HK1251257A1 - 用於醫治疾病的外泌體的用途 - Google Patents

用於醫治疾病的外泌體的用途

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Publication number
HK1251257A1
HK1251257A1 HK18110744.8A HK18110744A HK1251257A1 HK 1251257 A1 HK1251257 A1 HK 1251257A1 HK 18110744 A HK18110744 A HK 18110744A HK 1251257 A1 HK1251257 A1 HK 1251257A1
Authority
HK
Hong Kong
Prior art keywords
exosomes
disease
treatment
Prior art date
Application number
HK18110744.8A
Other languages
English (en)
Inventor
Raghu Kalluri
Sonia Melo
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of HK1251257A1 publication Critical patent/HK1251257A1/zh

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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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HK18110744.8A 2015-06-10 2018-08-21 用於醫治疾病的外泌體的用途 HK1251257A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562173838P 2015-06-10 2015-06-10
PCT/US2016/037018 WO2016201323A1 (en) 2015-06-10 2016-06-10 Use of exosomes for the treatment of disease

Publications (1)

Publication Number Publication Date
HK1251257A1 true HK1251257A1 (zh) 2019-01-25

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Country Status (15)

Country Link
US (2) US20180177727A1 (zh)
EP (1) EP3307890A1 (zh)
JP (3) JP2018520125A (zh)
KR (1) KR20180017119A (zh)
CN (2) CN113694075A (zh)
AU (1) AU2016275046B2 (zh)
BR (1) BR112017026467A2 (zh)
CA (1) CA2988585A1 (zh)
EA (1) EA201890006A1 (zh)
HK (1) HK1251257A1 (zh)
IL (1) IL256175B1 (zh)
MA (1) MA45481A (zh)
MX (1) MX2017015962A (zh)
NZ (1) NZ738149A (zh)
WO (1) WO2016201323A1 (zh)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
CN106727548B (zh) * 2016-12-23 2020-08-21 蒋培都 烷基吡啶类化合物在制备诱导细胞自噬药物的应用及方法
WO2018124835A1 (ko) * 2016-12-29 2018-07-05 한국과학기술연구원 신규 엑소좀 계열 항암제
CN108066361A (zh) * 2017-01-23 2018-05-25 广州中科蓝华生物科技有限公司 一种外泌体，其制备方法及其在制备抗肿瘤的药物或者制剂中的用途
US20200338133A1 (en) * 2017-04-19 2020-10-29 Figene, Llc Stimulation of angiogenesis by fibroblast derived exosomes
EP3658125A4 (en) * 2017-07-28 2021-04-28 National University of Singapore BIOMOLECULAR COMPOSITES INCLUDING MODIFIED CELL PHANTOMS
TR201716062A2 (tr) * 2017-10-18 2019-05-21 Tuerkiye Bilimsel Ve Teknolojik Arastirma Kurumu Tuebitak Bi̇r eksozomal terapöti̇k taşiyici üreti̇m yöntemi̇ ve bu yönteme uygun bi̇r şeki̇lde elde edi̇len bi̇r eksozomal terapöti̇k taşiyici
WO2019118826A1 (en) * 2017-12-15 2019-06-20 Board Of Regents, The University Of Texas System Methods and compositions for treating cancer using exosomes-associated gene editing
JP7253762B2 (ja) * 2017-12-27 2023-04-07 慈濟大學 タンパク質を表面に発現させた小胞によるオートファジー細胞およびアポトーシス細胞への薬剤送達
WO2019157535A1 (en) * 2018-02-12 2019-08-15 Codiak Biosciences, Inc. Methods and compositions for macrophage polarization
WO2019169141A1 (en) * 2018-02-28 2019-09-06 Lester Smith Medical Research Institute Production and use of extracellular vesicles
CN108486060B (zh) * 2018-03-12 2021-09-14 绍兴优铭生物科技有限公司 一种用于治疗肿瘤的外泌体及其制备方法和应用
KR20200130410A (ko) * 2018-03-12 2020-11-18 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 면역-엑소좀 및 이의 사용 방법
CA3093849A1 (en) * 2018-03-23 2019-09-26 Codiak Biosciences, Inc. Extracellular vesicles comprising sting-agonist
CA3095136A1 (en) * 2018-03-28 2019-10-03 Board Of Regents,The University Of Texas System Use of exosomes for targeted delivery of therapeutic agents
CN112236131A (zh) * 2018-03-29 2021-01-15 技术研究及发展基金有限公司 包含pten抑制剂的囊泡及其用途
