HK14789A - Indoles - Google Patents

Indoles

Info

Publication number
HK14789A
HK14789A HK147/89A HK14789A HK14789A HK 14789 A HK14789 A HK 14789A HK 147/89 A HK147/89 A HK 147/89A HK 14789 A HK14789 A HK 14789A HK 14789 A HK14789 A HK 14789A
Authority
HK
Hong Kong
Prior art keywords
alkyl
group
compounds
alkenyl
disclosed
Prior art date
Application number
HK147/89A
Other languages
English (en)
Inventor
Dennis Dowle Michael
Harold Coates Ian
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10530876&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK14789(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HK14789A publication Critical patent/HK14789A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
HK147/89A 1982-06-07 1989-02-16 Indoles HK14789A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8216526 1982-06-07

Publications (1)

Publication Number Publication Date
HK14789A true HK14789A (en) 1989-02-24

Family

ID=10530876

Family Applications (1)

Application Number Title Priority Date Filing Date
HK147/89A HK14789A (en) 1982-06-07 1989-02-16 Indoles

Country Status (33)

Country Link
US (1) US4816470A (cs)
JP (1) JPS5942366A (cs)
KR (1) KR900006681B1 (cs)
AT (1) AT381933B (cs)
AU (1) AU566149B2 (cs)
BE (1) BE896986A (cs)
CA (1) CA1199643A (cs)
CH (1) CH657359A5 (cs)
CY (1) CY1458A (cs)
CZ (1) CZ280529B6 (cs)
DE (2) DE3320521A1 (cs)
DK (1) DK260183D0 (cs)
DO (1) DOP1989476000A (cs)
ES (3) ES523039A0 (cs)
FI (1) FI79530C (cs)
FR (1) FR2530625B1 (cs)
GB (1) GB2124210B (cs)
GR (1) GR79215B (cs)
HK (1) HK14789A (cs)
IE (1) IE55358B1 (cs)
IL (1) IL68913A (cs)
IT (1) IT1170387B (cs)
KE (1) KE3833A (cs)
LU (1) LU84852A1 (cs)
MX (1) MX9202623A (cs)
MY (1) MY8700179A (cs)
NL (1) NL193694C (cs)
NZ (1) NZ204482A (cs)
PH (1) PH19908A (cs)
PT (1) PT76830B (cs)
SE (1) SE452459B (cs)
SK (1) SK277877B6 (cs)
ZA (1) ZA834110B (cs)

