029179A2 (en) * | 2004-09-08 | 2006-03-16 | Cv Therapeutics, Inc. | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors |
RU2384332C2 (ru) * | 2005-01-06 | 2010-03-20 | Си Ви Терапьютикс, Инк. | Фармацевтические препаративные формы замедленного высвобождения |
WO2008047388A2 (en) * | 2006-10-20 | 2008-04-24 | Ind-Swift Laboratories Limited | Improved process for the preparation of ranolazine |
US20090111826A1 (en) * | 2007-02-13 | 2009-04-30 | Louis Lange | Use of ranolazine for the treatment of cardiovascular diseases |
US20080248112A1 (en) * | 2007-02-13 | 2008-10-09 | Brent Blackburn | Use of ranolazine for the treatment of coronary microvascular diseases |
WO2008100992A1 (en) * | 2007-02-13 | 2008-08-21 | Cv Therapeutics, Inc. | Intravenous solutions comprising ranolazine |
EP2117550A1 (en) * | 2007-02-13 | 2009-11-18 | CV Therapeutics Inc. | Use of ranolazine for the treatment of non-coronary microvascular diseases |
JP2010520291A (ja) * | 2007-03-07 | 2010-06-10 | コンサート ファーマシューティカルズ インコーポレイテッド | 抗狭心症化合物としての重水素化ピペラジン誘導体 |
WO2008116083A1 (en) * | 2007-03-22 | 2008-09-25 | Cv Therapeutics, Inc. | Use of ranolazine for elevated brain-type natriuretic peptide |
WO2008139492A2 (en) * | 2007-05-15 | 2008-11-20 | Natco Pharma Limited | A process for the preparation of highly pure ranolazine base |
CA2689633A1 (en) * | 2007-05-31 | 2008-12-11 | Cv Therapeutics, Inc. | Use of ranolazine for elevated brain-type natriuretic peptide |
AU2008266124A1 (en) * | 2007-06-13 | 2008-12-24 | Auspex Pharmaceuticals, Inc. | Substituted piperazines |
US20090247535A1 (en) * | 2008-03-26 | 2009-10-01 | Duke University | Use of ranolazine for non-cardiovascular disorders |
US20090318697A1 (en) * | 2008-06-19 | 2009-12-24 | Medichem, S.A. | Process for preparing a piperazine derivative |
WO2010023687A2 (en) * | 2008-08-28 | 2010-03-04 | Shodhana Laboratories Limited | Preparation of ranolazine, its salts and intermediates thereof |
WO2010025370A2 (en) * | 2008-08-28 | 2010-03-04 | Dr. Reddy's Laboratories Ltd. | Preparation of ranolazine |
WO2010029436A2 (en) * | 2008-09-09 | 2010-03-18 | Actavis Group Ptc Ehf | Novel solid state forms of ranolazine salts |
WO2010043976A2 (en) * | 2008-10-15 | 2010-04-22 | Actavis Group Ptc Ehf | Highly pure ranolazine or a pharmaceutically acceptable salt thereof |
WO2010097805A1 (en) | 2009-02-24 | 2010-09-02 | Lupin Limited | A process for the preparation of ranolazine |
WO2010137040A2 (en) | 2009-05-28 | 2010-12-02 | Lupin Limited | Novel pharmaceutical compositions of ranolazine |
US20120177729A1 (en) | 2009-09-25 | 2012-07-12 | Lupin Limited | Sustained release composition of ranolazine |
TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
TW201215392A (en) * | 2010-06-16 | 2012-04-16 | Gilead Sciences Inc | Use of ranolazine for treating pulmonary hypertension |
NO3175985T3 (sv) | 2011-07-01 | 2018-04-28 | ||
EP2758053A1 (en) | 2011-09-21 | 2014-07-30 | Gilead Sciences, Inc. | Sodium channel blockers reduce glucagon secretion |
CN103570645A (zh) * | 2012-08-01 | 2014-02-12 | 上海迪赛诺化学制药有限公司 | 一种制备n-(2,6-二甲基苯基)-2-(1-哌嗪基)乙酰胺的方法 |
