HK46791A - X-ray contrast agents - Google Patents

X-ray contrast agents

Info

Publication number
HK46791A
HK46791A HK467/91A HK46791A HK46791A HK 46791 A HK46791 A HK 46791A HK 467/91 A HK467/91 A HK 467/91A HK 46791 A HK46791 A HK 46791A HK 46791 A HK46791 A HK 46791A
Authority
HK
Hong Kong
Prior art keywords
bis
compound
compounds
acetylamino
group
Prior art date
Application number
HK467/91A
Other languages
German (de)
English (en)
French (fr)
Inventor
Per-Egil Hansen
Hugo Holtermann
Knut Wille
Original Assignee
Nycomed As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed As filed Critical Nycomed As
Publication of HK46791A publication Critical patent/HK46791A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Meat, Egg Or Seafood Products (AREA)
  • Medicinal Preparation (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyesters Or Polycarbonates (AREA)
HK467/91A 1982-11-08 1991-06-11 X-ray contrast agents HK46791A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8231796 1982-11-08

Publications (1)

Publication Number Publication Date
HK46791A true HK46791A (en) 1991-06-21

Family

ID=10534110

Family Applications (1)

Application Number Title Priority Date Filing Date
HK467/91A HK46791A (en) 1982-11-08 1991-06-11 X-ray contrast agents

Country Status (10)