CN112236130A (zh) * 2018-04-09 2021-01-15 得克萨斯州大学系统董事会 使用外排体对癌基因的治疗性靶向
US20210115449A1 (en) * 2018-04-19 2021-04-22 Board Of Regents, The University Of Texas System Therapeutic modulation of tumor suppressors using exosomes
CN108635372A (zh) * 2018-05-17 2018-10-12 广东芙金干细胞再生医学有限公司 一种人间充质干细胞源外泌体的生物制剂的制备方法
CN108587998B (zh) * 2018-05-17 2021-05-18 浙江大学 一种外泌体、外泌体的制备方法及其在制备皮肤浅表性肿瘤的药物中的应用
CN108866058B (zh) * 2018-07-12 2021-09-10 苏州吉玛基因股份有限公司 靶向KRAS的siRNA及其在制备胰腺癌治疗药物中的应用
CN108865976B (zh) * 2018-07-19 2022-06-28 复旦大学附属中山医院 一种离散汲取收集外泌体(exosome)的方法及试剂
CN108815187A (zh) * 2018-07-20 2018-11-16 深圳市第二人民医院 一种包含人关节液外泌体的制剂及其使用方法
AU2019314475A1 (en) * 2018-08-01 2021-02-18 The Regents Of The University Of Colorado A Body Corporate Programmable designer therapeutic fusogenic secreted gectosome vesicles for macromolecule delivery and genome modification
CN110960688A (zh) * 2018-09-30 2020-04-07 复旦大学 用于提高胰腺癌疗效的低毒仿生化纳米系统及制备方法
EP3870700A1 (en) 2018-10-24 2021-09-01 Codiak BioSciences, Inc. Methods to improve potency of electroporation
EP3918327A4 (en) * 2019-01-31 2022-11-23 National University of Singapore METHOD FOR DETECTION OF A NEURODEGENERATIVE DISEASE
EP3920889A4 (en) * 2019-02-08 2022-12-07 Board of Regents, The University of Texas System TELOMERASE-CONTAINING EXOSOMES FOR THE TREATMENT OF DISEASES RELATED TO AGE-RELATED ORGANDYS FUNCTION
EP3946269A4 (en) * 2019-03-27 2023-05-03 University of Georgia Research Foundation, Inc. METHODS FOR MAKING TARGETED VESICLES, AND COMPOSITIONS SO MADE
CN110004110A (zh) * 2019-04-09 2019-07-12 江苏省人民医院（南京医科大学第一附属医院） 一种肠道外泌体提取方法
CA3137525A1 (en) * 2019-04-23 2020-10-29 Children's Medical Center Corporation Use of rab7 gtpase (rab7) inhibitors in enhancing permeability of the blood brain barrier (bbb)
JP2022544290A (ja) * 2019-08-14 2022-10-17 コディアック バイオサイエンシーズ， インコーポレイテッド Ｋｒａｓを標的とするアンチセンスオリゴヌクレオチドを有する細胞外小胞
CN114173807B (zh) * 2019-09-02 2024-03-19 庆北大学校产学协力团 包含il-2表面表达-细胞外囊泡作为活性成分的用于预防或治疗癌症的组合物
CN112823811B (zh) * 2019-11-18 2022-07-29 深圳先进技术研究院 一种跨越血脑屏障和特异性靶向脑胶质瘤治疗药物的投递系统的制备方法
US20230013636A1 (en) * 2019-12-05 2023-01-19 Board Of Regents, The University Of Texas System Exosomes-based therapy for liver fibrosis and other diseases with fibrosis
CN112972702A (zh) * 2019-12-17 2021-06-18 南京大学 用于治疗耐药菌感染的外泌体制剂
US20210338822A1 (en) * 2020-01-22 2021-11-04 Agex Therapeutics, Inc. Therapeutic exosomes and method of producing them
CN111358957B (zh) * 2020-03-06 2024-03-26 西安组织工程与再生医学研究所 磁性纳米颗粒
CN114164276B (zh) * 2020-03-30 2022-05-20 中国医学科学院肿瘤医院 用于肺癌诊断的试剂盒、装置及方法
CA3169550A1 (en) * 2020-04-07 2021-10-14 Chad PECOT Methods and compositions using rna interference and antisense oligonucleotides for inhibition of kras
WO2022120366A1 (en) * 2020-12-02 2022-06-09 Northwestern University Methods and compositions for the treatment of coronavirus infection, including sars-cov-2
CN113144222B (zh) * 2021-04-14 2023-05-23 台州学院 外泌体用于防止脑型疟疾发生的实验方法
IT202100021779A1 (it) * 2021-08-11 2023-02-11 Plasfer S R L Piastrine trasfettate con sirna e loro usi terapeutici
CN115990261B (zh) * 2021-10-20 2024-01-05 光武惠文生物科技(北京)有限公司 外泌体冻干粉针剂或外泌体液体制剂的保护剂
WO2023102550A2 (en) 2021-12-03 2023-06-08 The Broad Institute, Inc. Compositions and methods for efficient in vivo delivery
WO2024039896A1 (en) * 2022-08-19 2024-02-22 Northeastern University Cationic peptide/protein-modified exosomes for applications in drug delivery
CN115895998A (zh) * 2022-11-16 2023-04-04 大连理工大学 一种不同植物组织来源的完整外泌体的分离方法

