HK1216184A1 - 種血漿中游離的目標 低頻突變富集測序方法 - Google Patents

種血漿中游離的目標 低頻突變富集測序方法

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Publication number
HK1216184A1
HK1216184A1 HK16104032.4A HK16104032A HK1216184A1 HK 1216184 A1 HK1216184 A1 HK 1216184A1 HK 16104032 A HK16104032 A HK 16104032A HK 1216184 A1 HK1216184 A1 HK 1216184A1
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Hong Kong
Prior art keywords
dna
low
sequencing method
free target
frequency mutation
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HK16104032.4A
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English (en)
Inventor
吕小星
易鑫
趙美茹
管彥芳
劉濤
楊玲
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Beijing Geneplus Tech Co Ltd
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Publication of HK1216184A1 publication Critical patent/HK1216184A1/zh

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HK16104032.4A 2015-08-10 2016-04-08 種血漿中游離的目標 低頻突變富集測序方法 HK1216184A1 (zh)

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CN201510487759.1A CN105063208B (zh) 2015-08-10 2015-08-10 一种血浆中游离的目标dna低频突变富集测序方法

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US (1) US11001837B2 (zh)
CN (1) CN105063208B (zh)
HK (1) HK1216184A1 (zh)
WO (1) WO2017024784A1 (zh)

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CN105063208B (zh) * 2015-08-10 2018-03-06 北京吉因加科技有限公司 一种血浆中游离的目标dna低频突变富集测序方法
CN105602938A (zh) * 2016-01-22 2016-05-25 北京圣谷同创科技发展有限公司 血浆cfDNA提取方法
CN105950709A (zh) * 2016-03-30 2016-09-21 广州精科生物技术有限公司 试剂盒、建库方法以及检测目标区域变异的方法及系统
CN106047998B (zh) * 2016-05-27 2019-11-12 深圳市海普洛斯生物科技有限公司 一种肺癌基因的检测方法及应用
CN105950739A (zh) * 2016-05-30 2016-09-21 哈尔滨医科大学 用于人乳腺癌循环肿瘤dna检测的探针及其用途
CN107723351A (zh) * 2016-08-12 2018-02-23 嘉兴允英医学检验有限公司 一种循环肿瘤dna肺癌驱动基因的高通量检测方法
CN107723352A (zh) * 2016-08-12 2018-02-23 嘉兴允英医学检验有限公司 一种循环肿瘤dna肝癌驱动基因高通量检测方法
CN107881230A (zh) * 2016-09-30 2018-04-06 复旦大学 一种检测肺癌血浆游离目标dna多位点低频突变的方法和试剂盒
CN106570349B (zh) * 2016-10-28 2019-05-14 深圳华大基因科技服务有限公司 用于目标区域捕获高通量测序的特异性肿瘤探针区域设计方法和装置以及探针
CN106676169B (zh) * 2016-11-15 2021-01-12 上海派森诺医学检验所有限公司 一种用于乳腺癌易感基因brca1和brca2突变检测的杂交捕获试剂盒及其方法
CN108070586A (zh) * 2016-11-18 2018-05-25 杭州拓宏生物科技有限公司 Pcr扩增引物及其应用
CN106755505A (zh) * 2016-12-27 2017-05-31 安诺优达基因科技(北京)有限公司 用于检测血浆ctDNA中基因变异的试剂盒
CN108256294A (zh) * 2016-12-29 2018-07-06 安诺优达基因科技(北京)有限公司 一种用于检测体细胞突变的装置
CN106834275A (zh) * 2017-02-22 2017-06-13 天津诺禾医学检验所有限公司 ctDNA超低频突变检测文库的构建方法、试剂盒及文库检测数据的分析方法
CN108660135B (zh) * 2017-03-31 2022-09-02 天津华大医学检验所有限公司 一种用于dna建库的试剂盒及其应用
CN108315321A (zh) * 2017-03-31 2018-07-24 索真（北京）医学科技有限公司 尿液ctDNA中K-ras基因突变位点的检测
CA3220983A1 (en) * 2017-05-01 2018-11-08 Illumina, Inc. Optimal index sequences for multiplex massively parallel sequencing
CN107446996A (zh) * 2017-07-14 2017-12-08 艾吉泰康生物科技(北京)有限公司 一种检测靶序列的超低频突变的接头序列及方法
CN107523563A (zh) * 2017-09-08 2017-12-29 杭州和壹基因科技有限公司 一种用于循环肿瘤dna分析的生物信息处理方法
CN107545152A (zh) * 2017-09-18 2018-01-05 杭州和壹基因科技有限公司 一种基于Illumina数据找变异的方法
CN107782903B (zh) * 2017-10-18 2020-02-04 江西省妇幼保健院 一种通过Sufu蛋白阳性表达情况对宫颈鳞癌恶性程度的评价方法
CN107881232A (zh) * 2017-10-26 2018-04-06 上海仁东医学检验所有限公司 探针组合物及基于ngs方法检测肺癌和结直肠癌基因的应用
CN108048915A (zh) * 2017-12-01 2018-05-18 北京科迅生物技术有限公司 用于ctDNA文库构建的接头混合物、包括其的试剂盒及应用
CN108866174B (zh) * 2017-12-25 2023-05-19 厦门基源医疗科技有限公司 一种循环肿瘤dna低频突变的检测方法
CN108103160A (zh) * 2017-12-27 2018-06-01 沃森克里克（北京）生物科技有限公司 一种XPC基因rs2228001位点SNP核酸质谱检测方法
CN110029041B (zh) * 2018-01-12 2022-07-12 浙江安诺优达生物科技有限公司 基因检测芯片区域设计装置
JP2021513342A (ja) * 2018-02-12 2021-05-27 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 腫瘍の遺伝的不均一性を評価することによって治療法に対する応答を予測する方法
CA3093092A1 (en) * 2018-03-06 2019-09-12 Cancer Research Technology Limited Improvements in variant detection
CN110241209B (zh) * 2018-03-09 2022-11-29 浙江品级基因科技有限公司 一种引物、试剂盒及用途
CN108676845A (zh) * 2018-04-13 2018-10-19 深圳蓝图基因科技有限公司 利用crispr技术剪切非突变靶点以凸显低频突变的方法
CN108531583B (zh) * 2018-05-18 2022-05-17 中国人民解放军陆军军医大学第一附属医院 用于无创检测mitf基因突变的引物组合及检测方法
CN108486230B (zh) * 2018-05-18 2022-02-08 中国人民解放军陆军军医大学第一附属医院 用于无创检测mitf基因突变的试剂盒及其制备方法
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