HK39790A - Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes - Google Patents

Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes

Info

Publication number
HK39790A
HK39790A HK397/90A HK39790A HK39790A HK 39790 A HK39790 A HK 39790A HK 397/90 A HK397/90 A HK 397/90A HK 39790 A HK39790 A HK 39790A HK 39790 A HK39790 A HK 39790A
Authority
HK
Hong Kong
Prior art keywords
hydroxymorphinans
intermediates
processes
prodrug derivatives
ester prodrug
Prior art date
Application number
HK397/90A
Other languages
English (en)
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of HK39790A publication Critical patent/HK39790A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK397/90A 1984-07-05 1990-05-24 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes HK39790A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists

Publications (1)

Publication Number Publication Date
HK39790A true HK39790A (en) 1990-06-01

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
HK397/90A HK39790A (en) 1984-07-05 1990-05-24 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans,intermediates thereto,and processes

Country Status (18)

Country Link
US (1) US4668685A (cs)
EP (1) EP0170090B1 (cs)
AU (1) AU578391B2 (cs)
CA (1) CA1301150C (cs)
DE (1) DE3573251D1 (cs)
DK (1) DK160501C (cs)
ES (1) ES8704443A1 (cs)
FI (1) FI83215C (cs)
GR (1) GR851653B (cs)
HK (1) HK39790A (cs)
HU (1) HU193995B (cs)
IE (1) IE58136B1 (cs)
IL (1) IL75721A (cs)
MX (1) MX160445A (cs)
NO (1) NO171209C (cs)
NZ (1) NZ212641A (cs)
PT (1) PT80773B (cs)
SU (2) SU1450742A3 (cs)

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EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
WO2006034343A2 (en) * 2004-09-23 2006-03-30 Alexander Michalow methods for regulating neurotransmitter systems by inducing counteradaptationS
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3228308A1 (en) * 2005-01-28 2017-10-11 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
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US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
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US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
US9108975B2 (en) * 2010-11-12 2015-08-18 Shionogi & Co., Ltd. Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
CA2856608C (en) 2011-10-26 2017-05-16 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
NZ731591A (en) 2014-11-25 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
MA40937A (fr) 2014-12-02 2017-10-11 Kempharm Inc Acide benzoïque, dérivés d'acide benzoïque et conjugués d'acide hétéroarylcarboxylique d'oxymorphone, promédicaments, leurs procédés de fabrication et d'utilisation
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JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
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Also Published As

Publication number Publication date
NZ212641A (en) 1988-10-28
DE3573251D1 (en) 1989-11-02
NO171209B (no) 1992-11-02
NO852699L (no) 1986-01-06
FI852659L (fi) 1986-01-06
FI83215B (fi) 1991-02-28
IE58136B1 (en) 1993-07-14
FI852659A0 (fi) 1985-07-04
DK306885A (da) 1986-01-06
DK160501C (da) 1991-08-26
DK160501B (da) 1991-03-18
EP0170090B1 (en) 1989-09-27
IL75721A0 (en) 1985-11-29
HU193995B (en) 1987-12-28
US4668685A (en) 1987-05-26
PT80773A (en) 1985-08-01
IL75721A (en) 1990-04-29
SU1508960A3 (ru) 1989-09-15
MX160445A (es) 1990-03-02
ES544852A0 (es) 1987-04-01
SU1450742A3 (ru) 1989-01-07
EP0170090A1 (en) 1986-02-05
HUT40132A (en) 1986-11-28
DK306885D0 (da) 1985-07-04
IE851683L (en) 1986-01-05
CA1301150C (en) 1992-05-19
FI83215C (fi) 1991-06-10
PT80773B (pt) 1987-10-20
GR851653B (cs) 1985-11-26
AU578391B2 (en) 1988-10-20
NO171209C (no) 1993-02-10
ES8704443A1 (es) 1987-04-01
AU4451685A (en) 1986-01-09

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