DK160501C - Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne - Google Patents

Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Info

Publication number
DK160501C
DK160501C DK306885A DK306885A DK160501C DK 160501 C DK160501 C DK 160501C DK 306885 A DK306885 A DK 306885A DK 306885 A DK306885 A DK 306885A DK 160501 C DK160501 C DK 160501C
Authority
DK
Denmark
Prior art keywords
hydroxymorphinanes
testers
sugar
pharmaceutical preparations
preparations containing
Prior art date
Application number
DK306885A
Other languages
Danish (da)
English (en)
Other versions
DK306885A (da
DK160501B (da
DK306885D0 (da
Inventor
Elie Gabriel Shami
Original Assignee
Du Pont
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont filed Critical Du Pont
Publication of DK306885D0 publication Critical patent/DK306885D0/da
Publication of DK306885A publication Critical patent/DK306885A/da
Publication of DK160501B publication Critical patent/DK160501B/da
Application granted granted Critical
Publication of DK160501C publication Critical patent/DK160501C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK306885A 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne DK160501C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62792384A 1984-07-05 1984-07-05
US62792384 1984-07-05
US06/733,464 US4668685A (en) 1984-07-05 1985-05-14 Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US73346485 1985-05-14

Publications (4)

Publication Number Publication Date
DK306885D0 DK306885D0 (da) 1985-07-04
DK306885A DK306885A (da) 1986-01-06
DK160501B DK160501B (da) 1991-03-18
DK160501C true DK160501C (da) 1991-08-26

Family

ID=27090564

Family Applications (1)

Application Number Title Priority Date Filing Date
DK306885A DK160501C (da) 1984-07-05 1985-07-04 Substituerede benzoatestere af 3-hydroxymorphinaner samt farmaceutiske praeparater indeholdende saadanne

Country Status (18)

Country Link
US (1) US4668685A (cs)
EP (1) EP0170090B1 (cs)
AU (1) AU578391B2 (cs)
CA (1) CA1301150C (cs)
DE (1) DE3573251D1 (cs)
DK (1) DK160501C (cs)
ES (1) ES8704443A1 (cs)
FI (1) FI83215C (cs)
GR (1) GR851653B (cs)
HK (1) HK39790A (cs)
HU (1) HU193995B (cs)
IE (1) IE58136B1 (cs)
IL (1) IL75721A (cs)
MX (1) MX160445A (cs)
NO (1) NO171209C (cs)
NZ (1) NZ212641A (cs)
PT (1) PT80773B (cs)
SU (2) SU1450742A3 (cs)