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824311A (en) 1987-11-30 1998-10-20 Trustees Of The University Of Pennsylvania Treatment of tumors with monoclonal antibodies against oncogene antigens
US4870287A (en) 1988-03-03 1989-09-26 Loma Linda University Medical Center Multi-station proton beam therapy system
US5801029A (en) 1993-02-16 1998-09-01 Onyx Pharmaceuticals, Inc. Cytopathic viruses for therapy and prophylaxis of neoplasia
US5801005A (en) 1993-03-17 1998-09-01 University Of Washington Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated
GB9506466D0 (en) 1994-08-26 1995-05-17 Prolifix Ltd Cell cycle regulated repressor and dna element
US5760395A (en) 1996-04-18 1998-06-02 Universities Research Assoc., Inc. Method and apparatus for laser-controlled proton beam radiology
US5739169A (en) 1996-05-31 1998-04-14 Procept, Incorporated Aromatic compounds for inhibiting immune response
US20030064949A1 (en) 1998-02-17 2003-04-03 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
US6391582B2 (en) 1998-08-14 2002-05-21 Rigel Pharmaceuticlas, Inc. Shuttle vectors
FR2785543B1 (fr) 1998-11-05 2003-02-28 Inst Nat Sante Rech Med Exosomes modifies et utilisations
GB9927320D0 (en) 1999-11-18 2000-01-12 Chiron Spa Exosome separation
US6812023B1 (en) 2000-04-27 2004-11-02 Anosys, Inc. Methods of producing membrane vesicles
CA2411542A1 (en) 2000-06-09 2001-12-13 Teni Boulikas Encapsulation of polynucleotides and drugs into targeted liposomes
HU230458B1 (hu) 2000-12-01 2016-07-28 Europäisches Laboratorium für Molekularbiologie (EMBL) Az RNS interferenciát közvetítő kis RNS molekulák
EP1381276A4 (en) 2001-04-13 2005-02-02 Univ Pennsylvania METHOD FOR TREATMENT OR DEVELOPMENT SLUDGE DEGRADATION
US20050159378A1 (en) 2001-05-18 2005-07-21 Sirna Therapeutics, Inc. RNA interference mediated inhibition of Myc and/or Myb gene expression using short interfering nucleic acid (siNA)
FR2827872A1 (fr) 2001-07-30 2003-01-31 Roussy Inst Gustave Vesicules membranaires de fluide biologique preleve in vivo, leur preparation et utilisation dans la stimulation d'une reponse immunitaire
EP1417229B1 (en) 2001-08-17 2011-06-15 Exothera L.L.C. Methods and compounds for the targeting of protein to exosomes
WO2003044166A2 (en) 2001-11-15 2003-05-30 The Regents Of The University Of California METHODS AND COMPOSITIONS FOR REGULATION OF GENE EXPRESSION THROUGH MODULATION OF mRNA TURNOVER
US7405292B2 (en) 2002-02-19 2008-07-29 The Children's Hospital Of Philadelphia Cellular genes regulated by HIV-1 infection and methods of use thereof
US7803906B2 (en) 2002-03-22 2010-09-28 Gene Signal International Sa Composition comprising an angiogenesis related protein
KR100519384B1 (ko) 2002-08-13 2005-10-06 (주)누백스 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도
WO2004100987A2 (en) 2003-05-06 2004-11-25 Regeneron Pharmaceuticals, Inc. Methods of using il-1 antagonists to treat neointimal hyperplasia