EP3233814A4 (en) | 2015-03-10 | 2018-07-18 | Unichem Laboratories Limited | Novel process for the preparation of ranolazine |
TW201717919A (zh) | 2015-07-02 | 2017-06-01 | 國際藥品股份公司 | 雷諾多重壓縮錠劑 |
WO2018001582A1 (en) | 2016-06-30 | 2018-01-04 | Interquim, S.A. | Ranolazine multiple compressed tablets |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3829441A (en) * | 1962-01-29 | 1974-08-13 | Smith Kline French Lab | Guanidinoalkylbenzodioxan derivatives |
US3360529A (en) * | 1962-01-29 | 1967-12-26 | Smith Kline French Lab | Guanidinoalkylbenzodioxan derivatives |
US3496183A (en) * | 1964-11-19 | 1970-02-17 | Egyt Gyogyszervegyeszeti Gyar | Beta-guanidino-ethyl-piperazine derivatives |
DE1795362A1 (de) * | 1968-09-19 | 1972-01-05 | Boehringer Mannheim Gmbh | Basische AEther und Verfahren zur Herstellung derselben |
DE1795375A1 (de) * | 1968-09-21 | 1972-01-05 | Boehringer Mannheim Gmbh | Basische AEther und Verfahren zur Herstellung derselben |
FR2154493B1 (sv) * | 1971-09-13 | 1975-10-31 | Kali Chemie Ag | |
GB1332008A (en) * | 1971-09-28 | 1973-10-03 | Pfizer Ltd | Piperazine derivatives their preparation and pharmaceutical compositions containing them |
GB1374366A (en) * | 1972-07-21 | 1974-11-20 | Science Union & Cie | Propanol derivatives and a process for their preparation |
GB1425559A (en) * | 1972-09-01 | 1976-02-18 | Wyeth John & Brother Ltd | Pyridine tetrahydropyridine and piperidine derivatives |
GB1411531A (en) * | 1972-10-24 | 1975-10-29 | Lafon Labor | Amino derivatives of 1,4-benzodioxan |
US3953448A (en) * | 1972-12-07 | 1976-04-27 | Delmar Chemicals Limited | Piperazino-anilido compounds |
FR2267104A1 (en) * | 1974-04-12 | 1975-11-07 | Ferlux Labo Sa | Hypotensive and antiarrhythmic piperazines - 1-(3-phenoxy-2-hydroxy propyl)-4-substd. piperazines |
FR2310763A1 (fr) * | 1975-05-13 | 1976-12-10 | Buzas Andre | Derives 1,4-disubstitues de la piperazine, leur procede de preparation et leurs applications |
US4335126A (en) * | 1977-03-10 | 1982-06-15 | Degussa Aktiengesellschaft | 1-[3-(3,4,5-Trimethoxyphenoxy)-2-hydroxy-propyl]-4-aryl-piperazine-derivatives having pharmaceutical activity |
FR2387971A1 (fr) * | 1977-04-19 | 1978-11-17 | Delalande Sa | Nouvelles trimethoxy cinnamoyles piperazines, leur procede de preparation et leur application en therapeutique |
FR2462432A2 (fr) * | 1979-08-03 | 1981-02-13 | Delalande Sa | Nouveaux derives de la 3,4,5 trimethoxy cinnamoyle piperazine, leur procede de preparation et leur application en therapeutique |
FR2456738A2 (fr) * | 1978-04-10 | 1980-12-12 | Delalande Sa | Nouvelles cinnamoyles piperazines et homopiperazines, leur procede de preparation et leur application en therapeutique |
JPS6042795B2 (ja) * | 1978-10-23 | 1985-09-25 | 日本新薬株式会社 | カルバモイルピペラジン誘導体 |
EP0025111B1 (en) * | 1979-08-10 | 1984-07-25 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
DE2941597A1 (de) * | 1979-10-13 | 1981-04-23 | Basf Ag, 6700 Ludwigshafen | Piperidinderivate von 4,5-dialkyl-3-hydroxy-pyrrol-2-carbonsaeureestern, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