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GB8615599D0 (en) * 1986-06-26 1986-07-30 Glaxo Group Ltd Chemical compounds
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US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8903036D0 (en) * 1989-02-10 1989-03-30 Glaxo Group Ltd Chemical compounds
HUT57185A (en) * 1990-03-21 1991-11-28 Merrell Dow Pharma Process for producing 8-sulfamil-methylen-2-amino-tetraline derivatives and pharmaceutical compositions containing them
US5155218A (en) 1990-05-08 1992-10-13 Neurogenetic Corporation Dna encoding human 5-ht1d receptors
US5935925A (en) * 1990-05-08 1999-08-10 Synaptic Pharmaceutical Corporation Methods of treating migraine and compounds useful for such methods
HU219974B (hu) * 1990-06-07 2001-10-28 Astrazeneca Ab, Heterociklusos csoporttal helyettesített indolszármazék, előállítása és a vegyületet hatóanyagként tartalmazó gyógyszerkészítmények
GB9013845D0 (en) * 1990-06-21 1990-08-15 Glaxo Group Ltd Process
US5077293A (en) * 1990-06-29 1991-12-31 Bristol-Myers Squibb Co. 1-indolyalkyl-4-(alkoxypyrimidinyl)piperazines
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GB9022250D0 (en) * 1990-10-12 1990-11-28 Glaxo Group Ltd Medicaments
GB9103770D0 (en) * 1991-02-22 1991-04-10 Glaxo Group Ltd Chemical compounds
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CA2084531A1 (en) 1991-12-19 1993-06-20 David W. Smith Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines
GB9209882D0 (en) * 1992-05-07 1992-06-24 Glaxo Lab Sa Compositions
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GB9211276D0 (en) * 1992-05-28 1992-07-15 Glaxo Lab Sa Pharmaceutical compositions
ES2055651B1 (es) * 1992-07-20 1995-03-01 Vita Invest Sa Procedimiento para la obtencion de nuevas amidinas derivadas de 3-aminoetilindoles.
GB9216009D0 (en) * 1992-07-28 1992-09-09 Almirall Lab New indol derivatives
ES2056025B1 (es) * 1992-10-08 1995-05-01 Almirall Lab Nuevos derivados de indol.
RU2108326C1 (ru) * 1993-02-26 1998-04-10 Вита-Инвест С.А. Способ получения 2-карбокси-3-[2-(диметиламино)этил]-n-метил-1h-индол-5-метансульфонамида или его сложных эфиров
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US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
ES2079323B1 (es) * 1994-06-21 1996-10-16 Vita Invest Sa Derivados de indol utiles para el tratamiento de la migraña, composicion y uso correspondientes.
US5618816A (en) * 1995-03-02 1997-04-08 Bristol-Myers Squibb Company Antimigraine 1,2,5-thiadiazole derivatives of indolylalkyl-pyridnyl and pyrimidinylpiperazines
FR2731224B1 (fr) * 1995-03-02 1997-05-30 Pf Medicament Nouveaux derives bi-tryptaminiques sulfonamides, leur procede de preparation et leur utilisation a titre de medicaments
US5872145A (en) * 1996-08-16 1999-02-16 Pozen, Inc. Formulation of 5-HT agonist and NSAID for treatment of migraine
US6586458B1 (en) 1996-08-16 2003-07-01 Pozen Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US8022095B2 (en) 1996-08-16 2011-09-20 Pozen, Inc. Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs
US7189753B1 (en) 1997-11-06 2007-03-13 Cady Roger K Preemptive prophylaxis of migraine
US6066092A (en) * 1997-11-06 2000-05-23 Cady; Roger K. Preemptive prophylaxis of migraine device and method
US6416472B1 (en) 1997-11-06 2002-07-09 Edus Inc. Method and device for measuring cognitive efficiency
GB9926250D0 (en) * 1999-11-06 2000-01-12 Knoll Ag Chemical process
WO2002015899A1 (en) * 2000-08-23 2002-02-28 Bristol-Myers Squibb Company Combination therapy for the treatment of migraine
WO2002076426A2 (en) * 2001-03-27 2002-10-03 Galen (Chemicals) Limited Intravaginal drug delivery devices for the administration of an antimicrobial agent
US8329734B2 (en) 2009-07-27 2012-12-11 Afgin Pharma Llc Topical therapy for migraine
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IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
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US20040068000A1 (en) * 2002-10-02 2004-04-08 Mintong Guo Compression coated tablets
EP1572647B1 (en) 2002-12-20 2016-09-21 Basf Se Synthesis of amines and intermediates for the synthesis thereof
WO2004060355A1 (en) 2002-12-26 2004-07-22 Pozen Inc. Multilayer Dosage Forms Containing NSAIDs and Triptans
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
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JP2006527195A (ja) * 2003-06-06 2006-11-30 グラクソ　グループ　リミテッド トリプタンおよびｎｓａｉｄを含む組成物
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EA201000808A1 (ru) * 2007-11-16 2011-04-29 Ньюраксон, Инк. Индольные соединения и способы лечения висцеральной боли
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US20090252791A1 (en) * 2008-04-02 2009-10-08 Venkata Nookaraju Sreedharala Pharmaceutical compositions comprising a triptan and a nonsteroidal anti-inflammatory drug
KR20110019759A (ko) 2008-05-27 2011-02-28 비오타 사이언티픽 매니지먼트 피티와이 엘티디 항바이러스 염
CN102088966B (zh) * 2008-06-20 2015-06-10 阿尔法制药有限公司 药物制剂
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US11337962B2 (en) 2009-09-25 2022-05-24 Upsher-Smith Laboratories, Llc Formulations comprising triptan compounds
DK2480197T3 (en) 2009-09-25 2016-01-25 Reddys Lab Ltd Dr Compositions containing triptanforbindelser
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US10383816B2 (en) 2015-03-02 2019-08-20 Afgin Pharma, Llc Topical regional neuro-affective therapy with cannabinoid combination products
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US12194158B2 (en) 2016-01-27 2025-01-14 Instar Technologies A.S. Oromucosal nanofiber carriers for therapeutic treatment
US20180049994A1 (en) 2016-08-16 2018-02-22 Afgin Pharma, Llc Topical regional neuro-affective therapy with caryophyllene
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ZA795239B (en) * 1978-10-12 1980-11-26 Glaxo Group Ltd Heterocyclic compounds
GB2082175B (en) * 1980-08-12 1984-05-02 Glaxo Group Ltd Heterocyclic compounds
DK157920C (da) * 1980-08-12 1990-08-06 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af indolderivater
ZW19381A1 (en) * 1980-08-12 1983-03-09 Glaxo Group Ltd Heterocyclic compounds
NL8103764A (nl) * 1980-08-12 1982-03-01 Glaxo Group Ltd Heterocyclische verbindingen, werkwijze ter bereiding daarvan, alsmede farmaceutische preparaten die deze verbindingen als actieve component bevatten.