EP1766053A4 (en) 2004-06-02 2007-12-12 Sourcepharm Inc MICROVESICLES CONTAINING RNA AND METHODS
GB0416120D0 (en) 2004-07-19 2004-08-18 Health Prot Agency Stable compositions containing OMV's
ES2439641T3 (es) 2005-12-20 2014-01-24 Bristol-Myers Squibb Company Composiciones y procedimientos de producción de una composición
US9085778B2 (en) 2006-05-03 2015-07-21 VL27, Inc. Exosome transfer of nucleic acids to cells
EP2613149B1 (en) 2007-07-25 2014-09-17 University Of Louisville Research Foundation, Inc. Exosome-associated microRNA as a diagnostic marker
JP5769417B2 (ja) 2007-08-16 2015-08-26 ザ ロイヤル インスティチューション フォー ザ アドバンスメント オブ ラーニング／マギル ユニバーシティ 腫瘍細胞由来微小胞
CN102084000B (zh) 2008-02-01 2016-03-16 总医院有限公司 微泡在医学疾病和病况的诊断、预后以及治疗中的用途
CN104031984A (zh) 2008-02-28 2014-09-10 俄亥俄州立大学研究基金会 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物
US20110177054A1 (en) 2008-06-06 2011-07-21 Derrick Gibbings Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
CN102301002A (zh) 2008-11-12 2011-12-28 卡里斯生命科学卢森堡控股有限责任公司 使用外来体来确定表现型的方法和系统
PT2419144T (pt) 2009-04-17 2019-09-16 Univ Oxford Innovation Ltd Composição para a administração de material genético
KR101314868B1 (ko) 2009-07-01 2013-10-08 주식회사이언메딕스 포유류의 유핵세포에서 유래된 마이크로베시클 및 이의 용도
US20120315324A1 (en) * 2010-02-05 2012-12-13 University Of Louisville Research Foundation, Inc. Exosomal compositions and methods for the treatment of disease
JP2013526852A (ja) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス 疾患に対する循環バイオマーカー
WO2011126010A1 (ja) * 2010-04-06 2011-10-13 三菱化学株式会社 癌細胞選択的膜透過性ペプチドおよびその利用
US10081542B2 (en) 2010-04-20 2018-09-25 University of Florida Research Foundation, lnc. Nanozymes, methods of making nanozymes, and methods of using nanozymes
WO2011147086A1 (zh) 2010-05-26 2011-12-01 江苏命码生物科技有限公司 载有干扰核糖核酸的细胞微粒子、其制备方法及其应用
CN101869715A (zh) 2010-05-26 2010-10-27 江苏命码生物科技有限公司 载有干扰核糖核酸的细胞微粒子、其制备方法及其应用
WO2011147175A1 (zh) 2010-05-26 2011-12-01 Zhang Chenyu 细胞微粒子-siRNA复合物的制备及其在艾滋病治疗中的应用
EP2603592A2 (en) 2010-08-13 2013-06-19 The University Court of the University of Glasgow Therapeutic uses of microvesicles and related micrornas
WO2012048372A1 (en) 2010-10-11 2012-04-19 Medsaic Pty Ltd Assay for disease detection
SG192226A1 (en) 2011-01-31 2013-09-30 Esoterix Genetic Lab Llc Methods for enriching microparticles or nucleic acids using binding molecules
CN109432126B (zh) 2011-03-11 2022-06-14 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物
WO2012131733A2 (en) 2011-03-31 2012-10-04 Godavari Biorefineries Limited Media compositions, method of initiating and enriching cultures of stem cells and/or cancer stem-like cells
ES2685333T3 (es) * 2011-06-02 2018-10-08 The Regents Of The University Of California Nanopartículas encapsuladas en membrana y método de utilización
EP2742154A4 (en) 2011-08-08 2015-08-12 Caris Life Sciences Switzerland Holdings Gmbh BIOMARKER COMPOSITIONS AND METHODS