Country Link
US (1) US5349085A (member.php)
EP (1) EP0108638B1 (member.php)
JP (1) JPS59104352A (member.php)
AT (1) ATE20733T1 (member.php)
DE (1) DE3364536D1 (member.php)
DK (1) DK160868C (member.php)
HK (1) HK46791A (member.php)
LU (1) LU88639I2 (member.php)
NL (1) NL950010I1 (member.php)
NO (2) NO161368C (member.php)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3731542A1 (de) * 1987-09-17 1989-03-30 Schering Ag Neue dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6-triiod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
DE3739098A1 (de) * 1987-11-16 1989-05-24 Schering Ag Neue substituierte dicarbonsaeure-bis(3,5-dicarbamoyl-2,4,6- trijod-anilide), verfahren zu deren herstellung sowie diese enthaltende roentgenkontrastmittel
GB8919929D0 (en) * 1989-09-04 1989-10-18 Nycomed As Compositions
IT1252180B (it) * 1991-12-10 1995-06-05 Bracco Ind Chimica Spa 5,5'-(1,3-propandiil) bis (imino (2-osso-2,1-etandiil)acetilimino)-bis(2,4,6-triiodo-1,3-benzendicarbossiamidi),loro metodo di preparazione e mezzi di contrasto roentgenografici che li contengono
WO1994022810A1 (es) * 1993-04-01 1994-10-13 Centro Investigacion Justesa Imagen, S.A. Nuevos dimeros iodados no ionicos como agentes de contraste a los rayos x, metodo para su preparacion y composiciones galenicas que los contienen
US5840967A (en) * 1996-08-29 1998-11-24 Nycomed Imaging As Process for the preparation of contrast agents
GB9618056D0 (en) * 1996-08-29 1996-10-09 Nycomed Imaging As Process
GB9720969D0 (en) 1997-10-02 1997-12-03 Nycomed Imaging As Process
GB9903109D0 (en) * 1999-02-11 1999-04-07 Nycomed Imaging As Process
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6660248B2 (en) 2000-11-10 2003-12-09 William Marsh Rice University Fullerene (C60)-based X-ray contrast agent for diagnostic imaging
KR100574087B1 (ko) 2004-09-09 2006-04-27 주식회사태준제약 아이오디사놀의 제조방법
EP1836239B1 (en) 2005-01-13 2008-10-29 Cinvention Ag Composite materials containing carbon nanoparticles
ES2413761T3 (es) 2005-12-19 2013-07-17 Ge Healthcare As Procedimiento de purificación de iodixanol
ES2357861T3 (es) 2006-02-15 2011-05-03 Ge Healthcare As Agentes de contraste.
FR2899581B1 (fr) * 2006-04-07 2008-06-27 Guerbet Sa Procede d'atomisation du ioxilan
US7662859B2 (en) 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
DK2178568T3 (da) * 2007-07-12 2014-07-21 Ge Healthcare As Kontrastmidler
EP2200971B1 (en) 2007-10-12 2013-04-24 GE Healthcare AS Contrast agents
US20100221191A1 (en) 2007-10-12 2010-09-02 Duncan George Wynn Contrast agents
EP2200655B1 (en) 2007-10-12 2012-07-18 GE Healthcare AS Contrast agents
JP2011500533A (ja) 2007-10-12 2011-01-06 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
US20110008263A1 (en) * 2008-02-27 2011-01-13 Hanno Priebe Contrast agents
WO2009106552A2 (en) * 2008-02-27 2009-09-03 Ge Healthcare As Contrast agents
WO2010060941A2 (en) * 2008-11-27 2010-06-03 Ge Healthcare As Contrast agents
EP2385845A1 (en) * 2009-01-09 2011-11-16 Ge Healthcare As Contrast media compositions
US7999134B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using milling
US8962887B2 (en) * 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in 1-methoxy-2-propanol and water or methanol
US7754920B1 (en) * 2009-07-21 2010-07-13 Ge Healthcare As Solvent reduction in crystallisation of intermediate for non-ionic X-ray contrast agents
US7999135B2 (en) 2009-07-21 2011-08-16 Ge Healthcare As Crystallization of iodixanol using ultrasound
US7696381B1 (en) * 2009-07-21 2010-04-13 Ge Healthcare As Alternative dimerisation reagents for synthesis of iodixanol
US20110021832A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Synthesis of iodixanol in water
US8962886B2 (en) 2009-07-21 2015-02-24 Ge Healthcare As Synthesis of iodixanol in methanol
US20110021821A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As Continuous acetylation process in synthesis of non-ionic x-ray contrast agents
US20110021822A1 (en) * 2009-07-21 2011-01-27 Ge Healthcare As continuous deacetylation and purification process in synthesis of non-ionic x-ray contrast agents
US8969619B2 (en) * 2009-07-21 2015-03-03 Ge Healthcare As Synthesis of iodixanol in propyleneglycol
EP2493511B1 (en) * 2009-10-29 2013-10-16 GE Healthcare AS Diagnostic composition comprising plasma cations having a superior safety profile
KR101699226B1 (ko) 2009-11-26 2017-01-24 호비온 차이나 홀딩 리미티드 이오딕사놀의 제조 및 정제
MX2013000476A (es) 2010-07-12 2013-02-11 Ge Healthcare As Generacion de imagenes de rayos x en bajas concentraciones de agente y/o dosis de radiacion.
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
CN102816125B (zh) * 2011-06-08 2014-03-26 浙江司太立制药股份有限公司 一种造影剂
NZ626988A (en) 2012-01-11 2015-10-30 Ge Healthcare As X-ray imaging contrast media with low iodine concentration and x-ray imaging process
JP6431842B2 (ja) 2012-09-27 2018-11-28 ジーイー・ヘルスケア・アクスイェ・セルスカプ イオホルミノールの中間体化合物の調製
AU2013341615B2 (en) 2012-11-12 2017-12-14 Ge Healthcare As Preparation of intermediates of X-ray contrast agents
CN115501172A (zh) 2014-11-21 2022-12-23 丹麦技术大学 用于局部药物释放的凝胶制剂
PT108524B (pt) 2015-06-02 2017-12-15 Hovione Farmaciência S A Processo para a preparação de intermediários úteis na preparação de agentes de contraste não-iónicos
MX2018014087A (es) 2016-05-20 2019-06-10 Univ Denmark Tech Dtu Composicion de marcaje palpable.
CN111440084B (zh) * 2019-01-16 2023-01-06 苏州纳微科技股份有限公司 一种碘克沙醇的纯化方法
US20220339285A1 (en) 2019-06-12 2022-10-27 Technical University Of Denmark Dissacharide formulations for controlled drug release
CN113121377A (zh) * 2019-12-31 2021-07-16 江苏汉邦科技有限公司 碘克沙醇的纯化方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE344166B (member.php) * 1966-12-13 1972-04-04 Pharmacia Ab
US3763227A (en) * 1967-12-28 1973-10-02 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
SE315974B (member.php) * 1967-12-28 1969-10-13 Pharmacia Ab
SE315975B (member.php) * 1967-12-28 1969-10-13 Pharmacia Ab
US3804892A (en) * 1967-12-28 1974-04-16 Pharmacia Ab Novel 3,5-substituted 2,4,6-triiodobenzoic acids and salts thereof
IT1047908B (it) * 1969-06-27 1980-10-20 Nyegaard & Co As Procedimento per preparare agenti di contrasto per raggi x a base di alcanoli
NL7102816A (member.php) * 1970-03-12 1971-09-14
DD104193A5 (member.php) * 1972-12-22 1974-03-05
GB1548594A (en) * 1976-06-11 1979-07-18 Nyegaard & Co As Triiodoisophthalic acid amides
DE2628517C2 (de) * 1976-06-23 1985-02-21 Schering AG, 1000 Berlin und 4709 Bergkamen Dicarbonsäure-bis(3,5-dicarbamoyl-2,4,6-trijodanilid)-Verbindungen, Verfahren zu ihrer Herstellung und Röntgenkontrastmittel
IT1207226B (it) * 1979-08-09 1989-05-17 Bracco Ind Chimica Spa Derivati dell'acido 2,4,6-triiodo-isoftalico, metodo per la loro preparazione e mezzi di contrasto che li contengono.
DE3038853A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue n-hydroxy-alkylierte dicarbonsaeure-bis-(3,5-dicarbamoyl-2,4,6-trijodanilide), deren herstellung und diese enthaltende roentgenkonstrastmittel (ii)
FR2511871A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants et produits opacifiants ainsi obtenus

Also Published As

Publication number Publication date
EP0108638B1 (en) 1986-07-16
LU88639I2 (fr) 1996-02-01
ATE20733T1 (de) 1986-08-15
EP0108638A1 (en) 1984-05-16
DK160868B (da) 1991-04-29
JPS6355509B2 (member.php) 1988-11-02
NL950010I2 (nl) 1997-02-03
US5349085A (en) 1994-09-20
JPS59104352A (ja) 1984-06-16
NO161368C (no) 1989-08-09
NO834056L (no) 1984-05-09
DK160868C (da) 1991-10-14
DK508283A (da) 1984-05-09
NO1994015I1 (no) 1994-09-05
DK508283D0 (da) 1983-11-07
NL950010I1 (nl) 1997-02-03
DE3364536D1 (en) 1986-08-21
NO161368B (no) 1989-05-02

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Legal Events

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