GR71991B (sv) * | 1980-01-21 | 1983-08-26 | Delalande Sa | |
DE3005287A1 (de) * | 1980-02-13 | 1981-08-20 | Basf Ag, 6700 Ludwigshafen | Phenylpiperazinderivate von 1,3,4-oxadiazolylphenolen, ihre herstellung und diese enthaltende therapeutische mittel |
US4302469A (en) * | 1980-09-10 | 1981-11-24 | Syntex (U.S.A.) Inc. | 2-(1,4-Benzodioxan-2-ylalkyl)imidazoles useful as antidepressants |
US4684651A (en) * | 1981-03-17 | 1987-08-04 | Mitsubishi Chemical Industries Limited | Alkylenedioxybenzene and acid addition salts thereof useful as hypotensives |
US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
US4374837A (en) * | 1981-07-31 | 1983-02-22 | Laroche Navarron, S.A. | Piperazine derivatives of theobromine |
US4353901A (en) * | 1981-10-19 | 1982-10-12 | Syntex (U.S.A.) Inc. | 9-(1,4-Benzodioxan-2-ylalkyl and hydroxyalkyl)-1-oxa-4,9-diazaspiro[5.5]undecan-3-ones |
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1983
- 1983-05-18 US US06/495,904 patent/US4567264A/en not_active Expired - Lifetime
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1984
- 1984-05-16 NO NO841968A patent/NO163618C/no not_active IP Right Cessation
- 1984-05-17 DE DE8484105643T patent/DE3468215D1/de not_active Expired
- 1984-05-17 SG SG598/89A patent/SG25086G/en unknown
- 1984-05-17 PH PH30692A patent/PH20016A/en unknown
- 1984-05-17 AT AT84105643T patent/ATE31533T1/de not_active IP Right Cessation
- 1984-05-17 DK DK248384A patent/DK168535B1/da not_active IP Right Cessation
- 1984-05-17 JP JP59097630A patent/JPS59219271A/ja active Granted
- 1984-05-17 PT PT78604A patent/PT78604B/pt unknown
- 1984-05-17 AU AU28346/84A patent/AU566489B2/en not_active Expired
- 1984-05-17 NZ NZ208188A patent/NZ208188A/en unknown
- 1984-05-17 PL PL1984247722A patent/PL142760B1/pl unknown
- 1984-05-17 KR KR1019840002696A patent/KR890000020B1/ko not_active IP Right Cessation
- 1984-05-17 EP EP84105643A patent/EP0126449B1/en not_active Expired
- 1984-05-17 PL PL1984252856A patent/PL143558B1/pl unknown
- 1984-05-17 ZA ZA843746A patent/ZA843746B/xx unknown
- 1984-05-17 IL IL71863A patent/IL71863A/xx not_active IP Right Cessation
- 1984-05-17 RU SU843741049A patent/RU2071471C1/ru active
- 1984-05-17 IE IE1224/84A patent/IE57487B1/en not_active IP Right Cessation
- 1984-05-17 HU HU841902A patent/HU192404B/hu unknown
- 1984-05-17 FI FI841989A patent/FI78479C/sv not_active IP Right Cessation
- 1984-05-17 ES ES532565A patent/ES8601947A1/es not_active Expired
- 1984-05-17 CA CA000454628A patent/CA1256874A/en not_active Expired
- 1984-05-17 CS CS843680A patent/CS246080B2/cs unknown
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1989
- 1989-11-16 HK HK919/89A patent/HK91989A/xx not_active IP Right Cessation
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1991
- 1991-11-12 RU SU915001933A patent/RU2083570C1/ru active
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1992
- 1992-06-18 MX MX9203001A patent/MX9203001A/es unknown
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1997
- 1997-05-05 BR BR1100474-6A patent/BR1100474A/pt active IP Right Grant
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