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US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
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US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
US20080020028A1 (en) * 2003-08-20 2008-01-24 Euro-Celtique S.A. Transdermal dosage form comprising an active agent and a salt and a free-base form of an adverse agent
EP1604666A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD)
EP1604667A1 (en) * 2004-06-08 2005-12-14 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
WO2006034343A2 (en) * 2004-09-23 2006-03-30 Alexander Michalow methods for regulating neurotransmitter systems by inducing counteradaptationS
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP3228308A1 (en) * 2005-01-28 2017-10-11 Euro-Celtique S.A. Alcohol resistant dosage forms
EP1695700A1 (en) * 2005-02-28 2006-08-30 Euro-Celtique S.A. Dosage form containing oxycodone and naloxone
EP1702558A1 (en) * 2005-02-28 2006-09-20 Euro-Celtique S.A. Method and device for the assessment of bowel function
WO2006126529A1 (ja) * 2005-05-25 2006-11-30 Shionogi & Co., Ltd. ６，７－不飽和－７－カルバモイル置換モルヒナン誘導体
WO2007022535A2 (en) 2005-08-19 2007-02-22 Pharmacofore, Inc. Prodrugs of active agents
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US8178551B2 (en) * 2007-03-09 2012-05-15 Green Cross Corporation Orally bioavailable prodrugs of (+)-3-hydroxymorphinan for Parkinson'S disease prevention or treatment
CA2730211C (en) * 2008-07-07 2016-11-08 Euro-Celtique S.A. Use of opioid antagonists for treating urinary retention
ME03298B (me) 2009-03-10 2019-07-20 Euro Celtique Sa Farmaceutske kombinacije sa trenutnim oslobađanjem које obuhvataju oksikodon i nalokson
US10849981B2 (en) 2009-07-02 2020-12-01 KemPham, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US8623888B2 (en) * 2009-07-15 2014-01-07 Mallinckrodt Llc 3-oxy-hydromorphone derivatives
US9108975B2 (en) * 2010-11-12 2015-08-18 Shionogi & Co., Ltd. Crystal of 6,7-unsaturated-7-carbamoyl morphinan derivative and method for producing the same
CA2856608C (en) 2011-10-26 2017-05-16 Travis Mickle Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
WO2015011189A1 (en) 2013-07-23 2015-01-29 Euro-Celtique S.A. A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation
NZ731591A (en) 2014-11-25 2018-06-29 Kempharm Inc Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone
MA40937A (fr) 2014-12-02 2017-10-11 Kempharm Inc Acide benzoïque, dérivés d'acide benzoïque et conjugués d'acide hétéroarylcarboxylique d'oxymorphone, promédicaments, leurs procédés de fabrication et d'utilisation
US10155771B2 (en) * 2015-11-04 2018-12-18 Noramco, Inc. Selective reduction of morphinan alkaloids
US10807995B2 (en) 2018-07-13 2020-10-20 Alkermes Pharma Ireland Limited Thienothiophene compounds for long-acting injectable compositions and related methods
US10799496B2 (en) 2018-07-13 2020-10-13 Alkermes Pharma Ireland Limited Naphthylenyl compounds for long-acting injectable compositions and related methods
US11186585B2 (en) 2018-08-17 2021-11-30 Kappa-Pharma LLC Compositions and methods of enhancing opioid receptor engagement by opioid hexadienoates and optionally substituted hexadienoates
WO2020094634A1 (en) 2018-11-05 2020-05-14 Alkermes Pharma Ireland Limited Thiophene prodrugs of naltroxene for long-acting injectable compositions and related methods
EP4010078A4 (en) 2019-08-11 2023-08-09 Kappa-Pharma LLC COMPOSITIONS AND METHODS FOR ENHANCING OPIOID RECEPTOR MOBILIZATION BY OPIOID HEXADENOATES AND OPTIONALLY SUBSTITUTED HEXADIENATES

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JPS59184182A (ja) * 1983-04-02 1984-10-19 Res Inst For Prod Dev ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン
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Also Published As

Publication number Publication date
NZ212641A (en) 1988-10-28
DE3573251D1 (en) 1989-11-02
HK39790A (en) 1990-06-01
NO171209B (no) 1992-11-02
NO852699L (no) 1986-01-06
FI852659L (fi) 1986-01-06
FI83215B (fi) 1991-02-28
IE58136B1 (en) 1993-07-14
FI852659A0 (fi) 1985-07-04
DK306885A (da) 1986-01-06
DK160501B (da) 1991-03-18
EP0170090B1 (en) 1989-09-27
IL75721A0 (en) 1985-11-29
HU193995B (en) 1987-12-28
US4668685A (en) 1987-05-26
PT80773A (en) 1985-08-01
IL75721A (en) 1990-04-29
SU1508960A3 (ru) 1989-09-15
MX160445A (es) 1990-03-02
ES544852A0 (es) 1987-04-01
SU1450742A3 (ru) 1989-01-07
EP0170090A1 (en) 1986-02-05
HUT40132A (en) 1986-11-28
DK306885D0 (da) 1985-07-04
IE851683L (en) 1986-01-05
CA1301150C (en) 1992-05-19
FI83215C (fi) 1991-06-10
PT80773B (pt) 1987-10-20
GR851653B (cs) 1985-11-26
AU578391B2 (en) 1988-10-20
NO171209C (no) 1993-02-10
ES8704443A1 (es) 1987-04-01
AU4451685A (en) 1986-01-09

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