GB201121070D0 (en) * 2011-12-07 2012-01-18 Isis Innovation composition for delivery of biotherapeutics
US9777042B2 (en) 2011-12-15 2017-10-03 Morehouse School Of Medicine Method of purifying HIV/SIV Nef from exosomal fusion proteins
WO2013138427A1 (en) 2012-03-16 2013-09-19 The General Hospital Corporation Microvesicle-mediated delivery of therapeutic molecules
US20130273544A1 (en) 2012-04-17 2013-10-17 Life Technologies Corporation Methods and compositions for exosome isolation
KR20150006477A (ko) * 2012-05-09 2015-01-16 그래댈리스, 인코포레이티드 단일-뉴클레오타이드 ｋｒａｓ 돌연변이에 특이적인 이-기능성 짧은-헤어핀 ｒｎａ (ｂｉ-ｓｈｒｎａ)
US9076953B2 (en) * 2012-05-09 2015-07-07 Qualcomm Incorporated Spin transistors employing a piezoelectric layer and related memory, memory systems, and methods
WO2013185032A1 (en) * 2012-06-07 2013-12-12 President And Fellows Of Harvard College Nanotherapeutics for drug targeting
WO2014076137A1 (en) 2012-11-13 2014-05-22 Lötvall Jan Delivery of therapeutic agent
US20150301058A1 (en) 2012-11-26 2015-10-22 Caris Science, Inc. Biomarker compositions and methods
EP3825401A1 (en) 2012-12-12 2021-05-26 The Broad Institute, Inc. Crispr-cas component systems, methods and compositions for sequence manipulation
MX2015013141A (es) 2013-03-15 2016-06-21 Univ Texas Biogénesis de miarn en exosomas para diagnóstico y terapia.
JP6137894B2 (ja) * 2013-03-22 2017-05-31 国立大学法人京都大学 リポソーム−エキソソームハイブリッドベシクル及びその調製法
EP3335721A1 (en) * 2013-04-12 2018-06-20 Evox Therapeutics Limited Therapeutic delivery vesicles
KR20150043937A (ko) 2013-10-15 2015-04-23 삼성전자주식회사 개체의 간암 진단용 조성물, 개체의 간암 진단하는 방법 및 개체의 간암 진단에 필요한 정보를 얻는 방법
EP3076949B1 (en) 2013-12-04 2019-09-04 Board of Regents, The University of Texas System Method for isolating cancer cell-derived exoxomes
CN106536729A (zh) 2013-12-12 2017-03-22 布罗德研究所有限公司 使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用
CA2964114A1 (en) 2014-10-09 2016-04-14 Anthrogenesis Corporation Placenta-derived adherent cell exosomes and uses thereof
US20160113966A1 (en) 2014-10-27 2016-04-28 Hans Klingemann Composition and methods of culture supernatant of khyg-1 cells
WO2016077639A2 (en) 2014-11-12 2016-05-19 VL27, Inc. Nanovesicular therapies
EP3307890A1 (en) 2015-06-10 2018-04-18 Board of Regents, The University of Texas System Use of exosomes for the treatment of disease
EP3368665A4 (en) 2015-10-30 2019-08-28 National Health Research Institutes MDCK CELL LINES IN SUSPENSION IN CHEMICALLY DEFINED SERUM-FREE MEDIA FOR VACCINE PRODUCTION
KR20180122433A (ko) 2016-03-15 2018-11-12 코디악 바이오사이언시즈, 인크. 치료용 막 소포
EP3500244A4 (en) 2016-08-22 2020-05-13 Codiak BioSciences, Inc. METHOD FOR SUPPRESSING THE DELIVERY OF EXOSOMES TO LIVER AND SPLEEN
IL259023B (en) * 2016-09-30 2022-09-01 Cellex Life Sciences Incorporated Preparations containing protein-charged exosomes, methods for their production and uses thereof

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