Also Published As

Publication number Publication date
NL193694B (nl) 2000-03-01
BE896986A (fr) 1983-12-07
IL68913A (en) 1987-08-31
MY8700179A (en) 1987-12-31
DK260183D0 (da) 1983-06-06
AT381933B (de) 1986-12-10
FI832035A0 (fi) 1983-06-07
CA1199643A (en) 1986-01-21
SE452459B (sv) 1987-11-30
NL8302031A (nl) 1984-01-02
JPS5942366A (ja) 1984-03-08
GB2124210A (en) 1984-02-15
FI79530C (fi) 1990-01-10
SE8303208L (sv) 1983-12-08
ATA208483A (de) 1986-05-15
NL193694C (nl) 2000-07-04
CY1458A (en) 1989-07-21
GB8315564D0 (en) 1983-07-13
KR840005095A (ko) 1984-11-03
PT76830B (en) 1986-04-21
US4816470A (en) 1989-03-28
PT76830A (en) 1983-07-01
SK404091A3 (en) 1995-06-07
ES544281A0 (es) 1986-07-16
CZ404091A3 (en) 1993-04-14
LU84852A1 (fr) 1985-03-29
ES529802A0 (es) 1985-11-16
ES8601880A1 (es) 1985-11-16
CZ280529B6 (cs) 1996-02-14
ES8407473A1 (es) 1984-10-01
ES523039A0 (es) 1984-10-01
AU1544183A (en) 1983-12-15
JPH0329069B2 (cs) 1991-04-23
IT8348422A0 (it) 1983-06-03
FI79530B (fi) 1989-09-29
MX9202623A (es) 1992-06-30
IT1170387B (it) 1987-06-03
NZ204482A (en) 1986-09-10
CH657359A5 (fr) 1986-08-29
FR2530625A1 (fr) 1984-01-27
IE55358B1 (en) 1990-08-29
FI832035L (fi) 1983-12-08
KR900006681B1 (ko) 1990-09-17
GR79215B (cs) 1984-10-22
IE831335L (en) 1983-12-07
FR2530625B1 (fr) 1986-04-18
DE3320521C2 (cs) 1992-06-25
SE8303208D0 (sv) 1983-06-07
SK277877B6 (en) 1995-06-07
ZA834110B (en) 1985-01-30
KE3833A (en) 1988-11-18
DOP1989476000A (es) 1996-02-03
DE3320521A1 (de) 1983-12-08
AU566149B2 (en) 1987-10-08
GB2124210B (en) 1985-11-13
DE19375045I2 (de) 2002-09-05
ES8609247A1 (es) 1986-07-16
PH19908A (en) 1986-08-13
IL68913A0 (en) 1983-10-31

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PE Patent expired